Tony Fearns

PRINCIPAL LABORATORY RESEARCH SCIENTIST

Human cells infected with Mycobacterium tuberculosis

Gutierrez lab

Host-Pathogen Interactions in Tuberculosis Laboratory

Email Address:
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Selected Publications

Mycobacterium tuberculosis cords within lymphatic endothelial cells to evade host immunity

Authors (9)

JCI insight

Published 21 May 2020

Crick labs/ facilities

Full details

LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages

Authors (18)

Anetta Härtlova
Susanne Herbst
Julien Peltier
Angela Rodgers
Orsolya Bilkei‐Gorzo
Tony Fearns
[...]
Jennifer Martinez
Dario R Alessi
Alastair D Reith
Matthias Trost
Maximiliano Gutierrez

EMBO Journal

Published 15 June 2018

Crick labs

Maximiliano Gutierrez

Full details

Phthiocerol dimycocerosates promote access to the cytosol and intracellular burden of Mycobacterium tuberculosis in lymphatic endothelial cells

Authors (6)

Thomas R Lerner
Christophe Queval
Tony Fearns
Urska Repnik
Gareth Griffiths
Maximiliano Gutierrez

BMC Biology

Published 4 January 2018

Crick labs

Maximiliano Gutierrez

Full details

Displaying 1 - 13 of 13

Last updated : 08 December 2023 02:42

Stress granules plug and stabilize damaged endolysosomal membranes

Authors (12)

Claudio Bussi
Agustín Mangiarotti
Christian Vanhille-Campos
Beren Aylan
Enrica Pellegrino
Natalia Athanasiadi
[...]
Angela Rodgers
Titus M Franzmann
Anđela Šarić
Rumiana Dimova
Maximiliano Gutierrez

Nature

Published 30 November 2023

Crick labs/ facilities

Full details

Peroxisomal ROS control cytosolic Mycobacterium tuberculosis replication in human macrophages

Authors (9)

The Journal of Cell Biology

Published 4 December 2023

Crick labs/ facilities

Full details

ATG7 and ATG14 restrict cytosolic and phagosomal Mycobacterium tuberculosis replication in human macrophages

Authors (9)

Nature Microbiology

Published 1 May 2023

Crick labs/ facilities

Full details

Lysosomal damage drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism

Authors (17)

Nature Communications

Published 28 November 2022

Crick labs/ facilities

Full details

Intracellular localisation of Mycobacterium tuberculosis affects efficacy of the antibiotic pyrazinamide

Authors (6)

Nature Communications

Published 21 June 2021

Crick labs/ facilities

Full details

Macrophage-specific responses to human- and animal-adapted tubercle bacilli reveal pathogen and host factors driving multinucleated cell formation

Authors (15)

Christophe Queval
Tony Fearns
Laure Botella
Alicia Smyth
Laura Schnettger
Morgane Mitermite
[...]
Matthias Trost
Dirk Werling
Francisco J Salguero
Stephen V Gordon
Maximiliano Gutierrez

PLOS Pathogens

Published 15 March 2021

Crick labs/ facilities

Full details

Correlative light electron ion microscopy reveals in vivo localisation of bedaquiline in Mycobacterium tuberculosis-infected lungs

Authors (5)

PLOS Biology

Published 31 December 2020

Crick labs/ facilities

Full details

M. tuberculosis infection of human iPSC-derived macrophages reveals complex membrane dynamics during xenophagy evasion

Authors (8)

Journal of Cell Science

Published 1 March 2021

Crick labs/ facilities

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Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers

Authors (341)

Catherine F Houlihan
Nina Vora
Thomas Byrne
Dan Lewer
Gavin Kelly
Judith Heaney
[...]
Andrew Hayward
Richard Gilson
Gavin Kelly
Fiona Roberts
Emine Hatipoglu

Mycobacterium tuberculosis cords within lymphatic endothelial cells to evade host immunity

Authors (9)

JCI insight

Published 21 May 2020

Crick labs/ facilities

Full details

LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages

Authors (18)

Anetta Härtlova
Susanne Herbst
Julien Peltier
Angela Rodgers
Orsolya Bilkei‐Gorzo
Tony Fearns
[...]
Jennifer Martinez
Dario R Alessi
Alastair D Reith
Matthias Trost
Maximiliano Gutierrez

EMBO Journal

Published 15 June 2018

Crick labs

Maximiliano Gutierrez

Full details

Phthiocerol dimycocerosates promote access to the cytosol and intracellular burden of Mycobacterium tuberculosis in lymphatic endothelial cells

Authors (6)

Thomas R Lerner
Christophe Queval
Tony Fearns
Urska Repnik
Gareth Griffiths
Maximiliano Gutierrez

BMC Biology

Published 4 January 2018

Crick labs

Maximiliano Gutierrez

Full details

Tumour cell-derived Wnt7a recruits and activates fibroblasts to promote tumour aggressiveness

Authors (11)

Alexandra Avgustinova
Marjan Iravani
David Robertson
Tony Fearns
Qiong Gao
Pamela Klingbeil
Andrew M Hanby
Valerie Speirs
Erik Sahai
Fernando Calvo
Clare M Isacke

Nature Communications

Published 18 January 2016

Crick labs

Erik Sahai

Full details

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About us

Tony Fearns

PRINCIPAL LABORATORY RESEARCH SCIENTIST

Gutierrez lab

Selected Publications

Mycobacterium tuberculosis cords within lymphatic endothelial cells to evade host immunity

LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages

Phthiocerol dimycocerosates promote access to the cytosol and intracellular burden of Mycobacterium tuberculosis in lymphatic endothelial cells

Year published

Research topics

Publication type

Journal

Crick Pre-Crick

Stress granules plug and stabilize damaged endolysosomal membranes

Peroxisomal ROS control cytosolic Mycobacterium tuberculosis replication in human macrophages

ATG7 and ATG14 restrict cytosolic and phagosomal Mycobacterium tuberculosis replication in human macrophages

Lysosomal damage drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism

Intracellular localisation of Mycobacterium tuberculosis affects efficacy of the antibiotic pyrazinamide

Macrophage-specific responses to human- and animal-adapted tubercle bacilli reveal pathogen and host factors driving multinucleated cell formation

Correlative light electron ion microscopy reveals in vivo localisation of bedaquiline in Mycobacterium tuberculosis-infected lungs

M. tuberculosis infection of human iPSC-derived macrophages reveals complex membrane dynamics during xenophagy evasion

Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers

Mycobacterium tuberculosis cords within lymphatic endothelial cells to evade host immunity

LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages

Phthiocerol dimycocerosates promote access to the cytosol and intracellular burden of Mycobacterium tuberculosis in lymphatic endothelial cells

Tumour cell-derived Wnt7a recruits and activates fibroblasts to promote tumour aggressiveness

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