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Breadcrumb Adrian Hayday Hayday lab Immunosurveillance Laboratory : Publications Lab contentLab contentIn this section Overview Exhibit at the Royal Society Vacancies Areas of interest Publications Members Gut Gamma Delta T cells detected by their expression of TCR delta chain RNA (red) line the human colonic epithelium (DAPI; blue) where they are well-placed to perform frontline immune surveillance. Toggle to view hero caption PublicationsYear published2024 (1)2023 (8)2022 (2)2020 (3)2019 (1)2018 (1)2015 (1) Facet Year publishedResearch topicsHuman Biology & Physiology (17)Immunology (17)Model Organisms (17)Computational & Systems Biology (16)Genetics & Genomics (12)Genome Integrity & Repair (12)Tumour Biology (12)Developmental Biology (3)Metabolism (3)Stem Cells (3)Synthetic Biology (3)Cell Biology (2)Signalling & Oncogenes (2)Biochemistry & Proteomics (1)Cell Cycle & Chromosomes (1)Imaging (1)Infectious Disease (1)Neurosciences (1)Structural Biology & Biophysics (1) (-)Chemical Biology & High Throughput (17) Facet Research topicsPublication typeJournal article (17)Primary research (16)Review (1) Facet Publication typeJournalNature Communications (3)Nature Cancer (2)Annual Review of Cancer Biology (1)Developmental Cell (1)EClinicalMedicine (1)Frontiers in Immunology (1)Immunity (1)Journal of Allergy and Clinical Immunology (1)Mucosal Immunology (1)Nature Immunology (1)Proceedings of the National Academy of Sciences of the United States of America (1)Science (1)The Lancet Regional Health - Europe (1)The Lancet Respiratory Medicine (1) Facet Journal Publications Displaying 1 - 17 of 17Last updated : 28 March 2024 03:10 PD-1 defines a distinct, functional, tissue-adapted state in Vδ1+ T cells with implications for cancer immunotherapy Authors (16) Daniel Davies Shraddha Kamdar Richard Woolf Iva Zlatareva Maria Luisa Iannitto Cienne Morton[...] Cheryl GillettOlga O'Neill Oliver NussbaumerAdrian Hayday Yin Wu Nature Cancer Published 1 March 2024 Crick labs/ facilitiesAdrian HaydayAdvanced SequencingFull details Conserved γδ T cell selection by BTNL proteins limits progression of human inflammatory bowel disease Authors (14) Robin J Dart Iva Zlatareva Pierre Vantourout Efstathios Theodoridis Ariella Amar Shichina Kannambath[...] Christopher A Lamb Miles Parkes Peter M Irving Natalie J PrescottAdrian Hayday Science Published 15 September 2023 Crick labs/ facilitiesAdrian HaydayBioinformatics and BiostatisticsAdvanced SequencingFull details Defining the identity and the niches of epithelial stem cells with highly pleiotropic multilineage potency in the human thymus Authors (17)Roberta RagazziniStefan BoeingLuca ZanieriMary GreenGiuseppe D'Agostino Kerol Bartolovic[...] David Scoville Andy NamAdrian HaydayDominique BonnetPaola Bonfanti Developmental Cell Published 20 November 2023 Crick labs/ facilitiesAdrian HaydayDominique BonnetPaola BonfantiFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsLight MicroscopyAdvanced SequencingFull details IFN-γ–dependent interactions between tissue-intrinsic γδ T cells and tissue-infiltrating CD8 T cells limit allergic contact dermatitis Authors (15)Miguel Munoz-Ruiz Miriam LlorianRocco D'Antuono Anna PavlovaAnna Maria MavrigiannakiDuncan McKenzie[...] Daniel Davies Mariam Jamal-Hanjani Anett Jandke Dmitry S UshakovAdrian Hayday Journal of Allergy and Clinical Immunology Published 1 December 2023 Crick labs/ facilitiesVassilis PachnisAdrian HaydayLight MicroscopyBioinformatics and BiostatisticsFull details Determinants of recovery from post-COVID-19 dyspnoea: analysis of UK prospective cohorts of hospitalised COVID-19 patients and community-based controls Authors (37) B Zheng G Vivaldi L Daines OC Leavy M Richardson O Elneima[...] RA Evans CE Brightling A Martineau A Sheikh The PHOSP-COVID Study Collaborative Group The Lancet Regional Health - Europe Published 1 June 2023 Crick labsMarkus RalserAdrian HaydayFull details Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study Authors (62) Callum Jackson Iain D Stewart Tatiana Plekhanova Peter S Cunningham Andrew L Hazel Bashar Al-Sheklly[...] Rachael A Evans Samuel E Jones Martin K Rutter John F Blaikley PHOSP-COVID Study Collaborative Group The Lancet Respiratory Medicine Published 1 August 2023 Crick labsMarkus RalserAdrian HaydayFull details Prevalence of physical frailty, including risk factors, up to 1 year after hospitalisation for COVID-19 in the UK: a multicentre, longitudinal cohort study Authors (38) HJC McAuley RA Evans CE Bolton CE Brightling JD Chalmers AB Docherty[...] J Whitney MD Witham J Lord NJ Greening The PHOSP-COVID Study Collaborative Group EClinicalMedicine Published 1 March 2023 Crick labsMarkus RalserAdrian HaydayFull details Improved memory CD8 T cell response to delayed vaccine boost is associated with a distinct molecular signature Authors (16)Ambra Natalini Sonia Simonetti Gabriele Favaretto Lorenzo Lucantonio Giovanna PeruzziMiguel Munoz-Ruiz[...] Antonella Folgori Alfredo Nicosia Angela SantoniAdrian Hayday Francesca Di Rosa Frontiers in Immunology Published 14 February 2023 Crick labs/ facilitiesAdrian HaydayBioinformatics and BiostatisticsAdvanced SequencingFull details The effects of clonal heterogeneity on cancer immunosurveillance Authors (3)Krijn Dijkstra Yin WuCharles Swanton Annual Review of Cancer Biology Published 1 April 2023 Crick labsCharles SwantonAdrian HaydayFull details A local human Vδ1 T cell population is associated with survival in nonsmall-cell lung cancer Authors (21) Yin WuDhruva Biswas Ieva UsaiteMihaela Angelova Stefan BoeingTakahiro Karasaki[...] Mariam Jamal-Hanjani Allan Hackshaw Sergio A QuezadaAdrian HaydayCharles Swanton Nature Cancer Published 1 June 2022 Crick labs/ facilitiesCharles SwantonAdrian HaydayBioinformatics and BiostatisticsFull details Normality sensing licenses local T cells for innate-like tissue surveillance Authors (7)Duncan McKenzie Rosie Hart Nourdine Bah Dmitry S UshakovMiguel Munoz-Ruiz Regina FeederleAdrian Hayday Nature Immunology Published 1 March 2022 Crick labs/ facilitiesAdrian HaydayBioinformatics and BiostatisticsLight MicroscopyFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityAdvanced SequencingFull details Reconstitution of a functional human thymus by postnatal stromal progenitor cells and natural whole-organ scaffolds Authors (22)Sara CampinotiAsllan GjinovciRoberta RagazziniLuca ZanieriLinda Ariza-Mcnaughton Marco Catucci[...] Sarah A Teichmann Neil J SebireAdrian HaydayDominique BonnetPaola Bonfanti Nature Communications Published 11 December 2020 Crick labs/ facilitiesAdrian HaydayDominique BonnetPaola BonfantiBioinformatics and BiostatisticsLight MicroscopyFlow CytometryExperimental HistopathologyElectron MicroscopyBiological Research FacilityAdvanced SequencingFull details Butyrophilin-like proteins display combinatorial diversity in selecting and maintaining signature intraepithelial γδ T cell compartments Authors (12) Anett Jandke Daisy MelandriLeticia Monin Aldama Dmitry S Ushakov Adam G Laing Pierre Vantourout[...] Takeshi Nitta Tomoya Narita Hiroshi Takayanagi Regina FeederleAdrian Hayday Nature Communications Published 28 July 2020 Crick labs/ facilitiesAdrian HaydayBioinformatics and BiostatisticsProteomicsFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityAdvanced SequencingFull details γδ T cells compose a developmentally regulated intrauterine population and protect against vaginal candidiasis Authors (18)Leticia Monin Aldama DS Ushakov H Arnesen N Bah A JandkeMiguel Munoz-Ruiz[...] M Curtis H Carlsen U Steinhoff P BoysenAdrian Hayday Mucosal Immunology Published 1 November 2020 Crick labs/ facilitiesAdrian HaydayExperimental HistopathologyBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityAdvanced SequencingFull details Butyrophilin-like 3 directly binds a human Vγ4+ T cell receptor using a modality distinct from clonally-restricted antigen Authors (12) Carrie R Willcox Pierre Vantourout Mahboob Salim Iva Zlatareva Daisy Melandri Leonor Zanardo[...]Svend Kjaer Mark Jeeves Fiyaz MohammedAdrian Hayday Benjamin E Willcox Immunity Published 19 November 2019 Crick labs/ facilitiesAdrian HaydayStructural BiologyFull details Heteromeric interactions regulate butyrophilin (BTN) and BTN-like molecules governing γδ T cell biology Authors (9) Pierre Vantourout Adam Laing Martin J Woodward Iva Zlatareva Luis ApoloniaAndrew JonesBram Snijders Michael H MalimAdrian Hayday Proceedings of the National Academy of Sciences of the United States of America Published 30 January 2018 Crick labs/ facilitiesAdrian HaydayProteomicsStructural BiologyFull details Intestinal intraepithelial lymphocyte activation promotes innate antiviral resistance Authors (12) Mahima Swamy Lucie Abeler-Dörner James Chettle Tanel Mahlakõiv Delphine Goubau Probir Chakravarty[...]Caetano Reis e Sousa Peter Staeheli Barbara A Blacklaws Jonathan L HeeneyAdrian Hayday Nature Communications Published 19 May 2015 Crick labs/ facilitiesCaetano Reis e SousaAdrian HaydayBioinformatics and BiostatisticsFlow CytometryExperimental HistopathologyBiological Research FacilityFull details Share the page Share on Twitter Share on Facebook 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PD-1 defines a distinct, functional, tissue-adapted state in Vδ1+ T cells with implications for cancer immunotherapy Authors (16) Daniel Davies Shraddha Kamdar Richard Woolf Iva Zlatareva Maria Luisa Iannitto Cienne Morton[...] Cheryl GillettOlga O'Neill Oliver NussbaumerAdrian Hayday Yin Wu Nature Cancer Published 1 March 2024 Crick labs/ facilitiesAdrian HaydayAdvanced SequencingFull details
Conserved γδ T cell selection by BTNL proteins limits progression of human inflammatory bowel disease Authors (14) Robin J Dart Iva Zlatareva Pierre Vantourout Efstathios Theodoridis Ariella Amar Shichina Kannambath[...] Christopher A Lamb Miles Parkes Peter M Irving Natalie J PrescottAdrian Hayday Science Published 15 September 2023 Crick labs/ facilitiesAdrian HaydayBioinformatics and BiostatisticsAdvanced SequencingFull details
Defining the identity and the niches of epithelial stem cells with highly pleiotropic multilineage potency in the human thymus Authors (17)Roberta RagazziniStefan BoeingLuca ZanieriMary GreenGiuseppe D'Agostino Kerol Bartolovic[...] David Scoville Andy NamAdrian HaydayDominique BonnetPaola Bonfanti Developmental Cell Published 20 November 2023 Crick labs/ facilitiesAdrian HaydayDominique BonnetPaola BonfantiFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsLight MicroscopyAdvanced SequencingFull details
IFN-γ–dependent interactions between tissue-intrinsic γδ T cells and tissue-infiltrating CD8 T cells limit allergic contact dermatitis Authors (15)Miguel Munoz-Ruiz Miriam LlorianRocco D'Antuono Anna PavlovaAnna Maria MavrigiannakiDuncan McKenzie[...] Daniel Davies Mariam Jamal-Hanjani Anett Jandke Dmitry S UshakovAdrian Hayday Journal of Allergy and Clinical Immunology Published 1 December 2023 Crick labs/ facilitiesVassilis PachnisAdrian HaydayLight MicroscopyBioinformatics and BiostatisticsFull details
Determinants of recovery from post-COVID-19 dyspnoea: analysis of UK prospective cohorts of hospitalised COVID-19 patients and community-based controls Authors (37) B Zheng G Vivaldi L Daines OC Leavy M Richardson O Elneima[...] RA Evans CE Brightling A Martineau A Sheikh The PHOSP-COVID Study Collaborative Group The Lancet Regional Health - Europe Published 1 June 2023 Crick labsMarkus RalserAdrian HaydayFull details
Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study Authors (62) Callum Jackson Iain D Stewart Tatiana Plekhanova Peter S Cunningham Andrew L Hazel Bashar Al-Sheklly[...] Rachael A Evans Samuel E Jones Martin K Rutter John F Blaikley PHOSP-COVID Study Collaborative Group The Lancet Respiratory Medicine Published 1 August 2023 Crick labsMarkus RalserAdrian HaydayFull details
Prevalence of physical frailty, including risk factors, up to 1 year after hospitalisation for COVID-19 in the UK: a multicentre, longitudinal cohort study Authors (38) HJC McAuley RA Evans CE Bolton CE Brightling JD Chalmers AB Docherty[...] J Whitney MD Witham J Lord NJ Greening The PHOSP-COVID Study Collaborative Group EClinicalMedicine Published 1 March 2023 Crick labsMarkus RalserAdrian HaydayFull details
Improved memory CD8 T cell response to delayed vaccine boost is associated with a distinct molecular signature Authors (16)Ambra Natalini Sonia Simonetti Gabriele Favaretto Lorenzo Lucantonio Giovanna PeruzziMiguel Munoz-Ruiz[...] Antonella Folgori Alfredo Nicosia Angela SantoniAdrian Hayday Francesca Di Rosa Frontiers in Immunology Published 14 February 2023 Crick labs/ facilitiesAdrian HaydayBioinformatics and BiostatisticsAdvanced SequencingFull details
The effects of clonal heterogeneity on cancer immunosurveillance Authors (3)Krijn Dijkstra Yin WuCharles Swanton Annual Review of Cancer Biology Published 1 April 2023 Crick labsCharles SwantonAdrian HaydayFull details
A local human Vδ1 T cell population is associated with survival in nonsmall-cell lung cancer Authors (21) Yin WuDhruva Biswas Ieva UsaiteMihaela Angelova Stefan BoeingTakahiro Karasaki[...] Mariam Jamal-Hanjani Allan Hackshaw Sergio A QuezadaAdrian HaydayCharles Swanton Nature Cancer Published 1 June 2022 Crick labs/ facilitiesCharles SwantonAdrian HaydayBioinformatics and BiostatisticsFull details
Normality sensing licenses local T cells for innate-like tissue surveillance Authors (7)Duncan McKenzie Rosie Hart Nourdine Bah Dmitry S UshakovMiguel Munoz-Ruiz Regina FeederleAdrian Hayday Nature Immunology Published 1 March 2022 Crick labs/ facilitiesAdrian HaydayBioinformatics and BiostatisticsLight MicroscopyFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityAdvanced SequencingFull details
Reconstitution of a functional human thymus by postnatal stromal progenitor cells and natural whole-organ scaffolds Authors (22)Sara CampinotiAsllan GjinovciRoberta RagazziniLuca ZanieriLinda Ariza-Mcnaughton Marco Catucci[...] Sarah A Teichmann Neil J SebireAdrian HaydayDominique BonnetPaola Bonfanti Nature Communications Published 11 December 2020 Crick labs/ facilitiesAdrian HaydayDominique BonnetPaola BonfantiBioinformatics and BiostatisticsLight MicroscopyFlow CytometryExperimental HistopathologyElectron MicroscopyBiological Research FacilityAdvanced SequencingFull details
Butyrophilin-like proteins display combinatorial diversity in selecting and maintaining signature intraepithelial γδ T cell compartments Authors (12) Anett Jandke Daisy MelandriLeticia Monin Aldama Dmitry S Ushakov Adam G Laing Pierre Vantourout[...] Takeshi Nitta Tomoya Narita Hiroshi Takayanagi Regina FeederleAdrian Hayday Nature Communications Published 28 July 2020 Crick labs/ facilitiesAdrian HaydayBioinformatics and BiostatisticsProteomicsFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityAdvanced SequencingFull details
γδ T cells compose a developmentally regulated intrauterine population and protect against vaginal candidiasis Authors (18)Leticia Monin Aldama DS Ushakov H Arnesen N Bah A JandkeMiguel Munoz-Ruiz[...] M Curtis H Carlsen U Steinhoff P BoysenAdrian Hayday Mucosal Immunology Published 1 November 2020 Crick labs/ facilitiesAdrian HaydayExperimental HistopathologyBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityAdvanced SequencingFull details
Butyrophilin-like 3 directly binds a human Vγ4+ T cell receptor using a modality distinct from clonally-restricted antigen Authors (12) Carrie R Willcox Pierre Vantourout Mahboob Salim Iva Zlatareva Daisy Melandri Leonor Zanardo[...]Svend Kjaer Mark Jeeves Fiyaz MohammedAdrian Hayday Benjamin E Willcox Immunity Published 19 November 2019 Crick labs/ facilitiesAdrian HaydayStructural BiologyFull details
Heteromeric interactions regulate butyrophilin (BTN) and BTN-like molecules governing γδ T cell biology Authors (9) Pierre Vantourout Adam Laing Martin J Woodward Iva Zlatareva Luis ApoloniaAndrew JonesBram Snijders Michael H MalimAdrian Hayday Proceedings of the National Academy of Sciences of the United States of America Published 30 January 2018 Crick labs/ facilitiesAdrian HaydayProteomicsStructural BiologyFull details
Intestinal intraepithelial lymphocyte activation promotes innate antiviral resistance Authors (12) Mahima Swamy Lucie Abeler-Dörner James Chettle Tanel Mahlakõiv Delphine Goubau Probir Chakravarty[...]Caetano Reis e Sousa Peter Staeheli Barbara A Blacklaws Jonathan L HeeneyAdrian Hayday Nature Communications Published 19 May 2015 Crick labs/ facilitiesCaetano Reis e SousaAdrian HaydayBioinformatics and BiostatisticsFlow CytometryExperimental HistopathologyBiological Research FacilityFull details