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Breadcrumb Bart de Strooper | Lorena Arancibia de Strooper & Arancibia lab Cellular Phase of Alzheimer’s Disease Laboratory : Publications Lab contentLab contentIn this section Overview Vacancies Publications Lab members Publications Displaying 1 - 20 of 150Last updated : 25 April 2024 03:11 Xenografted human microglia display diverse transcriptomic states in response to Alzheimer's disease-related amyloid-β pathology Authors (17) Renzo Mancuso Nicola Fattorelli Anna Martinez-MurianaEmma Davis Leen Wolfs Johanna Van Den Daele[...] Suresh Poovathingal Sriram Balusu Catherine Verfaillie Mark FiersBart De Strooper Nature Neuroscience Published 27 March 2024 Crick labsBart de Strooper | Lorena ArancibiaFull details The proteomic landscape of microglia in health and disease Authors (2)Emma Davis Amy F Lloyd Frontiers in Cellular Neuroscience Published 15 March 2024 Crick labsBart de Strooper | Lorena ArancibiaFull details New precision medicine avenues to the prevention of Alzheimer's disease from insights into the structure and function of γ-secretases Authors (2)Bart De Strooper Eric Karran The EMBO Journal Published 23 February 2024 Crick labsBart de Strooper | Lorena ArancibiaFull details Functional and topological analysis of PSENEN, the fourth subunit of the γ-secretase complex Authors (6) Lutgarde Serneels Leen Bammens An Zwijsen Alexandra Tolia Lucía Chávez-GutiérrezBart De Strooper Journal of Biological Chemistry Published 1 January 2024 Crick labsBart de Strooper | Lorena ArancibiaFull details The γ-secretase substrate proteome and its role in cell signaling regulation Authors (14) Pengfei Hou Magdalena Zielonka Lutgarde Serneels Anna Martinez-Muriana Nicola Fattorelli Leen Wolfs[...] Tom Theys Mark Fiers Renzo Mancuso Andrew JM HowdenBart De Strooper Molecular Cell Published 16 November 2023 Crick labsBart de Strooper | Lorena ArancibiaFull details MEG3 activates necroptosis in human neuron xenografts modeling Alzheimer’s disease Authors (18) Sriram Balusu Katrien Horré Nicola Thrupp Katleen Craessaerts An Snellinx Lutgarde Serneels[...] Wei-Ting Chen Dietmar Rudolf Thal Evgenia Salta Mark FiersBart De Strooper Science Published 15 September 2023 Crick labsBart de Strooper | Lorena ArancibiaFull details Intracerebral hemorrhage among blood donors and their transfusion recipients Authors (11) Jingcheng Zhao Klaus Rostgaard Elsa Lauwers Torsten Dahlén Sisse Rye Ostrowski Christian Erikstrup Ole Birger PedersenBart De Strooper Robin Lemmens Henrik Hjalgrim Gustaf Edgren JAMA Published 12 September 2023 Crick labsBart de Strooper | Lorena ArancibiaFull details Discovery of brain permeable 2-Azabicyclo[2.2.2]octane sulfonamides as a novel class of presenilin-1 selective γ-secretase inhibitors Authors (6) Rajeshwar Narlawar Lutgarde Serneels Celia Gaffric Harrie JM GijsenBart De Strooper François Bischoff European Journal of Medicinal Chemistry Published 15 November 2023 Crick labsBart de Strooper | Lorena ArancibiaFull details A fully automated home cage for long-term continuous phenotyping of mouse cognition and behavior Authors (8) H Ho N Kejzar H Sasaguri T Saito TC SaidoBart De Strooper M Bauza J Krupic Cell Reports Methods Published 24 July 2023 Crick labsBart de Strooper | Lorena ArancibiaFull details Novel human/non-human primate cross-reactive anti-transferrin receptor nanobodies for brain delivery of biologics Authors (7) Laura Rué Tom Jaspers Isabelle MS Degors Sam Noppen Dominique ScholsBart De Strooper Maarten Dewilde Pharmaceutics Published 16 June 2023 Crick labsBart de Strooper | Lorena ArancibiaFull details Early alterations in the MCH system link aberrant neuronal activity and sleep disturbances in a mouse model of Alzheimer’s disease Authors (28) Sara Calafate Gökhan Özturan Nicola Thrupp Jeroen Vanderlinden Luísa Santa-Marinha Rafaela Morais-Ribeiro[...] Tiago Gil Oliveira Inna Slutsky Antoine AdamantidisBart De Strooper Joris de Wit Nature Neuroscience Published 1 June 2023 Crick labsBart de Strooper | Lorena ArancibiaFull details Selective inhibitors of the PSEN1-gamma-secretase complex Authors (13) Lutgarde Serneels Rajeshwar Narlawar Laura Perez Benito Marti Municoy Victor Guallar Dries T’Syen[...] Erwin Fraiponts Gary Tresadern Peter WM Roevens Harrie JM GijsenBart De Strooper Journal of Biological Chemistry Published 1 June 2023 Crick labsBart de Strooper | Lorena ArancibiaFull details microRNA-132 regulates gene expression programs involved in microglial homeostasis Authors (18) H Walgrave A Penning G Tosoni S Snoeck K Davie E Davis[...] R Mancuso M Fiers AJM HowdenBart De Strooper E Salta iScience Published 16 June 2023 Crick labsBart de Strooper | Lorena ArancibiaFull details Apoptotic cell death in disease-Current understanding of the NCCD 2023 Authors (228) Ilio Vitale Federico Pietrocola Emma Guilbaud Stuart A Aaronson John M Abrams Dieter Adam[...] Boris Zhivotovsky Wenzhao Zhou Mauro Piacentini Guido Kroemer Lorenzo Galluzzi Cell Death and Differentiation Published 1 May 2023 Crick labsKaren VousdenBart de Strooper | Lorena ArancibiaFull details Neurodegeneration cell per cell Authors (5) Sriram Balusu Roman Praschberger Elsa LauwersBart De Strooper Patrik Verstreken Neuron Published 15 March 2023 Crick labsBart de Strooper | Lorena ArancibiaFull details Microglial expression of the Wnt signaling modulator DKK2 differs between human Alzheimer’s disease brains and mouse neurodegeneration models Authors (9) Nozie D Aghaizu Sarah Jolly Satinder K Samra Bernadett Kalmar Katleen Craessaerts Linda Greensmith Patricia C SalinasBart De Strooper Paul J Whiting eNeuro Published 4 January 2023 Crick labsBart de Strooper | Lorena ArancibiaFull details Astrocytes mediate neuronal network hyperactivity in early AD Authors (22) D Shah W Gsell J Wahis ES Luckett T Jamoulle P Preman[...] R D'Hooge R Vandenberghe U Himmelreich V BoninBart De Strooper Alzheimer's and Dementia Published 1 December 2022 Crick labsBart de Strooper | Lorena ArancibiaFull details Pyroptosis in Alzheimer’s disease: cell type-specific activation in microglia, astrocytes and neurons Authors (9) Sebastiaan Moonen Marta J Koper Evelien Van Schoor Jolien M Schaeverbeke Rik Vandenberghe Christine AF von Arnim Thomas TousseynBart De Strooper Dietmar Rudolf Thal Acta Neuropathologica Published 1 February 2023 Crick labsBart de Strooper | Lorena ArancibiaFull details Microglia states and nomenclature: A field at its crossroads Authors (96) Rosa C Paolicelli Amanda Sierra Beth Stevens Marie-Eve Tremblay Adriano Aguzzi Bahareh Ajami[...] Hiroaki Wake Valérie Wittamer Susanne A Wolf Long-Jun Wu Tony Wyss-Coray Neuron Published 2 November 2022 Crick labsBart de Strooper | Lorena ArancibiaFull details Diabetes and Alzheimer's disease: shared genetic susceptibility? Authors (3) John HardyBart De Strooper Valentina Escott-Price The Lancet Neurology Published 1 November 2022 Crick labsBart de Strooper | Lorena ArancibiaFull details Pagination Current page 1 Page 2 Page 3 Page 4 Page 5 Page 6 Page 7 Page 8 Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Xenografted human microglia display diverse transcriptomic states in response to Alzheimer's disease-related amyloid-β pathology Authors (17) Renzo Mancuso Nicola Fattorelli Anna Martinez-MurianaEmma Davis Leen Wolfs Johanna Van Den Daele[...] Suresh Poovathingal Sriram Balusu Catherine Verfaillie Mark FiersBart De Strooper Nature Neuroscience Published 27 March 2024 Crick labsBart de Strooper | Lorena ArancibiaFull details
The proteomic landscape of microglia in health and disease Authors (2)Emma Davis Amy F Lloyd Frontiers in Cellular Neuroscience Published 15 March 2024 Crick labsBart de Strooper | Lorena ArancibiaFull details
New precision medicine avenues to the prevention of Alzheimer's disease from insights into the structure and function of γ-secretases Authors (2)Bart De Strooper Eric Karran The EMBO Journal Published 23 February 2024 Crick labsBart de Strooper | Lorena ArancibiaFull details
Functional and topological analysis of PSENEN, the fourth subunit of the γ-secretase complex Authors (6) Lutgarde Serneels Leen Bammens An Zwijsen Alexandra Tolia Lucía Chávez-GutiérrezBart De Strooper Journal of Biological Chemistry Published 1 January 2024 Crick labsBart de Strooper | Lorena ArancibiaFull details
The γ-secretase substrate proteome and its role in cell signaling regulation Authors (14) Pengfei Hou Magdalena Zielonka Lutgarde Serneels Anna Martinez-Muriana Nicola Fattorelli Leen Wolfs[...] Tom Theys Mark Fiers Renzo Mancuso Andrew JM HowdenBart De Strooper Molecular Cell Published 16 November 2023 Crick labsBart de Strooper | Lorena ArancibiaFull details
MEG3 activates necroptosis in human neuron xenografts modeling Alzheimer’s disease Authors (18) Sriram Balusu Katrien Horré Nicola Thrupp Katleen Craessaerts An Snellinx Lutgarde Serneels[...] Wei-Ting Chen Dietmar Rudolf Thal Evgenia Salta Mark FiersBart De Strooper Science Published 15 September 2023 Crick labsBart de Strooper | Lorena ArancibiaFull details
Intracerebral hemorrhage among blood donors and their transfusion recipients Authors (11) Jingcheng Zhao Klaus Rostgaard Elsa Lauwers Torsten Dahlén Sisse Rye Ostrowski Christian Erikstrup Ole Birger PedersenBart De Strooper Robin Lemmens Henrik Hjalgrim Gustaf Edgren JAMA Published 12 September 2023 Crick labsBart de Strooper | Lorena ArancibiaFull details
Discovery of brain permeable 2-Azabicyclo[2.2.2]octane sulfonamides as a novel class of presenilin-1 selective γ-secretase inhibitors Authors (6) Rajeshwar Narlawar Lutgarde Serneels Celia Gaffric Harrie JM GijsenBart De Strooper François Bischoff European Journal of Medicinal Chemistry Published 15 November 2023 Crick labsBart de Strooper | Lorena ArancibiaFull details
A fully automated home cage for long-term continuous phenotyping of mouse cognition and behavior Authors (8) H Ho N Kejzar H Sasaguri T Saito TC SaidoBart De Strooper M Bauza J Krupic Cell Reports Methods Published 24 July 2023 Crick labsBart de Strooper | Lorena ArancibiaFull details
Novel human/non-human primate cross-reactive anti-transferrin receptor nanobodies for brain delivery of biologics Authors (7) Laura Rué Tom Jaspers Isabelle MS Degors Sam Noppen Dominique ScholsBart De Strooper Maarten Dewilde Pharmaceutics Published 16 June 2023 Crick labsBart de Strooper | Lorena ArancibiaFull details
Early alterations in the MCH system link aberrant neuronal activity and sleep disturbances in a mouse model of Alzheimer’s disease Authors (28) Sara Calafate Gökhan Özturan Nicola Thrupp Jeroen Vanderlinden Luísa Santa-Marinha Rafaela Morais-Ribeiro[...] Tiago Gil Oliveira Inna Slutsky Antoine AdamantidisBart De Strooper Joris de Wit Nature Neuroscience Published 1 June 2023 Crick labsBart de Strooper | Lorena ArancibiaFull details
Selective inhibitors of the PSEN1-gamma-secretase complex Authors (13) Lutgarde Serneels Rajeshwar Narlawar Laura Perez Benito Marti Municoy Victor Guallar Dries T’Syen[...] Erwin Fraiponts Gary Tresadern Peter WM Roevens Harrie JM GijsenBart De Strooper Journal of Biological Chemistry Published 1 June 2023 Crick labsBart de Strooper | Lorena ArancibiaFull details
microRNA-132 regulates gene expression programs involved in microglial homeostasis Authors (18) H Walgrave A Penning G Tosoni S Snoeck K Davie E Davis[...] R Mancuso M Fiers AJM HowdenBart De Strooper E Salta iScience Published 16 June 2023 Crick labsBart de Strooper | Lorena ArancibiaFull details
Apoptotic cell death in disease-Current understanding of the NCCD 2023 Authors (228) Ilio Vitale Federico Pietrocola Emma Guilbaud Stuart A Aaronson John M Abrams Dieter Adam[...] Boris Zhivotovsky Wenzhao Zhou Mauro Piacentini Guido Kroemer Lorenzo Galluzzi Cell Death and Differentiation Published 1 May 2023 Crick labsKaren VousdenBart de Strooper | Lorena ArancibiaFull details
Neurodegeneration cell per cell Authors (5) Sriram Balusu Roman Praschberger Elsa LauwersBart De Strooper Patrik Verstreken Neuron Published 15 March 2023 Crick labsBart de Strooper | Lorena ArancibiaFull details
Microglial expression of the Wnt signaling modulator DKK2 differs between human Alzheimer’s disease brains and mouse neurodegeneration models Authors (9) Nozie D Aghaizu Sarah Jolly Satinder K Samra Bernadett Kalmar Katleen Craessaerts Linda Greensmith Patricia C SalinasBart De Strooper Paul J Whiting eNeuro Published 4 January 2023 Crick labsBart de Strooper | Lorena ArancibiaFull details
Astrocytes mediate neuronal network hyperactivity in early AD Authors (22) D Shah W Gsell J Wahis ES Luckett T Jamoulle P Preman[...] R D'Hooge R Vandenberghe U Himmelreich V BoninBart De Strooper Alzheimer's and Dementia Published 1 December 2022 Crick labsBart de Strooper | Lorena ArancibiaFull details
Pyroptosis in Alzheimer’s disease: cell type-specific activation in microglia, astrocytes and neurons Authors (9) Sebastiaan Moonen Marta J Koper Evelien Van Schoor Jolien M Schaeverbeke Rik Vandenberghe Christine AF von Arnim Thomas TousseynBart De Strooper Dietmar Rudolf Thal Acta Neuropathologica Published 1 February 2023 Crick labsBart de Strooper | Lorena ArancibiaFull details
Microglia states and nomenclature: A field at its crossroads Authors (96) Rosa C Paolicelli Amanda Sierra Beth Stevens Marie-Eve Tremblay Adriano Aguzzi Bahareh Ajami[...] Hiroaki Wake Valérie Wittamer Susanne A Wolf Long-Jun Wu Tony Wyss-Coray Neuron Published 2 November 2022 Crick labsBart de Strooper | Lorena ArancibiaFull details
Diabetes and Alzheimer's disease: shared genetic susceptibility? Authors (3) John HardyBart De Strooper Valentina Escott-Price The Lancet Neurology Published 1 November 2022 Crick labsBart de Strooper | Lorena ArancibiaFull details