Coronavirus (COVID-19) research Crick researchers are working at the forefront of the scientific response to answer some of the most urgent questions about the SARS-CoV-2 pathogen, from how we can improve testing, to why it’s deadly in some people but causes no symptoms in others.
Francis Crick Institute coronavirus (COVID-19) response The Francis Crick Institute is working at the forefront of the scientific response to coronavirus, volunteering expertise and facilities to help tackle the COVID-19 pandemic.
Dendritic cells are white blood cells that get their name from their tree-like shape (dendron is the Greek word for tree). Toggle to view hero caption Caetano Reis e Sousa : Publications Lab MenuLab Menu Overview Areas of interest View more Back Past and current work Publications Members Vacancies News Alumni Breadcrumb Home Research Labs Caetano Reis e Sousa Publications PublicationsYear published2020 (3)2019 (4)2018 (9)2017 (2)2016 (7)2015 (12)2014 (7)2013 (8)2012 (7)2011 (7)2010 (6)Research topicsInfectious Disease (34)Tumour Biology (34)Immunology (33)Model Organisms (33)Chemical Biology & High Throughput (16)Computational & Systems Biology (13)Genetics & Genomics (11)Genome Integrity & Repair (11)Cell Biology (9)Imaging (7)Biochemistry & Proteomics (6)Signalling & Oncogenes (6)Structural Biology & Biophysics (5)Human Biology & Physiology (4)Stem Cells (4)Cell Cycle & Chromosomes (3)Developmental Biology (3)Metabolism (2)Neurosciences (2)Gene Expression (1)Microfabrication & Bioengineering (1)Synthetic Biology (1)Publication typeJournal article (72)Primary research (48)Review (13)Commentary (6)Editorial (2)Method (2)Letter (1)JournalEuropean Journal of Immunology (10)Immunity (9)EMBO Journal (5)Cell (4)Journal of Immunology (4)Current Opinion in Immunology (3)eLife (3)Science (3)Blood (2)Cell Reports (2)Journal of Clinical Investigation (2)Nature (2)Nature Communications (2)Nature Immunology (2)Science Immunology (2)Annual Review of Immunology (1)BioEssays (1)Cell Host & Microbe (1)Current Opinion in Microbiology (1)EMBO Molecular Medicine (1)European Journal of Clinical Investigation (1)Frontiers in Immunology (1)Immunological Reviews (1)Journal of Experimental Medicine (1)Nature Biotechnology (1)Oncoimmunology (1)PLOS Pathogens (1)Proceedings of the National Academy of Sciences of the United States of America (1)Seminars in Immunology (1)The Lancet (1)Trends in Cancer (1)Trends in Immunology (1) Publications Displaying 1 - 20 of 72Last updated : 12 August 2020 02:11 Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers Authors (341) Catherine F Houlihan Nina Vora Thomas Byrne Dan Lewer Gavin Kelly Judith Heaney[...] Andrew Hayward Richard Gilson Gavin KellyFiona Roberts Emine Hatipoglu The Lancet Published 25 July 2020 Crick labs/ facilitiesLuiz Pedro CarvalhoMike BlackmanDominique BonnetPeter Cherepanov Steve GamblinMaximiliano GutierrezGeorge KassiotisPaul NurseAnne O’GarraVenizelos PapayannopoulosLucia Prieto-GodinoPeter RatcliffeCaetano Reis e SousaErik SahaiCharles SwantonMoritz TreeckJames TurnerJernej UleKaren VousdenAndreas WackSonia GandhiRupert BealeAdam SaterialeAdvanced SequencingCell ServicesBioinformatics and BiostatisticsElectron MicroscopyExperimental HistopathologyFlow CytometryGenomics/Equipment ParkHigh Throughput ScreeningMetabolomicsPeptide ChemistryStructural BiologyFermentationWorldwide Influenza CentreHuman Embryonic Stem CellScientific computingFull details Cross-presentation of dead-cell-associated antigens by DNGR-1+ dendritic cells contributes to chronic allograft rejection in mice Authors (13) Saidou Balam Rebecca Kesselring Eggenhofer Elke Stephanie Blaimer Katja Evert Matthias Evert[...] Janneke van BlijswijkSonia LeeCaetano Reis e Sousa Stefan M Brunner Stefan Fichtner-Feigl European Journal of Immunology Published 8 July 2020 Crick labsCaetano Reis e SousaFull details Scalable and robust SARS-CoV-2 testing in an academic center Authors (81) The Crick COVID-19 Consortium Jim Aitken Karen AmbroseSam BarrellRupert BealeGanka Bineva-Todd[...]Philip WalkerSophia Ward Wai Keong WongJoshua WrightMary Wu Nature Biotechnology Published 18 June 2020 Crick labs/ facilitiesPeter Cherepanov Steve GamblinGeorge KassiotisVenizelos PapayannopoulosPeter RatcliffeCaetano Reis e SousaCharles SwantonJames TurnerAndreas WackSonia GandhiRupert BealeAdvanced SequencingGenomics/Equipment ParkHigh Throughput ScreeningMetabolomicsPeptide ChemistryStructural BiologyFermentationScientific computingFull details Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition) Authors (436) Andrea Cossarizza Hyun-Dong Chang Andreas Radbruch Andreas Acs Dieter Adam Sabine Adam-Klages[...] Yi Zhao Susanne Maria Ziegler Christina Zielinski Jakob Zimmermann Arturo Zychlinsky European Journal of Immunology Published 21 October 2019 Crick labs/ facilitiesCaetano Reis e SousaRobert J WilkinsonFlow CytometryFull details Cytoskeletal exposure in the regulation of immunity and initiation of tissue repair Authors (2)Oliver GordonCaetano Reis e Sousa BioEssays Published 3 June 2019 Crick labsCaetano Reis e SousaFull details Slicing and dicing viruses: antiviral RNA interference in mammals Authors (4) Pierre V Maillard Annemarthe G van der Veen Enzo Z PoirierCaetano Reis e Sousa EMBO Journal Published 15 April 2019 Crick labsCaetano Reis e SousaFull details Tissue clonality of dendritic cell subsets and emergency DCpoiesis revealed by multicolor fate mapping of DC progenitors Authors (19) Mar Cabeza-Cabrerizo Janneke van Blijswijk Stephan Wienert Daniel HeimRob Jenkins Probir Chakravarty[...] Michael Gerner Ronald N GermainErik Sahai Frederick KlauschenCaetano Reis e Sousa Science Immunology Published 1 March 2019 Crick labs/ facilitiesCaetano Reis e SousaErik SahaiBioinformatics and BiostatisticsLight MicroscopyFlow CytometryBiological Research FacilityFull details Direct reprogramming of fibroblasts into antigen-presenting dendritic cells Authors (13) Fábio F Rosa Cristiana F Pires Ilia Kurochkin Alexandra G Ferreira Andreia M Gomes Luís G Palma[...] Cláudia Azenha Dmitri PapatsenkoOliver SchulzCaetano Reis e Sousa Carlos-Filipe Pereira Science Immunology Published 7 December 2018 Crick labsCaetano Reis e SousaFull details The role of type 1 conventional dendritic cells in cancer immunity Authors (2) Jan P BöttcherCaetano Reis e Sousa Trends in Cancer Published 29 September 2018 Crick labsCaetano Reis e SousaFull details α-actinin accounts for the bioactivity of actin preparations in inducing STAT target genes in Drosophila melanogaster Authors (19)Oliver GordonConor Henry Naren Srinivasan Susan Ahrens Anna Franz Safia Deddouche[...] Luis TeixeiraBarry Thompson Marc S Dionne Will WoodCaetano Reis e Sousa eLife Published 27 September 2018 Crick labs/ facilitiesBarry ThompsonCaetano Reis e SousaBioinformatics and BiostatisticsGenomics/Equipment ParkProteomicsStructural BiologyFull details Cysteine-reactive free ISG15 generates IL-1β-producing CD8α+ dendritic cells at the site of infection Authors (11) Anna Napolitano Annemarthe G van der Veen Monique Bunyan Annabel BorgDavid Frith Steven HowellSvend Kjaer Antje BelingBram Snijders Klaus-Peter KnobelochEva Frickel Journal of Immunology Published 15 July 2018 Crick labs/ facilitiesEva FrickelCaetano Reis e SousaProteomicsStructural BiologyFlow CytometryBiological Research FacilityFull details Myosin II synergizes with F-actin to promote DNGR-1-dependent cross-presentation of dead cell-associated antigens Authors (7)Oliver Schulz Pavel Hanč Jan P Böttcher Robbert Hoogeboom Sandra S DieboldPavel TolarCaetano Reis e Sousa Cell Reports Published 10 July 2018 Crick labsCaetano Reis e SousaPavel TolarFull details Molecular mechanism of influenza A NS1-mediated TRIM25 recognition and inhibition Authors (11) Marios G Koliopoulos Mathilde Lethier Annemarthe G van der Veen Kevin Haubrich Janosch Hennig Eva KowalinskiRebecca Stevens Stephen R MartinCaetano Reis e Sousa Stephen CusackKatrin Rittinger Nature Communications Published 8 May 2018 Crick labs/ facilitiesCaetano Reis e SousaKatrin RittingerStructural BiologyProteomicsFull details Clec9a-mediated ablation of conventional dendritic cells suggests a lymphoid path to generating dendritic cells in vivo Authors (11) J Salvermoser J van Blijswijk NE Papaioannou S Rambichler M Pasztoi D PakalniškytėNeil Rogers SJ Keppler T StraubCaetano Reis e Sousa BU Schraml Frontiers in Immunology Published 2 May 2018 Crick labsCaetano Reis e SousaFull details NK cells stimulate recruitment of cDC1 into the tumor microenvironment promoting cancer immune control Authors (10) Jan P Böttcher Eduardo Bonavita Probir ChakravartyHanna BleesMar Cabeza Cabrerizo Stefano SammicheliNeil RogersErik Sahai Santiago ZelenayCaetano Reis e Sousa Cell Published 22 February 2018 Crick labs/ facilitiesCaetano Reis e SousaErik SahaiBioinformatics and BiostatisticsFull details The RIG-I-like receptor LGP2 inhibits Dicer-dependent processing of long double-stranded RNA and blocks RNA interference in mammalian cells Authors (9) Annemarthe G van der Veen Pierre V Maillard Jan Marten Schmidt Sonia A Lee Safia Deddouche-Grass Annabel BorgSvend KjaerBram SnijdersCaetano Reis e Sousa EMBO Journal Published 15 February 2018 Crick labs/ facilitiesCaetano Reis e SousaProteomicsStructural BiologyFlow CytometryGenomics/Equipment ParkFull details Dendritic cell lineage potential in human early hematopoietic progenitors Authors (6) Julie Helft Fernando Anjos-Afonso Annemarthe G van der Veen Probir ChakravartyDominique BonnetCaetano Reis e Sousa Cell Reports Published 18 July 2017 Crick labs/ facilitiesDominique BonnetCaetano Reis e SousaBioinformatics and BiostatisticsFull details Sensing infection and tissue damage Authors (1)Caetano Reis e Sousa EMBO Molecular Medicine Published 24 January 2017 Crick labsCaetano Reis e SousaFull details Actin is an evolutionarily-conserved damage-associated molecular pattern that signals tissue injury in Drosophila melanogaster Authors (15) Naren SrinivasanOliver Gordon Susan Ahrens Anna Franz Safia Deddouche Probir Chakravarty[...] Luis TeixeiraBarry Thompson Marc S Dionne Will WoodCaetano Reis e Sousa eLife Published 22 November 2016 Crick labs/ facilitiesBarry ThompsonCaetano Reis e SousaBioinformatics and BiostatisticsGenomics/Equipment ParkFull details Inactivation of the type I interferon pathway reveals long double-stranded RNA-mediated RNA interference in mammalian cells Authors (6) Pierre V Maillard Annemarthe G Van der Veen Safia Deddouche-GrassNeil Rogers Andres MeritsCaetano Reis e Sousa EMBO Journal Published 4 November 2016 Crick labsCaetano Reis e SousaFull details Pagination Current page 1 Page 2 Page 3 Page 4 Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers Authors (341) Catherine F Houlihan Nina Vora Thomas Byrne Dan Lewer Gavin Kelly Judith Heaney[...] Andrew Hayward Richard Gilson Gavin KellyFiona Roberts Emine Hatipoglu The Lancet Published 25 July 2020 Crick labs/ facilitiesLuiz Pedro CarvalhoMike BlackmanDominique BonnetPeter Cherepanov Steve GamblinMaximiliano GutierrezGeorge KassiotisPaul NurseAnne O’GarraVenizelos PapayannopoulosLucia Prieto-GodinoPeter RatcliffeCaetano Reis e SousaErik SahaiCharles SwantonMoritz TreeckJames TurnerJernej UleKaren VousdenAndreas WackSonia GandhiRupert BealeAdam SaterialeAdvanced SequencingCell ServicesBioinformatics and BiostatisticsElectron MicroscopyExperimental HistopathologyFlow CytometryGenomics/Equipment ParkHigh Throughput ScreeningMetabolomicsPeptide ChemistryStructural BiologyFermentationWorldwide Influenza CentreHuman Embryonic Stem CellScientific computingFull details
Cross-presentation of dead-cell-associated antigens by DNGR-1+ dendritic cells contributes to chronic allograft rejection in mice Authors (13) Saidou Balam Rebecca Kesselring Eggenhofer Elke Stephanie Blaimer Katja Evert Matthias Evert[...] Janneke van BlijswijkSonia LeeCaetano Reis e Sousa Stefan M Brunner Stefan Fichtner-Feigl European Journal of Immunology Published 8 July 2020 Crick labsCaetano Reis e SousaFull details
Scalable and robust SARS-CoV-2 testing in an academic center Authors (81) The Crick COVID-19 Consortium Jim Aitken Karen AmbroseSam BarrellRupert BealeGanka Bineva-Todd[...]Philip WalkerSophia Ward Wai Keong WongJoshua WrightMary Wu Nature Biotechnology Published 18 June 2020 Crick labs/ facilitiesPeter Cherepanov Steve GamblinGeorge KassiotisVenizelos PapayannopoulosPeter RatcliffeCaetano Reis e SousaCharles SwantonJames TurnerAndreas WackSonia GandhiRupert BealeAdvanced SequencingGenomics/Equipment ParkHigh Throughput ScreeningMetabolomicsPeptide ChemistryStructural BiologyFermentationScientific computingFull details
Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition) Authors (436) Andrea Cossarizza Hyun-Dong Chang Andreas Radbruch Andreas Acs Dieter Adam Sabine Adam-Klages[...] Yi Zhao Susanne Maria Ziegler Christina Zielinski Jakob Zimmermann Arturo Zychlinsky European Journal of Immunology Published 21 October 2019 Crick labs/ facilitiesCaetano Reis e SousaRobert J WilkinsonFlow CytometryFull details
Cytoskeletal exposure in the regulation of immunity and initiation of tissue repair Authors (2)Oliver GordonCaetano Reis e Sousa BioEssays Published 3 June 2019 Crick labsCaetano Reis e SousaFull details
Slicing and dicing viruses: antiviral RNA interference in mammals Authors (4) Pierre V Maillard Annemarthe G van der Veen Enzo Z PoirierCaetano Reis e Sousa EMBO Journal Published 15 April 2019 Crick labsCaetano Reis e SousaFull details
Tissue clonality of dendritic cell subsets and emergency DCpoiesis revealed by multicolor fate mapping of DC progenitors Authors (19) Mar Cabeza-Cabrerizo Janneke van Blijswijk Stephan Wienert Daniel HeimRob Jenkins Probir Chakravarty[...] Michael Gerner Ronald N GermainErik Sahai Frederick KlauschenCaetano Reis e Sousa Science Immunology Published 1 March 2019 Crick labs/ facilitiesCaetano Reis e SousaErik SahaiBioinformatics and BiostatisticsLight MicroscopyFlow CytometryBiological Research FacilityFull details
Direct reprogramming of fibroblasts into antigen-presenting dendritic cells Authors (13) Fábio F Rosa Cristiana F Pires Ilia Kurochkin Alexandra G Ferreira Andreia M Gomes Luís G Palma[...] Cláudia Azenha Dmitri PapatsenkoOliver SchulzCaetano Reis e Sousa Carlos-Filipe Pereira Science Immunology Published 7 December 2018 Crick labsCaetano Reis e SousaFull details
The role of type 1 conventional dendritic cells in cancer immunity Authors (2) Jan P BöttcherCaetano Reis e Sousa Trends in Cancer Published 29 September 2018 Crick labsCaetano Reis e SousaFull details
α-actinin accounts for the bioactivity of actin preparations in inducing STAT target genes in Drosophila melanogaster Authors (19)Oliver GordonConor Henry Naren Srinivasan Susan Ahrens Anna Franz Safia Deddouche[...] Luis TeixeiraBarry Thompson Marc S Dionne Will WoodCaetano Reis e Sousa eLife Published 27 September 2018 Crick labs/ facilitiesBarry ThompsonCaetano Reis e SousaBioinformatics and BiostatisticsGenomics/Equipment ParkProteomicsStructural BiologyFull details
Cysteine-reactive free ISG15 generates IL-1β-producing CD8α+ dendritic cells at the site of infection Authors (11) Anna Napolitano Annemarthe G van der Veen Monique Bunyan Annabel BorgDavid Frith Steven HowellSvend Kjaer Antje BelingBram Snijders Klaus-Peter KnobelochEva Frickel Journal of Immunology Published 15 July 2018 Crick labs/ facilitiesEva FrickelCaetano Reis e SousaProteomicsStructural BiologyFlow CytometryBiological Research FacilityFull details
Myosin II synergizes with F-actin to promote DNGR-1-dependent cross-presentation of dead cell-associated antigens Authors (7)Oliver Schulz Pavel Hanč Jan P Böttcher Robbert Hoogeboom Sandra S DieboldPavel TolarCaetano Reis e Sousa Cell Reports Published 10 July 2018 Crick labsCaetano Reis e SousaPavel TolarFull details
Molecular mechanism of influenza A NS1-mediated TRIM25 recognition and inhibition Authors (11) Marios G Koliopoulos Mathilde Lethier Annemarthe G van der Veen Kevin Haubrich Janosch Hennig Eva KowalinskiRebecca Stevens Stephen R MartinCaetano Reis e Sousa Stephen CusackKatrin Rittinger Nature Communications Published 8 May 2018 Crick labs/ facilitiesCaetano Reis e SousaKatrin RittingerStructural BiologyProteomicsFull details
Clec9a-mediated ablation of conventional dendritic cells suggests a lymphoid path to generating dendritic cells in vivo Authors (11) J Salvermoser J van Blijswijk NE Papaioannou S Rambichler M Pasztoi D PakalniškytėNeil Rogers SJ Keppler T StraubCaetano Reis e Sousa BU Schraml Frontiers in Immunology Published 2 May 2018 Crick labsCaetano Reis e SousaFull details
NK cells stimulate recruitment of cDC1 into the tumor microenvironment promoting cancer immune control Authors (10) Jan P Böttcher Eduardo Bonavita Probir ChakravartyHanna BleesMar Cabeza Cabrerizo Stefano SammicheliNeil RogersErik Sahai Santiago ZelenayCaetano Reis e Sousa Cell Published 22 February 2018 Crick labs/ facilitiesCaetano Reis e SousaErik SahaiBioinformatics and BiostatisticsFull details
The RIG-I-like receptor LGP2 inhibits Dicer-dependent processing of long double-stranded RNA and blocks RNA interference in mammalian cells Authors (9) Annemarthe G van der Veen Pierre V Maillard Jan Marten Schmidt Sonia A Lee Safia Deddouche-Grass Annabel BorgSvend KjaerBram SnijdersCaetano Reis e Sousa EMBO Journal Published 15 February 2018 Crick labs/ facilitiesCaetano Reis e SousaProteomicsStructural BiologyFlow CytometryGenomics/Equipment ParkFull details
Dendritic cell lineage potential in human early hematopoietic progenitors Authors (6) Julie Helft Fernando Anjos-Afonso Annemarthe G van der Veen Probir ChakravartyDominique BonnetCaetano Reis e Sousa Cell Reports Published 18 July 2017 Crick labs/ facilitiesDominique BonnetCaetano Reis e SousaBioinformatics and BiostatisticsFull details
Sensing infection and tissue damage Authors (1)Caetano Reis e Sousa EMBO Molecular Medicine Published 24 January 2017 Crick labsCaetano Reis e SousaFull details
Actin is an evolutionarily-conserved damage-associated molecular pattern that signals tissue injury in Drosophila melanogaster Authors (15) Naren SrinivasanOliver Gordon Susan Ahrens Anna Franz Safia Deddouche Probir Chakravarty[...] Luis TeixeiraBarry Thompson Marc S Dionne Will WoodCaetano Reis e Sousa eLife Published 22 November 2016 Crick labs/ facilitiesBarry ThompsonCaetano Reis e SousaBioinformatics and BiostatisticsGenomics/Equipment ParkFull details
Inactivation of the type I interferon pathway reveals long double-stranded RNA-mediated RNA interference in mammalian cells Authors (6) Pierre V Maillard Annemarthe G Van der Veen Safia Deddouche-GrassNeil Rogers Andres MeritsCaetano Reis e Sousa EMBO Journal Published 4 November 2016 Crick labsCaetano Reis e SousaFull details
