Dendritic cells

Caetano Reis e Sousa : Areas of interest

Intro page

Dendritic cells stained for F-actin.

Figure 1: Dendritic cells stained for F-actin.

Dendritic cells (DC) play a key role in the initiation and regulation of adaptive immune responses and, therefore, the manipulation of DC has tremendous potential for cancer immunotherapy and for vaccination against infectious agents.

We study innate immune receptors and signalling pathways that trigger DC activation and promote T cell priming or that generally act to modulate the function of DC. Many of these pathways are shared with other cell types and are triggered in response to infection or cell death.

In a related research programme, we study DC and myeloid cell heterogeneity and ontogeny with a view to understand the role of distinct DC subtypes in mouse and in human.

Selected recent publications