O&#039;Garra lab Immunoregulation and Infection Laboratory : Publications

Transcriptomic characterization of tuberculous sputum reveals a host Warburg effect and microbial cholesterol catabolism

Authors (11)

Rachel Lai
Teresa Cortes
Suzaan Marais
Neesha Rockwood
Melissa L Burke
Acely Garza-Garcia
Stuart Horswell
Abdul K Sesay
Anne O’Garra
Douglas B Young
Robert Wilkinson

mBio

Published 7 December 2021

Crick labs/ facilities

Blood transcriptomics reveal the evolution and resolution of the immune response in tuberculosis

Authors (15)

Olivier Tabone
Raman Verma
Akul Singhania
Probir Chakravarty
William Branchett
Christine Graham
[...]
Karine Kaiser
Marc Rodrigue
Gerrit Woltmann
Pranabashis Haldar
Anne O'Garra

Published 4 October 2021

Crick labs/ facilities

Development of a fixed module repertoire for the analysis and interpretation of blood transcriptome data

Authors (33)

Matthew C Altman
Darawan Rinchai
Nicole Baldwin
Mohammed Toufiq
Elizabeth Whalen
Mathieu Garand
[...]
Octavio Ramilo
Karolina Palucka
Virginia Pascual
Jacques Banchereau
Damien Chaussabel

Published 19 July 2021

Crick labs

Airway macrophage-intrinsic TGF-β1 regulates pulmonary immunity during early life allergen exposure

Authors (10)

William Branchett
James Cook
Robert A Oliver
Nicoletta Bruno
Simone A Walker
Helen Stӧlting
Matthias Mack
Anne O'Garra
Sejal Saglani
Clare M Lloyd

Journal of Allergy and Clinical Immunology

Published 1 May 2021

Crick labs/ facilities

Type I IFN exacerbates disease in tuberculosis-susceptible mice by inducing neutrophil-mediated lung inflammation and NETosis

Authors (19)

Lucia Moreira-Teixeira
Philippa J Stimpson
Evangelos Stavropoulos
Sabelo Hadebe
Probir Chakravarty
Marianna Ioannou
[...]
Paula Rodríguez-Martínez
Cristina Vilaplana
Margarida Saraiva
Venizelos Papayannopoulos
Anne O'Garra

Published 4 November 2020

Crick labs/ facilities

Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers

Authors (341)

Catherine F Houlihan
Nina Vora
Thomas Byrne
Dan Lewer
Gavin Kelly
Judith Heaney
[...]
Andrew Hayward
Richard Gilson
Gavin Kelly
Fiona Roberts
Emine Hatipoglu

Transcriptomic analysis reveals diverse gene expression changes in airway macrophages during experimental allergic airway disease

Authors (3)

Wellcome Open Research

Published 22 June 2020

Crick labs/ facilities

Mouse transcriptome reveals potential signatures of protection and pathogenesis in human tuberculosis

Authors (19)

Lucia Moreira-Teixeira
Olivier Tabone
Christine Graham
Akul Singhania
Evangelos Stavropoulos
Paul S Redford
[...]
Baltazar Cá
Raman Verma
Pranabashis Haldar
Margarida Saraiva
Anne O'Garra

Nature Immunology

Published 1 April 2020

Crick labs/ facilities

JEM women in STEM: Unique journeys with a common purpose

Authors (6)

Anne O'Garra
Yasmine Belkaid
Arlene Sharpe
Susan Kaech
Sara Cherry
Emmanuelle Passegué

Published 2 March 2020

Crick labs

Anne O’Garra

Biology and therapeutic potential of interleukin-10

Authors (3)

Margarida Saraiva
Paulo Vieira
Anne O'Garra

Published 6 January 2020

Crick labs

Anne O’Garra

A T cell-myeloid IL-10 axis regulates pathogenic IFN-γ-dependent immunity in a mouse model of type 2-low asthma

Authors (10)

William Branchett
Helen Stölting
Robert A Oliver
Simone A Walker
Franz Puttur
Lisa G Gregory
Leona Gabrysova
Mark S Wilson
Anne O'Garra
Clare M Lloyd

Journal of Allergy and Clinical Immunology

Published 1 February 2020

Crick labs

Anne O’Garra

Transcriptional profiling unveils type I and II interferon networks in blood and tissues across diseases

Authors (35)

Published 28 June 2019

Crick labs/ facilities

IL-10 family cytokines IL-10 and IL-22: from basic science to clinical translation

Authors (2)

Wenjun Ouyang
Anne O'Garra

Immunity

Published 16 April 2019

Crick labs

Anne O’Garra

High-dose IL-2 skews a glucocorticoid-driven IL-17+IL-10+ memory CD4+ T cell response towards a single IL-10-producing phenotype

Authors (5)

Elizabeth Mann
Leona Gabrysova
Paul E Pfeffer
Anne O'Garra
Catherine M Hawrylowicz

Journal of Immunology

Published 1 February 2019

Crick labs/ facilities

The value of transcriptomics in advancing knowledge of the immune response and diagnosis in tuberculosis

Authors (5)

Akul Singhania
Robert Wilkinson
Marc Rodrigue
Pranabashis Haldar
Anne O'Garra

Nature Immunology

Published 1 November 2018

Crick labs

A modular transcriptional signature identifies phenotypic heterogeneity of human tuberculosis infection

Authors (15)

Akul Singhania
Raman Verma
Christine Graham
Jo Lee
Trang Tran
Matthew Richardson
[...]
Karine Kaiser
Marc Rodrigue
Gerrit Woltmann
Pranabashis Haldar
Anne O'Garra

Published 19 June 2018

Crick labs/ facilities

Regulating the regulator: Bhlhe40 directly keeps IL-10 in check

Authors (2)

Published 2 July 2018

Crick labs

Anne O’Garra

Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza

Authors (17)

Jake Dunning
Simon Blankley
Long T Hoang
Mike Cox
Christine Graham
Philip L James
[...]
Peter JM Openshaw
MOSAIC investigators
Alan Hay
John Mccauley
Wendy Barclay

Nature Immunology

Published 1 June 2018

Crick labs/ facilities

Type I interferons in tuberculosis: Foe and occasionally friend

Authors (4)

Lucia Moreira-Teixeira
Katrin Mayer-Barber
Alan Sher
Anne O'Garra

Published 7 May 2018

Crick labs

Anne O’Garra