Check below for funding opportunities in the fascinating world of Chemical Glycobiology.
Outstanding candidates are invited to get in touch for fellowship opportunities.
PhD Studentship vacancy, drug discovery
Combining multiple bullets against a sweet target - Fragment-based drug discovery to tackle cancer glycosylation
- Funded by the CDT in Chemical Biology: Innovation in Life Sciences
- 1+3 year PhD studentship
- This studentship is co-funded with GSK.
- Supervisors: Dr Benjamin Schumann | Dr David House | Professor Ed Tate
Glycosylation is a ubiquitous posttranslational protein modification, and highly glycosylated proteins are overexpressed as a hallmark of metastatic cancer. The addiction of cancer cells to structural alterations of glycans makes the process of glycosylation an important yet underexplored target for therapeutic intervention. This project, co-funded by GlaxoSmithKline, will focus on fragment-based drug discovery to generate glycosylation enzyme inhibitors. We will combine newly-available chemical space and modelling approaches to generate lead compounds with suitable interaction profiles. Biological evaluation will be performed to develop a drug that hits glycosylation, the sweet tooth of cancer.