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Breadcrumb Alex Gould Gould lab Physiology and Metabolism Laboratory : Publications Lab contentLab contentIn this section Overview Lab social gallery Areas of interest Lab news Publications Members Vacancies Lipid droplets (shown in green) can build up in cells from malnourished humans and other animals, image captured at the Crick by Annick Sawala and Alex Gould. Toggle to view hero caption PublicationsYear published2023 (2)2022 (2)2021 (2)2020 (1)2019 (3)2018 (2)2017 (5)2016 (1)2015 (1)2014 (2)2013 (3)2012 (1)2011 (3)2010 (3) Facet Year publishedResearch topicsDevelopmental Biology (19)Genetics & Genomics (19)Metabolism (19)Model Organisms (19)Neurosciences (19)Stem Cells (19)Tumour Biology (19)Computational & Systems Biology (7)Biochemistry & Proteomics (6)Cell Biology (6)Human Biology & Physiology (6)Immunology (6)Infectious Disease (6)Signalling & Oncogenes (6)Chemical Biology & High Throughput (2)Imaging (2)Genome Integrity & Repair (1)Synthetic Biology (1) Facet Research topicsPublication typeJournal article (31)Primary research (22)Review (6)Commentary (3) Facet Publication typeJournalNature (3)PLOS Biology (3)Biochimica et Biophysica Acta (2)Cell (2)Developmental Cell (2)Nature Communications (2)Analytical Chemistry (1)Angewandte Chemie International Edition (1)Annals of the New York Academy of Sciences (1)Annual Review of Entomology (1)Cell Metabolism (1)Cell Reports (1)Cell systems (1)Current Opinion in Neurobiology (1)Development (1)Disease Models & Mechanisms (1)EMBO Journal (1)Fly (1)Frontiers in Cell and Developmental Biology (1)Journal of Proteome Research (1)Methods in Molecular Biology (1)PLOS Genetics (1)Wellcome Open Research (1) Facet Journal Publications Displaying 1 - 20 of 31Last updated : 03 October 2023 03:18 Diet suppresses glioblastoma initiation in mice by maintaining quiescence of mutation-bearing neural stem cells Authors (14) Valeria Amodeo Timothy Davies Amalia Martinez-Segura Melanie P Clements Holly Simpson RagdaleAndrew Bailey[...] Holger Kramer Claudia Garcia-DiazAlex Gould Samuel Marguerat Simona Parrinello Developmental Cell Published 22 May 2023 Crick labs/ facilitiesAlex GouldMetabolomicsFull details The dietary sweetener sucralose is a negative modulator of T cell-mediated responses Authors (16)Fabio ZaniJulianna Blagih Tim GruberMichael Buck Nicholas JonesMarc Hennequart[...]Eric Cheung Ian S GilmoreAlex Gould Cristina Garcia-CaceresKaren Vousden Nature Published 23 March 2023 Crick labs/ facilitiesKaren VousdenCaetano Reis e SousaAlex GouldMetabolomicsBioinformatics and BiostatisticsLight MicroscopyFlow CytometryBiological Research FacilityAdvanced SequencingFull details Quantification of fetal organ sparing in maternal low-protein dietary models Authors (5)Patricia SerpenteYing ZhangEva IslimyeSarah Hart-JohnsonAlex Gould Wellcome Open Research Published 4 May 2022 Crick labs/ facilitiesAlex GouldBiological Research FacilityFull details Functions of stress-induced lipid droplets in the nervous system Authors (3)Eva IslimyeVictor GirardAlex Gould Frontiers in Cell and Developmental Biology Published 14 April 2022 Crick labsAlex GouldFull details Metabolic decisions in development and disease-a Keystone Symposia report Authors (25) Jennifer Cable Olivier Pourquié Kathryn E Wellen Lydia WS Finley Alexander AulehlaAlex Gould[...] Navdeep S Chandel Jared Rutter Jason W Locasale Juan C Landoni Heather Christofk Annals of the New York Academy of Sciences Published 1 December 2021 Crick labsMarkus RalserAlex GouldFull details Adipose triglyceride lipase protects renal cell endocytosis in a Drosophila dietary model of chronic kidney disease Authors (9)Aleksandra Lubojemska M Irina StefanaSebastian SorgeAndrew BaileyLena LampeAzumi Yoshimura Alana BurrellLucy CollinsonAlex Gould PLOS Biology Published 4 May 2021 Crick labs/ facilitiesAlex GouldElectron MicroscopyFull details Cryogenic OrbiSIMS localizes semi-volatile molecules in biological tissues Authors (5)Clare Newell Jean-Luc VorngJames Macrae Ian S GilmoreAlex Gould Angewandte Chemie International Edition Published 5 October 2020 Crick labs/ facilitiesAlex GouldMetabolomicsTranslation teamMedia PreparationFull details Histidine is selectively required for the growth of Myc-dependent dedifferentiation tumours in the Drosophila CNS Authors (7) Francesca Froldi Panayotis Pachnis Milán Szuperák Olivia CostasTharindu FernandoAlex Gould Louise Y Cheng EMBO Journal Published 25 February 2019 Crick labs/ facilitiesAlex GouldMRC Biomedical NMR CentreMetabolomicsFull details An improved method for measuring absolute metabolite concentrations in small biofluid or tissue samples Authors (5) Tharindu Fernando Annick SawalaAndrew BaileyAlex GouldPaul Driscoll Journal of Proteome Research Published 13 February 2019 Crick labs/ facilitiesAlex GouldMetabolomicsMRC Biomedical NMR CentreFull details Two negatives make a positive for insulin secretion and growth Authors (2) Annick SawalaAlex Gould Developmental Cell Published 7 January 2019 Crick labsAlex GouldFull details Sex-lethal in neurons controls female body growth in Drosophila Authors (2)Annick SawalaAlex Gould Fly Published 21 August 2018 Crick labsAlex GouldFull details Early-life exposure to low-dose oxidants can increase longevity via microbiome remodelling in Drosophila Authors (3) Fumiaki Obata Clara O FonsAlex Gould Nature Communications Published 7 March 2018 Crick labsAlex GouldFull details Principles of Systems Biology, No. 24 : Sub-cellular imaging of metabolites with 3D OrbiSIMS Authors (4) Ian Gilmore Andy West Morgan AlexanderAlex Gould Cell systems Published 27 December 2017 Crick labsAlex GouldFull details Developmental diet regulates Drosophila lifespan via lipid autotoxins Authors (7) M Irina StefanaPaul Driscoll Fumiaki Obata Ana Raquel PengellyClare NewellJames MacraeAlex Gould Nature Communications Published 9 November 2017 Crick labs/ facilitiesAlex GouldMetabolomicsMRC Biomedical NMR CentreFull details The sex of specific neurons controls female body growth in Drosophila Authors (2)Annick SawalaAlex Gould PLOS Biology Published 4 October 2017 Crick labsAlex GouldFull details Lipid droplet functions beyond energy storage Authors (2) Michael A WelteAlex Gould Biochimica et Biophysica Acta Published 19 July 2017 Crick labsAlex GouldFull details Stable isotope analysis of dynamic lipidomics Authors (5) Joost BrandsmaAndrew Bailey Grielof KosterAlex Gould Anthony D Postle Biochimica et Biophysica Acta Published 13 March 2017 Crick labsAlex GouldFull details Drosophila Spidey/Kar regulates oenocyte growth via PI3-kinase signaling Authors (8) Einat Cinnamon Rami MakkiAnnick Sawala Leah P Wickenberg Gary J Blomquist Claus Tittiger Ze'ev ParoushAlex Gould PLOS Genetics Published 8 August 2016 Crick labs/ facilitiesAlex GouldMetabolomicsFull details Antioxidant role for lipid droplets in a stem cell niche of Drosophila Authors (8)Andrew Bailey Grielof Koster Christelle Guillermier Elizabeth MA HirstJames Macrae Claude P Lechene Anthony D PostleAlex Gould Cell Published 8 October 2015 Crick labs/ facilitiesAlex GouldMetabolomicsElectron MicroscopyFull details Hox proteins drive cell segregation and non-autonomous apical remodelling during hindbrain segmentation Authors (4)Fabrice Prin Patricia Serpente Nobue ItasakiAlex Gould Development Published 26 February 2014 Crick labsAlex 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Diet suppresses glioblastoma initiation in mice by maintaining quiescence of mutation-bearing neural stem cells Authors (14) Valeria Amodeo Timothy Davies Amalia Martinez-Segura Melanie P Clements Holly Simpson RagdaleAndrew Bailey[...] Holger Kramer Claudia Garcia-DiazAlex Gould Samuel Marguerat Simona Parrinello Developmental Cell Published 22 May 2023 Crick labs/ facilitiesAlex GouldMetabolomicsFull details
The dietary sweetener sucralose is a negative modulator of T cell-mediated responses Authors (16)Fabio ZaniJulianna Blagih Tim GruberMichael Buck Nicholas JonesMarc Hennequart[...]Eric Cheung Ian S GilmoreAlex Gould Cristina Garcia-CaceresKaren Vousden Nature Published 23 March 2023 Crick labs/ facilitiesKaren VousdenCaetano Reis e SousaAlex GouldMetabolomicsBioinformatics and BiostatisticsLight MicroscopyFlow CytometryBiological Research FacilityAdvanced SequencingFull details
Quantification of fetal organ sparing in maternal low-protein dietary models Authors (5)Patricia SerpenteYing ZhangEva IslimyeSarah Hart-JohnsonAlex Gould Wellcome Open Research Published 4 May 2022 Crick labs/ facilitiesAlex GouldBiological Research FacilityFull details
Functions of stress-induced lipid droplets in the nervous system Authors (3)Eva IslimyeVictor GirardAlex Gould Frontiers in Cell and Developmental Biology Published 14 April 2022 Crick labsAlex GouldFull details
Metabolic decisions in development and disease-a Keystone Symposia report Authors (25) Jennifer Cable Olivier Pourquié Kathryn E Wellen Lydia WS Finley Alexander AulehlaAlex Gould[...] Navdeep S Chandel Jared Rutter Jason W Locasale Juan C Landoni Heather Christofk Annals of the New York Academy of Sciences Published 1 December 2021 Crick labsMarkus RalserAlex GouldFull details
Adipose triglyceride lipase protects renal cell endocytosis in a Drosophila dietary model of chronic kidney disease Authors (9)Aleksandra Lubojemska M Irina StefanaSebastian SorgeAndrew BaileyLena LampeAzumi Yoshimura Alana BurrellLucy CollinsonAlex Gould PLOS Biology Published 4 May 2021 Crick labs/ facilitiesAlex GouldElectron MicroscopyFull details
Cryogenic OrbiSIMS localizes semi-volatile molecules in biological tissues Authors (5)Clare Newell Jean-Luc VorngJames Macrae Ian S GilmoreAlex Gould Angewandte Chemie International Edition Published 5 October 2020 Crick labs/ facilitiesAlex GouldMetabolomicsTranslation teamMedia PreparationFull details
Histidine is selectively required for the growth of Myc-dependent dedifferentiation tumours in the Drosophila CNS Authors (7) Francesca Froldi Panayotis Pachnis Milán Szuperák Olivia CostasTharindu FernandoAlex Gould Louise Y Cheng EMBO Journal Published 25 February 2019 Crick labs/ facilitiesAlex GouldMRC Biomedical NMR CentreMetabolomicsFull details
An improved method for measuring absolute metabolite concentrations in small biofluid or tissue samples Authors (5) Tharindu Fernando Annick SawalaAndrew BaileyAlex GouldPaul Driscoll Journal of Proteome Research Published 13 February 2019 Crick labs/ facilitiesAlex GouldMetabolomicsMRC Biomedical NMR CentreFull details
Two negatives make a positive for insulin secretion and growth Authors (2) Annick SawalaAlex Gould Developmental Cell Published 7 January 2019 Crick labsAlex GouldFull details
Sex-lethal in neurons controls female body growth in Drosophila Authors (2)Annick SawalaAlex Gould Fly Published 21 August 2018 Crick labsAlex GouldFull details
Early-life exposure to low-dose oxidants can increase longevity via microbiome remodelling in Drosophila Authors (3) Fumiaki Obata Clara O FonsAlex Gould Nature Communications Published 7 March 2018 Crick labsAlex GouldFull details
Principles of Systems Biology, No. 24 : Sub-cellular imaging of metabolites with 3D OrbiSIMS Authors (4) Ian Gilmore Andy West Morgan AlexanderAlex Gould Cell systems Published 27 December 2017 Crick labsAlex GouldFull details
Developmental diet regulates Drosophila lifespan via lipid autotoxins Authors (7) M Irina StefanaPaul Driscoll Fumiaki Obata Ana Raquel PengellyClare NewellJames MacraeAlex Gould Nature Communications Published 9 November 2017 Crick labs/ facilitiesAlex GouldMetabolomicsMRC Biomedical NMR CentreFull details
The sex of specific neurons controls female body growth in Drosophila Authors (2)Annick SawalaAlex Gould PLOS Biology Published 4 October 2017 Crick labsAlex GouldFull details
Lipid droplet functions beyond energy storage Authors (2) Michael A WelteAlex Gould Biochimica et Biophysica Acta Published 19 July 2017 Crick labsAlex GouldFull details
Stable isotope analysis of dynamic lipidomics Authors (5) Joost BrandsmaAndrew Bailey Grielof KosterAlex Gould Anthony D Postle Biochimica et Biophysica Acta Published 13 March 2017 Crick labsAlex GouldFull details
Drosophila Spidey/Kar regulates oenocyte growth via PI3-kinase signaling Authors (8) Einat Cinnamon Rami MakkiAnnick Sawala Leah P Wickenberg Gary J Blomquist Claus Tittiger Ze'ev ParoushAlex Gould PLOS Genetics Published 8 August 2016 Crick labs/ facilitiesAlex GouldMetabolomicsFull details
Antioxidant role for lipid droplets in a stem cell niche of Drosophila Authors (8)Andrew Bailey Grielof Koster Christelle Guillermier Elizabeth MA HirstJames Macrae Claude P Lechene Anthony D PostleAlex Gould Cell Published 8 October 2015 Crick labs/ facilitiesAlex GouldMetabolomicsElectron MicroscopyFull details
Hox proteins drive cell segregation and non-autonomous apical remodelling during hindbrain segmentation Authors (4)Fabrice Prin Patricia Serpente Nobue ItasakiAlex Gould Development Published 26 February 2014 Crick labsAlex GouldFull details