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A drop of hope A collection of poems inspired by the words of those who have been vaccinated within the Crick, the reflections of the volunteers working at the vaccination centre, and the experiences our local communities.Exhibition entry: Available to view between May and August 2021
Coronavirus (COVID-19) research Crick researchers are working at the forefront of the scientific response to answer some of the most urgent questions about the SARS-CoV-2 pathogen, from how we can improve testing, to why it’s deadly in some people but causes no symptoms in others.
Coronavirus (COVID-19) response The Francis Crick Institute is working at the forefront of the scientific response to coronavirus, volunteering expertise and facilities to help tackle the COVID-19 pandemic.
Gut Gamma Delta T cells detected by their expression of TCR delta chain RNA (red) line the human colonic epithelium (DAPI; blue) where they are well-placed to perform frontline immune surveillance. Toggle to view hero caption Adrian Hayday : Publications Lab MenuLab Menu Overview Areas of interest View more Back T cell regulation Big science Publications Members Breadcrumb Research A Z of research labs Adrian Hayday PublicationsYear published2021 (6)2020 (10)2019 (6)2018 (3)2017 (6)2016 (6)2015 (3)2014 (6)2013 (5)2012 (10)2011 (11)2010 (7) Facet Year publishedResearch topicsHuman Biology & Physiology (39)Immunology (39)Model Organisms (39)Genetics & Genomics (7)Tumour Biology (7)Chemical Biology & High Throughput (6)Computational & Systems Biology (6)Genome Integrity & Repair (6)Stem Cells (4)Gene Expression (3)Structural Biology & Biophysics (3)Biochemistry & Proteomics (2)Cell Biology (2)Cell Cycle & Chromosomes (2)Developmental Biology (1)Infectious Disease (1) Facet Research topicsPublication typeJournal article (79)Primary research (65)Review (7)Commentary (3)Letter (1)Method (1)Obituary (1)Systematic review (1) Facet Publication typeJournalNature Immunology (9)Journal of Immunology (6)Immunity (5)Proceedings of the National Academy of Sciences of the United States of America (4)Nature Communications (3)Science Translational Medicine (3)Cancer Causes & Control (2)Cell (2)Frontiers in Immunology (2)Journal of Investigative Dermatology (2)Mucosal Immunology (2)Nature Genetics (2)Nature Medicine (2)PLOS ONE (2)Proceedings of the National Academy of Sciences of USA (2)Science (2)ACS Chemical Biology (1)American Journal of Respiratory Cell and Molecular Biology (1)Annual Review of Immunology (1)Arthritis & Rheumatology (1)Biomolecular NMR Assignments (1)Biopreservation and Biobanking (1)Cancer Cell (1)Cancer Immunology Research (1)Cancer Research (1)Clinical and Experimental Immunology (1)eLife (1)Human Molecular Genetics (1)Immunological Reviews (1)Immunology (1)International Journal of Cancer (1)Journal of Autoimmunity (1)Journal of Biological Chemistry (1)Journal of Crohns & Colitis (1)Journal of Experimental Medicine (1)Journal of Translational Autoimmunity (1)Médecine Sciences : M/S (1)Methods (1)Nature Reviews Immunology (1)PLOS Genetics (1)Scientific Reports (1)Seminars in Immunology (1)The Lancet Oncology (1)Transfusion and Apheresis Science (1)Trends in Immunology (1) Facet Journal Publications Displaying 1 - 20 of 79Last updated : 12 May 2021 02:31 Safety and immunogenicity of one versus two doses of the COVID-19 vaccine BNT162b2 for patients with cancer: interim analysis of a prospective observational study Authors (44)Leticia Monin Aldama Adam G Laing Miguel Muñoz-Ruiz Duncan R McKenzie Irene Del Molino Del Barrio Thanussuyah Alaguthurai[...] Sophie Papa Timothy Tree Katie J DooresAdrian Hayday Sheeba Irshad The Lancet Oncology Published 27 April 2021 Crick labsAdrian HaydayFull details To Ki or not to Ki: Re-evaluating the use and potentials of Ki-67 for T cell analysis Authors (3) Francesca Di Rosa Andrea CossarizzaAdrian Hayday Frontiers in Immunology Published 1 April 2021 Crick labs/ facilitiesAdrian HaydayFlow CytometryFull details Neutralization potency of monoclonal antibodies recognizing dominant and subdominant epitopes on SARS-CoV-2 Spike is impacted by the B.1.1.7 variant Authors (29) Carl Graham Jeffrey Seow Isabella Huettner Hataf Khan Neophytos Kouphou Sam Acors[...] Laura E McCoyAdrian Hayday Stuart JD Neil Michael H Malim Katie J Doores Immunity Published 1 April 2021 Crick labsAdrian HaydayPeter Cherepanov Full details Response to "caution regarding interpretations of intrauterine γδ T cells in protection against experimental vaginal candidiasis" Authors (2)Leticia Monin AldamaAdrian Hayday Mucosal Immunology Published 1 May 2021 Crick labsAdrian HaydayFull details S95021, a novel selective and pan-neutralizing anti interferon alpha (IFN-α) monoclonal antibody as a candidate treatment for selected autoimmune rheumatic diseases Authors (14) Fanny Duguet Céline Ortega-Ferreira Benjamin Fould Hélène Darville Sylvie Berger Agnès Chomel[...]Adrian Hayday Emiko Desvaux Emmanuel Nony Philippe Moingeon Frédéric De Ceuninck Journal of Translational Autoimmunity Published 1 March 2021 Crick labsAdrian HaydayFull details Acute immune signatures and their legacies in severe acute respiratory syndrome coronavirus-2 infected cancer patients Authors (51) Sultan Abdul-Jawad Luca Baù Thanussuyah Alaguthurai Irene Del Molino Del Barrio Adam G Laing Thomas S Hayday[...] Anne Rigg Sophie PapaAdrian Hayday Piers EM Patten Sheeba Irshad Cancer Cell Published 8 February 2021 Crick labsAdrian HaydayFull details Reconstitution of a functional human thymus by postnatal stromal progenitor cells and natural whole-organ scaffolds Authors (22)Sara CampinotiAsllan GjinovciRoberta RagazziniLuca ZanieriLinda Ariza-Mcnaughton Marco Catucci[...] Sarah A Teichmann Neil J SebireAdrian HaydayDominique BonnetPaola Bonfanti Nature Communications Published 11 December 2020 Crick labs/ facilitiesAdrian HaydayDominique BonnetPaola BonfantiBioinformatics and BiostatisticsLight MicroscopyGenomics/Equipment ParkFlow CytometryExperimental HistopathologyElectron MicroscopyBiological Research FacilityAdvanced SequencingFull details Longitudinal proteomic profiling reveals increased early inflammation and sustained apoptosis proteins in severe COVID-19 Authors (16) Liis Haljasmägi Ahto Salumets Anna Pauliina Rumm Meeri Jürgenson Ekaterina Krassohhina Anu Remm[...] Lili Milani Anu TammAdrian Hayday Kai Kisand Pärt Peterson Scientific Reports Published 25 November 2020 Crick labsAdrian HaydayFull details Wendy Havran: Scientist, mentor, advocate Authors (7) Willi Born Juan Carlos Zúñiga-Pflücker Karen Edelblum Dieter KabelitzAdrian Hayday Deborah Witherden Julie Jameson Immunological Reviews Published 1 November 2020 Crick labsAdrian HaydayFull details Human γδ T cells recognize CD1b by two distinct mechanisms Authors (9) Josephine F Reijneveld Tonatiuh A Ocampo Adam Shahine Benjamin S Gully Pierre VantouroutAdrian Hayday Jamie Rossjohn D Branch Moody Ildiko Van Rhijn Proceedings of the National Academy of Sciences of USA Published 15 September 2020 Crick labsAdrian HaydayFull details β2 Integrins differentially regulate γδ T cell subset thymic development and peripheral maintenance Authors (7) Claire L McIntyreLeticia Monin Aldama Jesse C Rop Thomas D Otto Carl S GoodyearAdrian Hayday Vicky L Morrison Proceedings of the National Academy of Sciences of USA Published 8 September 2020 Crick labsAdrian HaydayFull details A dynamic COVID-19 immune signature includes associations with poor prognosis Authors (50) Adam G Laing Anna Lorenc Irene Del Molino Del Barrio Abhishek Das Matthew FishLeticia Monin Aldama[...] Katie J Doores Francesca Di Rosa Jonathan Edgeworth Manu Shankar-HariAdrian Hayday Nature Medicine Published 1 October 2020 Crick labs/ facilitiesAdrian HaydayGenomics/Equipment ParkFull details Butyrophilin-like proteins display combinatorial diversity in selecting and maintaining signature intraepithelial γδ T cell compartments Authors (12) Anett Jandke Daisy MelandriLeticia Monin Aldama Dmitry S Ushakov Adam G Laing Pierre Vantourout[...] Takeshi Nitta Tomoya Narita Hiroshi Takayanagi Regina FeederleAdrian Hayday Nature Communications Published 28 July 2020 Crick labs/ facilitiesAdrian HaydayBioinformatics and BiostatisticsProteomicsGenomics/Equipment ParkFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityFull details γδ T cells compose a developmentally regulated intrauterine population and protect against vaginal candidiasis Authors (18)Leticia Monin Aldama DS Ushakov H Arnesen N Bah A Jandke M Muñoz-Ruiz[...] M Curtis H Carlsen U Steinhoff P BoysenAdrian Hayday Mucosal Immunology Published 1 November 2020 Crick labs/ facilitiesAdrian HaydayExperimental HistopathologyBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityAdvanced SequencingFull details Tracking immunodynamics by identification of S-G2/M-phase T cells in human peripheral blood Authors (9) Miguel Munoz-Ruiz Irma Pujol-AutonellHefin Rhys Heather M LongMaria Greco Mark Peakman Tim TreeAdrian Hayday Francesca Di Rosa Journal of Autoimmunity Published 1 August 2020 Crick labs/ facilitiesAdrian HaydayGenomics/Equipment ParkFlow CytometryBioinformatics and BiostatisticsFull details The innate biologies of adaptive antigen receptors Authors (2)Adrian Hayday Pierre Vantourout Annual Review of Immunology Published 4 February 2020 Crick labsAdrian HaydayFull details High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation Authors (58) Lucie Abeler-Dörner Adam G Laing Anna Lorenc Dmitry S Ushakov Simon Clare Anneliese O Speak[...] Kevin J Maloy Richard K Grencis Gillian M Griffiths David J AdamsAdrian Hayday Nature Immunology Published 1 January 2020 Crick labs/ facilitiesAdrian HaydayFlow CytometryFull details Immune responses in the human female reproductive tract Authors (3)Leticia Monin Aldama Emily M Whettlock Victoria Male Immunology Published 1 June 2020 Crick labsAdrian HaydayFull details Butyrophilin-like 3 directly binds a human Vγ4+ T cell receptor using a modality distinct from clonally-restricted antigen Authors (12) Carrie R Willcox Pierre Vantourout Mahboob Salim Iva Zlatareva Daisy Melandri Leonor Zanardo[...]Svend Kjaer Mark Jeeves Fiyaz MohammedAdrian Hayday Benjamin E Willcox Immunity Published 19 November 2019 Crick labs/ facilitiesAdrian HaydayStructural BiologyFull details An innate-like Vδ1+ γδ T cell compartment in the human breast is associated with remission in triple-negative breast cancer Authors (12) Yin Wu Fernanda Kyle-Cezar Richard T Woolf Cristina Naceur-Lombardelli Julie OwenDhruva Biswas[...] Pierre Vantourout Patrycja Gazinska Anita Grigoriadis Andrew TuttAdrian Hayday Science Translational Medicine Published 9 October 2019 Crick labsAdrian HaydayFull details Pagination Current page 1 Page 2 Page 3 Page 4 Next page Next Last page Last Share the page Share on Twitter Share on Facebook 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Safety and immunogenicity of one versus two doses of the COVID-19 vaccine BNT162b2 for patients with cancer: interim analysis of a prospective observational study Authors (44)Leticia Monin Aldama Adam G Laing Miguel Muñoz-Ruiz Duncan R McKenzie Irene Del Molino Del Barrio Thanussuyah Alaguthurai[...] Sophie Papa Timothy Tree Katie J DooresAdrian Hayday Sheeba Irshad The Lancet Oncology Published 27 April 2021 Crick labsAdrian HaydayFull details
To Ki or not to Ki: Re-evaluating the use and potentials of Ki-67 for T cell analysis Authors (3) Francesca Di Rosa Andrea CossarizzaAdrian Hayday Frontiers in Immunology Published 1 April 2021 Crick labs/ facilitiesAdrian HaydayFlow CytometryFull details
Neutralization potency of monoclonal antibodies recognizing dominant and subdominant epitopes on SARS-CoV-2 Spike is impacted by the B.1.1.7 variant Authors (29) Carl Graham Jeffrey Seow Isabella Huettner Hataf Khan Neophytos Kouphou Sam Acors[...] Laura E McCoyAdrian Hayday Stuart JD Neil Michael H Malim Katie J Doores Immunity Published 1 April 2021 Crick labsAdrian HaydayPeter Cherepanov Full details
Response to "caution regarding interpretations of intrauterine γδ T cells in protection against experimental vaginal candidiasis" Authors (2)Leticia Monin AldamaAdrian Hayday Mucosal Immunology Published 1 May 2021 Crick labsAdrian HaydayFull details
S95021, a novel selective and pan-neutralizing anti interferon alpha (IFN-α) monoclonal antibody as a candidate treatment for selected autoimmune rheumatic diseases Authors (14) Fanny Duguet Céline Ortega-Ferreira Benjamin Fould Hélène Darville Sylvie Berger Agnès Chomel[...]Adrian Hayday Emiko Desvaux Emmanuel Nony Philippe Moingeon Frédéric De Ceuninck Journal of Translational Autoimmunity Published 1 March 2021 Crick labsAdrian HaydayFull details
Acute immune signatures and their legacies in severe acute respiratory syndrome coronavirus-2 infected cancer patients Authors (51) Sultan Abdul-Jawad Luca Baù Thanussuyah Alaguthurai Irene Del Molino Del Barrio Adam G Laing Thomas S Hayday[...] Anne Rigg Sophie PapaAdrian Hayday Piers EM Patten Sheeba Irshad Cancer Cell Published 8 February 2021 Crick labsAdrian HaydayFull details
Reconstitution of a functional human thymus by postnatal stromal progenitor cells and natural whole-organ scaffolds Authors (22)Sara CampinotiAsllan GjinovciRoberta RagazziniLuca ZanieriLinda Ariza-Mcnaughton Marco Catucci[...] Sarah A Teichmann Neil J SebireAdrian HaydayDominique BonnetPaola Bonfanti Nature Communications Published 11 December 2020 Crick labs/ facilitiesAdrian HaydayDominique BonnetPaola BonfantiBioinformatics and BiostatisticsLight MicroscopyGenomics/Equipment ParkFlow CytometryExperimental HistopathologyElectron MicroscopyBiological Research FacilityAdvanced SequencingFull details
Longitudinal proteomic profiling reveals increased early inflammation and sustained apoptosis proteins in severe COVID-19 Authors (16) Liis Haljasmägi Ahto Salumets Anna Pauliina Rumm Meeri Jürgenson Ekaterina Krassohhina Anu Remm[...] Lili Milani Anu TammAdrian Hayday Kai Kisand Pärt Peterson Scientific Reports Published 25 November 2020 Crick labsAdrian HaydayFull details
Wendy Havran: Scientist, mentor, advocate Authors (7) Willi Born Juan Carlos Zúñiga-Pflücker Karen Edelblum Dieter KabelitzAdrian Hayday Deborah Witherden Julie Jameson Immunological Reviews Published 1 November 2020 Crick labsAdrian HaydayFull details
Human γδ T cells recognize CD1b by two distinct mechanisms Authors (9) Josephine F Reijneveld Tonatiuh A Ocampo Adam Shahine Benjamin S Gully Pierre VantouroutAdrian Hayday Jamie Rossjohn D Branch Moody Ildiko Van Rhijn Proceedings of the National Academy of Sciences of USA Published 15 September 2020 Crick labsAdrian HaydayFull details
β2 Integrins differentially regulate γδ T cell subset thymic development and peripheral maintenance Authors (7) Claire L McIntyreLeticia Monin Aldama Jesse C Rop Thomas D Otto Carl S GoodyearAdrian Hayday Vicky L Morrison Proceedings of the National Academy of Sciences of USA Published 8 September 2020 Crick labsAdrian HaydayFull details
A dynamic COVID-19 immune signature includes associations with poor prognosis Authors (50) Adam G Laing Anna Lorenc Irene Del Molino Del Barrio Abhishek Das Matthew FishLeticia Monin Aldama[...] Katie J Doores Francesca Di Rosa Jonathan Edgeworth Manu Shankar-HariAdrian Hayday Nature Medicine Published 1 October 2020 Crick labs/ facilitiesAdrian HaydayGenomics/Equipment ParkFull details
Butyrophilin-like proteins display combinatorial diversity in selecting and maintaining signature intraepithelial γδ T cell compartments Authors (12) Anett Jandke Daisy MelandriLeticia Monin Aldama Dmitry S Ushakov Adam G Laing Pierre Vantourout[...] Takeshi Nitta Tomoya Narita Hiroshi Takayanagi Regina FeederleAdrian Hayday Nature Communications Published 28 July 2020 Crick labs/ facilitiesAdrian HaydayBioinformatics and BiostatisticsProteomicsGenomics/Equipment ParkFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityFull details
γδ T cells compose a developmentally regulated intrauterine population and protect against vaginal candidiasis Authors (18)Leticia Monin Aldama DS Ushakov H Arnesen N Bah A Jandke M Muñoz-Ruiz[...] M Curtis H Carlsen U Steinhoff P BoysenAdrian Hayday Mucosal Immunology Published 1 November 2020 Crick labs/ facilitiesAdrian HaydayExperimental HistopathologyBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityAdvanced SequencingFull details
Tracking immunodynamics by identification of S-G2/M-phase T cells in human peripheral blood Authors (9) Miguel Munoz-Ruiz Irma Pujol-AutonellHefin Rhys Heather M LongMaria Greco Mark Peakman Tim TreeAdrian Hayday Francesca Di Rosa Journal of Autoimmunity Published 1 August 2020 Crick labs/ facilitiesAdrian HaydayGenomics/Equipment ParkFlow CytometryBioinformatics and BiostatisticsFull details
The innate biologies of adaptive antigen receptors Authors (2)Adrian Hayday Pierre Vantourout Annual Review of Immunology Published 4 February 2020 Crick labsAdrian HaydayFull details
High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation Authors (58) Lucie Abeler-Dörner Adam G Laing Anna Lorenc Dmitry S Ushakov Simon Clare Anneliese O Speak[...] Kevin J Maloy Richard K Grencis Gillian M Griffiths David J AdamsAdrian Hayday Nature Immunology Published 1 January 2020 Crick labs/ facilitiesAdrian HaydayFlow CytometryFull details
Immune responses in the human female reproductive tract Authors (3)Leticia Monin Aldama Emily M Whettlock Victoria Male Immunology Published 1 June 2020 Crick labsAdrian HaydayFull details
Butyrophilin-like 3 directly binds a human Vγ4+ T cell receptor using a modality distinct from clonally-restricted antigen Authors (12) Carrie R Willcox Pierre Vantourout Mahboob Salim Iva Zlatareva Daisy Melandri Leonor Zanardo[...]Svend Kjaer Mark Jeeves Fiyaz MohammedAdrian Hayday Benjamin E Willcox Immunity Published 19 November 2019 Crick labs/ facilitiesAdrian HaydayStructural BiologyFull details
An innate-like Vδ1+ γδ T cell compartment in the human breast is associated with remission in triple-negative breast cancer Authors (12) Yin Wu Fernanda Kyle-Cezar Richard T Woolf Cristina Naceur-Lombardelli Julie OwenDhruva Biswas[...] Pierre Vantourout Patrycja Gazinska Anita Grigoriadis Andrew TuttAdrian Hayday Science Translational Medicine Published 9 October 2019 Crick labsAdrian HaydayFull details
