Svend Kjaer

WHO's therapeutics and COVID-19 living guideline on mAbs needs to be reassessed

Authors (19)

Mary Wu
Edward Carr
Ruth Harvey
Harriet Mears
Svend Kjaer
Hermaleigh Townsley
[...]
Bryan Williams
Sonia Gandhi
Charles Swanton
Emma C Wall
David LV Bauer

The Lancet

Published 17 December 2022

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Functional immune responses against SARS-CoV-2 variants of concern after fourth COVID-19 vaccine dose or infection in patients with blood cancer

Authors (64)

Annika Fendler
Scott Shepherd
Lewis Au
Mary Wu
Ruth Harvey
Katalin Wilkinson
[...]
Emma Nicholson
Susanna Walker
Robert Wilkinson
James Larkin
Samra Turajlic

Cell Reports Medicine

Published 18 October 2022

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Structural analysis and development of Notum fragment screening hits

Authors (21)

Yuguang Zhao
William Mahy
Nicky J Willis
Hannah L Woodward
David Steadman
Elliott D Bayle
[...]
Patricia C Salinas
Paul Whiting
Jean-Paul Vincent
Paul V Fish
E Yvonne Jones

ACS Chemical Neuroscience

Published 6 July 2022

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Design of a potent, selective, and brain-penetrant inhibitor of Wnt-deactivating enzyme Notum by optimization of a crystallographic fragment hit

Authors (24)

Nicky J Willis
William Mahy
James Sipthorp
Yuguang Zhao
Hannah L Woodward
Benjamin N Atkinson
[...]
Patricia C Salinas
Jean-Paul Vincent
E Yvonne Jones
Paul Whiting
Paul V Fish

Journal of Medicinal Chemistry

Published 26 May 2022

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Omicron neutralising antibodies after third COVID-19 vaccine dose in patients with cancer

Authors (62)

Annika Fendler
Scott Shepherd
Lewis Au
Mary Wu
Ruth Harvey
Andreas M Schmitt
[...]
Emma Nicholson
Susanna Walker
James Larkin
Samra Turajlic
The CAPTURE consortium

The Lancet

Published 5 March 2022

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Three-dose vaccination elicits neutralising antibodies against omicron

Authors (26)

Mary Wu
Emma C Wall
Edward Carr
Ruth Harvey
Hermaleigh Townsley
Harriet Mears
[...]
Vincenzo Libri
Bryan Williams
Sonia Gandhi
Charles Swanton
David LV Bauer

The Lancet

Published 19 February 2022

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Immune responses following third COVID-19 vaccination are reduced in patients with hematological malignancies compared to patients with solid cancer

Authors (65)

Annika Fendler
Scott Shepherd
Lewis Au
Katalin Wilkinson
Mary Wu
Andreas M Schmitt
[...]
Susanna Walker
Robert Wilkinson
James Larkin
Samra Turajlic
CAPTURE consortium

Cancer Cell

Published 14 February 2022

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Neutralising antibodies after COVID-19 vaccination in UK haemodialysis patients

Authors (86)

The Lancet

Published 18 September 2021

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Reduced antibody cross-reactivity following infection with B.1.1.7 than with parental SARS-CoV-2 strains

Authors (30)

Nikhil Faulkner
Kevin Ng
Mary Wu
Ruth Harvey
Marios Margaritis
Stavroula Paraskevopoulou
[...]
Michael Howell
David LV Bauer
Eleni Nastouli
SAFER Investigators
George Kassiotis

eLife

Published 29 July 2021

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MICAL2 enhances branched actin network disassembly by oxidizing Arp3B-containing Arp2/3 complexes

Authors (10)

Chiara Galloni
Davide Carra
Jasmine VG Abella
Svend Kjaer
Pavithra Singaravelu
David Barry
Naoko Kogata
Christophe Guérin
Laurent Blanchoin
Michael Way

Journal of Cell Biology

Published 2 August 2021

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SARS-CoV-2 can recruit a haem metabolite to evade antibody immunity

Authors (40)

Annachiara Rosa
Val Pye
Carl Graham
Luke Muir
Jeffrey Seow
Kevin Ng
[...]
Richard S Tedder
George Kassiotis
Laura E Mccoy
Katie J Doores
Peter Cherepanov

Science advances

Published 28 May 2021

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A two-site flexible clamp mechanism for RET-GDNF-GFRα1 assembly reveals both conformational adaptation and strict geometric spacing

Authors (14)

Sarah Adams
Andrew G Purkiss
Phillip P Knowles
Andrea Nans
David Briggs
Annabel Borg
[...]
Aaron J Borg
Pauline B McIntosh
Frankie Houghton
Svend Kjaer
Neil McDonald

Structure

Published 1 July 2021

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Mutations in SKI in Shprintzen-Goldberg syndrome lead to attenuated TGF-β responses through SKI stabilization

Authors (11)

Ilaria Gori
Roger George
Andrew G Purkiss
Stephanie Strohbuecker
Rebecca A Randall
Roksana Ogrodowicz
Virginie Carmignac
Laurence Faivre
Dhira Joshi
Svend Kjaer
Caroline Hill

eLife

Published 8 January 2021

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Preexisting and de novo humoral immunity to SARS-CoV-2 in humans

Authors (47)

Kevin Ng
Nikhil Faulkner
Georgina H Cornish
Annachiara Rosa
Ruth Harvey
Saira Hussain
[...]
Steve Gamblin
Laura E Mccoy
Peter Cherepanov
Eleni Nastouli
George Kassiotis

Science

Published 11 December 2020

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5-Phenyl-1,3,4-oxadiazol-2(3H)-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit

Authors (18)

William Mahy
Nicky J Willis
Yuguang Zhao
Hannah L Woodward
Fredrik Svensson
James Sipthorp
[...]
Patricia C Salinas
Paul Whiting
Jean-Paul Vincent
E Yvonne Jones
Paul V Fish

Journal of Medicinal Chemistry

Published 12 November 2020

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Metabolic precision labeling enables selective probing of O-linked N-acetylgalactosamine glycosylation

Authors (27)

Marjoke F Debets
Omur Yilmaz Tastan
Simon P Wisnovsky
Stacy A Malaker
Nikos Angelis
Leonhard KR Moeckl
[...]
Michael C Bassik
WE Moerner
Vivian Li
Carolyn R Bertozzi
Ben Schumann

Proceedings of the National Academy of Sciences of USA

Published 13 October 2020

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A small molecule inhibitor of HER3: a proof-of-concept study

Authors (17)

Audrey Colomba
Martina Fitzek
Roger George
Gregory Weitsman
Selene Roberts
Laura Zanetti-Domingues
[...]
Bram Snijders
Tony Ng
Marisa Martin-Fernandez
David M Smith
Peter Parker

Biochemical Journal

Published 10 September 2020

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Cryo-EM of human Arp2/3 complexes provides structural insights into actin nucleation modulation by ARPC5 isoforms

Authors (8)

Ottilie von Loeffelholz
Andrew Purkiss
Luyan Cao
Svend Kjaer
Naoko Kogata
Guillaume Romet-Lemonne
Michael Way
Carolyn A Moores

Biology Open

Published 31 July 2020

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Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers

Authors (341)

Catherine F Houlihan
Nina Vora
Thomas Byrne
Dan Lewer
Gavin Kelly
Judith Heaney
[...]
Andrew Hayward
Richard Gilson
Gavin Kelly
Fiona Roberts
Emine Hatipoglu

Scalable and robust SARS-CoV-2 testing in an academic center

Authors (81)

Jim Aitken
Karen Ambrose
Sam Barrell
Rupert Beale
Ganka Bineva-Todd
Dhruva Biswas
[...]
Sophie Ward
Wai Keong Wong
Joshua Wright
Mary Wu
The Crick COVID-19 Consortium

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Svend Kjaer

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Crick Pre-Crick

WHO's therapeutics and COVID-19 living guideline on mAbs needs to be reassessed

Functional immune responses against SARS-CoV-2 variants of concern after fourth COVID-19 vaccine dose or infection in patients with blood cancer

Structural analysis and development of Notum fragment screening hits

Design of a potent, selective, and brain-penetrant inhibitor of Wnt-deactivating enzyme Notum by optimization of a crystallographic fragment hit

Omicron neutralising antibodies after third COVID-19 vaccine dose in patients with cancer

Three-dose vaccination elicits neutralising antibodies against omicron

Immune responses following third COVID-19 vaccination are reduced in patients with hematological malignancies compared to patients with solid cancer

Neutralising antibodies after COVID-19 vaccination in UK haemodialysis patients

Reduced antibody cross-reactivity following infection with B.1.1.7 than with parental SARS-CoV-2 strains

MICAL2 enhances branched actin network disassembly by oxidizing Arp3B-containing Arp2/3 complexes

SARS-CoV-2 can recruit a haem metabolite to evade antibody immunity

A two-site flexible clamp mechanism for RET-GDNF-GFRα1 assembly reveals both conformational adaptation and strict geometric spacing

Mutations in SKI in Shprintzen-Goldberg syndrome lead to attenuated TGF-β responses through SKI stabilization

Preexisting and de novo humoral immunity to SARS-CoV-2 in humans

5-Phenyl-1,3,4-oxadiazol-2(3H)-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit

Metabolic precision labeling enables selective probing of O-linked N-acetylgalactosamine glycosylation

A small molecule inhibitor of HER3: a proof-of-concept study

Cryo-EM of human Arp2/3 complexes provides structural insights into actin nucleation modulation by ARPC5 isoforms

Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers

Scalable and robust SARS-CoV-2 testing in an academic center

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