Research case studies Explore a selection of reports that spotlight particular areas of research at the Crick over the past five years.
Postdoctoral clinical fellows Opportunities for postdoctoral clinicians to consolidate their research experience.
Breadcrumb Anne Schreiber Schreiber lab Cellular Degradation Systems Laboratory : Publications Lab contentLab contentIn this section Overview Publications Members Vacancies PublicationsYear published2023 (2)2021 (2) Facet Year publishedResearch topicsBiochemistry & Proteomics (4)Cell Biology (4)Imaging (4)Metabolism (4)Model Organisms (4)Synthetic Biology (4)Chemical Biology & High Throughput (2)Genome Integrity & Repair (2)Cell Cycle & Chromosomes (1)Computational & Systems Biology (1)Genetics & Genomics (1)Microfabrication & Bioengineering (1)Signalling & Oncogenes (1) (-)Structural Biology & Biophysics (4) Facet Research topicsCrick/Pre-CrickCrick publications (4)Pre-Crick publications (8) Facet Crick/Pre-CrickPublication typeJournal article (4)Primary research (3)Commentary (1) Facet Publication typeJournalMolecular Cell (2)eLife (1)Nature Structural and Molecular Biology (1) Facet Journal Publications Displaying 1 - 12 of 12Last updated : 28 March 2024 02:35 A non-canonical role: The Hippo pathway regulator MAP4K2 controls autophagy and cell survival upon energy stress Authors (1)Anne Schreiber Molecular Cell Published 7 September 2023 Crick labsAnne SchreiberFull details Autophagosome membrane expansion is mediated by the N-terminus and cis-membrane association of human ATG8s Authors (9)Wenxin Zhang Taki Nishimura Deepanshi Gahlot Chieko SaitoColin DavisHarold JefferiesAnne Schreiber Lipi ThukralSharon Tooze eLife Published 8 June 2023 Crick labs/ facilitiesSharon ToozeAnne SchreiberStructural BiologyFull details Structural mechanism for the selective phosphorylation of DNA-loaded MCM double hexamers by the Dbf4-dependent kinase Authors (9)Julia GreiweThomas MillerJulia LockeFabrizio Martino Steven HowellAnne SchreiberAndrea NansJohn DiffleyAlessandro Costa Nature Structural and Molecular Biology Published 1 January 2022 Crick labs/ facilitiesAnne SchreiberJohn DiffleyAlessandro CostaStructural BiologyProteomicsFull details Multilayered regulation of autophagy by the Atg1 kinase orchestrates spatial and temporal control of autophagosome formation Authors (8)Anne Schreiber Ben C CollinsColin DavisRadoslav Enchev Angie SedraRocco D'Antuono Ruedi Aebersold Matthias Peter Molecular Cell Published 16 December 2021 Crick labs/ facilitiesAnne SchreiberRadoslav EnchevLight MicroscopyFermentationFull details Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery Authors (25) Fiorenza Fumagalli Julia Noack Timothy J Bergmann Eduardo Cebollero Giorgia Brambilla Pisoni Elisa Fasana[...] Kay Hofmann Matthias Peter Manfredo Quadroni Richard Zimmermann Maurizio Molinari Nature Cell Biology Published 1 November 2016 Crick labsAnne SchreiberFull details Structural and kinetic analysis of the COP9-Signalosome activation and the cullin-RING ubiquitin ligase deneddylation cycle Authors (16) Ruzbeh Mosadeghi Kurt M Reichermeier Martin WinklerAnne Schreiber Justin M Reitsma Yaru Zhang[...] Alexander Leitner Ruedi Aebersold Matthias Peter Raymond J DeshaiesRadoslav Enchev eLife Published 31 March 2016 Crick labsAnne SchreiberRadoslav EnchevFull details Lytic water dynamics reveal evolutionarily conserved mechanisms of ATP hydrolysis by TIP49 AAA+ ATPases Authors (11) Arina Afanasyeva Angela HirtreiterAnne Schreiber Dina GrohmannGeorge Pobegalov Adam R McKay Irina Tsaneva Michael Petukhov Emmanuel Käs Mikhail Grigoriev Finn Werner Structure Published 8 April 2014 Crick labsAnne SchreiberFull details Substrate recognition in selective autophagy and the ubiquitin-proteasome system Authors (2)Anne Schreiber Matthias Peter Biochimica et Biophysica Acta Published 1 January 2014 Crick labsAnne SchreiberFull details Structural basis for a reciprocal regulation between SCF and CSN Authors (8)Radoslav Enchev Daniel C Scott Paula CA da FonsecaAnne Schreiber Julie K Monda Brenda A Schulman Matthias Peter Edward P Morris Cell Reports Published 27 September 2012 Crick labsAnne SchreiberRadoslav EnchevFull details Structural basis for the subunit assembly of the anaphase-promoting complex Authors (9)Anne Schreiber Florian Stengel Ziguo ZhangRadoslav Enchev Eric H Kong Edward P Morris Carol V Robinson Paula CA da Fonseca David Barford Nature Published 10 February 2011 Crick labsAnne SchreiberRadoslav EnchevFull details Structures of APC/CCdh1 with substrates identify Cdh1 and Apc10 as the D-box co-receptor Authors (7) Paula CA da Fonseca Eric H Kong Ziguo ZhangAnne Schreiber Mark A Williams Edward P Morris David Barford Nature Published 10 February 2011 Crick labsAnne SchreiberFull details Structural insights into the COP9 signalosome and its common architecture with the 26S proteasome lid and eIF3 Authors (4)Radoslav EnchevAnne Schreiber Fabienne Beuron Edward P Morris Structure Published 14 March 2010 Crick labsAnne SchreiberRadoslav EnchevFull details Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
A non-canonical role: The Hippo pathway regulator MAP4K2 controls autophagy and cell survival upon energy stress Authors (1)Anne Schreiber Molecular Cell Published 7 September 2023 Crick labsAnne SchreiberFull details
Autophagosome membrane expansion is mediated by the N-terminus and cis-membrane association of human ATG8s Authors (9)Wenxin Zhang Taki Nishimura Deepanshi Gahlot Chieko SaitoColin DavisHarold JefferiesAnne Schreiber Lipi ThukralSharon Tooze eLife Published 8 June 2023 Crick labs/ facilitiesSharon ToozeAnne SchreiberStructural BiologyFull details
Structural mechanism for the selective phosphorylation of DNA-loaded MCM double hexamers by the Dbf4-dependent kinase Authors (9)Julia GreiweThomas MillerJulia LockeFabrizio Martino Steven HowellAnne SchreiberAndrea NansJohn DiffleyAlessandro Costa Nature Structural and Molecular Biology Published 1 January 2022 Crick labs/ facilitiesAnne SchreiberJohn DiffleyAlessandro CostaStructural BiologyProteomicsFull details
Multilayered regulation of autophagy by the Atg1 kinase orchestrates spatial and temporal control of autophagosome formation Authors (8)Anne Schreiber Ben C CollinsColin DavisRadoslav Enchev Angie SedraRocco D'Antuono Ruedi Aebersold Matthias Peter Molecular Cell Published 16 December 2021 Crick labs/ facilitiesAnne SchreiberRadoslav EnchevLight MicroscopyFermentationFull details
Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery Authors (25) Fiorenza Fumagalli Julia Noack Timothy J Bergmann Eduardo Cebollero Giorgia Brambilla Pisoni Elisa Fasana[...] Kay Hofmann Matthias Peter Manfredo Quadroni Richard Zimmermann Maurizio Molinari Nature Cell Biology Published 1 November 2016 Crick labsAnne SchreiberFull details
Structural and kinetic analysis of the COP9-Signalosome activation and the cullin-RING ubiquitin ligase deneddylation cycle Authors (16) Ruzbeh Mosadeghi Kurt M Reichermeier Martin WinklerAnne Schreiber Justin M Reitsma Yaru Zhang[...] Alexander Leitner Ruedi Aebersold Matthias Peter Raymond J DeshaiesRadoslav Enchev eLife Published 31 March 2016 Crick labsAnne SchreiberRadoslav EnchevFull details
Lytic water dynamics reveal evolutionarily conserved mechanisms of ATP hydrolysis by TIP49 AAA+ ATPases Authors (11) Arina Afanasyeva Angela HirtreiterAnne Schreiber Dina GrohmannGeorge Pobegalov Adam R McKay Irina Tsaneva Michael Petukhov Emmanuel Käs Mikhail Grigoriev Finn Werner Structure Published 8 April 2014 Crick labsAnne SchreiberFull details
Substrate recognition in selective autophagy and the ubiquitin-proteasome system Authors (2)Anne Schreiber Matthias Peter Biochimica et Biophysica Acta Published 1 January 2014 Crick labsAnne SchreiberFull details
Structural basis for a reciprocal regulation between SCF and CSN Authors (8)Radoslav Enchev Daniel C Scott Paula CA da FonsecaAnne Schreiber Julie K Monda Brenda A Schulman Matthias Peter Edward P Morris Cell Reports Published 27 September 2012 Crick labsAnne SchreiberRadoslav EnchevFull details
Structural basis for the subunit assembly of the anaphase-promoting complex Authors (9)Anne Schreiber Florian Stengel Ziguo ZhangRadoslav Enchev Eric H Kong Edward P Morris Carol V Robinson Paula CA da Fonseca David Barford Nature Published 10 February 2011 Crick labsAnne SchreiberRadoslav EnchevFull details
Structures of APC/CCdh1 with substrates identify Cdh1 and Apc10 as the D-box co-receptor Authors (7) Paula CA da Fonseca Eric H Kong Ziguo ZhangAnne Schreiber Mark A Williams Edward P Morris David Barford Nature Published 10 February 2011 Crick labsAnne SchreiberFull details
Structural insights into the COP9 signalosome and its common architecture with the 26S proteasome lid and eIF3 Authors (4)Radoslav EnchevAnne Schreiber Fabienne Beuron Edward P Morris Structure Published 14 March 2010 Crick labsAnne SchreiberRadoslav EnchevFull details