Hanyaloglu & Jonas lab Single Molecule GPCR Laboratory

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Our research focuses primarily on the superfamily of receptors that allow messages to pass in and out of our cells’ membranes known as G protein-coupled receptors (GPCRs). 

With more than 800 different receptor types, GPCRs respond to light, smells, taste, chemical transmitters in the brain and a variety of different hormones, making them a popular target for therapeutic drugs. 

Recently demand has been growing for new drugs that are more specific, have fewer side effects, and remain active for longer. Such developments require an in-depth understanding of the molecular mechanisms from complex biological systems to have a high level of control over receptor activity.

Our collaborative team, including commercial project partners, are applying a trans-disciplinary approach to these fundamental mechanisms. We are developing nanobody technology, biophysical sensors and automated super-resolution imaging with machine learning to study GPCR complexes in the ovary to help us identify potential targets for new therapies.

We anticipate that the information generated can be directly applied to improve the quality of life of women with conditions such as polycystic ovarian syndrome, hormone-dependent cancer, infertility, premature ovarian failure, and potentially applied to other diseases that involve GPCRs.