Svend Kjaer

O-linked sialoglycans modulate the proteolysis of SARS-CoV-2 spike and likely contribute to the mutational trajectory in variants of concern

Authors (22)

Edgar Gonzalez-Rodriguez
Mia Zol-Hanlon
Ganka Bineva-Todd
Andrea Marchesi
Mark Skehel
Keira E Mahoney
[...]
Robert Wilkinson
Emma C Wall
Ramón Hurtado-Guerrero
Stacy A Malaker
Ben Schumann

ACS Central Science

Published 22 March 2023

Crick labs/ facilities

Full details

Cell-specific bioorthogonal tagging of glycoproteins

Authors (31)

Anna Cioce
Bea Calle
Tatiana Rizou
Sarah C Lowery
Vicky Bridgeman
Keira E Mahoney
[...]
Stuart M Haslam
Sabine L Flitsch
Stacy A Malaker
Ilaria Malanchi
Ben Schumann

Nature Communications

Published 25 October 2022

Crick labs/ facilities

Full details

Structural analysis and development of Notum fragment screening hits

Authors (21)

Yuguang Zhao
William Mahy
Nicky J Willis
Hannah L Woodward
David Steadman
Elliott D Bayle
[...]
Patricia C Salinas
Paul Whiting
Jean-Paul Vincent
Paul V Fish
E Yvonne Jones

ACS Chemical Neuroscience

Published 6 July 2022

Crick labs/ facilities

Full details

Design of a potent, selective, and brain-penetrant inhibitor of Wnt-deactivating enzyme Notum by optimization of a crystallographic fragment hit

Authors (24)

Nicky J Willis
William Mahy
James Sipthorp
Yuguang Zhao
Hannah L Woodward
Benjamin N Atkinson
[...]
Patricia C Salinas
Jean-Paul Vincent
E Yvonne Jones
Paul Whiting
Paul V Fish

Journal of Medicinal Chemistry

Published 26 May 2022

Crick labs/ facilities

Full details

Immune responses following third COVID-19 vaccination are reduced in patients with hematological malignancies compared to patients with solid cancer

Authors (65)

Annika Fendler
Scott Shepherd
Lewis Au
Katalin Wilkinson
Mary Wu
Andreas M Schmitt
[...]
Susanna Walker
Robert Wilkinson
James Larkin
Samra Turajlic
CAPTURE consortium

Cancer Cell

Published 14 February 2022

Crick labs/ facilities

Full details

Optimization of metabolic oligosaccharide engineering with Ac4GalNAlk and Ac4GlcNAlk by an engineered pyrophosphorylase

Authors (14)

Anna Cioce
Ganka Bineva-Todd
Anthony J Agbay
Junwon Choi
Thomas M Wood
Marjoke F Debets
[...]
Omur Yilmaz Tastan
Svend Kjaer
Jacob T Bush
Carolyn R Bertozzi
Ben Schumann

ACS Chemical Biology

Published 15 October 2021

Crick labs/ facilities

Full details

5-Phenyl-1,3,4-oxadiazol-2(3H)-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit

Authors (18)

William Mahy
Nicky J Willis
Yuguang Zhao
Hannah L Woodward
Fredrik Svensson
James Sipthorp
[...]
Patricia C Salinas
Paul Whiting
Jean-Paul Vincent
E Yvonne Jones
Paul V Fish

Journal of Medicinal Chemistry

Published 12 November 2020

Crick labs/ facilities

Full details

Metabolic precision labeling enables selective probing of O-linked N-acetylgalactosamine glycosylation

Authors (27)

Marjoke F Debets
Omur Yilmaz Tastan
Simon P Wisnovsky
Stacy A Malaker
Nikos Angelis
Leonhard KR Moeckl
[...]
Michael C Bassik
WE Moerner
Vivian Li
Carolyn R Bertozzi
Ben Schumann

Proceedings of the National Academy of Sciences of USA

Published 13 October 2020

Crick labs/ facilities

Full details

Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers

Authors (341)

Catherine F Houlihan
Nina Vora
Thomas Byrne
Dan Lewer
Gavin Kelly
Judith Heaney
[...]
Andrew Hayward
Richard Gilson
Gavin Kelly
Fiona Roberts
Emine Hatipoglu

Research case studies

Postdoctoral clinical fellows

Hello Brain!

News and reports

About us

Svend Kjaer

STP Deputy

Structural Biology

Year published

Research topics

Publication type

Journal

Crick Pre-Crick

O-linked sialoglycans modulate the proteolysis of SARS-CoV-2 spike and likely contribute to the mutational trajectory in variants of concern

Cell-specific bioorthogonal tagging of glycoproteins

Structural analysis and development of Notum fragment screening hits

Design of a potent, selective, and brain-penetrant inhibitor of Wnt-deactivating enzyme Notum by optimization of a crystallographic fragment hit

Immune responses following third COVID-19 vaccination are reduced in patients with hematological malignancies compared to patients with solid cancer

Optimization of metabolic oligosaccharide engineering with Ac4GalNAlk and Ac4GlcNAlk by an engineered pyrophosphorylase

5-Phenyl-1,3,4-oxadiazol-2(3H)-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit

Metabolic precision labeling enables selective probing of O-linked N-acetylgalactosamine glycosylation

Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers

The Francis Crick Institute is a unique partnership between