Tom Watkins

Pervasive chromosomal instability and karyotype order in tumour evolution

Authors (55)

Tom Watkins
Emilia Lim
Marina Petkovic
Sergi Elizalde
Nicolai Birkbak
Gareth Wilson
[...]
Peter Van Loo
Samuel F Bakhoum
Roland F Schwarz
Nicholas McGranahan
Charles Swanton

Nature

Published 2 September 2020

Crick labs/ facilities

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The National Lung Matrix Trial of personalized therapy in lung cancer

Authors (27)

Gary Middleton
Peter Fletcher
Sanjay Popat
Joshua Savage
Yvonne Summers
Alastair Greystoke
[...]
Timothy A Yap
Tom Watkins
Emilia Lim
Charles Swanton
Lucinda Billingham

Nature

Published 30 July 2020

Crick labs

Charles Swanton

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Representative sequencing: Unbiased sampling of solid tumor tissue

Authors (33)

Kevin Litchfield
Stacey Stanislaw
Lavinia Spain
Lisa L Gallegos
Andrew Rowan
Desiree Schnidrig
[...]
PEACE Consortium
James Larkin
Charles Swanton
Nelson R Alexander
Samra Turajlic

Cell Reports

Published 5 May 2020

Crick labs/ facilities

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Interplay between whole-genome doubling and the accumulation of deleterious alterations in cancer evolution

Authors (17)

Saioa López
Emilia Lim
Stuart Horswell
Kerstin Haase
Ariana Huebner
Michelle Dietzen
[...]
Peter Van Loo
Mariam Jamal-Hanjani
TRACERx Consortium
Charles Swanton
Nicholas McGranahan

Nature Genetics

Published 5 March 2020

Crick labs/ facilities

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A clonal expression biomarker associates with lung cancer mortality

Authors (36)

Dhruva Biswas
Nicolai Birkbak
Rachel Rosenthal
Crispin T Hiley
Emilia Lim
Krisztian Papp
[...]
Zoltan Szallasi
Javier Herrero
Nicholas McGranahan
Charles Swanton
TRACERx Consortium

Nature Medicine

Published 7 October 2019

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Deterministic evolutionary trajectories influence primary tumor growth: TRACERx Renal

Authors (71)

Samra Turajlic
Hang Xu
Kevin Litchfield
Andrew Rowan
Stuart Horswell
Tim Chambers
[...]
Peter Van Loo
Peter Campbell
James Larkin
Charles Swanton
TRACERx Renal Consortium

Cell

Published 19 April 2018

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Tracking cancer evolution reveals constrained routes to metastases: TRACERx Renal

Authors (51)

Samra Turajlic
Hang Xu
Kevin Litchfield
Andrew Rowan
Tim Chambers
Jose I Lopez
[...]
Daniel L Burgess
Nelson R Alexander
Charles Swanton
PEACE
TRACERx Renal Consortium

Cell

Published 19 April 2018

Crick labs/ facilities

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Expansion of airway basal epithelial cells from primary human non-small cell lung cancer tumors

Authors (12)

Rob Hynds
Assma Ben Aissa
Kate HC Gowers
Tom Watkins
Leticia Bosshard-Carter
Andrew Rowan
[...]
Gareth Wilson
Sergio A Quezada
Charles Swanton
TRACERx Consortium
Sam M Janes

International Journal of Cancer

Published 1 July 2018

Crick labs

Charles Swanton

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Chromosomal instability drives metastasis through a cytosolic DNA response

Authors (33)

Samuel F Bakhoum
Bryan Ngo
Ashley M Laughney
Julie-Ann Cavallo
Charles J Murphy
Peter Ly
[...]
Don W Cleveland
Simon N Powell
Jan Lammerding
Charles Swanton
Lewis C Cantley

Nature

Published 17 January 2018

Crick labs

Charles Swanton

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Evolution and clinical impact of co-occurring genetic alterations in advanced-stage EGFR-mutant lung cancers

Authors (29)

Collin M Blakely
Tom Watkins
Wei Wu
Beatrice Gini
Jacob J Chabon
Caroline E McCoach
[...]
Robert C Doebele
Jonathan W Riess
Maximilian Diehn
Charles Swanton
Trever G Bivona

Nature Genetics

Published 6 November 2017

Crick labs

Charles Swanton

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Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution

Authors (105)

Christopher Abbosh
Nicolai Birkbak
Gareth A Wilson
Mariam Jamal-Hanjani
Tudor Constantin
Raheleh Salari
[...]
Jacqui A Shaw
Bernhard G Zimmermann
The TRACERx Consortium
The PEACE Consortium
Charles Swanton

Nature

Published 25 May 2017

Crick labs/ facilities

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Tracking the evolution of non-small-cell lung cancer

Authors (84)

Mariam Jamal-Hanjani
Gareth A Wilson
Nicholas McGranahan
Nicolai Birkbak
Tom Watkins
Selvaraju Veeriah
[...]
Peter Van Loo
Caroline Dive
Allan Hackshaw
Charles Swanton
The TRACERx Consortium

New England Journal of Medicine

Published 26 April 2017

Crick labs/ facilities

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Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade

Authors (36)

Nicholas McGranahan
Andrew JS Furness
Rachel Rosenthal
Sofie Ramskov
Rikke Lyngaa
Sunil Kumar Saini
[...]
Karl S Peggs
Timothy A Chan
Sine R Hadrup
Sergio A Quezada
Charles Swanton

Science

Published 25 March 2016

Crick labs/ facilities

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Tracking the genomic evolution of esophageal adenocarcinoma through neoadjuvant chemotherapy

Authors (18)

Nirupa Murugaesu
Gareth Wilson
Nicolai Birkbak
Tom Watkins
Nicholas McGranahan
Sacheen Kumar
[...]
Sharmin Begum
Nik Matthews
Daniel Hochhauser
George B Hanna
Charles Swanton

Cancer Discovery

Published 1 August 2015

Crick labs/ facilities

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Tom Watkins

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Journal

Pervasive chromosomal instability and karyotype order in tumour evolution

The National Lung Matrix Trial of personalized therapy in lung cancer

Representative sequencing: Unbiased sampling of solid tumor tissue

Interplay between whole-genome doubling and the accumulation of deleterious alterations in cancer evolution

A clonal expression biomarker associates with lung cancer mortality

Deterministic evolutionary trajectories influence primary tumor growth: TRACERx Renal

Tracking cancer evolution reveals constrained routes to metastases: TRACERx Renal

Expansion of airway basal epithelial cells from primary human non-small cell lung cancer tumors

Chromosomal instability drives metastasis through a cytosolic DNA response

Evolution and clinical impact of co-occurring genetic alterations in advanced-stage EGFR-mutant lung cancers

Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution

Tracking the evolution of non-small-cell lung cancer

Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade

Tracking the genomic evolution of esophageal adenocarcinoma through neoadjuvant chemotherapy

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