Research case studies Explore a selection of reports that spotlight particular areas of research at the Crick over the past five years.
Postdoctoral clinical fellows Opportunities for postdoctoral clinicians to consolidate their research experience.
Breadcrumb Research A Z researchers Valerie Borel Principal Laboratory Research Scientist Boulton lab DSB Repair Metabolism Laboratory Phone Number: +44 (0)20 3796 1199 Year published (-)2022 (2) Facet Year publishedResearch topicsBiochemistry & Proteomics (2)Cell Biology (2)Cell Cycle & Chromosomes (2)Chemical Biology & High Throughput (1)Computational & Systems Biology (1)Genetics & Genomics (2)Genome Integrity & Repair (2)Model Organisms (2)Tumour Biology (1) Facet Research topicsPublication typeJournal article (2)Primary research (2) Facet Publication typeJournalCell Reports (1)Molecular Cell (1) Facet JournalCrick Pre-CrickCrick publications (2) Facet Crick Pre-Crick Displaying 1 - 2 of 2Last updated : 18 April 2024 02:58 Disrupted control of origin activation compromises genome integrity upon destabilization of Polε and dysfunction of the TRP53-CDKN1A/P21 axis Authors (12)Valerie BorelStefan Boeing Niek Van Wietmarschen Sriram Sridharan Bethany Rebekah Hill Luigi Ombrato[...]Deb JacksonRobert GoldstoneSimon Boulton Andre Nussenzweig Roberto Bellelli Cell Reports Published 31 May 2022 Crick labs/ facilitiesSimon BoultonBioinformatics and BiostatisticsAdvanced SequencingFull details H3K4 methylation by SETD1A/BOD1L facilitates RIF1-dependent NHEJ Authors (14) Rachel BayleyValerie Borel Rhiannon J Moss Ellie SweatmanPhil Ruis Alice Ormrod[...] Graeme Hewitt Marco Saponaro Grant S StewartSimon Boulton Martin R Higgs Molecular Cell Published 19 May 2022 Crick labs/ facilitiesSimon BoultonGenetic Modification ServiceBiological Research FacilityFull details
Disrupted control of origin activation compromises genome integrity upon destabilization of Polε and dysfunction of the TRP53-CDKN1A/P21 axis Authors (12)Valerie BorelStefan Boeing Niek Van Wietmarschen Sriram Sridharan Bethany Rebekah Hill Luigi Ombrato[...]Deb JacksonRobert GoldstoneSimon Boulton Andre Nussenzweig Roberto Bellelli Cell Reports Published 31 May 2022 Crick labs/ facilitiesSimon BoultonBioinformatics and BiostatisticsAdvanced SequencingFull details
H3K4 methylation by SETD1A/BOD1L facilitates RIF1-dependent NHEJ Authors (14) Rachel BayleyValerie Borel Rhiannon J Moss Ellie SweatmanPhil Ruis Alice Ormrod[...] Graeme Hewitt Marco Saponaro Grant S StewartSimon Boulton Martin R Higgs Molecular Cell Published 19 May 2022 Crick labs/ facilitiesSimon BoultonGenetic Modification ServiceBiological Research FacilityFull details