Publications

Mechanism of replication origin melting nucleated by CMG helicase assembly

Authors (8)

Nature

Published 30 June 2022

Crick labs/ facilities

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ReconSil: An electron microscopy toolbox to study helicase function at an origin of replication

Authors (4)

Methods in Enzymology

Published 5 August 2022

Crick labs

Alessandro Costa

Full details

The initiation of eukaryotic DNA replication

Authors (2)

Annual Review of Biochemistry

Published 1 June 2022

Crick labs

Full details

Multiple roles of Pol epsilon in eukaryotic chromosome replication

Authors (4)

Biochemical Society Transactions

Published 1 February 2022

Crick labs

Alessandro Costa

Full details

Mechanism of Bloom syndrome complex assembly required for double Holliday junction dissolution and genome stability

Authors (19)

Charlotte Hodson
Jason KK Low
Sylvie van Twest
Samuel E Jones
Paolo Swuec
Vincent Murphy
[...]
Michael W Parker
Joel P Mackay
Andrew N Blackford
Alessandro Costa
Andrew J Deans

Proceedings of the National Academy of Sciences of USA

Published 8 February 2022

Crick labs/ facilities

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In silico reconstitution of DNA replication. Lessons from single-molecule imaging and cryo-tomography applied to single-particle cryo-EM

Authors (4)

Current Opinion in Structural Biology

Published 1 February 2022

Crick labs

Alessandro Costa

Full details

Structural mechanism for the selective phosphorylation of DNA-loaded MCM double hexamers by the Dbf4-dependent kinase

Authors (9)

Nature Structural and Molecular Biology

Published 1 January 2022

Crick labs/ facilities

Full details

A structural framework for DNA replication and transcription through chromatin

Authors (2)

Current Opinion in Structural Biology

Published 1 December 2021

Crick labs

Alessandro Costa

Full details

Towards a structural mechanism for sister chromatid cohesion establishment at the eukaryotic replication fork

Authors (2)

Biology (Basel)

Published 26 May 2021

Crick labs

Alessandro Costa

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Mechanistic insights into regulation of the ALC1 remodeler by the nucleosome acidic patch

Authors (14)

Laura C Lehmann
Luka Bacic
Graeme Hewitt
Klaus Brackmann
Anton Sabantsev
Guillaume Gaullier
[...]
Song Tan
Alessandro Costa
Mark Skehel
Simon Boulton
Sebastian Deindl

Cell Reports

Published 22 December 2020

Crick labs

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A structure-based mechanism for DNA entry into the cohesin ring

Authors (14)

Torahiko Higashi
Patrik Eickhoff
Joana S Sousa
Julia Locke
Andrea Nans
Helen R Flynn
[...]
Zhuo A Chen
Francis J O’Reilly
Juri Rappsilber
Alessandro Costa
Frank Uhlmann

Molecular Cell

Published 17 September 2020

Crick labs/ facilities

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Microtubule nucleation properties of single human γTuRCs explained by their cryo-EM structure

Authors (12)

Tanja Consolati
Julia Locke
Johanna Roostalu
Zhuo Angel Chen
Julian Gannon
Jayant Asthana
[...]
Fabrizio Martino
Milos Cvetkovic
Juri Rappsilber
Alessandro Costa
Thomas Surrey

Developmental Cell

Published 8 June 2020

Crick labs/ facilities

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Caught in the act: structural dynamics of replication origin activation and fork progression

Authors (2)

Biochemical Society Transactions

Published 5 May 2020

Crick labs

Alessandro Costa

Full details

A different twist on centromeric chromatin

Authors (2)

Fabrizio Martino
Alessandro Costa

Structure

Published 7 January 2020

Crick labs

Alessandro Costa

Full details

Mechanism of head-to-head MCM double-hexamer formation revealed by cryo-EM

Authors (5)

Nature

Published 20 November 2019

Crick labs/ facilities

Full details

A combined structural and biochemical approach reveals translocation and stalling of UvrB on the DNA lesion as a mechanism of damage verification in bacterial nucleotide excision repair

Authors (10)

Marcin Jaciuk
Paolo Swuec
Vineet Gaur
Joanna M Kasprzak
Ludovic Renault
Mateusz Dobrychłop
Shivlee Nirwal
Janusz M Bujnicki
Alessandro Costa
Marcin Nowotny

DNA Repair

Published 1 January 2020

Crick labs

Alessandro Costa

Full details

Retroviral integration into nucleosomes through DNA looping and sliding along the histone octamer

Authors (9)

Marcus D Wilson
Ludovic Renault
Daniel P Maskell
Mohamed Ghoneim
Val Pye
Andrea Nans
David S Rueda
Peter Cherepanov
Alessandro Costa

Nature Communications

Published 13 September 2019

Crick labs/ facilities

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Molecular basis for ATP-hydrolysis-driven DNA translocation by the CMG helicase of the eukaryotic replisome

Authors (12)

Patrik Eickhoff
Hazal Kose
Fabrizio Martino
Tatjana Petojevic
Ferdos Abid Ali
Julia Locke
[...]
Andrea Nans
James M Berger
Michael R Botchan
Hasan Yardimci
Alessandro Costa

Cell Reports

Published 3 September 2019

Crick labs/ facilities

Full details

Structure of DNA-CMG-Pol epsilon elucidates the roles of the non-catalytic polymerase modules in the eukaryotic replisome

Authors (12)

Panchali Goswami
Ferdos Abid Ali
Max E Douglas
Julia Locke
Andrew Purkiss
Agnieszka Janska
[...]
Anne Early
Andrea Nans
Alan MC Cheung
John Diffley
Alessandro Costa

Nature Communications

Published 29 November 2018

Crick labs/ facilities

Full details

Preparing frozen-hydrated protein-nucleic acid assemblies for high-resolution cryo-EM imaging

Authors (3)

Panchali Goswami
Julia Locke
Alessandro Costa

Methods in Molecular Biology

Published 29 June 2018

Crick labs

Alessandro Costa

Full details

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Publications

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Mechanism of replication origin melting nucleated by CMG helicase assembly

ReconSil: An electron microscopy toolbox to study helicase function at an origin of replication

The initiation of eukaryotic DNA replication

Multiple roles of Pol epsilon in eukaryotic chromosome replication

Mechanism of Bloom syndrome complex assembly required for double Holliday junction dissolution and genome stability

In silico reconstitution of DNA replication. Lessons from single-molecule imaging and cryo-tomography applied to single-particle cryo-EM

Structural mechanism for the selective phosphorylation of DNA-loaded MCM double hexamers by the Dbf4-dependent kinase

A structural framework for DNA replication and transcription through chromatin

Towards a structural mechanism for sister chromatid cohesion establishment at the eukaryotic replication fork

Mechanistic insights into regulation of the ALC1 remodeler by the nucleosome acidic patch

A structure-based mechanism for DNA entry into the cohesin ring

Microtubule nucleation properties of single human γTuRCs explained by their cryo-EM structure

Caught in the act: structural dynamics of replication origin activation and fork progression

A different twist on centromeric chromatin

Mechanism of head-to-head MCM double-hexamer formation revealed by cryo-EM

A combined structural and biochemical approach reveals translocation and stalling of UvrB on the DNA lesion as a mechanism of damage verification in bacterial nucleotide excision repair

Retroviral integration into nucleosomes through DNA looping and sliding along the histone octamer

Molecular basis for ATP-hydrolysis-driven DNA translocation by the CMG helicase of the eukaryotic replisome

Structure of DNA-CMG-Pol epsilon elucidates the roles of the non-catalytic polymerase modules in the eukaryotic replisome

Preparing frozen-hydrated protein-nucleic acid assemblies for high-resolution cryo-EM imaging

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