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Tom WatkinsLab: Cancer Evolution and Genome Instability LaboratoryJob Title: PhD Student Breadcrumb Home Research Researchers Tom Watkins Year published2020 (4)2019 (1)2018 (4)2017 (3)2016 (1)2015 (1) Facet Year publishedResearch topicsChemical Biology & High Throughput (14)Computational & Systems Biology (14)Developmental Biology (2)Gene Expression (4)Genetics & Genomics (14)Genome Integrity & Repair (14)Human Biology & Physiology (14)Model Organisms (2)Signalling & Oncogenes (14)Tumour Biology (14) Facet Research topicsCrick Pre-CrickCrick publications (14) Facet Crick Pre-CrickPublication typeJournal article (14)Primary research (14) Facet Publication typeJournalCancer Discovery (1)Cell (2)Cell Reports (1)International Journal of Cancer (1)Nature (4)Nature Genetics (2)Nature Medicine (1)New England Journal of Medicine (1)Science (1) Facet Journal Displaying 1 - 14 of 14Last updated : 24 January 2021 03:32 Pervasive chromosomal instability and karyotype order in tumour evolution Authors (55)Tom WatkinsEmilia Lim Marina Petkovic Sergi ElizaldeNicolai BirkbakGareth Wilson[...]Peter Van Loo Samuel F Bakhoum Roland F Schwarz Nicholas McGranahanCharles Swanton Nature Published 5 November 2020 Crick labs/ facilitiesPeter Van LooSamra TurajlicCharles SwantonNicholas LuscombeBioinformatics and BiostatisticsScientific computingFull details The National Lung Matrix Trial of personalized therapy in lung cancer Authors (27) Gary Middleton Peter Fletcher Sanjay Popat Joshua Savage Yvonne Summers Alastair Greystoke[...] Timothy A YapTom WatkinsEmilia LimCharles Swanton Lucinda Billingham Nature Published 30 July 2020 Crick labsCharles SwantonFull details Representative sequencing: Unbiased sampling of solid tumor tissue Authors (33)Kevin Litchfield Stacey Stanislaw Lavinia Spain Lisa L GallegosAndrew RowanDesiree Schnidrig[...] PEACE Consortium James LarkinCharles Swanton Nelson R AlexanderSamra Turajlic Cell Reports Published 5 May 2020 Crick labs/ facilitiesPeter Van LooSamra TurajlicCharles SwantonExperimental HistopathologyBioinformatics and BiostatisticsFull details Interplay between whole-genome doubling and the accumulation of deleterious alterations in cancer evolution Authors (17) Saioa LópezEmilia Lim Stuart HorswellKerstin HaaseAriana HuebnerMichelle Dietzen[...]Peter Van Loo Mariam Jamal-Hanjani TRACERx ConsortiumCharles Swanton Nicholas McGranahan Nature Genetics Published 5 March 2020 Crick labs/ facilitiesPeter Van LooCharles SwantonBioinformatics and BiostatisticsFull details A clonal expression biomarker associates with lung cancer mortality Authors (36)Dhruva BiswasNicolai BirkbakRachel Rosenthal Crispin T HileyEmilia Lim Krisztian Papp[...] Zoltan Szallasi Javier Herrero Nicholas McGranahanCharles Swanton TRACERx Consortium Nature Medicine Published 7 October 2019 Crick labs/ facilitiesCharles SwantonGenomics/Equipment ParkBioinformatics and BiostatisticsFull details Deterministic evolutionary trajectories influence primary tumor growth: TRACERx Renal Authors (71)Samra TurajlicHang XuKevin LitchfieldAndrew Rowan Stuart Horswell Tim Chambers[...]Peter Van Loo Peter Campbell James LarkinCharles Swanton TRACERx Renal Consortium Cell Published 19 April 2018 Crick labs/ facilitiesPeter Van LooSamra TurajlicCharles SwantonNicholas LuscombeExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Tracking cancer evolution reveals constrained routes to metastases: TRACERx Renal Authors (51)Samra TurajlicHang XuKevin LitchfieldAndrew Rowan Tim Chambers Jose I Lopez[...] Daniel L Burgess Nelson R AlexanderCharles Swanton PEACE TRACERx Renal Consortium Cell Published 19 April 2018 Crick labs/ facilitiesSamra TurajlicCharles SwantonExperimental HistopathologyBioinformatics and BiostatisticsScientific computingAdvanced SequencingFull details Expansion of airway basal epithelial cells from primary human non-small cell lung cancer tumors Authors (12)Rob Hynds Assma Ben Aissa Kate HC GowersTom Watkins Leticia Bosshard-CarterAndrew Rowan[...]Gareth Wilson Sergio A QuezadaCharles Swanton TRACERx Consortium Sam M Janes International Journal of Cancer Published 1 July 2018 Crick labsCharles SwantonFull details Chromosomal instability drives metastasis through a cytosolic DNA response Authors (33) Samuel F Bakhoum Bryan Ngo Ashley M Laughney Julie-Ann Cavallo Charles J Murphy Peter Ly[...] Don W Cleveland Simon N Powell Jan LammerdingCharles Swanton Lewis C Cantley Nature Published 25 January 2018 Crick labsCharles SwantonFull details Evolution and clinical impact of co-occurring genetic alterations in advanced-stage EGFR-mutant lung cancers Authors (29) Collin M BlakelyTom Watkins Wei Wu Beatrice Gini Jacob J Chabon Caroline E McCoach[...] Robert C Doebele Jonathan W Riess Maximilian DiehnCharles Swanton Trever G Bivona Nature Genetics Published 6 November 2017 Crick labsCharles SwantonFull details Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution Authors (105) Christopher AbboshNicolai BirkbakGareth Wilson Mariam Jamal-Hanjani Tudor Constantin Raheleh Salari[...] Jacqui A Shaw Bernhard G Zimmermann The TRACERx Consortium The PEACE ConsortiumCharles Swanton Nature Published 25 May 2017 Crick labs/ facilitiesPeter Van LooSamra TurajlicCharles SwantonBioinformatics and BiostatisticsAdvanced SequencingFull details Tracking the evolution of non-small-cell lung cancer Authors (84) Mariam Jamal-Hanjani Gareth A Wilson Nicholas McGranahanNicolai BirkbakTom WatkinsSelvaraju Veeriah[...]Peter Van Loo Caroline Dive Allan HackshawCharles Swanton The TRACERx Consortium New England Journal of Medicine Published 26 April 2017 Crick labs/ facilitiesPeter Van LooSamra TurajlicCharles SwantonBioinformatics and BiostatisticsAdvanced SequencingFull details Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade Authors (36) Nicholas McGranahan Andrew JS FurnessRachel Rosenthal Sofie Ramskov Rikke Lyngaa Sunil Kumar Saini[...] Karl S Peggs Timothy A Chan Sine R Hadrup Sergio A QuezadaCharles Swanton Science Published 25 March 2016 Crick labs/ facilitiesCharles SwantonBioinformatics and BiostatisticsFull details Tracking the genomic evolution of esophageal adenocarcinoma through neoadjuvant chemotherapy Authors (18) Nirupa MurugaesuGareth WilsonNicolai BirkbakTom Watkins Nicholas McGranahan Sacheen Kumar[...] Sharmin Begum Nik Matthews Daniel Hochhauser George B HannaCharles Swanton Cancer Discovery Published 1 August 2015 Crick labs/ facilitiesCharles SwantonBioinformatics and BiostatisticsAdvanced SequencingFull details
Pervasive chromosomal instability and karyotype order in tumour evolution Authors (55)Tom WatkinsEmilia Lim Marina Petkovic Sergi ElizaldeNicolai BirkbakGareth Wilson[...]Peter Van Loo Samuel F Bakhoum Roland F Schwarz Nicholas McGranahanCharles Swanton Nature Published 5 November 2020 Crick labs/ facilitiesPeter Van LooSamra TurajlicCharles SwantonNicholas LuscombeBioinformatics and BiostatisticsScientific computingFull details
The National Lung Matrix Trial of personalized therapy in lung cancer Authors (27) Gary Middleton Peter Fletcher Sanjay Popat Joshua Savage Yvonne Summers Alastair Greystoke[...] Timothy A YapTom WatkinsEmilia LimCharles Swanton Lucinda Billingham Nature Published 30 July 2020 Crick labsCharles SwantonFull details
Representative sequencing: Unbiased sampling of solid tumor tissue Authors (33)Kevin Litchfield Stacey Stanislaw Lavinia Spain Lisa L GallegosAndrew RowanDesiree Schnidrig[...] PEACE Consortium James LarkinCharles Swanton Nelson R AlexanderSamra Turajlic Cell Reports Published 5 May 2020 Crick labs/ facilitiesPeter Van LooSamra TurajlicCharles SwantonExperimental HistopathologyBioinformatics and BiostatisticsFull details
Interplay between whole-genome doubling and the accumulation of deleterious alterations in cancer evolution Authors (17) Saioa LópezEmilia Lim Stuart HorswellKerstin HaaseAriana HuebnerMichelle Dietzen[...]Peter Van Loo Mariam Jamal-Hanjani TRACERx ConsortiumCharles Swanton Nicholas McGranahan Nature Genetics Published 5 March 2020 Crick labs/ facilitiesPeter Van LooCharles SwantonBioinformatics and BiostatisticsFull details
A clonal expression biomarker associates with lung cancer mortality Authors (36)Dhruva BiswasNicolai BirkbakRachel Rosenthal Crispin T HileyEmilia Lim Krisztian Papp[...] Zoltan Szallasi Javier Herrero Nicholas McGranahanCharles Swanton TRACERx Consortium Nature Medicine Published 7 October 2019 Crick labs/ facilitiesCharles SwantonGenomics/Equipment ParkBioinformatics and BiostatisticsFull details
Deterministic evolutionary trajectories influence primary tumor growth: TRACERx Renal Authors (71)Samra TurajlicHang XuKevin LitchfieldAndrew Rowan Stuart Horswell Tim Chambers[...]Peter Van Loo Peter Campbell James LarkinCharles Swanton TRACERx Renal Consortium Cell Published 19 April 2018 Crick labs/ facilitiesPeter Van LooSamra TurajlicCharles SwantonNicholas LuscombeExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Tracking cancer evolution reveals constrained routes to metastases: TRACERx Renal Authors (51)Samra TurajlicHang XuKevin LitchfieldAndrew Rowan Tim Chambers Jose I Lopez[...] Daniel L Burgess Nelson R AlexanderCharles Swanton PEACE TRACERx Renal Consortium Cell Published 19 April 2018 Crick labs/ facilitiesSamra TurajlicCharles SwantonExperimental HistopathologyBioinformatics and BiostatisticsScientific computingAdvanced SequencingFull details
Expansion of airway basal epithelial cells from primary human non-small cell lung cancer tumors Authors (12)Rob Hynds Assma Ben Aissa Kate HC GowersTom Watkins Leticia Bosshard-CarterAndrew Rowan[...]Gareth Wilson Sergio A QuezadaCharles Swanton TRACERx Consortium Sam M Janes International Journal of Cancer Published 1 July 2018 Crick labsCharles SwantonFull details
Chromosomal instability drives metastasis through a cytosolic DNA response Authors (33) Samuel F Bakhoum Bryan Ngo Ashley M Laughney Julie-Ann Cavallo Charles J Murphy Peter Ly[...] Don W Cleveland Simon N Powell Jan LammerdingCharles Swanton Lewis C Cantley Nature Published 25 January 2018 Crick labsCharles SwantonFull details
Evolution and clinical impact of co-occurring genetic alterations in advanced-stage EGFR-mutant lung cancers Authors (29) Collin M BlakelyTom Watkins Wei Wu Beatrice Gini Jacob J Chabon Caroline E McCoach[...] Robert C Doebele Jonathan W Riess Maximilian DiehnCharles Swanton Trever G Bivona Nature Genetics Published 6 November 2017 Crick labsCharles SwantonFull details
Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution Authors (105) Christopher AbboshNicolai BirkbakGareth Wilson Mariam Jamal-Hanjani Tudor Constantin Raheleh Salari[...] Jacqui A Shaw Bernhard G Zimmermann The TRACERx Consortium The PEACE ConsortiumCharles Swanton Nature Published 25 May 2017 Crick labs/ facilitiesPeter Van LooSamra TurajlicCharles SwantonBioinformatics and BiostatisticsAdvanced SequencingFull details
Tracking the evolution of non-small-cell lung cancer Authors (84) Mariam Jamal-Hanjani Gareth A Wilson Nicholas McGranahanNicolai BirkbakTom WatkinsSelvaraju Veeriah[...]Peter Van Loo Caroline Dive Allan HackshawCharles Swanton The TRACERx Consortium New England Journal of Medicine Published 26 April 2017 Crick labs/ facilitiesPeter Van LooSamra TurajlicCharles SwantonBioinformatics and BiostatisticsAdvanced SequencingFull details
Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade Authors (36) Nicholas McGranahan Andrew JS FurnessRachel Rosenthal Sofie Ramskov Rikke Lyngaa Sunil Kumar Saini[...] Karl S Peggs Timothy A Chan Sine R Hadrup Sergio A QuezadaCharles Swanton Science Published 25 March 2016 Crick labs/ facilitiesCharles SwantonBioinformatics and BiostatisticsFull details
Tracking the genomic evolution of esophageal adenocarcinoma through neoadjuvant chemotherapy Authors (18) Nirupa MurugaesuGareth WilsonNicolai BirkbakTom Watkins Nicholas McGranahan Sacheen Kumar[...] Sharmin Begum Nik Matthews Daniel Hochhauser George B HannaCharles Swanton Cancer Discovery Published 1 August 2015 Crick labs/ facilitiesCharles SwantonBioinformatics and BiostatisticsAdvanced SequencingFull details