Tony Fearns

Principal Laboratory Research Scientist

Human cells infected with Mycobacterium tuberculosis

Gutierrez lab

Host-Pathogen Interactions in Tuberculosis Laboratory

Email Address:

Email

Selected Publications

Mycobacterium tuberculosis cords within lymphatic endothelial cells to evade host immunity

Authors (9)

Thomas R Lerner
Christophe Queval
Rachel Lai
Matt Russell
Tony Fearns
Daniel Greenwood
Lucy Collinson
Robert Wilkinson
Maximiliano Gutierrez

JCI insight

Published 21 May 2020

Crick labs/ facilities

Full details

LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages

Authors (18)

Anetta Härtlova
Susanne Herbst
Julien Peltier
Angela Rodgers
Orsolya Bilkei‐Gorzo
Tony Fearns
[...]
Jennifer Martinez
Dario R Alessi
Alastair D Reith
Matthias Trost
Maximiliano Gutierrez

EMBO Journal

Published 15 June 2018

Crick labs

Maximiliano Gutierrez

Full details

Phthiocerol dimycocerosates promote access to the cytosol and intracellular burden of Mycobacterium tuberculosis in lymphatic endothelial cells

Authors (6)

Thomas R Lerner
Christophe Queval
Tony Fearns
Urska Repnik
Gareth Griffiths
Maximiliano Gutierrez

BMC Biology

Published 4 January 2018

Crick labs

Maximiliano Gutierrez

Full details

Displaying 1 - 20 of 22

Last updated : 09 October 2026 03:52

ESX-1 remodels the Mycobacterium tuberculosis antigen storage compartment in macrophages

Preprint

Authors (7)

bioRxiv

Published 6 October 2026

Crick labs/ facilities

Full details

Fast-growing intracellular Mycobacterium tuberculosis populations evade antibiotic treatment

Authors (12)

Nathan Day
Baptiste Pradel
Jakson Luk
Pierre Santucci
Tony Fearns
Angela Rodgers
[...]
Laure Botella
Julien Vaubourgeix
Julio Ortiz Canseco
Natalia Athanasiadi
Maximiliano Gutierrez

Nature Communications

Published 28 August 2026

Crick labs/ facilities

Full details

IFITM1 differentially regulates antibacterial immunity and immunopathology but is dispensable for antiparasitic responses

Authors (13)

Sibongiseni KL Poswayo
Mumin Ozturk
Rudranil Hazra
Tony Fearns
Christophe Queval
Narjis Thawer
[...]
Reto Guler
Ramona Hurdayal
Frank Brombacher
Maximiliano Gutierrez
Suraj P Parihar

Journal of Immunology

Published 1 June 2026

Crick labs/ facilities

Full details

Ca²⁺ leakage is a conserved signal for non-canonical ATG8/LC3 lipidation and membrane repair

Authors (4)

EMBO Journal

Published 5 May 2026

Crick labs/ facilities

Full details

BioStudies entry S-SCDT-10_1038-S44318-026-00741-Z: Ca²⁺ leakage is a conserved signal for non-canonical ATG8/LC3 lipidation and membrane repair

Authors (4)

BioStudies

Published 10 March 2026

Crick labs/ facilities

Full details

Autologous human iPSC-derived alveolus-on-chip reveals early pathological events of Mycobacterium tuberculosis infection

Authors (12)

Jakson Luk
Gabriel Conway
Kim Goh
Tony Fearns
Irene Rodriguez Hernandez
Nathan Day
[...]
Rocco D'Antuono
Enrica Pellegrino
Janick D Stucki
Nina Hobi
Maximiliano Gutierrez

Science advances

Published 2 January 2026

Crick labs/ facilities

Full details

Mycobacterium tuberculosis overcomes phosphate starvation by extensively remodelling its lipidome with phosphorus-free lipids

Authors (13)

Robert Gray
Debbie M Hunt
Mariana Silva Dos Santos
Jiuyu Liu
Aleksandra Agapova
Angela Rodgers
[...]
Acely Garza-Garcia
James MacRae
Maximiliano Gutierrez
Richard E Lee
Luiz Pedro Carvalho

Nature Communications

Published 22 December 2025

Crick labs/ facilities

Full details

Mycobacterium tuberculosis phagosome Ca2+ leakage triggers multimembrane ATG8/LC3 lipidation to restrict damage in human macrophages

Authors (3)

Science advances

Published 26 March 2025

Crick labs/ facilities

Full details

Lysosomes drive the piecemeal removal of mitochondrial inner membrane

Authors (8)

Akriti Prashar
Claudio Bussi
Tony Fearns
Mariana I Capurro
Xiaodong Gao
Hiromi Sesaki
Maximiliano Gutierrez
Nicola L Jones

Nature

Published 29 August 2024

Crick labs

Maximiliano Gutierrez

Full details

Stress granules plug and stabilize damaged endolysosomal membranes

Authors (12)

Claudio Bussi
Agustín Mangiarotti
Christian Vanhille-Campos
Beren Aylan
Enrica Pellegrino
Natalia Athanasiadi
[...]
Angela Rodgers
Titus M Franzmann
Anđela Šarić
Rumiana Dimova
Maximiliano Gutierrez

Nature

Published 30 November 2023

Crick labs/ facilities

Full details

Peroxisomal ROS control cytosolic Mycobacterium tuberculosis replication in human macrophages

Authors (9)

Enrica Pellegrino
Beren Aylan
Claudio Bussi
Tony Fearns
Elliott Bernard
Natalia Athanasiadi
Pierre Santucci
Laure Botella
Maximiliano Gutierrez

Journal of Cell Biology

Published 4 December 2023

Crick labs/ facilities

Full details

ATG7 and ATG14 restrict cytosolic and phagosomal Mycobacterium tuberculosis replication in human macrophages

Authors (9)

Beren Aylan
Elliott Bernard
Enrica Pellegrino
Laure Botella
Tony Fearns
Natalia Athanasiadi
Claudio Bussi
Pierre Santucci
Maximiliano Gutierrez

Nature Microbiology

Published 1 May 2023

Crick labs/ facilities

Full details

Lysosomal damage drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism

Authors (17)

Claudio Bussi
Tiaan Heunis
Enrica Pellegrino
Elliott Bernard
Nourdine Bah
Mariana Silva Dos Santos
[...]
James MacRae
Maria Greco
Thomas Reinheckel
Matthias Trost
Maximiliano Gutierrez

Nature Communications

Published 28 November 2022

Crick labs/ facilities

Full details

Intracellular localisation of Mycobacterium tuberculosis affects efficacy of the antibiotic pyrazinamide

Authors (6)

Pierre Santucci
Daniel Greenwood
Tony Fearns
Kai Chen
Haibo Jiang
Maximiliano Gutierrez

Nature Communications

Published 21 June 2021

Crick labs/ facilities

Full details

Macrophage-specific responses to human- and animal-adapted tubercle bacilli reveal pathogen and host factors driving multinucleated cell formation

Authors (15)

Christophe Queval
Tony Fearns
Laure Botella
Alicia Smyth
Laura Schnettger
Morgane Mitermite
[...]
Matthias Trost
Dirk Werling
Francisco J Salguero
Stephen V Gordon
Maximiliano Gutierrez

PLOS Pathogens

Published 15 March 2021

Crick labs/ facilities

Full details

Correlative light electron ion microscopy reveals in vivo localisation of bedaquiline in Mycobacterium tuberculosis-infected lungs

Authors (5)

Tony Fearns
Daniel Greenwood
Angela Rodgers
Haibo Jiang
Maximiliano Gutierrez

PLOS Biology

Published 31 December 2020

Crick labs/ facilities

Full details

M. tuberculosis infection of human iPSC-derived macrophages reveals complex membrane dynamics during xenophagy evasion

Authors (8)

Elliott Bernard
Tony Fearns
Claudio Bussi
Pierre Santucci
Chris Peddie
Rachel Lai
Lucy Collinson
Maximiliano Gutierrez

Journal of Cell Science

Published 1 March 2021

Crick labs/ facilities

Full details

Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers

Authors (341)

Catherine F Houlihan
Nina Vora
Thomas Byrne
Dan Lewer
Gavin Kelly
Judith Heaney
[...]
Andrew Hayward
Richard Gilson
Gavin Kelly
Fiona Roberts
Emine Hatipoglu

The Lancet

Published 25 July 2020

Crick labs/ facilities

Full details

Mycobacterium tuberculosis cords within lymphatic endothelial cells to evade host immunity

Authors (9)

Thomas R Lerner
Christophe Queval
Rachel Lai
Matt Russell
Tony Fearns
Daniel Greenwood
Lucy Collinson
Robert Wilkinson
Maximiliano Gutierrez

JCI insight

Published 21 May 2020

Crick labs/ facilities

Full details

LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages

Authors (18)

Anetta Härtlova
Susanne Herbst
Julien Peltier
Angela Rodgers
Orsolya Bilkei‐Gorzo
Tony Fearns
[...]
Jennifer Martinez
Dario R Alessi
Alastair D Reith
Matthias Trost
Maximiliano Gutierrez

EMBO Journal

Published 15 June 2018

Crick labs

Maximiliano Gutierrez

Full details

Research partnerships

PhD students

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Tony Fearns

Principal Laboratory Research Scientist

Gutierrez lab

Selected Publications

Mycobacterium tuberculosis cords within lymphatic endothelial cells to evade host immunity

LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages

Phthiocerol dimycocerosates promote access to the cytosol and intracellular burden of Mycobacterium tuberculosis in lymphatic endothelial cells

Year published

Research topics

Crick Pre-Crick

Publication type

Journal

ESX-1 remodels the Mycobacterium tuberculosis antigen storage compartment in macrophages

Fast-growing intracellular Mycobacterium tuberculosis populations evade antibiotic treatment

IFITM1 differentially regulates antibacterial immunity and immunopathology but is dispensable for antiparasitic responses

Ca²⁺ leakage is a conserved signal for non-canonical ATG8/LC3 lipidation and membrane repair

BioStudies entry S-SCDT-10_1038-S44318-026-00741-Z: Ca²⁺ leakage is a conserved signal for non-canonical ATG8/LC3 lipidation and membrane repair

Autologous human iPSC-derived alveolus-on-chip reveals early pathological events of Mycobacterium tuberculosis infection

Mycobacterium tuberculosis overcomes phosphate starvation by extensively remodelling its lipidome with phosphorus-free lipids

Mycobacterium tuberculosis phagosome Ca2+ leakage triggers multimembrane ATG8/LC3 lipidation to restrict damage in human macrophages

Lysosomes drive the piecemeal removal of mitochondrial inner membrane

Stress granules plug and stabilize damaged endolysosomal membranes

Peroxisomal ROS control cytosolic Mycobacterium tuberculosis replication in human macrophages

ATG7 and ATG14 restrict cytosolic and phagosomal Mycobacterium tuberculosis replication in human macrophages

Lysosomal damage drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism

Intracellular localisation of Mycobacterium tuberculosis affects efficacy of the antibiotic pyrazinamide

Macrophage-specific responses to human- and animal-adapted tubercle bacilli reveal pathogen and host factors driving multinucleated cell formation

Correlative light electron ion microscopy reveals in vivo localisation of bedaquiline in Mycobacterium tuberculosis-infected lungs

M. tuberculosis infection of human iPSC-derived macrophages reveals complex membrane dynamics during xenophagy evasion

Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers

Mycobacterium tuberculosis cords within lymphatic endothelial cells to evade host immunity

LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages

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