Svend Kjaer

O-linked sialoglycans modulate the proteolysis of SARS-CoV-2 spike and likely contribute to the mutational trajectory in variants of concern

Authors (22)

Edgar Gonzalez-Rodriguez
Mia Zol-Hanlon
Ganka Bineva-Todd
Andrea Marchesi
Mark Skehel
Keira E Mahoney
[...]
Robert Wilkinson
Emma C Wall
Ramón Hurtado-Guerrero
Stacy A Malaker
Ben Schumann

ACS Central Science

Published 22 March 2023

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Strong peak immunogenicity but rapid antibody waning following third vaccine dose in older residents of care homes

Authors (68)

G Tut
T Lancaster
M Krutikov
P Sylla
D Bone
E Spalkova
[...]
A Irwin-Singer
A Hayward
A Copas
L Shallcross
P Moss

Nature Aging

Published 1 January 2023

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Cell-specific bioorthogonal tagging of glycoproteins

Authors (31)

Anna Cioce
Bea Calle
Tatiana Rizou
Sarah C Lowery
Vicky Bridgeman
Keira E Mahoney
[...]
Stuart M Haslam
Sabine L Flitsch
Stacy A Malaker
Ilaria Malanchi
Ben Schumann

Nature Communications

Published 25 October 2022

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WHO's therapeutics and COVID-19 living guideline on mAbs needs to be reassessed

Authors (19)

Mary Wu
Edward Carr
Ruth Harvey
Harriet Mears
Svend Kjaer
Hermaleigh Townsley
[...]
Bryan Williams
Sonia Gandhi
Charles Swanton
Emma C Wall
David LV Bauer

The Lancet

Published 17 December 2022

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Functional immune responses against SARS-CoV-2 variants of concern after fourth COVID-19 vaccine dose or infection in patients with blood cancer

Authors (64)

Annika Fendler
Scott Shepherd
Lewis Au
Mary Wu
Ruth Harvey
Katalin Wilkinson
[...]
Emma Nicholson
Susanna Walker
Robert Wilkinson
James Larkin
Samra Turajlic

Cell Reports Medicine

Published 18 October 2022

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Structural analysis and development of Notum fragment screening hits

Authors (21)

Yuguang Zhao
William Mahy
Nicky J Willis
Hannah L Woodward
David Steadman
Elliott D Bayle
[...]
Patricia C Salinas
Paul Whiting
Jean-Paul Vincent
Paul V Fish
E Yvonne Jones

ACS Chemical Neuroscience

Published 6 July 2022

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Design of a potent, selective, and brain-penetrant inhibitor of Wnt-deactivating enzyme Notum by optimization of a crystallographic fragment hit

Authors (24)

Nicky J Willis
William Mahy
James Sipthorp
Yuguang Zhao
Hannah L Woodward
Benjamin N Atkinson
[...]
Patricia C Salinas
Jean-Paul Vincent
E Yvonne Jones
Paul Whiting
Paul V Fish

Journal of Medicinal Chemistry

Published 26 May 2022

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Omicron neutralising antibodies after third COVID-19 vaccine dose in patients with cancer

Authors (62)

Annika Fendler
Scott Shepherd
Lewis Au
Mary Wu
Ruth Harvey
Andreas M Schmitt
[...]
Emma Nicholson
Susanna Walker
James Larkin
Samra Turajlic
The CAPTURE consortium

The Lancet

Published 5 March 2022

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Three-dose vaccination elicits neutralising antibodies against omicron

Authors (26)

Mary Wu
Emma C Wall
Edward Carr
Ruth Harvey
Hermaleigh Townsley
Harriet Mears
[...]
Vincenzo Libri
Bryan Williams
Sonia Gandhi
Charles Swanton
David LV Bauer

The Lancet

Published 19 February 2022

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Immune responses following third COVID-19 vaccination are reduced in patients with hematological malignancies compared to patients with solid cancer

Authors (65)

Annika Fendler
Scott Shepherd
Lewis Au
Katalin Wilkinson
Mary Wu
Andreas M Schmitt
[...]
Susanna Walker
Robert Wilkinson
James Larkin
Samra Turajlic
CAPTURE consortium

Cancer Cell

Published 14 February 2022

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Neutralising antibodies after COVID-19 vaccination in UK haemodialysis patients

Authors (86)

The Lancet

Published 18 September 2021

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Reduced antibody cross-reactivity following infection with B.1.1.7 than with parental SARS-CoV-2 strains

Authors (30)

Nikhil Faulkner
Kevin Ng
Mary Wu
Ruth Harvey
Marios Margaritis
Stavroula Paraskevopoulou
[...]
Michael Howell
David LV Bauer
Eleni Nastouli
SAFER Investigators
George Kassiotis

eLife

Published 29 July 2021

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MICAL2 enhances branched actin network disassembly by oxidizing Arp3B-containing Arp2/3 complexes

Authors (10)

Chiara Galloni
Davide Carra
Jasmine VG Abella
Svend Kjaer
Pavithra Singaravelu
David Barry
Naoko Kogata
Christophe Guérin
Laurent Blanchoin
Michael Way

Journal of Cell Biology

Published 2 August 2021

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SARS-CoV-2 can recruit a haem metabolite to evade antibody immunity

Authors (40)

Annachiara Rosa
Val Pye
Carl Graham
Luke Muir
Jeffrey Seow
Kevin Ng
[...]
Richard S Tedder
George Kassiotis
Laura E Mccoy
Katie J Doores
Peter Cherepanov

Science advances

Published 28 May 2021

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Optimization of metabolic oligosaccharide engineering with Ac4GalNAlk and Ac4GlcNAlk by an engineered pyrophosphorylase

Authors (14)

Anna Cioce
Ganka Bineva-Todd
Anthony J Agbay
Junwon Choi
Thomas M Wood
Marjoke F Debets
[...]
Omur Yilmaz Tastan
Svend Kjaer
Jacob T Bush
Carolyn R Bertozzi
Ben Schumann

ACS Chemical Biology

Published 15 October 2021

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Mutations in SKI in Shprintzen-Goldberg syndrome lead to attenuated TGF-β responses through SKI stabilization

Authors (11)

Ilaria Gori
Roger George
Andrew G Purkiss
Stephanie Strohbuecker
Rebecca A Randall
Roksana Ogrodowicz
Virginie Carmignac
Laurence Faivre
Dhira Joshi
Svend Kjaer
Caroline Hill

eLife

Published 8 January 2021

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Preexisting and de novo humoral immunity to SARS-CoV-2 in humans

Authors (47)

Kevin Ng
Nikhil Faulkner
Georgina H Cornish
Annachiara Rosa
Ruth Harvey
Saira Hussain
[...]
Steve Gamblin
Laura E Mccoy
Peter Cherepanov
Eleni Nastouli
George Kassiotis

Science

Published 11 December 2020

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5-Phenyl-1,3,4-oxadiazol-2(3H)-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit

Authors (18)

William Mahy
Nicky J Willis
Yuguang Zhao
Hannah L Woodward
Fredrik Svensson
James Sipthorp
[...]
Patricia C Salinas
Paul Whiting
Jean-Paul Vincent
E Yvonne Jones
Paul V Fish

Journal of Medicinal Chemistry

Published 12 November 2020

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Crick Pre-Crick

O-linked sialoglycans modulate the proteolysis of SARS-CoV-2 spike and likely contribute to the mutational trajectory in variants of concern

Strong peak immunogenicity but rapid antibody waning following third vaccine dose in older residents of care homes

Cell-specific bioorthogonal tagging of glycoproteins

WHO's therapeutics and COVID-19 living guideline on mAbs needs to be reassessed

Functional immune responses against SARS-CoV-2 variants of concern after fourth COVID-19 vaccine dose or infection in patients with blood cancer

SARS-CoV-2 S2-targeted vaccination elicits broadly neutralizing antibodies

Structural analysis and development of Notum fragment screening hits

Design of a potent, selective, and brain-penetrant inhibitor of Wnt-deactivating enzyme Notum by optimization of a crystallographic fragment hit

Omicron neutralising antibodies after third COVID-19 vaccine dose in patients with cancer

Three-dose vaccination elicits neutralising antibodies against omicron

Immune responses following third COVID-19 vaccination are reduced in patients with hematological malignancies compared to patients with solid cancer

Neutralising antibodies after COVID-19 vaccination in UK haemodialysis patients

Reduced antibody cross-reactivity following infection with B.1.1.7 than with parental SARS-CoV-2 strains

Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp13 helicase

MICAL2 enhances branched actin network disassembly by oxidizing Arp3B-containing Arp2/3 complexes

SARS-CoV-2 can recruit a haem metabolite to evade antibody immunity

Optimization of metabolic oligosaccharide engineering with Ac4GalNAlk and Ac4GlcNAlk by an engineered pyrophosphorylase

Mutations in SKI in Shprintzen-Goldberg syndrome lead to attenuated TGF-β responses through SKI stabilization

Preexisting and de novo humoral immunity to SARS-CoV-2 in humans

5-Phenyl-1,3,4-oxadiazol-2(3H)-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit

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