Introduction
Understanding how complex behaviour emerges from the properties of molecules, cells and ensembles of cells is one of the key challenges in neuroscience. We try to tackle this question employing the olfactory system of mice as a model system.
Understanding how complex behaviour emerges from the properties of molecules, cells and ensembles of cells is one of the key challenges in neuroscience. We try to tackle this question employing the olfactory system of mice as a model system.
To understand how smells are processed we modify specific selected brain areas - in particular the olfactory bulb - using transgenic mice, pharmacological tools or targeted virus injections. We then probe how these specific modifications alter the neural networks and the resulting cellular function and physiology in vivo and in vitro. Ultimately, we perform quantitative behavioural tasks in such modified mice.
Combining these genetic, physiological and behavioural techniques with computational modelling approaches we aim to elucidate the cellular basis of olfactory behaviour and ultimately more general complex behaviours.