Introduction

We use the latest technologies for in vitro modelling to understand the molecular mechanisms behind neurodegeneration and aging.

Longer axons for motor neurons in a bioengineered device to model ALS (LAMBDA)

A bioengineered platform to better model motor neurone diseases

The questions of length dependent vulnerability of motor neurones (MNs) in amyotrophic lateral sclerosis (ALS), and how specific changes related to extremely long axons can present a molecular bottleneck for vulnerability, is important and cannot at present be systematically addressed with current in vitro paradigms. This project represents the first instance in which length-dependent vulnerability and changes in axonal transport and local translation can be investigated directly in vitro using patient-derived cells, combining bioengineered substrates, high-content imaging and advanced molecular probes.

Diagram of long axon motor neuron arrays.

Bioengineered cortical neuronal network (BioCoNNet)

A stem-cell derived bioengineered platform to recreate the human cerebral cortex in vitro

"BioCoNNet" is a new bioengineered platform that aims to recreate the complexity of human cortical circuits in vitro using stem cell derived neurons. It uses this neuronal network to understand how connections in the cortex are established and maintained, and how they are lost in dementias.

Diagram of model of cortical-like circuit arrays
Images of different types of brain cells.