Valerie Pye

Cryo-EM structure of the deltaretroviral intasome in complex with the PP2A regulatory subunit B56γ

Authors (7)

Michał S Barski
Jordan J Minnell
Zuzana Hodakova
Valerie Pye
Andrea Nans
Peter Cherepanov
Goedele N Maertens

Nature Communications

Published 7 October 2020

Crick labs/ facilities

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Structural basis for the activation and target site specificity of CDC7 kinase

Authors (6)

Structure

Published 4 August 2020

Crick labs/ facilities

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A bipartite structural organization defines the SERINC family of HIV-1 restriction factors

Authors (17)

Valerie Pye
Annachiara Rosa
Cinzia Bertelli
Weston B Struwe
Sarah L Maslen
Robin Corey
[...]
Phillip J Stansfeld
J Mark Skehel
Carol V Robinson
Massimo Pizzato
Peter Cherepanov

Nature Structural and Molecular Biology

Published 6 January 2020

Crick labs/ facilities

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Retroviral integration into nucleosomes through DNA looping and sliding along the histone octamer

Authors (9)

Marcus D Wilson
Ludovic Renault
Daniel P Maskell
Mohamed Ghoneim
Valerie Pye
Andrea Nans
David S Rueda
Peter Cherepanov
Alessandro Costa

Nature Communications

Published 13 September 2019

Crick labs/ facilities

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Differential role for phosphorylation in alternative polyadenylation function versus nuclear import of SR-like protein CPSF6

Authors (8)

Sooin Jang
Nicola Cook
Valerie Pye
Gregory J Bedwell
Amanda M Dudek
Parmit K Singh
Peter Cherepanov
Alan N Engelman

Nucleic Acids Research

Published 21 May 2019

Crick labs

Peter Cherepanov

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POLE3-POLE4 is a histone H3-H4 chaperone that maintains chromatin integrity during DNA replication

Authors (9)

Roberto Bellelli
Ondrej Belan
Valerie Pye
Camille Clement
Sarah L Maslen
J Mark Skehel
Peter Cherepanov
Genevieve Almouzni
Simon Boulton

Molecular Cell

Published 4 October 2018

Crick labs/ facilities

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Cryo-EM structure of a licensed DNA replication origin

Authors (7)

Nature Communications

Published 21 December 2017

Crick labs/ facilities

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Structure-guided optimization of HIV integrase strand transfer inhibitors

Authors (11)

Xue Zhi Zhao
Steven J Smith
Daniel P Maskell
Mathieu Métifiot
Valerie Pye
Katherine Fesen
Christophe Marchand
Yves Pommier
Peter Cherepanov
Stephen H Hughes
Terrence R Burke

Journal of Medicinal Chemistry

Published 14 September 2017

Crick labs

Peter Cherepanov

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Cdt1 stabilizes an open MCM ring for helicase loading

Authors (10)

Jordi Frigola
Jun He
Kerstin Kinkelin
Valerie Pye
Ludovic Renault
Max E Douglas
Dirk Remus
Peter Cherepanov
Alessandro Costa
John Diffley

Nature Communications

Published 23 June 2017

Crick labs/ facilities

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Structural basis for spumavirus GAG tethering to chromatin

Authors (8)

Paul Lesbats
Erik Serrao
Daniel P Maskell
Valerie Pye
Nicola O'Reilly
Dirk Lindemann
Alan N Engelman
Peter Cherepanov

Proceedings of the National Academy of Sciences of the United States of America

Published 23 May 2017

Crick labs/ facilities

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A supramolecular assembly mediates lentiviral DNA integration

Authors (14)

Allison Ballandras-Colas
Daniel P Maskell
Erik Serrao
Julia Locke
Paolo Swuec
Stefán R Jónsson
[...]
Ian Taylor
Valgerdur Andrésdóttir
Alan N Engelman
Alessandro Costa
Peter Cherepanov

Science

Published 6 January 2017

Crick labs/ facilities

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HIV-1 integrase strand transfer inhibitors with reduced susceptibility to drug resistant mutant integrases

Authors (11)

Xue Zhi Zhao
Steven J Smith
Daniel P Maskell
Mathieu Metifiot
Valerie Pye
Katherine Fesen
Christophe Marchand
Yves Pommier
Peter Cherepanov
Stephen H Hughes
Terrence R Burke

ACS Chemical Biology

Published 15 April 2016

Crick labs

Peter Cherepanov

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Valerie Pye

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Cryo-EM structure of the deltaretroviral intasome in complex with the PP2A regulatory subunit B56γ

Structural basis for the activation and target site specificity of CDC7 kinase

A bipartite structural organization defines the SERINC family of HIV-1 restriction factors

Retroviral integration into nucleosomes through DNA looping and sliding along the histone octamer

Differential role for phosphorylation in alternative polyadenylation function versus nuclear import of SR-like protein CPSF6

POLE3-POLE4 is a histone H3-H4 chaperone that maintains chromatin integrity during DNA replication

Cryo-EM structure of a licensed DNA replication origin

Structure-guided optimization of HIV integrase strand transfer inhibitors

Cdt1 stabilizes an open MCM ring for helicase loading

Structural basis for spumavirus GAG tethering to chromatin

A supramolecular assembly mediates lentiviral DNA integration

HIV-1 integrase strand transfer inhibitors with reduced susceptibility to drug resistant mutant integrases

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