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Breadcrumb Andreas Wack Wack lab Immunoregulation Laboratory : Publications Lab contentLab contentIn this section Overview Vacancies Areas of interest Publications Members Scanning electron micrograph of epithelia lining the airways. Different cell types with different shapes and different functions compose this inner lining, and the right balance between these cell types is important for a healthy lung. Toggle to view hero caption PublicationsYear published2023 (3)2022 (3)2021 (2)2020 (4)2019 (1) Facet Year publishedResearch topicsComputational & Systems Biology (13)Genetics & Genomics (13)Genome Integrity & Repair (13)Human Biology & Physiology (13)Infectious Disease (13)Tumour Biology (13)Immunology (12)Model Organisms (12)Cell Biology (5)Cell Cycle & Chromosomes (3)Metabolism (3)Neurosciences (3)Signalling & Oncogenes (3)Stem Cells (3)Structural Biology & Biophysics (3)Biochemistry & Proteomics (2)Developmental Biology (2)Imaging (2)Gene Expression (1)Microfabrication & Bioengineering (1)Synthetic Biology (1) (-)Chemical Biology & High Throughput (13) Facet Research topicsCrick/Pre-CrickCrick publications (13) Facet Crick/Pre-CrickPublication typeJournal article (13)Primary research (12)Method (1) Facet Publication typeJournalJournal of Experimental Medicine (3)Nature Communications (2)Cell (1)Nature (1)Nature Biotechnology (1)Nature Immunology (1)Science (1)Science Immunology (1)Science Translational Medicine (1)The Lancet (1) Facet Journal Publications Displaying 1 - 13 of 13Last updated : 28 March 2024 03:36 Endothelial AHR activity prevents lung barrier disruption in viral infection Authors (13)Jack MajorStefania CrottaKatja Finsterbusch Probir ChakravartyKathleen ShahBruno Frederico[...] Lucy Meader Alejandro Suarez-BonnetSimon PriestnallBrigitta StockingerAndreas Wack Nature Published 28 September 2023 Crick labs/ facilitiesAndreas WackGitta StockingerCaetano Reis e SousaLight MicroscopyExperimental HistopathologyBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityAdvanced SequencingFull details Type I interferons drive MAIT cell functions againstbacterial pneumonia Authors (12)Juan Carlos Lopez-Rodriguez Steven J Hancock Kelin LiStefania Crotta Christopher Barrington Alejandro Suárez-Bonnet[...] Jeffrey AubéAndreas Wack Paul Klenerman Jose A BengoecheaPatricia Barral Journal of Experimental Medicine Published 2 October 2023 Crick labs/ facilitiesAndreas WackPatricia BarralExperimental HistopathologyBioinformatics and BiostatisticsLight MicroscopyFlow CytometryBiological Research FacilityAdvanced SequencingFull details Repair of airway epithelia requires metabolic rewiring towards fatty acid oxidation Authors (8)Stefania Crotta Matteo VillaJack MajorKatja Finsterbusch Miriam Llorian Peter Carmeliet Joerg BuescherAndreas Wack Nature Communications Published 13 February 2023 Crick labs/ facilitiesAndreas WackBioinformatics and BiostatisticsFlow CytometryExperimental HistopathologyBiological Research FacilityAdvanced SequencingFull details Impaired immune response drives age-dependent severity of COVID-19 Authors (20) Julius BeerStefania Crotta Angele Breithaupt Annette Ohnemus Jan Becker Benedikt Sachs[...] Jonas Fuchs Georg KochsAndreas Wack Martin Schwemmle Daniel Schnepf Journal of Experimental Medicine Published 5 December 2022 Crick labs/ facilitiesAndreas WackBioinformatics and BiostatisticsFull details SARS-CoV-2 S2-targeted vaccination elicits broadly neutralizing antibodies Authors (21)Kevin NgNikhil FaulknerKatja FinsterbuschMary Wu Ruth HarveySaira Hussain[...]Michael Howell Hisashi AraseAndreas WackDavid LV BauerGeorge Kassiotis Science Translational Medicine Published 27 July 2022 Crick labs/ facilitiesAndreas WackCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinPeter Cherepanov Rupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningFlow CytometryCell ServicesBiological Research FacilityFull details A family of conserved bacterial virulence factors dampens interferon responses by blocking calcium signaling Authors (24) Noémie Alphonse Joseph J Wanford Andrew A Voak Jack Gay Shayla Venkhaya Owen Burroughs[...] Martin W Berchtold Julien RC BergeronAndreas Wack Cammie F Lesser Charlotte Odendall Cell Published 23 June 2022 Crick labs/ facilitiesAndreas WackBioinformatics and BiostatisticsExperimental HistopathologyAdvanced SequencingFull details Selective Janus kinase inhibition preserves interferon-λ-mediated antiviral responses Authors (17) Daniel SchnepfStefania Crotta Thiprampai Thamamongood Megan Stanifer Laura Polcik Annette Ohnemus[...] Susanne Kirschnek Steeve Boulant Martin SchwemmleAndreas Wack Peter Staeheli Science Immunology Published 14 May 2021 Crick labs/ facilitiesAndreas WackBioinformatics and BiostatisticsAdvanced SequencingFull details Critical requirement for BCR, BAFF, and BAFFR in memory B cell survival Authors (8)Jennifer Mueller-Winkler Richard MitterJulie RappeLesley VanesEdina SchweighofferHamid MohammadiAndreas WackVictor Tybulewicz Journal of Experimental Medicine Published 1 February 2021 Crick labs/ facilitiesAndreas WackVictor TybulewiczBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityFull details Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers Authors (341) Catherine F Houlihan Nina Vora Thomas Byrne Dan LewerGavin Kelly Judith Heaney[...] Andrew Hayward Richard Gilson Gavin KellyFiona Roberts Emine Hatipoglu The Lancet Published 25 July 2020 Crick labs/ facilitiesAndreas WackKaren VousdenJernej UleJames TurnerMoritz TreeckCharles SwantonAdam SaterialeErik SahaiCaetano Reis e SousaPeter RatcliffeLucia Prieto-GodinoVenizelos PapayannopoulosAnne O’GarraPaul NurseGeorge KassiotisMaximiliano GutierrezSonia GandhiSteve GamblinPeter Cherepanov Luiz Pedro CarvalhoDominique BonnetMike BlackmanRupert BealeWorldwide Influenza CentreStructural BiologyMetabolomicsHuman Embryonic Stem CellHigh Throughput ScreeningGenetic Modification ServiceFlow CytometryFermentationExperimental HistopathologyElectron MicroscopyCell ServicesBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Scalable and robust SARS-CoV-2 testing in an academic center Authors (81) Jim Aitken Karen Ambrose Sam BarrellRupert Beale Ganka Bineva-Todd Dhruva Biswas[...]Sophie Ward Wai Keong WongJoshua Wright Mary Wu The Crick COVID-19 Consortium Nature Biotechnology Published 1 August 2020 Crick labs/ facilitiesAndreas WackJames TurnerCharles SwantonCaetano Reis e SousaPeter RatcliffeVenizelos PapayannopoulosGeorge KassiotisSonia GandhiSteve GamblinPeter Cherepanov Rupert BealeStructural BiologyMetabolomicsHigh Throughput ScreeningGenetic Modification ServiceFermentationBiological Research FacilityAdvanced SequencingScientific computingFull details Type I and III interferons disrupt lung epithelial repair during recovery from viral infection Authors (8)Jack MajorStefania CrottaMiriam Llorian Sopena Teresa M McCabe Hans Henrik GadSimon Priestnall Rune HartmannAndreas Wack Science Published 7 August 2020 Crick labs/ facilitiesAndreas WackExperimental HistopathologyBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityFull details Influenza-induced monocyte-derived alveolar macrophages confer prolonged antibacterial protection Authors (9) Helena AegerterJustina KulikauskaiteStefania Crotta Harshil PatelGavin Kelly Edith M Hessel Matthias Mack Soren BeinkeAndreas Wack Nature Immunology Published 1 February 2020 Crick labs/ facilitiesAndreas WackBioinformatics and BiostatisticsFlow CytometryExperimental HistopathologyBiological Research FacilityAdvanced SequencingFull details Transcriptional profiling unveils type I and II interferon networks in blood and tissues across diseases Authors (35)Akul SinghaniaChristine GrahamLeona GabrysovaLucia Moreira-TeixeiraEvangelos Stavropoulos Jonathan M Pitt[...]Venizelos PapayannopoulosAndreas Wack Jacques F Banchereau Virginia M PascualAnne O'Garra Nature Communications Published 28 June 2019 Crick labs/ facilitiesAndreas WackVenizelos PapayannopoulosAnne O’GarraJean LanghorneEva FrickelBioinformatics and BiostatisticsAdvanced SequencingFlow CytometryExperimental HistopathologyBiological Research FacilityFull details Share the page Share on Twitter Share on 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Endothelial AHR activity prevents lung barrier disruption in viral infection Authors (13)Jack MajorStefania CrottaKatja Finsterbusch Probir ChakravartyKathleen ShahBruno Frederico[...] Lucy Meader Alejandro Suarez-BonnetSimon PriestnallBrigitta StockingerAndreas Wack Nature Published 28 September 2023 Crick labs/ facilitiesAndreas WackGitta StockingerCaetano Reis e SousaLight MicroscopyExperimental HistopathologyBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityAdvanced SequencingFull details
Type I interferons drive MAIT cell functions againstbacterial pneumonia Authors (12)Juan Carlos Lopez-Rodriguez Steven J Hancock Kelin LiStefania Crotta Christopher Barrington Alejandro Suárez-Bonnet[...] Jeffrey AubéAndreas Wack Paul Klenerman Jose A BengoecheaPatricia Barral Journal of Experimental Medicine Published 2 October 2023 Crick labs/ facilitiesAndreas WackPatricia BarralExperimental HistopathologyBioinformatics and BiostatisticsLight MicroscopyFlow CytometryBiological Research FacilityAdvanced SequencingFull details
Repair of airway epithelia requires metabolic rewiring towards fatty acid oxidation Authors (8)Stefania Crotta Matteo VillaJack MajorKatja Finsterbusch Miriam Llorian Peter Carmeliet Joerg BuescherAndreas Wack Nature Communications Published 13 February 2023 Crick labs/ facilitiesAndreas WackBioinformatics and BiostatisticsFlow CytometryExperimental HistopathologyBiological Research FacilityAdvanced SequencingFull details
Impaired immune response drives age-dependent severity of COVID-19 Authors (20) Julius BeerStefania Crotta Angele Breithaupt Annette Ohnemus Jan Becker Benedikt Sachs[...] Jonas Fuchs Georg KochsAndreas Wack Martin Schwemmle Daniel Schnepf Journal of Experimental Medicine Published 5 December 2022 Crick labs/ facilitiesAndreas WackBioinformatics and BiostatisticsFull details
SARS-CoV-2 S2-targeted vaccination elicits broadly neutralizing antibodies Authors (21)Kevin NgNikhil FaulknerKatja FinsterbuschMary Wu Ruth HarveySaira Hussain[...]Michael Howell Hisashi AraseAndreas WackDavid LV BauerGeorge Kassiotis Science Translational Medicine Published 27 July 2022 Crick labs/ facilitiesAndreas WackCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinPeter Cherepanov Rupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningFlow CytometryCell ServicesBiological Research FacilityFull details
A family of conserved bacterial virulence factors dampens interferon responses by blocking calcium signaling Authors (24) Noémie Alphonse Joseph J Wanford Andrew A Voak Jack Gay Shayla Venkhaya Owen Burroughs[...] Martin W Berchtold Julien RC BergeronAndreas Wack Cammie F Lesser Charlotte Odendall Cell Published 23 June 2022 Crick labs/ facilitiesAndreas WackBioinformatics and BiostatisticsExperimental HistopathologyAdvanced SequencingFull details
Selective Janus kinase inhibition preserves interferon-λ-mediated antiviral responses Authors (17) Daniel SchnepfStefania Crotta Thiprampai Thamamongood Megan Stanifer Laura Polcik Annette Ohnemus[...] Susanne Kirschnek Steeve Boulant Martin SchwemmleAndreas Wack Peter Staeheli Science Immunology Published 14 May 2021 Crick labs/ facilitiesAndreas WackBioinformatics and BiostatisticsAdvanced SequencingFull details
Critical requirement for BCR, BAFF, and BAFFR in memory B cell survival Authors (8)Jennifer Mueller-Winkler Richard MitterJulie RappeLesley VanesEdina SchweighofferHamid MohammadiAndreas WackVictor Tybulewicz Journal of Experimental Medicine Published 1 February 2021 Crick labs/ facilitiesAndreas WackVictor TybulewiczBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityFull details
Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers Authors (341) Catherine F Houlihan Nina Vora Thomas Byrne Dan LewerGavin Kelly Judith Heaney[...] Andrew Hayward Richard Gilson Gavin KellyFiona Roberts Emine Hatipoglu The Lancet Published 25 July 2020 Crick labs/ facilitiesAndreas WackKaren VousdenJernej UleJames TurnerMoritz TreeckCharles SwantonAdam SaterialeErik SahaiCaetano Reis e SousaPeter RatcliffeLucia Prieto-GodinoVenizelos PapayannopoulosAnne O’GarraPaul NurseGeorge KassiotisMaximiliano GutierrezSonia GandhiSteve GamblinPeter Cherepanov Luiz Pedro CarvalhoDominique BonnetMike BlackmanRupert BealeWorldwide Influenza CentreStructural BiologyMetabolomicsHuman Embryonic Stem CellHigh Throughput ScreeningGenetic Modification ServiceFlow CytometryFermentationExperimental HistopathologyElectron MicroscopyCell ServicesBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Scalable and robust SARS-CoV-2 testing in an academic center Authors (81) Jim Aitken Karen Ambrose Sam BarrellRupert Beale Ganka Bineva-Todd Dhruva Biswas[...]Sophie Ward Wai Keong WongJoshua Wright Mary Wu The Crick COVID-19 Consortium Nature Biotechnology Published 1 August 2020 Crick labs/ facilitiesAndreas WackJames TurnerCharles SwantonCaetano Reis e SousaPeter RatcliffeVenizelos PapayannopoulosGeorge KassiotisSonia GandhiSteve GamblinPeter Cherepanov Rupert BealeStructural BiologyMetabolomicsHigh Throughput ScreeningGenetic Modification ServiceFermentationBiological Research FacilityAdvanced SequencingScientific computingFull details
Type I and III interferons disrupt lung epithelial repair during recovery from viral infection Authors (8)Jack MajorStefania CrottaMiriam Llorian Sopena Teresa M McCabe Hans Henrik GadSimon Priestnall Rune HartmannAndreas Wack Science Published 7 August 2020 Crick labs/ facilitiesAndreas WackExperimental HistopathologyBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityFull details
Influenza-induced monocyte-derived alveolar macrophages confer prolonged antibacterial protection Authors (9) Helena AegerterJustina KulikauskaiteStefania Crotta Harshil PatelGavin Kelly Edith M Hessel Matthias Mack Soren BeinkeAndreas Wack Nature Immunology Published 1 February 2020 Crick labs/ facilitiesAndreas WackBioinformatics and BiostatisticsFlow CytometryExperimental HistopathologyBiological Research FacilityAdvanced SequencingFull details
Transcriptional profiling unveils type I and II interferon networks in blood and tissues across diseases Authors (35)Akul SinghaniaChristine GrahamLeona GabrysovaLucia Moreira-TeixeiraEvangelos Stavropoulos Jonathan M Pitt[...]Venizelos PapayannopoulosAndreas Wack Jacques F Banchereau Virginia M PascualAnne O'Garra Nature Communications Published 28 June 2019 Crick labs/ facilitiesAndreas WackVenizelos PapayannopoulosAnne O’GarraJean LanghorneEva FrickelBioinformatics and BiostatisticsAdvanced SequencingFlow CytometryExperimental HistopathologyBiological Research FacilityFull details