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Breadcrumb Andreas Wack Wack lab Immunoregulation Laboratory : Publications Lab contentLab contentIn this section Overview Vacancies Areas of interest Publications Members Scanning electron micrograph of epithelia lining the airways. Different cell types with different shapes and different functions compose this inner lining, and the right balance between these cell types is important for a healthy lung. 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cell-positive selection Authors (14) Lingling Zhang Amparo Toboso-Navasa Arief Gunawan Abdouramane CamaraRinako NakagawaKatja Finsterbusch[...] Martin EilersAndreas WackPavel Tolar Kai-Michael ToellnerDinis Calado Science Immunology Published 5 April 2024 Crick labs/ facilitiesAndreas WackPavel TolarDinis CaladoBioinformatics and BiostatisticsStructural BiologyLight MicroscopyFlow CytometryExperimental HistopathologyBiological Research FacilityAdvanced SequencingFull details The role of recruitment versus training in influenza-induced lasting changes to alveolar macrophage function Authors (9)Chrysante IliakisJustina Kulikauskaite Helena Aegerter Fengqi Li Federica Piattini Claudia V Jakubzick Martin Guilliams Manfred KopfAndreas Wack Nature Immunology Published 1 October 2023 Crick labsAndreas WackFull details Endothelial AHR activity prevents lung barrier disruption in viral infection Authors (13)Jack MajorStefania CrottaKatja Finsterbusch Probir ChakravartyKathleen ShahBruno Frederico[...] Lucy Meader Alejandro Suarez-BonnetSimon PriestnallBrigitta StockingerAndreas Wack Nature Published 28 September 2023 Crick labs/ facilitiesAndreas WackGitta StockingerCaetano Reis e SousaLight MicroscopyExperimental HistopathologyBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityAdvanced SequencingFull details Interplay between CXCR4 and CCR2 regulates bone marrow exit of dendritic cell progenitors Authors (11)Mariana Pereira Da CostaCarlos Munoz MinuttiCecile PiotEvangelos GiampazoliasAna Matos Cardoso Da SilvaMaria Del Mar Cabeza CabrerizoNeil RogersMarta de Lebrusant FernandezChrysante IliakisAndreas WackCaetano Reis e Sousa Cell Reports Published 29 August 2023 Crick labs/ facilitiesAndreas WackCaetano Reis e SousaPatricia BarralFlow CytometryBiological Research FacilityFull details Type I interferons drive MAIT cell functions againstbacterial pneumonia Authors (12)Juan Carlos Lopez-Rodriguez Steven J Hancock Kelin LiStefania Crotta Christopher Barrington Alejandro Suárez-Bonnet[...] Jeffrey AubéAndreas Wack Paul Klenerman Jose A BengoecheaPatricia Barral Journal of Experimental Medicine Published 2 October 2023 Crick labs/ facilitiesAndreas WackPatricia BarralExperimental HistopathologyBioinformatics and BiostatisticsLight MicroscopyFlow CytometryBiological Research FacilityAdvanced SequencingFull details Repair of airway epithelia requires metabolic rewiring towards fatty acid oxidation Authors (8)Stefania Crotta Matteo VillaJack MajorKatja FinsterbuschMiriam Llorian Sopena Peter Carmeliet Joerg BuescherAndreas Wack Nature Communications Published 13 February 2023 Crick labs/ facilitiesAndreas WackBioinformatics and BiostatisticsFlow CytometryExperimental HistopathologyBiological Research FacilityAdvanced SequencingFull details Respiratory viruses: New frontiers-a Keystone Symposia report Authors (27) Jennifer Cable Jie Sun In Su Cheon Andrew E Vaughan Italo A Castro Sydney R Stein[...] Ketaki Ganti Kanta Subbarao Timothy P Sheahan Pablo Penaloza-MacMaster Taylor Eddens Annals of the New York Academy of Sciences Published 1 April 2023 Crick labsAndreas WackFull details Impaired immune response drives age-dependent severity of COVID-19 Authors (20) Julius BeerStefania Crotta Angele Breithaupt Annette Ohnemus Jan Becker Benedikt Sachs[...] Jonas Fuchs Georg KochsAndreas Wack Martin Schwemmle Daniel Schnepf Journal of Experimental Medicine Published 5 December 2022 Crick labs/ facilitiesAndreas WackBioinformatics and BiostatisticsFull details Hypoxia inducible factors regulate infectious SARS-CoV-2, epithelial damage and respiratory symptoms in a hamster COVID-19 model Authors (18) Peter AC Wing Maria Prange-Barczynska Amy CrossStefania Crotta Claudia Orbegozo Rubio Xiaotong Cheng[...] Peter BalfeAndreas Wack Tammie Bishop Francisco J Salguero Jane A McKeating PLOS Pathogens Published 6 September 2022 Crick labsAndreas WackFull details SARS-CoV-2 S2-targeted vaccination elicits broadly neutralizing antibodies Authors (21)Kevin NgNikhil FaulknerKatja FinsterbuschMary Wu Ruth HarveySaira Hussain[...]Michael Howell Hisashi AraseAndreas WackDavid LV BauerGeorge Kassiotis Science Translational Medicine Published 27 July 2022 Crick labs/ facilitiesAndreas WackCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinPeter Cherepanov Rupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningFlow CytometryCell ServicesBiological Research FacilityFull details Anti-type I interferon antibodies as a cause of severe COVID-19 Authors (6) David C FajgenbaumAdrian Hayday Angela J Rogers Greg J TowersAndreas Wack Ivan Zanoni Faculty Reviews Published 10 June 2022 Crick labsAndreas WackAdrian HaydayFull details Host-directed immunotherapy of viral and bacterial infections: past, present and future Authors (4) Robert S WallisAnne O'Garra Alan SherAndreas Wack Nature Reviews Immunology Published 1 February 2023 Crick labsAndreas WackAnne O’GarraFull details Functions of IFNλs in anti-bacterial immunity at mucosal barriers Authors (4) Noémie Alphonse Ruth E Dickenson Abrar Alrehaili Charlotte Odendall Frontiers in Immunology Published 18 May 2022 Crick labsAndreas WackFull details A family of conserved bacterial virulence factors dampens interferon responses by blocking calcium signaling Authors (24) Noémie Alphonse Joseph J Wanford Andrew A Voak Jack Gay Shayla Venkhaya Owen Burroughs[...] Martin W Berchtold Julien RC BergeronAndreas Wack Cammie F Lesser Charlotte Odendall Cell Published 23 June 2022 Crick labs/ facilitiesAndreas WackBioinformatics and BiostatisticsExperimental HistopathologyAdvanced SequencingFull details Recruitment of dendritic cell progenitors to foci of influenza A virus infection sustains immunity Authors (18)Maria Del Mar Cabeza CabrerizoCarlos Munoz Minutti Mariana Pereira da CostaAna Matos Cardoso Da SilvaRob JenkinsJustina Kulikauskaite[...] Judith E Allen Manolis PasparakisAndreas WackErik SahaiCaetano Reis e Sousa Science Immunology Published 5 November 2021 Crick labs/ facilitiesAndreas WackErik SahaiCaetano Reis e SousaNicola LewisDominique BonnetWorldwide Influenza CentreFlow CytometryBiological Research FacilityBioinformatics and BiostatisticsFull details Influenza A induces lactate formation to inhibit type I IFN in primary human airway epithelium Authors (12) Jacob Thyrsted Jacob Storgaard Julia Blay-Cadanet Alexander Heinz Anne Laugaard ThielkeStefania Crotta[...] David OlagnierAndreas Wack Karsten Hiller Anne Louise Hansen Christian Kanstrup Holm iScience Published 19 November 2021 Crick labsAndreas WackFull details A TLR7 antagonist restricts interferon-dependent and -independent immunopathology in a mouse model of severe influenza Authors (6)Julie RappeKatja FinsterbuschStefania Crotta Matthias MackSimon PriestnallAndreas Wack Journal of Experimental Medicine Published 1 November 2021 Crick labs/ facilitiesAndreas WackExperimental HistopathologyFlow CytometryBiological Research FacilityFull details The interferon landscape along the respiratory tract impacts the severity of COVID-19 Authors (28) Benedetta Sposito Achille Broggi Laura PandolfiStefania Crotta Nicola Clementi Roberto Ferrarese[...] Antonio E Pontiroli Federica MeloniAndreas Wack Nicasio Mancini Ivan Zanoni Cell Published 16 September 2021 Crick labsAndreas WackFull details Rotavirus susceptibility of antibiotic-treated mice ascribed to diminished expression of interleukin-22 Authors (15) Daniel Schnepf Pedro Hernandez Tanel MahlakõivStefania Crotta Meagan E Sullender Stefan T Peterson[...] Celso A Reis Andreas DiefenbachAndreas Wack Megan T Baldridge Peter Staeheli PLOS ONE Published 12 August 2021 Crick labsAndreas WackFull details Selective Janus kinase inhibition preserves interferon-λ-mediated antiviral responses Authors (17) Daniel SchnepfStefania Crotta Thiprampai Thamamongood Megan Stanifer Laura Polcik Annette Ohnemus[...] Susanne Kirschnek Steeve Boulant Martin SchwemmleAndreas Wack Peter Staeheli Science Immunology Published 14 May 2021 Crick labs/ facilitiesAndreas WackBioinformatics and BiostatisticsAdvanced SequencingFull details Pagination Current page 1 Page 2 Page 3 Page 4 Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Regulation of BCR-mediated Ca2+ mobilization by MIZ1-TMBIM4 safeguards IgG1+ GC B cell-positive selection Authors (14) Lingling Zhang Amparo Toboso-Navasa Arief Gunawan Abdouramane CamaraRinako NakagawaKatja Finsterbusch[...] Martin EilersAndreas WackPavel Tolar Kai-Michael ToellnerDinis Calado Science Immunology Published 5 April 2024 Crick labs/ facilitiesAndreas WackPavel TolarDinis CaladoBioinformatics and BiostatisticsStructural BiologyLight MicroscopyFlow CytometryExperimental HistopathologyBiological Research FacilityAdvanced SequencingFull details
The role of recruitment versus training in influenza-induced lasting changes to alveolar macrophage function Authors (9)Chrysante IliakisJustina Kulikauskaite Helena Aegerter Fengqi Li Federica Piattini Claudia V Jakubzick Martin Guilliams Manfred KopfAndreas Wack Nature Immunology Published 1 October 2023 Crick labsAndreas WackFull details
Endothelial AHR activity prevents lung barrier disruption in viral infection Authors (13)Jack MajorStefania CrottaKatja Finsterbusch Probir ChakravartyKathleen ShahBruno Frederico[...] Lucy Meader Alejandro Suarez-BonnetSimon PriestnallBrigitta StockingerAndreas Wack Nature Published 28 September 2023 Crick labs/ facilitiesAndreas WackGitta StockingerCaetano Reis e SousaLight MicroscopyExperimental HistopathologyBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityAdvanced SequencingFull details
Interplay between CXCR4 and CCR2 regulates bone marrow exit of dendritic cell progenitors Authors (11)Mariana Pereira Da CostaCarlos Munoz MinuttiCecile PiotEvangelos GiampazoliasAna Matos Cardoso Da SilvaMaria Del Mar Cabeza CabrerizoNeil RogersMarta de Lebrusant FernandezChrysante IliakisAndreas WackCaetano Reis e Sousa Cell Reports Published 29 August 2023 Crick labs/ facilitiesAndreas WackCaetano Reis e SousaPatricia BarralFlow CytometryBiological Research FacilityFull details
Type I interferons drive MAIT cell functions againstbacterial pneumonia Authors (12)Juan Carlos Lopez-Rodriguez Steven J Hancock Kelin LiStefania Crotta Christopher Barrington Alejandro Suárez-Bonnet[...] Jeffrey AubéAndreas Wack Paul Klenerman Jose A BengoecheaPatricia Barral Journal of Experimental Medicine Published 2 October 2023 Crick labs/ facilitiesAndreas WackPatricia BarralExperimental HistopathologyBioinformatics and BiostatisticsLight MicroscopyFlow CytometryBiological Research FacilityAdvanced SequencingFull details
Repair of airway epithelia requires metabolic rewiring towards fatty acid oxidation Authors (8)Stefania Crotta Matteo VillaJack MajorKatja FinsterbuschMiriam Llorian Sopena Peter Carmeliet Joerg BuescherAndreas Wack Nature Communications Published 13 February 2023 Crick labs/ facilitiesAndreas WackBioinformatics and BiostatisticsFlow CytometryExperimental HistopathologyBiological Research FacilityAdvanced SequencingFull details
Respiratory viruses: New frontiers-a Keystone Symposia report Authors (27) Jennifer Cable Jie Sun In Su Cheon Andrew E Vaughan Italo A Castro Sydney R Stein[...] Ketaki Ganti Kanta Subbarao Timothy P Sheahan Pablo Penaloza-MacMaster Taylor Eddens Annals of the New York Academy of Sciences Published 1 April 2023 Crick labsAndreas WackFull details
Impaired immune response drives age-dependent severity of COVID-19 Authors (20) Julius BeerStefania Crotta Angele Breithaupt Annette Ohnemus Jan Becker Benedikt Sachs[...] Jonas Fuchs Georg KochsAndreas Wack Martin Schwemmle Daniel Schnepf Journal of Experimental Medicine Published 5 December 2022 Crick labs/ facilitiesAndreas WackBioinformatics and BiostatisticsFull details
Hypoxia inducible factors regulate infectious SARS-CoV-2, epithelial damage and respiratory symptoms in a hamster COVID-19 model Authors (18) Peter AC Wing Maria Prange-Barczynska Amy CrossStefania Crotta Claudia Orbegozo Rubio Xiaotong Cheng[...] Peter BalfeAndreas Wack Tammie Bishop Francisco J Salguero Jane A McKeating PLOS Pathogens Published 6 September 2022 Crick labsAndreas WackFull details
SARS-CoV-2 S2-targeted vaccination elicits broadly neutralizing antibodies Authors (21)Kevin NgNikhil FaulknerKatja FinsterbuschMary Wu Ruth HarveySaira Hussain[...]Michael Howell Hisashi AraseAndreas WackDavid LV BauerGeorge Kassiotis Science Translational Medicine Published 27 July 2022 Crick labs/ facilitiesAndreas WackCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinPeter Cherepanov Rupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningFlow CytometryCell ServicesBiological Research FacilityFull details
Anti-type I interferon antibodies as a cause of severe COVID-19 Authors (6) David C FajgenbaumAdrian Hayday Angela J Rogers Greg J TowersAndreas Wack Ivan Zanoni Faculty Reviews Published 10 June 2022 Crick labsAndreas WackAdrian HaydayFull details
Host-directed immunotherapy of viral and bacterial infections: past, present and future Authors (4) Robert S WallisAnne O'Garra Alan SherAndreas Wack Nature Reviews Immunology Published 1 February 2023 Crick labsAndreas WackAnne O’GarraFull details
Functions of IFNλs in anti-bacterial immunity at mucosal barriers Authors (4) Noémie Alphonse Ruth E Dickenson Abrar Alrehaili Charlotte Odendall Frontiers in Immunology Published 18 May 2022 Crick labsAndreas WackFull details
A family of conserved bacterial virulence factors dampens interferon responses by blocking calcium signaling Authors (24) Noémie Alphonse Joseph J Wanford Andrew A Voak Jack Gay Shayla Venkhaya Owen Burroughs[...] Martin W Berchtold Julien RC BergeronAndreas Wack Cammie F Lesser Charlotte Odendall Cell Published 23 June 2022 Crick labs/ facilitiesAndreas WackBioinformatics and BiostatisticsExperimental HistopathologyAdvanced SequencingFull details
Recruitment of dendritic cell progenitors to foci of influenza A virus infection sustains immunity Authors (18)Maria Del Mar Cabeza CabrerizoCarlos Munoz Minutti Mariana Pereira da CostaAna Matos Cardoso Da SilvaRob JenkinsJustina Kulikauskaite[...] Judith E Allen Manolis PasparakisAndreas WackErik SahaiCaetano Reis e Sousa Science Immunology Published 5 November 2021 Crick labs/ facilitiesAndreas WackErik SahaiCaetano Reis e SousaNicola LewisDominique BonnetWorldwide Influenza CentreFlow CytometryBiological Research FacilityBioinformatics and BiostatisticsFull details
Influenza A induces lactate formation to inhibit type I IFN in primary human airway epithelium Authors (12) Jacob Thyrsted Jacob Storgaard Julia Blay-Cadanet Alexander Heinz Anne Laugaard ThielkeStefania Crotta[...] David OlagnierAndreas Wack Karsten Hiller Anne Louise Hansen Christian Kanstrup Holm iScience Published 19 November 2021 Crick labsAndreas WackFull details
A TLR7 antagonist restricts interferon-dependent and -independent immunopathology in a mouse model of severe influenza Authors (6)Julie RappeKatja FinsterbuschStefania Crotta Matthias MackSimon PriestnallAndreas Wack Journal of Experimental Medicine Published 1 November 2021 Crick labs/ facilitiesAndreas WackExperimental HistopathologyFlow CytometryBiological Research FacilityFull details
The interferon landscape along the respiratory tract impacts the severity of COVID-19 Authors (28) Benedetta Sposito Achille Broggi Laura PandolfiStefania Crotta Nicola Clementi Roberto Ferrarese[...] Antonio E Pontiroli Federica MeloniAndreas Wack Nicasio Mancini Ivan Zanoni Cell Published 16 September 2021 Crick labsAndreas WackFull details
Rotavirus susceptibility of antibiotic-treated mice ascribed to diminished expression of interleukin-22 Authors (15) Daniel Schnepf Pedro Hernandez Tanel MahlakõivStefania Crotta Meagan E Sullender Stefan T Peterson[...] Celso A Reis Andreas DiefenbachAndreas Wack Megan T Baldridge Peter Staeheli PLOS ONE Published 12 August 2021 Crick labsAndreas WackFull details
Selective Janus kinase inhibition preserves interferon-λ-mediated antiviral responses Authors (17) Daniel SchnepfStefania Crotta Thiprampai Thamamongood Megan Stanifer Laura Polcik Annette Ohnemus[...] Susanne Kirschnek Steeve Boulant Martin SchwemmleAndreas Wack Peter Staeheli Science Immunology Published 14 May 2021 Crick labs/ facilitiesAndreas WackBioinformatics and BiostatisticsAdvanced SequencingFull details