Research case studies Explore a selection of reports that spotlight particular areas of research at the Crick over the past five years.
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Coronavirus (COVID-19) research Crick researchers are working at the forefront of the scientific response to answer some of the most urgent questions about the SARS-CoV-2 pathogen, from how we can improve testing, to why it’s deadly in some people but causes no symptoms in others.
Breadcrumb Adrian Hayday Hayday lab Immunosurveillance Laboratory : Publications Lab contentLab contentIn this section Overview Vacancies Areas of interest Publications Members Gut Gamma Delta T cells detected by their expression of TCR delta chain RNA (red) line the human colonic epithelium (DAPI; blue) where they are well-placed to perform frontline immune surveillance. 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Colitis (1)Journal of Experimental Medicine (1)Journal of Translational Autoimmunity (1)Médecine Sciences : M/S (1)Methods (1)Nature Cancer (1)Nature Reviews Immunology (1)PLOS Genetics (1)Scientific Reports (1)Seminars in Immunology (1)The Lancet Oncology (1)Transfusion and Apheresis Science (1)Trends in Immunology (1) Facet Journal Publications Displaying 1 - 20 of 95Last updated : 23 March 2023 02:42 Improved memory CD8 T cell response to delayed vaccine boost is associated with a distinct molecular signature Authors (16)Ambra Natalini Sonia Simonetti Gabriele Favaretto Lorenzo Lucantonio Giovanna PeruzziMiguel Munoz-Ruiz[...] Antonella Folgori Alfredo Nicosia Angela SantoniAdrian Hayday Francesca Di Rosa Frontiers in Immunology Published 14 February 2023 Crick labs/ facilitiesAdrian HaydayBioinformatics and BiostatisticsAdvanced SequencingFull details Prolidase deficiency causes spontaneous T cell activation and lupus-like autoimmunity Authors (16) Rose Hodgson Tanya L Crockford Aneesha Bhandari Jessica D Kepple Jennifer Back Eleanor Cawthorne[...] Gordon DouganAdrian Hayday Mukta Deobagkar-Lele Richard J Cornall Katherine R Bull Journal of Immunology Published 1 March 2023 Crick labsAdrian HaydayFull details Durable CD8 T cell memory against SARS-CoV-2 by prime/boost and multi-dose vaccination: Considerations on inter-dose time intervals Authors (6)Ambra Natalini Sonia Simonetti Carmel Sher Ugo D'OroAdrian Hayday Francesca Di Rosa International Journal of Molecular Sciences Published 19 November 2022 Crick labsAdrian HaydayFull details Boosting of waned humoral and cellular responses to SARS-CoV-2 variants of concern among patients with cancer Authors (19)Duncan McKenzie Rosalind Graham Thomas Lechmere Clara Domingo-Vila Thanussuyah Alaguthurai Celeste Arman[...] Bernard V North Timothy Tree Katie J DooresAdrian Hayday Sheeba Irshad Cancer Research Communications Published 1 November 2022 Crick labsAdrian HaydayFull details Antibodies as drugs—a Keystone Symposia report Authors (31) Jennifer Cable Erica Ollmann SaphireAdrian Hayday Timothy D Wiltshire Jarrod J Mousa David P Humphreys[...] Rachael M Wolters Cecile AW Geuijen Matthew A Sleeman Niccolo Pengo Francesca Rose Donnellan Annals of the New York Academy of Sciences Published 1 January 2023 Crick labsAdrian HaydayFull details Global patterns of antigen receptor repertoire disruption across adaptive immune compartments in COVID-19 Authors (41) Magdalene Joseph Yin Wu Richard Dannebaum Florian Rubelt Iva Zlatareva Anna Lorenc[...] Katie J Doores Pierre Vantourout Khai Luong Jan BerkaAdrian Hayday Proceedings of the National Academy of Sciences of USA Published 23 August 2022 Crick labsAdrian HaydayFull details Anti-type I interferon antibodies as a cause of severe COVID-19 Authors (6) David C FajgenbaumAdrian Hayday Angela J Rogers Greg J TowersAndreas Wack Ivan Zanoni Faculty Reviews Published 10 June 2022 Crick labsAndreas WackAdrian HaydayFull details A local human Vδ1 T cell population is associated with survival in nonsmall-cell lung cancer Authors (21) Yin WuDhruva Biswas Ieva UsaiteMihaela Angelova Stefan BoeingTakahiro Karasaki[...] Mariam Jamal-Hanjani Allan Hackshaw Sergio A QuezadaAdrian HaydayCharles Swanton Nature Cancer Published 1 June 2022 Crick labs/ facilitiesCharles SwantonAdrian HaydayBioinformatics and BiostatisticsFull details Normality sensing licenses local T cells for innate-like tissue surveillance Authors (7)Duncan McKenzie Rosie Hart Nourdine Bah Dmitry S UshakovMiguel Munoz-Ruiz Regina FeederleAdrian Hayday Nature Immunology Published 1 March 2022 Crick labs/ facilitiesAdrian HaydayBioinformatics and BiostatisticsLight MicroscopyGenomics/Equipment ParkFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityAdvanced SequencingFull details Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition) Authors (193) Andrea Cossarizza Hyun-Dong Chang Andreas Radbruch Sergio Abrignani Richard Addo Mübeccel Akdis[...] James Wing Oliver Wirz Jens Wittner Jennie HM Yang Juhao Yang European Journal of Immunology Published 1 December 2021 Crick labs/ facilitiesAdrian HaydayFlow CytometryFull details COVID-19: Using high-throughput flow cytometry to dissect clinical heterogeneity Authors (5) Irene Del Molino Del Barrio Thomas S Hayday Adam G LaingAdrian Hayday Francesca Di Rosa Cytometry A Published 1 February 2023 Crick labsAdrian HaydayFull details Association of cardiometabolic microRNAs with COVID-19 severity and mortality Authors (26) Clemens Gutmann Kseniya Khamina Konstantinos Theofilatos Andreas B Diendorfer Sean A Burnap Adam Nabeebaccus[...] Ludwig Traby Matthias Hackl Sabine Eichinger Manu Shankar-Hari Manuel Mayr Cardiovascular Research Published 1 February 2022 Crick labsAdrian HaydayFull details OMIP-079: Cell cycle of CD4+ and CD8+ naïve/memory T cell subsets, and of Treg cells from mouse spleen Authors (9) Ambra Natalini Sonia Simonetti Gabriele Favaretto Giovanna Peruzzi Fabrizio Antonangeli Angela SantoniMiguel Munoz-RuizAdrian Hayday Francesca Di Rosa Cytometry A Published 1 December 2021 Crick labs/ facilitiesAdrian HaydayFlow CytometryFull details Humoral and cellular immunity to delayed second dose of SARS-CoV-2 BNT162b2 mRNA vaccination in patients with cancer Authors (28)Duncan McKenzieMiguel Munoz-RuizLeticia Monin Aldama Thanussuyah Alaguthurai Thomas Lechmere Sultan Abdul-Jawad[...] Bernard V North Timothy Tree Katie J DooresAdrian Hayday Sheeba Irshad Cancer Cell Published 8 November 2021 Crick labsAdrian HaydayFull details Comment on "Aberrant type 1 immunity drives susceptibility to mucosal fungal infections" Authors (4) Kai Kisand Anthony MeagerAdrian Hayday Nick Willcox Science Published 17 September 2021 Crick labsAdrian HaydayFull details SARS-CoV-2 RNAemia and proteomic trajectories inform prognostication in COVID-19 patients admitted to intensive care Authors (37) Clemens Gutmann Kaloyan Takov Sean A Burnap Bhawana Singh Hashim Ali Konstantinos Theofilatos[...] Torsten TonnAdrian Hayday Mauro Giacca Manu Shankar-Hari Manuel Mayr Nature Communications Published 7 June 2021 Crick labsAdrian HaydayFull details Safety and immunogenicity of one versus two doses of the COVID-19 vaccine BNT162b2 for patients with cancer: interim analysis of a prospective observational study Authors (44)Leticia Monin Aldama Adam G LaingMiguel Munoz-RuizDuncan McKenzie Irene Del Molino Del Barrio Thanussuyah Alaguthurai[...] Sophie Papa Timothy Tree Katie J DooresAdrian Hayday Sheeba Irshad The Lancet Oncology Published 1 June 2021 Crick labsAdrian HaydayFull details To Ki or not to Ki: Re-evaluating the use and potentials of Ki-67 for T cell analysis Authors (3) Francesca Di Rosa Andrea CossarizzaAdrian Hayday Frontiers in Immunology Published 1 April 2021 Crick labs/ facilitiesAdrian HaydayFlow CytometryFull details Neutralization potency of monoclonal antibodies recognizing dominant and subdominant epitopes on SARS-CoV-2 Spike is impacted by the B.1.1.7 variant Authors (29) Carl Graham Jeffrey Seow Isabella Huettner Hataf Khan Neophytos Kouphou Sam Acors[...] Laura E McCoyAdrian Hayday Stuart JD Neil Michael H Malim Katie J Doores Immunity Published 8 June 2021 Crick labsAdrian HaydayPeter Cherepanov Full details Response to "caution regarding interpretations of intrauterine γδ T cells in protection against experimental vaginal candidiasis" Authors (2)Leticia Monin AldamaAdrian Hayday Mucosal Immunology Published 1 May 2021 Crick labsAdrian HaydayFull details Pagination Current page 1 Page 2 Page 3 Page 4 Page 5 Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Improved memory CD8 T cell response to delayed vaccine boost is associated with a distinct molecular signature Authors (16)Ambra Natalini Sonia Simonetti Gabriele Favaretto Lorenzo Lucantonio Giovanna PeruzziMiguel Munoz-Ruiz[...] Antonella Folgori Alfredo Nicosia Angela SantoniAdrian Hayday Francesca Di Rosa Frontiers in Immunology Published 14 February 2023 Crick labs/ facilitiesAdrian HaydayBioinformatics and BiostatisticsAdvanced SequencingFull details
Prolidase deficiency causes spontaneous T cell activation and lupus-like autoimmunity Authors (16) Rose Hodgson Tanya L Crockford Aneesha Bhandari Jessica D Kepple Jennifer Back Eleanor Cawthorne[...] Gordon DouganAdrian Hayday Mukta Deobagkar-Lele Richard J Cornall Katherine R Bull Journal of Immunology Published 1 March 2023 Crick labsAdrian HaydayFull details
Durable CD8 T cell memory against SARS-CoV-2 by prime/boost and multi-dose vaccination: Considerations on inter-dose time intervals Authors (6)Ambra Natalini Sonia Simonetti Carmel Sher Ugo D'OroAdrian Hayday Francesca Di Rosa International Journal of Molecular Sciences Published 19 November 2022 Crick labsAdrian HaydayFull details
Boosting of waned humoral and cellular responses to SARS-CoV-2 variants of concern among patients with cancer Authors (19)Duncan McKenzie Rosalind Graham Thomas Lechmere Clara Domingo-Vila Thanussuyah Alaguthurai Celeste Arman[...] Bernard V North Timothy Tree Katie J DooresAdrian Hayday Sheeba Irshad Cancer Research Communications Published 1 November 2022 Crick labsAdrian HaydayFull details
Antibodies as drugs—a Keystone Symposia report Authors (31) Jennifer Cable Erica Ollmann SaphireAdrian Hayday Timothy D Wiltshire Jarrod J Mousa David P Humphreys[...] Rachael M Wolters Cecile AW Geuijen Matthew A Sleeman Niccolo Pengo Francesca Rose Donnellan Annals of the New York Academy of Sciences Published 1 January 2023 Crick labsAdrian HaydayFull details
Global patterns of antigen receptor repertoire disruption across adaptive immune compartments in COVID-19 Authors (41) Magdalene Joseph Yin Wu Richard Dannebaum Florian Rubelt Iva Zlatareva Anna Lorenc[...] Katie J Doores Pierre Vantourout Khai Luong Jan BerkaAdrian Hayday Proceedings of the National Academy of Sciences of USA Published 23 August 2022 Crick labsAdrian HaydayFull details
Anti-type I interferon antibodies as a cause of severe COVID-19 Authors (6) David C FajgenbaumAdrian Hayday Angela J Rogers Greg J TowersAndreas Wack Ivan Zanoni Faculty Reviews Published 10 June 2022 Crick labsAndreas WackAdrian HaydayFull details
A local human Vδ1 T cell population is associated with survival in nonsmall-cell lung cancer Authors (21) Yin WuDhruva Biswas Ieva UsaiteMihaela Angelova Stefan BoeingTakahiro Karasaki[...] Mariam Jamal-Hanjani Allan Hackshaw Sergio A QuezadaAdrian HaydayCharles Swanton Nature Cancer Published 1 June 2022 Crick labs/ facilitiesCharles SwantonAdrian HaydayBioinformatics and BiostatisticsFull details
Normality sensing licenses local T cells for innate-like tissue surveillance Authors (7)Duncan McKenzie Rosie Hart Nourdine Bah Dmitry S UshakovMiguel Munoz-Ruiz Regina FeederleAdrian Hayday Nature Immunology Published 1 March 2022 Crick labs/ facilitiesAdrian HaydayBioinformatics and BiostatisticsLight MicroscopyGenomics/Equipment ParkFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityAdvanced SequencingFull details
Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition) Authors (193) Andrea Cossarizza Hyun-Dong Chang Andreas Radbruch Sergio Abrignani Richard Addo Mübeccel Akdis[...] James Wing Oliver Wirz Jens Wittner Jennie HM Yang Juhao Yang European Journal of Immunology Published 1 December 2021 Crick labs/ facilitiesAdrian HaydayFlow CytometryFull details
COVID-19: Using high-throughput flow cytometry to dissect clinical heterogeneity Authors (5) Irene Del Molino Del Barrio Thomas S Hayday Adam G LaingAdrian Hayday Francesca Di Rosa Cytometry A Published 1 February 2023 Crick labsAdrian HaydayFull details
Association of cardiometabolic microRNAs with COVID-19 severity and mortality Authors (26) Clemens Gutmann Kseniya Khamina Konstantinos Theofilatos Andreas B Diendorfer Sean A Burnap Adam Nabeebaccus[...] Ludwig Traby Matthias Hackl Sabine Eichinger Manu Shankar-Hari Manuel Mayr Cardiovascular Research Published 1 February 2022 Crick labsAdrian HaydayFull details
OMIP-079: Cell cycle of CD4+ and CD8+ naïve/memory T cell subsets, and of Treg cells from mouse spleen Authors (9) Ambra Natalini Sonia Simonetti Gabriele Favaretto Giovanna Peruzzi Fabrizio Antonangeli Angela SantoniMiguel Munoz-RuizAdrian Hayday Francesca Di Rosa Cytometry A Published 1 December 2021 Crick labs/ facilitiesAdrian HaydayFlow CytometryFull details
Humoral and cellular immunity to delayed second dose of SARS-CoV-2 BNT162b2 mRNA vaccination in patients with cancer Authors (28)Duncan McKenzieMiguel Munoz-RuizLeticia Monin Aldama Thanussuyah Alaguthurai Thomas Lechmere Sultan Abdul-Jawad[...] Bernard V North Timothy Tree Katie J DooresAdrian Hayday Sheeba Irshad Cancer Cell Published 8 November 2021 Crick labsAdrian HaydayFull details
Comment on "Aberrant type 1 immunity drives susceptibility to mucosal fungal infections" Authors (4) Kai Kisand Anthony MeagerAdrian Hayday Nick Willcox Science Published 17 September 2021 Crick labsAdrian HaydayFull details
SARS-CoV-2 RNAemia and proteomic trajectories inform prognostication in COVID-19 patients admitted to intensive care Authors (37) Clemens Gutmann Kaloyan Takov Sean A Burnap Bhawana Singh Hashim Ali Konstantinos Theofilatos[...] Torsten TonnAdrian Hayday Mauro Giacca Manu Shankar-Hari Manuel Mayr Nature Communications Published 7 June 2021 Crick labsAdrian HaydayFull details
Safety and immunogenicity of one versus two doses of the COVID-19 vaccine BNT162b2 for patients with cancer: interim analysis of a prospective observational study Authors (44)Leticia Monin Aldama Adam G LaingMiguel Munoz-RuizDuncan McKenzie Irene Del Molino Del Barrio Thanussuyah Alaguthurai[...] Sophie Papa Timothy Tree Katie J DooresAdrian Hayday Sheeba Irshad The Lancet Oncology Published 1 June 2021 Crick labsAdrian HaydayFull details
To Ki or not to Ki: Re-evaluating the use and potentials of Ki-67 for T cell analysis Authors (3) Francesca Di Rosa Andrea CossarizzaAdrian Hayday Frontiers in Immunology Published 1 April 2021 Crick labs/ facilitiesAdrian HaydayFlow CytometryFull details
Neutralization potency of monoclonal antibodies recognizing dominant and subdominant epitopes on SARS-CoV-2 Spike is impacted by the B.1.1.7 variant Authors (29) Carl Graham Jeffrey Seow Isabella Huettner Hataf Khan Neophytos Kouphou Sam Acors[...] Laura E McCoyAdrian Hayday Stuart JD Neil Michael H Malim Katie J Doores Immunity Published 8 June 2021 Crick labsAdrian HaydayPeter Cherepanov Full details
Response to "caution regarding interpretations of intrauterine γδ T cells in protection against experimental vaginal candidiasis" Authors (2)Leticia Monin AldamaAdrian Hayday Mucosal Immunology Published 1 May 2021 Crick labsAdrian HaydayFull details