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Lipid droplets (shown in green) can build up in cells from malnourished humans and other animals, image captured at the Crick by Annick Sawala and Alex Gould. Toggle to view hero caption Alex Gould : Publications Lab MenuLab Menu Overview Areas of interest View more Back Lipid metabolism Malnutrition Metabolic research Publications Members Vacancies Breadcrumb Home Research Labs Alex Gould Publications PublicationsYear published2020 (1)2019 (3)2018 (2)2017 (5)2016 (1)2015 (1)2014 (2)2013 (3)2012 (1)2011 (3)2010 (3)Research topicsDevelopmental Biology (13)Genetics & Genomics (13)Metabolism (13)Model Organisms (13)Neurosciences (13)Stem Cells (13)Tumour Biology (13)Biochemistry & Proteomics (4)Cell Biology (4)Computational & Systems Biology (4)Human Biology & Physiology (4)Immunology (4)Infectious Disease (4)Signalling & Oncogenes (4)Publication typeJournal article (25)Primary research (18)Review (4)Commentary (3)JournalBiochimica et Biophysica Acta (2)Cell (2)Nature (2)Nature Communications (2)PLOS Biology (2)Analytical Chemistry (1)Angewandte Chemie International Edition (1)Annual Review of Entomology (1)Cell Metabolism (1)Cell Reports (1)Cell systems (1)Current Opinion in Neurobiology (1)Development (1)Developmental Cell (1)Disease Models & Mechanisms (1)EMBO Journal (1)Fly (1)Journal of Proteome Research (1)Methods in Molecular Biology (1)PLOS Genetics (1) Publications Displaying 1 - 20 of 25Last updated : 05 August 2020 03:08 Cryogenic OrbiSIMS localizes semi-volatile molecules in biological tissues Authors (5)Clare Newell Jean-Luc VorngJames MacRae Ian S GilmoreAlex Gould Angewandte Chemie International Edition Published 30 June 2020 Crick labs/ facilitiesAlex GouldMetabolomicsTranslation teamMedia and pressFull details Histidine is selectively required for the growth of Myc-dependent dedifferentiation tumours in the Drosophila CNS Authors (7) Francesca Froldi Panayotis Pachnis Milán Szuperák Olivia CostasThari FernandoAlex Gould Louise Y Cheng EMBO Journal Published 25 February 2019 Crick labs/ facilitiesAlex GouldMetabolomicsMRC Biomedical NMR CentreFull details An improved method for measuring absolute metabolite concentrations in small biofluid or tissue samples Authors (5) Tharindu Fernando Annick SawalaAndrew BaileyAlex GouldPaul Driscoll Journal of Proteome Research Published 13 February 2019 Crick labs/ facilitiesAlex GouldMetabolomicsMRC Biomedical NMR CentreFull details Two negatives make a positive for insulin secretion and growth Authors (2) Annick SawalaAlex Gould Developmental Cell Published 7 January 2019 Crick labsAlex GouldFull details Sex-lethal in neurons controls female body growth in Drosophila Authors (2) Annick SawalaAlex Gould Fly Published 21 August 2018 Crick labsAlex GouldFull details Early-life exposure to low-dose oxidants can increase longevity via microbiome remodelling in Drosophila Authors (3) Fumiaki Obata Clara O FonsAlex Gould Nature Communications Published 7 March 2018 Crick labsAlex GouldFull details Principles of Systems Biology, No. 24 : Sub-cellular imaging of metabolites with 3D OrbiSIMS Authors (4) Ian Gilmore Andy West Morgan AlexanderAlex Gould Cell systems Published 27 December 2017 Crick labsAlex GouldFull details Developmental diet regulates Drosophila lifespan via lipid autotoxins Authors (7) M Irina StefanaPaul Driscoll Fumiaki Obata Ana Raquel PengellyClare NewellJames MacRaeAlex Gould Nature Communications Published 9 November 2017 Crick labs/ facilitiesAlex GouldMetabolomicsFull details The sex of specific neurons controls female body growth in Drosophila Authors (2) Annick SawalaAlex Gould PLOS Biology Published 1 October 2017 Crick labsAlex GouldFull details Lipid droplet functions beyond energy storage Authors (2) Michael A WelteAlex Gould Biochimica et Biophysica Acta Published 19 July 2017 Crick labsAlex GouldFull details Stable isotope analysis of dynamic lipidomics Authors (5) Joost BrandsmaAndrew Bailey Grielof KosterAlex Gould Anthony D Postle Biochimica et Biophysica Acta Published 13 March 2017 Crick labsAlex GouldFull details Drosophila Spidey/Kar regulates oenocyte growth via PI3-kinase signaling Authors (8) Einat Cinnamon Rami MakkiAnnick Sawala Leah P Wickenberg Gary J Blomquist Claus Tittiger Ze'ev ParoushAlex Gould PLOS Genetics Published 8 August 2016 Crick labs/ facilitiesAlex GouldMetabolomicsFull details Antioxidant role for lipid droplets in a stem cell niche of Drosophila Authors (8)Andrew Bailey Grielof Koster Christelle Guillermier Elizabeth MA HirstJames MacRae Claude P Lechene Anthony D PostleAlex Gould Cell Published 8 October 2015 Crick labs/ facilitiesAlex GouldElectron MicroscopyMetabolomicsFull details Hox proteins drive cell segregation and non-autonomous apical remodelling during hindbrain segmentation Authors (4)Fabrice Prin Patricia Serpente Nobue ItasakiAlex Gould Development Published 26 February 2014 Crick labsAlex GouldFull details The development and functions of oenocytes Authors (3) Rami Makki Einat CinnamonAlex Gould Annual Review of Entomology Published 7 January 2014 Crick labsAlex GouldFull details Volume determination with two standards allows absolute quantification and improved chemometric analysis of metabolites by NMR from submicroliter samples Authors (4) Timothy J RaganAndrew BaileyAlex GouldPaul Driscoll Analytical Chemistry Published 19 November 2013 Crick labs/ facilitiesAlex GouldMetabolomicsFull details Hypoxic regulation of Hand1 controls the fetal-neonatal switch in cardiac metabolism Authors (19) Ross A Breckenridge Izabela Piotrowska Keat-Eng Ng Timothy J Ragan James A West Surendra Kotecha[...] Jason RB Dyck Jules L Griffin Andrey Y AbramovAlex GouldTim Mohun PLOS Biology Published 1 September 2013 Crick labsAlex GouldTim MohunFull details Protection of neuronal diversity at the expense of neuronal numbers during nutrient restriction in the Drosophila visual system Authors (3) Elodie LanetAlex Gould Cédric Maurange Cell Reports Published 1 January 2013 Crick labsAlex GouldFull details Multi-isotope imaging mass spectrometry quantifies stem cell division and metabolism Authors (8) ML SteinhauserAndrew Bailey SE Senyo C Guillermier TS PerlsteinAlex Gould RT Lee CP Lechene Nature Published 15 January 2012 Crick labsAlex GouldFull details Anaplastic lymphoma kinase spares organ growth during nutrient restriction in Drosophila Authors (6) Louise Y ChengAndrew Bailey Sally J Leevers Timothy J RaganPaul DriscollAlex Gould Cell Published 5 August 2011 Crick labs/ facilitiesAlex GouldMetabolomicsFull details Pagination Current page 1 Page 2 Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Cryogenic OrbiSIMS localizes semi-volatile molecules in biological tissues Authors (5)Clare Newell Jean-Luc VorngJames MacRae Ian S GilmoreAlex Gould Angewandte Chemie International Edition Published 30 June 2020 Crick labs/ facilitiesAlex GouldMetabolomicsTranslation teamMedia and pressFull details
Histidine is selectively required for the growth of Myc-dependent dedifferentiation tumours in the Drosophila CNS Authors (7) Francesca Froldi Panayotis Pachnis Milán Szuperák Olivia CostasThari FernandoAlex Gould Louise Y Cheng EMBO Journal Published 25 February 2019 Crick labs/ facilitiesAlex GouldMetabolomicsMRC Biomedical NMR CentreFull details
An improved method for measuring absolute metabolite concentrations in small biofluid or tissue samples Authors (5) Tharindu Fernando Annick SawalaAndrew BaileyAlex GouldPaul Driscoll Journal of Proteome Research Published 13 February 2019 Crick labs/ facilitiesAlex GouldMetabolomicsMRC Biomedical NMR CentreFull details
Two negatives make a positive for insulin secretion and growth Authors (2) Annick SawalaAlex Gould Developmental Cell Published 7 January 2019 Crick labsAlex GouldFull details
Sex-lethal in neurons controls female body growth in Drosophila Authors (2) Annick SawalaAlex Gould Fly Published 21 August 2018 Crick labsAlex GouldFull details
Early-life exposure to low-dose oxidants can increase longevity via microbiome remodelling in Drosophila Authors (3) Fumiaki Obata Clara O FonsAlex Gould Nature Communications Published 7 March 2018 Crick labsAlex GouldFull details
Principles of Systems Biology, No. 24 : Sub-cellular imaging of metabolites with 3D OrbiSIMS Authors (4) Ian Gilmore Andy West Morgan AlexanderAlex Gould Cell systems Published 27 December 2017 Crick labsAlex GouldFull details
Developmental diet regulates Drosophila lifespan via lipid autotoxins Authors (7) M Irina StefanaPaul Driscoll Fumiaki Obata Ana Raquel PengellyClare NewellJames MacRaeAlex Gould Nature Communications Published 9 November 2017 Crick labs/ facilitiesAlex GouldMetabolomicsFull details
The sex of specific neurons controls female body growth in Drosophila Authors (2) Annick SawalaAlex Gould PLOS Biology Published 1 October 2017 Crick labsAlex GouldFull details
Lipid droplet functions beyond energy storage Authors (2) Michael A WelteAlex Gould Biochimica et Biophysica Acta Published 19 July 2017 Crick labsAlex GouldFull details
Stable isotope analysis of dynamic lipidomics Authors (5) Joost BrandsmaAndrew Bailey Grielof KosterAlex Gould Anthony D Postle Biochimica et Biophysica Acta Published 13 March 2017 Crick labsAlex GouldFull details
Drosophila Spidey/Kar regulates oenocyte growth via PI3-kinase signaling Authors (8) Einat Cinnamon Rami MakkiAnnick Sawala Leah P Wickenberg Gary J Blomquist Claus Tittiger Ze'ev ParoushAlex Gould PLOS Genetics Published 8 August 2016 Crick labs/ facilitiesAlex GouldMetabolomicsFull details
Antioxidant role for lipid droplets in a stem cell niche of Drosophila Authors (8)Andrew Bailey Grielof Koster Christelle Guillermier Elizabeth MA HirstJames MacRae Claude P Lechene Anthony D PostleAlex Gould Cell Published 8 October 2015 Crick labs/ facilitiesAlex GouldElectron MicroscopyMetabolomicsFull details
Hox proteins drive cell segregation and non-autonomous apical remodelling during hindbrain segmentation Authors (4)Fabrice Prin Patricia Serpente Nobue ItasakiAlex Gould Development Published 26 February 2014 Crick labsAlex GouldFull details
The development and functions of oenocytes Authors (3) Rami Makki Einat CinnamonAlex Gould Annual Review of Entomology Published 7 January 2014 Crick labsAlex GouldFull details
Volume determination with two standards allows absolute quantification and improved chemometric analysis of metabolites by NMR from submicroliter samples Authors (4) Timothy J RaganAndrew BaileyAlex GouldPaul Driscoll Analytical Chemistry Published 19 November 2013 Crick labs/ facilitiesAlex GouldMetabolomicsFull details
Hypoxic regulation of Hand1 controls the fetal-neonatal switch in cardiac metabolism Authors (19) Ross A Breckenridge Izabela Piotrowska Keat-Eng Ng Timothy J Ragan James A West Surendra Kotecha[...] Jason RB Dyck Jules L Griffin Andrey Y AbramovAlex GouldTim Mohun PLOS Biology Published 1 September 2013 Crick labsAlex GouldTim MohunFull details
Protection of neuronal diversity at the expense of neuronal numbers during nutrient restriction in the Drosophila visual system Authors (3) Elodie LanetAlex Gould Cédric Maurange Cell Reports Published 1 January 2013 Crick labsAlex GouldFull details
Multi-isotope imaging mass spectrometry quantifies stem cell division and metabolism Authors (8) ML SteinhauserAndrew Bailey SE Senyo C Guillermier TS PerlsteinAlex Gould RT Lee CP Lechene Nature Published 15 January 2012 Crick labsAlex GouldFull details
Anaplastic lymphoma kinase spares organ growth during nutrient restriction in Drosophila Authors (6) Louise Y ChengAndrew Bailey Sally J Leevers Timothy J RaganPaul DriscollAlex Gould Cell Published 5 August 2011 Crick labs/ facilitiesAlex GouldMetabolomicsFull details
