Valerie Borel

EXO1 as a therapeutic target for Fanconi Anaemia, ZRSR2 and BRCA1-A complex deficient cancers

Authors (18)

Marija Maric
Sandra Segura-Bayona
Raviprasad Kuthethur
Tohru Takaki
Valerie Borel
Tyler Stanage
[...]
Scott Warchal
Michael Howell
Arnab Ray Chaudhuri
Panagiotis Kotsantis
Simon Boulton

Nature Communications

Published 26 September 2025

Crick labs/ facilities

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SLFN11 restricts escape from telomere crisis to prevent alternative lengthening of telomeres

Preprint

Authors (25)

Sandra Segura-Bayona
Valerie Borel
Tyler Stanage
Marija Maric
Melanie Walter
Rafaela A Oliveira
[...]
Roderick J O'Sullivan
Aatur D Singhi
Thijn R Brummelkamp
Anthony J Cesare
Simon Boulton

bioRxiv

Published 10 September 2025

Crick labs/ facilities

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Disrupted control of origin activation compromises genome integrity upon destabilization of Polε and dysfunction of the TRP53-CDKN1A/P21 axis

Authors (12)

Valerie Borel
Stefan Boeing
Niek Van Wietmarschen
Sriram Sridharan
Bethany Rebekah Hill
Luigi Ombrato
[...]
Deb Jackson
Robert Goldstone
Simon Boulton
Andre Nussenzweig
Roberto Bellelli

Cell Reports

Published 31 May 2022

Crick labs/ facilities

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H3K4 methylation by SETD1A/BOD1L facilitates RIF1-dependent NHEJ

Authors (14)

Rachel Bayley
Valerie Borel
Rhiannon J Moss
Ellie Sweatman
Phil Ruis
Alice Ormrod
[...]
Graeme Hewitt
Marco Saponaro
Grant S Stewart
Simon Boulton
Martin R Higgs

Molecular Cell

Published 19 May 2022

Crick labs/ facilities

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Disrupted control of origin activation promotes genomic instability upon loss of the Pole4 and Trp53 tumour suppressors

Preprint

Authors (10)

Valerie Borel
Stefan Boeing
Niek Van Wietmarschen
Sriram Sridharan
Jimena Perez-Lloret
Deb Jackson
Robert Goldstone
Simon Boulton
Andre Nussenzweig
Roberto Bellelli

SSRN

Published 3 May 2021

Crick labs/ facilities

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Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD

Authors (27)

Graeme Hewitt
Valerie Borel
Sandra Segura-Bayona
Tohru Takaki
Phil Ruis
Roberto Bellelli
[...]
Ivan Ahel
Dragana Ahel
J Ross Chapman
Sebastian Deindl
Simon Boulton

Molecular Cell

Published 18 February 2021

Crick labs/ facilities

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TRF2-independent chromosome end protection during pluripotency

Authors (13)

Phil Ruis
David Van Ly
Valerie Borel
Georgia R Kafer
Afshan Mccarthy
Steven Howell
[...]
James Briscoe
Kathy Niakan
Paulina Marzec
Anthony J Cesare
Simon Boulton

Nature

Published 7 January 2021

Crick labs/ facilities

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Synthetic lethality between DNA polymerase epsilon and RTEL1 in metazoan DNA replication

Authors (6)

Roberto Bellelli
Jillian Youds
Valerie Borel
Jennifer Svendsen
Visnja Pavicic-Kaltenbrunner
Simon Boulton

Cell Reports

Published 26 May 2020

Crick labs/ facilities

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CDK phosphorylation of TRF2 controls t-loop dynamics during the cell cycle

Authors (12)

Grzegorz Sarek
Panagiotis Kotsantis
Phil Ruis
David Van Ly
Pol Margalef
Valerie Borel
[...]
Helen R Flynn
Bram Snijders
Dipanjan Chowdhury
Anthony J Cesare
Simon Boulton

Nature

Published 13 November 2019

Crick labs/ facilities

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DNA polymerase epsilon deficiency causes IMAGe syndrome with variable immunodeficiency

Authors (47)

Clare V Logan
Jennie E Murray
David A Parry
Andrea Robertson
Roberto Bellelli
Žygimantė Tarnauskaitė
[...]
Michael B Bober
Robert K Semple
Simon Boulton
Jonathan J Rios
Andrew P Jackson

American Journal of Human Genetics

Published 29 November 2018

Crick labs

Simon Boulton

Full details

Polε instability drives replication stress, abnormal development, and tumorigenesis

Authors (14)

Roberto Bellelli
Valerie Borel
Clare Logan
Jennifer Svendsen
Danielle Cox
Emma Nye
[...]
Helen R Flynn
Bram Snijders
François Lassailly
Andrew Jackson
Simon Boulton

Molecular Cell

Published 17 May 2018

Crick labs/ facilities

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Stabilization of reversed replication forks by telomerase drives telomere catastrophe

Authors (6)

Pol Margalef
Panagiotis Kotsantis
Valerie Borel
Roberto Bellelli
Stephanie Panier
Simon Boulton

Cell

Published 25 January 2018

Crick labs/ facilities

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FANCJ suppresses microsatellite instability and lymphomagenesis independent of the Fanconi anemia pathway

Authors (5)

Kenichiro Matsuzaki
Valerie Borel
Carrie A Adelman
Detlev Schindler
Simon Boulton

Genes & Development

Published 15 December 2015

Crick labs/ facilities

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BOD1L is required to suppress deleterious resection of stressed replication forks

Authors (14)

Martin R Higgs
John J Reynolds
Alicja Winczura
Andrew N Blackford
Valerie Borel
Edward S Miller
[...]
Nicholas J Davies
Tatjana Stankovic
Simon Boulton
Wojciech Niedzwiedz
Grant S Stewart

Molecular Cell

Published 6 August 2015

Crick labs

Simon Boulton

Full details

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EXO1 as a therapeutic target for Fanconi Anaemia, ZRSR2 and BRCA1-A complex deficient cancers

SLFN11 restricts escape from telomere crisis to prevent alternative lengthening of telomeres

Disrupted control of origin activation compromises genome integrity upon destabilization of Polε and dysfunction of the TRP53-CDKN1A/P21 axis

H3K4 methylation by SETD1A/BOD1L facilitates RIF1-dependent NHEJ

Disrupted control of origin activation promotes genomic instability upon loss of the Pole4 and Trp53 tumour suppressors

Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD

TRF2-independent chromosome end protection during pluripotency

Synthetic lethality between DNA polymerase epsilon and RTEL1 in metazoan DNA replication

CDK phosphorylation of TRF2 controls t-loop dynamics during the cell cycle

DNA polymerase epsilon deficiency causes IMAGe syndrome with variable immunodeficiency

Polε instability drives replication stress, abnormal development, and tumorigenesis

Stabilization of reversed replication forks by telomerase drives telomere catastrophe

FANCJ suppresses microsatellite instability and lymphomagenesis independent of the Fanconi anemia pathway

BOD1L is required to suppress deleterious resection of stressed replication forks

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