Coronavirus (COVID-19) response The Francis Crick Institute is working at the forefront of the scientific response to coronavirus, volunteering expertise and facilities to help tackle the COVID-19 pandemic.
Vacancies Find links to current vacancies, and information about recruitment to various types of role.
A drop of hope A collection of poems inspired by the words of those who have been vaccinated within the Crick, the reflections of the volunteers working at the vaccination centre, and the experiences our local communities.Exhibition entry: Available to view between May and August 2021
Coronavirus (COVID-19) research Crick researchers are working at the forefront of the scientific response to answer some of the most urgent questions about the SARS-CoV-2 pathogen, from how we can improve testing, to why it’s deadly in some people but causes no symptoms in others.
Coronavirus (COVID-19) response The Francis Crick Institute is working at the forefront of the scientific response to coronavirus, volunteering expertise and facilities to help tackle the COVID-19 pandemic.
Dendritic cells are white blood cells that get their name from their tree-like shape (dendron is the Greek word for tree). Toggle to view hero caption Caetano Reis e Sousa : Publications Lab MenuLab Menu Overview Areas of interest View more Back Past and current work Publications Members Vacancies News Alumni Breadcrumb Research A Z of research labs Caetano Reis e Sousa PublicationsYear published2021 (3)2020 (5)2019 (4)2018 (9)2017 (2)2016 (6)2015 (11)2014 (8)2013 (8)2012 (7)2011 (7)2010 (6) Facet Year publishedResearch topicsInfectious Disease (39)Tumour Biology (39)Immunology (38)Model Organisms (38)Chemical Biology & High Throughput (19)Computational & Systems Biology (16)Genetics & Genomics (14)Genome Integrity & Repair (14)Cell Biology (11)Imaging (10)Biochemistry & Proteomics (7)Human Biology & Physiology (7)Signalling & Oncogenes (7)Stem Cells (6)Structural Biology & Biophysics (6)Cell Cycle & Chromosomes (4)Developmental Biology (4)Metabolism (3)Neurosciences (3)Gene Expression (1)Microfabrication & Bioengineering (1)Synthetic Biology (1) Facet Research topicsPublication typeJournal article (76)Primary research (51)Review (13)Commentary (6)Method (3)Editorial (2)Letter (1) Facet Publication typeJournalEuropean Journal of Immunology (10)Immunity (10)Cell (5)EMBO Journal (5)Journal of Immunology (4)Current Opinion in Immunology (3)eLife (3)Nature Immunology (3)Science (3)Annual Review of Immunology (2)Blood (2)Cell Reports (2)Journal of Clinical Investigation (2)Nature (2)Nature Communications (2)Science Immunology (2)BioEssays (1)Cell Host & Microbe (1)Current Opinion in Microbiology (1)EMBO Molecular Medicine (1)European Journal of Clinical Investigation (1)Frontiers in Immunology (1)Journal of Experimental Medicine (1)Nature Biotechnology (1)Oncoimmunology (1)PLOS Pathogens (1)Proceedings of the National Academy of Sciences of the United States of America (1)Seminars in Immunology (1)The Lancet (1)Trends in Cancer (1)Trends in Immunology (1)Wellcome Open Research (1) Facet Journal Publications Displaying 1 - 20 of 76Last updated : 22 June 2021 02:22 Secreted gelsolin inhibits DNGR-1-dependent cross-presentation and cancer immunity Authors (17)Evangelos GiampazoliasOliver SchulzJonathan LimNeil Rogers Probir Chakravarty Naren Srinivasan[...] Stefano Sammicheli Natalia MoncautSunita Varsani-BrownIan RosewellCaetano Reis e Sousa Cell Published 2 June 2021 Crick labs/ facilitiesCaetano Reis e SousaGenetic Modification ServiceBiological Research FacilityBioinformatics and BiostatisticsFlow CytometryFull details Dendritic cells revisited Authors (5)Mar Cabeza CabrerizoAna Matos Cardoso Da SilvaCarlos Munoz MinuttiMariana Pereira Da CostaCaetano Reis e Sousa Annual Review of Immunology Published 1 April 2021 Crick labsCaetano Reis e SousaFull details SARS-CoV-2 detection by a clinical diagnostic RT-LAMP assay Authors (41)Michael BuckEnzo PoirierCaetano Reis e SousaAna Matos Cardoso Da SilvaBruno Goncalves Frederico J Canton[...]Charles SwantonSamra TurajlicMary Wu Caetano Reis e Sousa The Crick COVID-19 Consortium Wellcome Open Research Published 21 May 2021 Crick labs/ facilitiesSamra TurajlicCharles SwantonCaetano Reis e SousaGeorge KassiotisSonia GandhiRupert BealePeptide ChemistryMetabolomicsHigh Throughput ScreeningGenetic Modification ServiceBiological Research FacilityAdvanced SequencingStructural BiologyScientific computingFull details The receptor DNGR-1 signals for phagosomal rupture to promote cross-presentation of dead-cell-associated antigens Authors (18) Johnathan CantonHanna BleesConor HenryMichael BuckOliver SchulzNeil Rogers[...] Sebastian AmigorenaVenizelos Papagiannopoulos David C Thomas Felix RandowCaetano Reis e Sousa Nature Immunology Published 1 February 2021 Crick labs/ facilitiesCaetano Reis e SousaFlow CytometryElectron MicroscopyProteomicsBiological Research FacilityFull details Antagonistic inflammatory phenotypes dictate tumor fate and response to immune checkpoint blockade Authors (20) Eduardo Bonavita Christian P Bromley Gustav Jonsson Victoria S Pelly Sudhakar Sahoo Katherine Walwyn-Brown[...] Alberto MantovaniCaetano Reis e Sousa Nadia Guerra Daniel M Davis Santiago Zelenay Immunity Published 15 December 2020 Crick labsCaetano Reis e SousaFull details Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers Authors (341)Catherine F HoulihanNina VoraThomas ByrneDan LewerGavin KellyJudith Heaney[...]Andrew HaywardRichard GilsonGavin KellyFiona RobertsEmine Hatipoglu The Lancet Published 25 July 2020 Crick labs/ facilitiesAndreas WackKaren VousdenJernej UleJames TurnerMoritz TreeckCharles SwantonAdam SaterialeErik SahaiCaetano Reis e SousaPeter RatcliffeLucia Prieto-GodinoVenizelos PapayannopoulosAnne O’GarraPaul NurseGeorge KassiotisMaximiliano GutierrezSonia GandhiSteve GamblinPeter Cherepanov Luiz Pedro CarvalhoDominique BonnetMike BlackmanRupert BealeGenetic Modification ServiceStructural BiologyPeptide ChemistryMetabolomicsFlow CytometryHigh Throughput ScreeningCell ServicesAdvanced SequencingBioinformatics and BiostatisticsBiological Research FacilityExperimental HistopathologyElectron MicroscopyScientific computingFull details Cross-presentation of dead-cell-associated antigens by DNGR-1+ dendritic cells contributes to chronic allograft rejection in mice Authors (13) Saidou Balam Rebecca Kesselring Eggenhofer Elke Stephanie Blaimer Katja Evert Matthias Evert[...] Janneke van BlijswijkSonia LeeCaetano Reis e Sousa Stefan M Brunner Stefan Fichtner-Feigl European Journal of Immunology Published 1 December 2020 Crick labsCaetano Reis e SousaFull details Scalable and robust SARS-CoV-2 testing in an academic center Authors (81)Jim AitkenKaren AmbroseSam BarrellRupert BealeGanka Bineva-ToddDhruva Biswas[...]Sophia WardWai Keong WongJoshua WrightMary Wu The Crick COVID-19 Consortium Nature Biotechnology Published 1 August 2020 Crick labs/ facilitiesAndreas WackJames TurnerCharles SwantonCaetano Reis e SousaPeter RatcliffeVenizelos PapayannopoulosGeorge KassiotisSonia GandhiSteve GamblinPeter Cherepanov Rupert BealeStructural BiologyPeptide ChemistryMetabolomicsHigh Throughput ScreeningGenetic Modification ServiceBiological Research FacilityAdvanced SequencingScientific computingFull details Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition) Authors (436) Andrea Cossarizza Hyun-Dong Chang Andreas Radbruch Andreas Acs Dieter Adam Sabine Adam-Klages[...] Yi Zhao Susanne Maria Ziegler Christina Zielinski Jakob Zimmermann Arturo Zychlinsky European Journal of Immunology Published 21 October 2019 Crick labs/ facilitiesRobert J WilkinsonCaetano Reis e SousaFlow CytometryFull details Cytoskeletal exposure in the regulation of immunity and initiation of tissue repair Authors (2)Oliver GordonCaetano Reis e Sousa BioEssays Published 1 July 2019 Crick labsCaetano Reis e SousaFull details Slicing and dicing viruses: antiviral RNA interference in mammals Authors (4) Pierre V Maillard Annemarthe G van der VeenEnzo PoirierCaetano Reis e Sousa EMBO Journal Published 15 April 2019 Crick labsCaetano Reis e SousaFull details Tissue clonality of dendritic cell subsets and emergency DCpoiesis revealed by multicolor fate mapping of DC progenitors Authors (19)Mar Cabeza Cabrerizo Janneke van Blijswijk Stephan Wienert Daniel HeimRob Jenkins Probir Chakravarty[...] Michael Gerner Ronald N GermainErik Sahai Frederick KlauschenCaetano Reis e Sousa Science Immunology Published 1 March 2019 Crick labs/ facilitiesErik SahaiCaetano Reis e SousaBioinformatics and BiostatisticsLight MicroscopyFlow CytometryBiological Research FacilityFull details Direct reprogramming of fibroblasts into antigen-presenting dendritic cells Authors (13) Fábio F Rosa Cristiana F Pires Ilia Kurochkin Alexandra G Ferreira Andreia M Gomes Luís G Palma[...] Cláudia Azenha Dmitri PapatsenkoOliver SchulzCaetano Reis e Sousa Carlos-Filipe Pereira Science Immunology Published 7 December 2018 Crick labsCaetano Reis e SousaFull details The role of type 1 conventional dendritic cells in cancer immunity Authors (2) Jan P BöttcherCaetano Reis e Sousa Trends in Cancer Published 1 November 2018 Crick labsCaetano Reis e SousaFull details α-actinin accounts for the bioactivity of actin preparations in inducing STAT target genes in Drosophila melanogaster Authors (19)Oliver GordonConor Henry Naren Srinivasan Susan Ahrens Anna Franz Safia Deddouche[...] Luis Teixeira Barry Thompson Marc S Dionne Will WoodCaetano Reis e Sousa eLife Published 27 September 2018 Crick labs/ facilitiesBarry ThompsonCaetano Reis e SousaStructural BiologyProteomicsGenomics/Equipment ParkBioinformatics and BiostatisticsFull details Myosin II synergizes with F-actin to promote DNGR-1-dependent cross-presentation of dead cell-associated antigens Authors (7)Oliver Schulz Pavel Hanč Jan P Böttcher Robbert Hoogeboom Sandra S DieboldPavel TolarCaetano Reis e Sousa Cell Reports Published 10 July 2018 Crick labsPavel TolarCaetano Reis e SousaFull details Cysteine-reactive free ISG15 generates IL-1β-producing CD8α+ dendritic cells at the site of infection Authors (11) Anna Napolitano Annemarthe G van der Veen Monique BunyanAnnabel BorgDavid Frith Steven HowellSvend Kjaer Antje BelingBram Snijders Klaus-Peter Knobeloch Eva-Maria Frickel Journal of Immunology Published 15 July 2018 Crick labs/ facilitiesCaetano Reis e SousaEva FrickelStructural BiologyProteomicsFlow CytometryBiological Research FacilityFull details Molecular mechanism of influenza A NS1-mediated TRIM25 recognition and inhibition Authors (11) Marios G Koliopoulos Mathilde Lethier Annemarthe G van der Veen Kevin Haubrich Janosch Hennig Eva KowalinskiRebecca Stevens Stephen R MartinCaetano Reis e Sousa Stephen CusackKatrin Rittinger Nature Communications Published 8 May 2018 Crick labs/ facilitiesKatrin RittingerCaetano Reis e SousaStructural BiologyProteomicsFull details Clec9a-mediated ablation of conventional dendritic cells suggests a lymphoid path to generating dendritic cells in vivo Authors (11) J Salvermoser J Van Blijswijk NE Papaioannou S Rambichler M Pasztoi D PakalniškytėNeil Rogers SJ Keppler T StraubCaetano Reis e Sousa BU Schraml Frontiers in Immunology Published 16 April 2018 Crick labsCaetano Reis e SousaFull details NK cells stimulate recruitment of cDC1 into the tumor microenvironment promoting cancer immune control Authors (10) Jan P Böttcher Eduardo Bonavita Probir ChakravartyHanna BleesMar Cabeza Cabrerizo Stefano SammicheliNeil RogersErik Sahai Santiago ZelenayCaetano Reis e Sousa Cell Published 22 February 2018 Crick labs/ facilitiesErik SahaiCaetano Reis e SousaBioinformatics and BiostatisticsFull details Pagination Current page 1 Page 2 Page 3 Page 4 Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Secreted gelsolin inhibits DNGR-1-dependent cross-presentation and cancer immunity Authors (17)Evangelos GiampazoliasOliver SchulzJonathan LimNeil Rogers Probir Chakravarty Naren Srinivasan[...] Stefano Sammicheli Natalia MoncautSunita Varsani-BrownIan RosewellCaetano Reis e Sousa Cell Published 2 June 2021 Crick labs/ facilitiesCaetano Reis e SousaGenetic Modification ServiceBiological Research FacilityBioinformatics and BiostatisticsFlow CytometryFull details
Dendritic cells revisited Authors (5)Mar Cabeza CabrerizoAna Matos Cardoso Da SilvaCarlos Munoz MinuttiMariana Pereira Da CostaCaetano Reis e Sousa Annual Review of Immunology Published 1 April 2021 Crick labsCaetano Reis e SousaFull details
SARS-CoV-2 detection by a clinical diagnostic RT-LAMP assay Authors (41)Michael BuckEnzo PoirierCaetano Reis e SousaAna Matos Cardoso Da SilvaBruno Goncalves Frederico J Canton[...]Charles SwantonSamra TurajlicMary Wu Caetano Reis e Sousa The Crick COVID-19 Consortium Wellcome Open Research Published 21 May 2021 Crick labs/ facilitiesSamra TurajlicCharles SwantonCaetano Reis e SousaGeorge KassiotisSonia GandhiRupert BealePeptide ChemistryMetabolomicsHigh Throughput ScreeningGenetic Modification ServiceBiological Research FacilityAdvanced SequencingStructural BiologyScientific computingFull details
The receptor DNGR-1 signals for phagosomal rupture to promote cross-presentation of dead-cell-associated antigens Authors (18) Johnathan CantonHanna BleesConor HenryMichael BuckOliver SchulzNeil Rogers[...] Sebastian AmigorenaVenizelos Papagiannopoulos David C Thomas Felix RandowCaetano Reis e Sousa Nature Immunology Published 1 February 2021 Crick labs/ facilitiesCaetano Reis e SousaFlow CytometryElectron MicroscopyProteomicsBiological Research FacilityFull details
Antagonistic inflammatory phenotypes dictate tumor fate and response to immune checkpoint blockade Authors (20) Eduardo Bonavita Christian P Bromley Gustav Jonsson Victoria S Pelly Sudhakar Sahoo Katherine Walwyn-Brown[...] Alberto MantovaniCaetano Reis e Sousa Nadia Guerra Daniel M Davis Santiago Zelenay Immunity Published 15 December 2020 Crick labsCaetano Reis e SousaFull details
Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers Authors (341)Catherine F HoulihanNina VoraThomas ByrneDan LewerGavin KellyJudith Heaney[...]Andrew HaywardRichard GilsonGavin KellyFiona RobertsEmine Hatipoglu The Lancet Published 25 July 2020 Crick labs/ facilitiesAndreas WackKaren VousdenJernej UleJames TurnerMoritz TreeckCharles SwantonAdam SaterialeErik SahaiCaetano Reis e SousaPeter RatcliffeLucia Prieto-GodinoVenizelos PapayannopoulosAnne O’GarraPaul NurseGeorge KassiotisMaximiliano GutierrezSonia GandhiSteve GamblinPeter Cherepanov Luiz Pedro CarvalhoDominique BonnetMike BlackmanRupert BealeGenetic Modification ServiceStructural BiologyPeptide ChemistryMetabolomicsFlow CytometryHigh Throughput ScreeningCell ServicesAdvanced SequencingBioinformatics and BiostatisticsBiological Research FacilityExperimental HistopathologyElectron MicroscopyScientific computingFull details
Cross-presentation of dead-cell-associated antigens by DNGR-1+ dendritic cells contributes to chronic allograft rejection in mice Authors (13) Saidou Balam Rebecca Kesselring Eggenhofer Elke Stephanie Blaimer Katja Evert Matthias Evert[...] Janneke van BlijswijkSonia LeeCaetano Reis e Sousa Stefan M Brunner Stefan Fichtner-Feigl European Journal of Immunology Published 1 December 2020 Crick labsCaetano Reis e SousaFull details
Scalable and robust SARS-CoV-2 testing in an academic center Authors (81)Jim AitkenKaren AmbroseSam BarrellRupert BealeGanka Bineva-ToddDhruva Biswas[...]Sophia WardWai Keong WongJoshua WrightMary Wu The Crick COVID-19 Consortium Nature Biotechnology Published 1 August 2020 Crick labs/ facilitiesAndreas WackJames TurnerCharles SwantonCaetano Reis e SousaPeter RatcliffeVenizelos PapayannopoulosGeorge KassiotisSonia GandhiSteve GamblinPeter Cherepanov Rupert BealeStructural BiologyPeptide ChemistryMetabolomicsHigh Throughput ScreeningGenetic Modification ServiceBiological Research FacilityAdvanced SequencingScientific computingFull details
Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition) Authors (436) Andrea Cossarizza Hyun-Dong Chang Andreas Radbruch Andreas Acs Dieter Adam Sabine Adam-Klages[...] Yi Zhao Susanne Maria Ziegler Christina Zielinski Jakob Zimmermann Arturo Zychlinsky European Journal of Immunology Published 21 October 2019 Crick labs/ facilitiesRobert J WilkinsonCaetano Reis e SousaFlow CytometryFull details
Cytoskeletal exposure in the regulation of immunity and initiation of tissue repair Authors (2)Oliver GordonCaetano Reis e Sousa BioEssays Published 1 July 2019 Crick labsCaetano Reis e SousaFull details
Slicing and dicing viruses: antiviral RNA interference in mammals Authors (4) Pierre V Maillard Annemarthe G van der VeenEnzo PoirierCaetano Reis e Sousa EMBO Journal Published 15 April 2019 Crick labsCaetano Reis e SousaFull details
Tissue clonality of dendritic cell subsets and emergency DCpoiesis revealed by multicolor fate mapping of DC progenitors Authors (19)Mar Cabeza Cabrerizo Janneke van Blijswijk Stephan Wienert Daniel HeimRob Jenkins Probir Chakravarty[...] Michael Gerner Ronald N GermainErik Sahai Frederick KlauschenCaetano Reis e Sousa Science Immunology Published 1 March 2019 Crick labs/ facilitiesErik SahaiCaetano Reis e SousaBioinformatics and BiostatisticsLight MicroscopyFlow CytometryBiological Research FacilityFull details
Direct reprogramming of fibroblasts into antigen-presenting dendritic cells Authors (13) Fábio F Rosa Cristiana F Pires Ilia Kurochkin Alexandra G Ferreira Andreia M Gomes Luís G Palma[...] Cláudia Azenha Dmitri PapatsenkoOliver SchulzCaetano Reis e Sousa Carlos-Filipe Pereira Science Immunology Published 7 December 2018 Crick labsCaetano Reis e SousaFull details
The role of type 1 conventional dendritic cells in cancer immunity Authors (2) Jan P BöttcherCaetano Reis e Sousa Trends in Cancer Published 1 November 2018 Crick labsCaetano Reis e SousaFull details
α-actinin accounts for the bioactivity of actin preparations in inducing STAT target genes in Drosophila melanogaster Authors (19)Oliver GordonConor Henry Naren Srinivasan Susan Ahrens Anna Franz Safia Deddouche[...] Luis Teixeira Barry Thompson Marc S Dionne Will WoodCaetano Reis e Sousa eLife Published 27 September 2018 Crick labs/ facilitiesBarry ThompsonCaetano Reis e SousaStructural BiologyProteomicsGenomics/Equipment ParkBioinformatics and BiostatisticsFull details
Myosin II synergizes with F-actin to promote DNGR-1-dependent cross-presentation of dead cell-associated antigens Authors (7)Oliver Schulz Pavel Hanč Jan P Böttcher Robbert Hoogeboom Sandra S DieboldPavel TolarCaetano Reis e Sousa Cell Reports Published 10 July 2018 Crick labsPavel TolarCaetano Reis e SousaFull details
Cysteine-reactive free ISG15 generates IL-1β-producing CD8α+ dendritic cells at the site of infection Authors (11) Anna Napolitano Annemarthe G van der Veen Monique BunyanAnnabel BorgDavid Frith Steven HowellSvend Kjaer Antje BelingBram Snijders Klaus-Peter Knobeloch Eva-Maria Frickel Journal of Immunology Published 15 July 2018 Crick labs/ facilitiesCaetano Reis e SousaEva FrickelStructural BiologyProteomicsFlow CytometryBiological Research FacilityFull details
Molecular mechanism of influenza A NS1-mediated TRIM25 recognition and inhibition Authors (11) Marios G Koliopoulos Mathilde Lethier Annemarthe G van der Veen Kevin Haubrich Janosch Hennig Eva KowalinskiRebecca Stevens Stephen R MartinCaetano Reis e Sousa Stephen CusackKatrin Rittinger Nature Communications Published 8 May 2018 Crick labs/ facilitiesKatrin RittingerCaetano Reis e SousaStructural BiologyProteomicsFull details
Clec9a-mediated ablation of conventional dendritic cells suggests a lymphoid path to generating dendritic cells in vivo Authors (11) J Salvermoser J Van Blijswijk NE Papaioannou S Rambichler M Pasztoi D PakalniškytėNeil Rogers SJ Keppler T StraubCaetano Reis e Sousa BU Schraml Frontiers in Immunology Published 16 April 2018 Crick labsCaetano Reis e SousaFull details
NK cells stimulate recruitment of cDC1 into the tumor microenvironment promoting cancer immune control Authors (10) Jan P Böttcher Eduardo Bonavita Probir ChakravartyHanna BleesMar Cabeza Cabrerizo Stefano SammicheliNeil RogersErik Sahai Santiago ZelenayCaetano Reis e Sousa Cell Published 22 February 2018 Crick labs/ facilitiesErik SahaiCaetano Reis e SousaBioinformatics and BiostatisticsFull details
