Research case studies Explore a selection of reports that spotlight particular areas of research at the Crick over the past five years.
Postdoctoral clinical fellows Opportunities for postdoctoral clinicians to consolidate their research experience.
Breadcrumb Adrian Hayday Hayday lab Immunosurveillance Laboratory : Publications Lab contentLab contentIn this section Overview Exhibit at the Royal Society Vacancies Areas of interest Publications Members Gut Gamma Delta T cells detected by their expression of TCR delta chain RNA (red) line the human colonic epithelium (DAPI; blue) where they are well-placed to perform frontline immune surveillance. Toggle to view hero caption PublicationsYear published2024 (1)2023 (5)2022 (2)2021 (1)2020 (3)2015 (2) Facet Year publishedResearch topicsHuman Biology & Physiology (14)Immunology (14)Model Organisms (14)Genetics & Genomics (13)Tumour Biology (13)Chemical Biology & High Throughput (12)Computational & Systems Biology (12)Stem Cells (4)Developmental Biology (3)Cell Biology (2)Cell Cycle & Chromosomes (2)Signalling & Oncogenes (2)Biochemistry & Proteomics (1)Gene Expression (1)Imaging (1)Infectious Disease (1)Neurosciences (1)Structural Biology & Biophysics (1) (-)Genome Integrity & Repair (14) Facet Research topicsPublication typeJournal article (14)Primary research (13)Review (1) Facet Publication typeJournalNature Communications (3)Nature Cancer (2)Annual Review of Cancer Biology (1)Developmental Cell (1)Frontiers in Immunology (1)Immunity (1)Journal of Allergy and Clinical Immunology (1)Mucosal Immunology (1)Nature Immunology (1)PLOS Genetics (1)Science (1) Facet Journal Publications Displaying 1 - 14 of 14Last updated : 18 April 2024 02:13 PD-1 defines a distinct, functional, tissue-adapted state in Vδ1+ T cells with implications for cancer immunotherapy Authors (16) Daniel Davies Shraddha Kamdar Richard Woolf Iva Zlatareva Maria Luisa Iannitto Cienne Morton[...] Cheryl GillettOlga O'Neill Oliver NussbaumerAdrian Hayday Yin Wu Nature Cancer Published 1 March 2024 Crick labs/ facilitiesAdrian HaydayAdvanced SequencingFull details Conserved γδ T cell selection by BTNL proteins limits progression of human inflammatory bowel disease Authors (14) Robin J Dart Iva Zlatareva Pierre Vantourout Efstathios Theodoridis Ariella Amar Shichina Kannambath[...] Christopher A Lamb Miles Parkes Peter M Irving Natalie J PrescottAdrian Hayday Science Published 15 September 2023 Crick labs/ facilitiesAdrian HaydayBioinformatics and BiostatisticsAdvanced SequencingFull details Defining the identity and the niches of epithelial stem cells with highly pleiotropic multilineage potency in the human thymus Authors (17)Roberta RagazziniStefan BoeingLuca ZanieriMary GreenGiuseppe D'Agostino Kerol Bartolovic[...] David Scoville Andy NamAdrian HaydayDominique BonnetPaola Bonfanti Developmental Cell Published 20 November 2023 Crick labs/ facilitiesAdrian HaydayDominique BonnetPaola BonfantiFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsLight MicroscopyAdvanced SequencingFull details IFN-γ–dependent interactions between tissue-intrinsic γδ T cells and tissue-infiltrating CD8 T cells limit allergic contact dermatitis Authors (15)Miguel Munoz-Ruiz Miriam LlorianRocco D'Antuono Anna PavlovaAnna Maria MavrigiannakiDuncan McKenzie[...] Daniel Davies Mariam Jamal-Hanjani Anett Jandke Dmitry S UshakovAdrian Hayday Journal of Allergy and Clinical Immunology Published 1 December 2023 Crick labs/ facilitiesVassilis PachnisAdrian HaydayLight MicroscopyBioinformatics and BiostatisticsFull details Improved memory CD8 T cell response to delayed vaccine boost is associated with a distinct molecular signature Authors (16)Ambra Natalini Sonia Simonetti Gabriele Favaretto Lorenzo Lucantonio Giovanna PeruzziMiguel Munoz-Ruiz[...] Antonella Folgori Alfredo Nicosia Angela SantoniAdrian Hayday Francesca Di Rosa Frontiers in Immunology Published 14 February 2023 Crick labs/ facilitiesAdrian HaydayBioinformatics and BiostatisticsAdvanced SequencingFull details The effects of clonal heterogeneity on cancer immunosurveillance Authors (3)Krijn Dijkstra Yin WuCharles Swanton Annual Review of Cancer Biology Published 1 April 2023 Crick labsCharles SwantonAdrian HaydayFull details A local human Vδ1 T cell population is associated with survival in nonsmall-cell lung cancer Authors (21) Yin WuDhruva Biswas Ieva UsaiteMihaela AngelovaStefan BoeingTakahiro Karasaki[...] Mariam Jamal-Hanjani Allan Hackshaw Sergio A QuezadaAdrian HaydayCharles Swanton Nature Cancer Published 1 June 2022 Crick labs/ facilitiesCharles SwantonAdrian HaydayBioinformatics and BiostatisticsFull details Normality sensing licenses local T cells for innate-like tissue surveillance Authors (7)Duncan McKenzie Rosie Hart Nourdine Bah Dmitry S UshakovMiguel Munoz-Ruiz Regina FeederleAdrian Hayday Nature Immunology Published 1 March 2022 Crick labs/ facilitiesAdrian HaydayBioinformatics and BiostatisticsLight MicroscopyFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityAdvanced SequencingFull details Neutralization potency of monoclonal antibodies recognizing dominant and subdominant epitopes on SARS-CoV-2 Spike is impacted by the B.1.1.7 variant Authors (29) Carl Graham Jeffrey Seow Isabella Huettner Hataf Khan Neophytos Kouphou Sam Acors[...] Laura E McCoyAdrian Hayday Stuart JD Neil Michael H Malim Katie J Doores Immunity Published 8 June 2021 Crick labsAdrian HaydayPeter Cherepanov Full details Reconstitution of a functional human thymus by postnatal stromal progenitor cells and natural whole-organ scaffolds Authors (22)Sara CampinotiAsllan GjinovciRoberta RagazziniLuca ZanieriLinda Ariza-Mcnaughton Marco Catucci[...] Sarah A Teichmann Neil J SebireAdrian HaydayDominique BonnetPaola Bonfanti Nature Communications Published 11 December 2020 Crick labs/ facilitiesAdrian HaydayDominique BonnetPaola BonfantiBioinformatics and BiostatisticsLight MicroscopyFlow CytometryExperimental HistopathologyElectron MicroscopyBiological Research FacilityAdvanced SequencingFull details Butyrophilin-like proteins display combinatorial diversity in selecting and maintaining signature intraepithelial γδ T cell compartments Authors (12) Anett Jandke Daisy MelandriLeticia Monin Aldama Dmitry S Ushakov Adam G Laing Pierre Vantourout[...] Takeshi Nitta Tomoya Narita Hiroshi Takayanagi Regina FeederleAdrian Hayday Nature Communications Published 28 July 2020 Crick labs/ facilitiesAdrian HaydayBioinformatics and BiostatisticsProteomicsFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityAdvanced SequencingFull details γδ T cells compose a developmentally regulated intrauterine population and protect against vaginal candidiasis Authors (18)Leticia Monin Aldama DS Ushakov H Arnesen N Bah A JandkeMiguel Munoz-Ruiz[...] M Curtis H Carlsen U Steinhoff P BoysenAdrian Hayday Mucosal Immunology Published 1 November 2020 Crick labs/ facilitiesAdrian HaydayExperimental HistopathologyBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityAdvanced SequencingFull details DNA repair cofactors ATMIN and NBS1 are required to suppress T cell activation Authors (16) Jana Prochazkova Shinya Sakaguchi Michel Owusu Abdelghani Mazouzi Marc Wiedner Georgia Velimezi[...]Axel Behrens Sylvia Knapp Lukas Kenner Wilfried Ellmeier Joanna I Loizou PLOS Genetics Published 6 November 2015 Crick labsAdrian HaydayAxel BehrensFull details Intestinal intraepithelial lymphocyte activation promotes innate antiviral resistance Authors (12) Mahima Swamy Lucie Abeler-Dörner James Chettle Tanel Mahlakõiv Delphine Goubau Probir Chakravarty[...]Caetano Reis e Sousa Peter Staeheli Barbara A Blacklaws Jonathan L HeeneyAdrian Hayday Nature Communications Published 19 May 2015 Crick labs/ facilitiesCaetano Reis e SousaAdrian HaydayBioinformatics and BiostatisticsFlow CytometryExperimental HistopathologyBiological Research FacilityFull details Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
PD-1 defines a distinct, functional, tissue-adapted state in Vδ1+ T cells with implications for cancer immunotherapy Authors (16) Daniel Davies Shraddha Kamdar Richard Woolf Iva Zlatareva Maria Luisa Iannitto Cienne Morton[...] Cheryl GillettOlga O'Neill Oliver NussbaumerAdrian Hayday Yin Wu Nature Cancer Published 1 March 2024 Crick labs/ facilitiesAdrian HaydayAdvanced SequencingFull details
Conserved γδ T cell selection by BTNL proteins limits progression of human inflammatory bowel disease Authors (14) Robin J Dart Iva Zlatareva Pierre Vantourout Efstathios Theodoridis Ariella Amar Shichina Kannambath[...] Christopher A Lamb Miles Parkes Peter M Irving Natalie J PrescottAdrian Hayday Science Published 15 September 2023 Crick labs/ facilitiesAdrian HaydayBioinformatics and BiostatisticsAdvanced SequencingFull details
Defining the identity and the niches of epithelial stem cells with highly pleiotropic multilineage potency in the human thymus Authors (17)Roberta RagazziniStefan BoeingLuca ZanieriMary GreenGiuseppe D'Agostino Kerol Bartolovic[...] David Scoville Andy NamAdrian HaydayDominique BonnetPaola Bonfanti Developmental Cell Published 20 November 2023 Crick labs/ facilitiesAdrian HaydayDominique BonnetPaola BonfantiFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsLight MicroscopyAdvanced SequencingFull details
IFN-γ–dependent interactions between tissue-intrinsic γδ T cells and tissue-infiltrating CD8 T cells limit allergic contact dermatitis Authors (15)Miguel Munoz-Ruiz Miriam LlorianRocco D'Antuono Anna PavlovaAnna Maria MavrigiannakiDuncan McKenzie[...] Daniel Davies Mariam Jamal-Hanjani Anett Jandke Dmitry S UshakovAdrian Hayday Journal of Allergy and Clinical Immunology Published 1 December 2023 Crick labs/ facilitiesVassilis PachnisAdrian HaydayLight MicroscopyBioinformatics and BiostatisticsFull details
Improved memory CD8 T cell response to delayed vaccine boost is associated with a distinct molecular signature Authors (16)Ambra Natalini Sonia Simonetti Gabriele Favaretto Lorenzo Lucantonio Giovanna PeruzziMiguel Munoz-Ruiz[...] Antonella Folgori Alfredo Nicosia Angela SantoniAdrian Hayday Francesca Di Rosa Frontiers in Immunology Published 14 February 2023 Crick labs/ facilitiesAdrian HaydayBioinformatics and BiostatisticsAdvanced SequencingFull details
The effects of clonal heterogeneity on cancer immunosurveillance Authors (3)Krijn Dijkstra Yin WuCharles Swanton Annual Review of Cancer Biology Published 1 April 2023 Crick labsCharles SwantonAdrian HaydayFull details
A local human Vδ1 T cell population is associated with survival in nonsmall-cell lung cancer Authors (21) Yin WuDhruva Biswas Ieva UsaiteMihaela AngelovaStefan BoeingTakahiro Karasaki[...] Mariam Jamal-Hanjani Allan Hackshaw Sergio A QuezadaAdrian HaydayCharles Swanton Nature Cancer Published 1 June 2022 Crick labs/ facilitiesCharles SwantonAdrian HaydayBioinformatics and BiostatisticsFull details
Normality sensing licenses local T cells for innate-like tissue surveillance Authors (7)Duncan McKenzie Rosie Hart Nourdine Bah Dmitry S UshakovMiguel Munoz-Ruiz Regina FeederleAdrian Hayday Nature Immunology Published 1 March 2022 Crick labs/ facilitiesAdrian HaydayBioinformatics and BiostatisticsLight MicroscopyFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityAdvanced SequencingFull details
Neutralization potency of monoclonal antibodies recognizing dominant and subdominant epitopes on SARS-CoV-2 Spike is impacted by the B.1.1.7 variant Authors (29) Carl Graham Jeffrey Seow Isabella Huettner Hataf Khan Neophytos Kouphou Sam Acors[...] Laura E McCoyAdrian Hayday Stuart JD Neil Michael H Malim Katie J Doores Immunity Published 8 June 2021 Crick labsAdrian HaydayPeter Cherepanov Full details
Reconstitution of a functional human thymus by postnatal stromal progenitor cells and natural whole-organ scaffolds Authors (22)Sara CampinotiAsllan GjinovciRoberta RagazziniLuca ZanieriLinda Ariza-Mcnaughton Marco Catucci[...] Sarah A Teichmann Neil J SebireAdrian HaydayDominique BonnetPaola Bonfanti Nature Communications Published 11 December 2020 Crick labs/ facilitiesAdrian HaydayDominique BonnetPaola BonfantiBioinformatics and BiostatisticsLight MicroscopyFlow CytometryExperimental HistopathologyElectron MicroscopyBiological Research FacilityAdvanced SequencingFull details
Butyrophilin-like proteins display combinatorial diversity in selecting and maintaining signature intraepithelial γδ T cell compartments Authors (12) Anett Jandke Daisy MelandriLeticia Monin Aldama Dmitry S Ushakov Adam G Laing Pierre Vantourout[...] Takeshi Nitta Tomoya Narita Hiroshi Takayanagi Regina FeederleAdrian Hayday Nature Communications Published 28 July 2020 Crick labs/ facilitiesAdrian HaydayBioinformatics and BiostatisticsProteomicsFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityAdvanced SequencingFull details
γδ T cells compose a developmentally regulated intrauterine population and protect against vaginal candidiasis Authors (18)Leticia Monin Aldama DS Ushakov H Arnesen N Bah A JandkeMiguel Munoz-Ruiz[...] M Curtis H Carlsen U Steinhoff P BoysenAdrian Hayday Mucosal Immunology Published 1 November 2020 Crick labs/ facilitiesAdrian HaydayExperimental HistopathologyBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityAdvanced SequencingFull details
DNA repair cofactors ATMIN and NBS1 are required to suppress T cell activation Authors (16) Jana Prochazkova Shinya Sakaguchi Michel Owusu Abdelghani Mazouzi Marc Wiedner Georgia Velimezi[...]Axel Behrens Sylvia Knapp Lukas Kenner Wilfried Ellmeier Joanna I Loizou PLOS Genetics Published 6 November 2015 Crick labsAdrian HaydayAxel BehrensFull details
Intestinal intraepithelial lymphocyte activation promotes innate antiviral resistance Authors (12) Mahima Swamy Lucie Abeler-Dörner James Chettle Tanel Mahlakõiv Delphine Goubau Probir Chakravarty[...]Caetano Reis e Sousa Peter Staeheli Barbara A Blacklaws Jonathan L HeeneyAdrian Hayday Nature Communications Published 19 May 2015 Crick labs/ facilitiesCaetano Reis e SousaAdrian HaydayBioinformatics and BiostatisticsFlow CytometryExperimental HistopathologyBiological Research FacilityFull details