William was awarded his PhD from Cardiff University for his work on cell competition at the earliest stages of pancreatic cancer. He demonstrated that KrasG12D mutant cells are selectively eliminated by normal neighbours from the adult pancreas in vivo. Loss of EphA2 was sufficient for retention of mutant cells and trigger early disease onset. William joined the group of Professor Charles Swanton in Autumn 2019. He is developing novel evolutionary animal models of lung cancer that better mimic what is observed in the clinic. This will improve our understanding of tumour evolution trajectories and intratumour heterogeneity.
