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Breadcrumb Caetano Reis e Sousa Reis e Sousa lab Immunobiology Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members Vacancies News Alumni Dendritic cells are white blood cells that get their name from their tree-like shape (dendron is the Greek word for tree). Toggle to view hero caption PublicationsYear published2023 (1)2022 (1)2021 (3)2020 (3)2019 (2)2018 (3)2015 (2) Facet Year publishedResearch topicsInfectious Disease (15)Tumour Biology (15)Immunology (14)Model Organisms (14)Chemical Biology & High Throughput (10)Imaging (10)Computational & Systems Biology (9)Genetics & Genomics (8)Genome Integrity & Repair (8)Human Biology & Physiology (8)Stem Cells (8)Biochemistry & Proteomics (5)Signalling & Oncogenes (5)Cell Cycle & Chromosomes (4)Metabolism (4)Neurosciences (4)Structural Biology & Biophysics (4)Developmental Biology (3)Gene Expression (1)Microfabrication & Bioengineering (1)Synthetic Biology (1) (-)Cell Biology (15) Facet Research topicsPublication typeJournal article (15)Primary research (12)Method (3) Facet Publication typeJournalCell (2)Science Immunology (2)Cell Reports (1)European Journal of Immunology (1)Immunity (1)Journal for ImmunoTherapy of Cancer (1)Journal of Immunology (1)Nature (1)Nature Biotechnology (1)Nature Immunology (1)Science (1)The Lancet (1)Wellcome Open Research (1) Facet Journal Publications Displaying 1 - 15 of 15Last updated : 23 April 2024 03:33 The dietary sweetener sucralose is a negative modulator of T cell-mediated responses Authors (16)Fabio ZaniJulianna Blagih Tim GruberMichael Buck Nicholas JonesMarc Hennequart[...]Eric Cheung Ian S GilmoreAlex Gould Cristina Garcia-CaceresKaren Vousden Nature Published 23 March 2023 Crick labs/ facilitiesKaren VousdenCaetano Reis e SousaAlex GouldMetabolomicsBioinformatics and BiostatisticsLight MicroscopyFlow CytometryBiological Research FacilityAdvanced SequencingFull details Loss of secreted gelsolin enhances response to anticancer therapies Authors (8)Jonathan LimEvangelos GiampazoliasOliver SchulzNeil Rogers Anna WilkinsErik Sahai Jessica StridCaetano Reis e Sousa Journal for ImmunoTherapy of Cancer Published 26 September 2022 Crick labs/ facilitiesErik SahaiCaetano Reis e SousaBiological Research FacilityFull details Recruitment of dendritic cell progenitors to foci of influenza A virus infection sustains immunity Authors (18)Maria Del Mar Cabeza CabrerizoCarlos Munoz Minutti Mariana Pereira da CostaAna Matos Cardoso Da SilvaRob JenkinsJustina Kulikauskaite[...] Judith E Allen Manolis PasparakisAndreas WackErik SahaiCaetano Reis e Sousa Science Immunology Published 5 November 2021 Crick labs/ facilitiesAndreas WackErik SahaiCaetano Reis e SousaNicola LewisDominique BonnetWorldwide Influenza CentreFlow CytometryBiological Research FacilityBioinformatics and BiostatisticsFull details An isoform of Dicer protects mammalian stem cells against multiple RNA viruses Authors (10)Enzo PoirierMichael Buck Probir ChakravartyJoana Do Vale Viegas Silva CarvalhoBruno FredericoAna Matos Cardoso Da SilvaLyn HealyRachel UlfertsRupert BealeCaetano Reis e Sousa Science Published 9 July 2021 Crick labs/ facilitiesCaetano Reis e SousaRupert BealeHuman Embryonic Stem CellExperimental HistopathologyBioinformatics and BiostatisticsFlow CytometryAdvanced SequencingFull details SARS-CoV-2 detection by a clinical diagnostic RT-LAMP assay Authors (40)Michael BuckEnzo PoirierAna Matos Cardoso Da SilvaBruno Frederico J CantonSam Barrell[...]Charles SwantonSamra TurajlicMary WuCaetano Reis e Sousa The Crick COVID-19 Consortium Wellcome Open Research Published 21 May 2021 Crick labs/ facilitiesSamra TurajlicCharles SwantonCaetano Reis e SousaGeorge KassiotisSonia GandhiRupert BealeMetabolomicsHigh Throughput ScreeningGenetic Modification ServiceBiological Research FacilityAdvanced SequencingStructural BiologyScientific computingFull details The receptor DNGR-1 signals for phagosomal rupture to promote cross-presentation of dead-cell-associated antigens Authors (18) Johnathan CantonHanna BleesConor HenryMichael BuckOliver SchulzNeil Rogers[...] Sebastian AmigorenaVenizelos Papayannopoulos David C Thomas Felix RandowCaetano Reis e Sousa Nature Immunology Published 1 February 2021 Crick labs/ facilitiesCaetano Reis e SousaFlow CytometryElectron MicroscopyProteomicsBiological Research FacilityFull details Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers Authors (341) Catherine F Houlihan Nina Vora Thomas Byrne Dan LewerGavin Kelly Judith Heaney[...] Andrew Hayward Richard Gilson Gavin KellyFiona Roberts Emine Hatipoglu The Lancet Published 25 July 2020 Crick labs/ facilitiesAndreas WackKaren VousdenJernej UleJames TurnerMoritz TreeckCharles SwantonAdam SaterialeErik SahaiCaetano Reis e SousaPeter RatcliffeLucia Prieto-GodinoVenizelos PapayannopoulosAnne O’GarraPaul NurseGeorge KassiotisMaximiliano GutierrezSonia GandhiSteve GamblinPeter Cherepanov Luiz Pedro CarvalhoDominique BonnetMike BlackmanRupert BealeWorldwide Influenza CentreStructural BiologyMetabolomicsHuman Embryonic Stem CellHigh Throughput ScreeningGenetic Modification ServiceFlow CytometryFermentationExperimental HistopathologyElectron MicroscopyCell ServicesBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Scalable and robust SARS-CoV-2 testing in an academic center Authors (81) Jim Aitken Karen Ambrose Sam BarrellRupert Beale Ganka Bineva-Todd Dhruva Biswas[...]Sophie Ward Wai Keong WongJoshua Wright Mary Wu The Crick COVID-19 Consortium Nature Biotechnology Published 1 August 2020 Crick labs/ facilitiesAndreas WackJames TurnerCharles SwantonCaetano Reis e SousaPeter RatcliffeVenizelos PapayannopoulosGeorge KassiotisSonia GandhiSteve GamblinPeter Cherepanov Rupert BealeStructural BiologyMetabolomicsHigh Throughput ScreeningGenetic Modification ServiceFermentationBiological Research FacilityAdvanced SequencingScientific computingFull details Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition) Authors (436) Andrea Cossarizza Hyun-Dong Chang Andreas Radbruch Andreas Acs Dieter Adam Sabine Adam-Klages[...] Yi Zhao Susanne Maria Ziegler Christina Zielinski Jakob Zimmermann Arturo Zychlinsky European Journal of Immunology Published 21 October 2019 Crick labs/ facilitiesRobert J WilkinsonCaetano Reis e SousaFlow CytometryFull details Tissue clonality of dendritic cell subsets and emergency DCpoiesis revealed by multicolor fate mapping of DC progenitors Authors (19)Maria Del Mar Cabeza Cabrerizo Janneke van Blijswijk Stephan Wienert Daniel HeimRob Jenkins Probir Chakravarty[...] Michael Gerner Ronald N GermainErik Sahai Frederick KlauschenCaetano Reis e Sousa Science Immunology Published 1 March 2019 Crick labs/ facilitiesErik SahaiCaetano Reis e SousaBioinformatics and BiostatisticsLight MicroscopyFlow CytometryBiological Research FacilityFull details Myosin II synergizes with F-actin to promote DNGR-1-dependent cross-presentation of dead cell-associated antigens Authors (7)Oliver Schulz Pavel Hanč Jan P Böttcher Robbert Hoogeboom Sandra S DieboldPavel TolarCaetano Reis e Sousa Cell Reports Published 10 July 2018 Crick labsPavel TolarCaetano Reis e SousaFull details Cysteine-reactive free ISG15 generates IL-1β-producing CD8α+ dendritic cells at the site of infection Authors (11) Anna Napolitano Annemarthe G van der Veen Monique BunyanAnnabel BorgDavid Frith Steven HowellSvend Kjaer Antje BelingBram Snijders Klaus-Peter Knobeloch Eva-Maria Frickel Journal of Immunology Published 15 July 2018 Crick labs/ facilitiesCaetano Reis e SousaEva FrickelStructural BiologyProteomicsFlow CytometryBiological Research FacilityFull details NK cells stimulate recruitment of cDC1 into the tumor microenvironment promoting cancer immune control Authors (10) Jan P Böttcher Eduardo Bonavita Probir ChakravartyHanna BleesMaria Del Mar Cabeza Cabrerizo Stefano SammicheliNeil RogersErik Sahai Santiago ZelenayCaetano Reis e Sousa Cell Published 22 February 2018 Crick labs/ facilitiesErik SahaiCaetano Reis e SousaBioinformatics and BiostatisticsFull details Cyclooxygenase-dependent tumor growth through evasion of immunity Authors (12) Santiago Zelenay Annemarthe G van der Veen Jan P Böttcher Kathryn J SnelgroveNeil Rogers Sophie E Acton[...] Maria Romina Girotti Richard Marais Sergio A QuezadaErik SahaiCaetano Reis e Sousa Cell Published 10 September 2015 Crick labs/ facilitiesErik SahaiCaetano Reis e SousaBioinformatics and BiostatisticsFull details Structure of the complex of F-actin and DNGR-1, a C-type lectin receptor involved in dendritic cell cross-presentation of dead cell-associated antigens Authors (12) Pavel Hanč Takashi Fujii Salvador Iborra Yurika Yamada Jatta HuotariOliver Schulz[...]Svend KjaerMichael Way David Sancho Keiichi NambaCaetano Reis e Sousa Immunity Published 19 May 2015 Crick labs/ facilitiesMichael WayCaetano Reis e SousaStructural BiologyFlow CytometryAdvanced SequencingFull details Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
The dietary sweetener sucralose is a negative modulator of T cell-mediated responses Authors (16)Fabio ZaniJulianna Blagih Tim GruberMichael Buck Nicholas JonesMarc Hennequart[...]Eric Cheung Ian S GilmoreAlex Gould Cristina Garcia-CaceresKaren Vousden Nature Published 23 March 2023 Crick labs/ facilitiesKaren VousdenCaetano Reis e SousaAlex GouldMetabolomicsBioinformatics and BiostatisticsLight MicroscopyFlow CytometryBiological Research FacilityAdvanced SequencingFull details
Loss of secreted gelsolin enhances response to anticancer therapies Authors (8)Jonathan LimEvangelos GiampazoliasOliver SchulzNeil Rogers Anna WilkinsErik Sahai Jessica StridCaetano Reis e Sousa Journal for ImmunoTherapy of Cancer Published 26 September 2022 Crick labs/ facilitiesErik SahaiCaetano Reis e SousaBiological Research FacilityFull details
Recruitment of dendritic cell progenitors to foci of influenza A virus infection sustains immunity Authors (18)Maria Del Mar Cabeza CabrerizoCarlos Munoz Minutti Mariana Pereira da CostaAna Matos Cardoso Da SilvaRob JenkinsJustina Kulikauskaite[...] Judith E Allen Manolis PasparakisAndreas WackErik SahaiCaetano Reis e Sousa Science Immunology Published 5 November 2021 Crick labs/ facilitiesAndreas WackErik SahaiCaetano Reis e SousaNicola LewisDominique BonnetWorldwide Influenza CentreFlow CytometryBiological Research FacilityBioinformatics and BiostatisticsFull details
An isoform of Dicer protects mammalian stem cells against multiple RNA viruses Authors (10)Enzo PoirierMichael Buck Probir ChakravartyJoana Do Vale Viegas Silva CarvalhoBruno FredericoAna Matos Cardoso Da SilvaLyn HealyRachel UlfertsRupert BealeCaetano Reis e Sousa Science Published 9 July 2021 Crick labs/ facilitiesCaetano Reis e SousaRupert BealeHuman Embryonic Stem CellExperimental HistopathologyBioinformatics and BiostatisticsFlow CytometryAdvanced SequencingFull details
SARS-CoV-2 detection by a clinical diagnostic RT-LAMP assay Authors (40)Michael BuckEnzo PoirierAna Matos Cardoso Da SilvaBruno Frederico J CantonSam Barrell[...]Charles SwantonSamra TurajlicMary WuCaetano Reis e Sousa The Crick COVID-19 Consortium Wellcome Open Research Published 21 May 2021 Crick labs/ facilitiesSamra TurajlicCharles SwantonCaetano Reis e SousaGeorge KassiotisSonia GandhiRupert BealeMetabolomicsHigh Throughput ScreeningGenetic Modification ServiceBiological Research FacilityAdvanced SequencingStructural BiologyScientific computingFull details
The receptor DNGR-1 signals for phagosomal rupture to promote cross-presentation of dead-cell-associated antigens Authors (18) Johnathan CantonHanna BleesConor HenryMichael BuckOliver SchulzNeil Rogers[...] Sebastian AmigorenaVenizelos Papayannopoulos David C Thomas Felix RandowCaetano Reis e Sousa Nature Immunology Published 1 February 2021 Crick labs/ facilitiesCaetano Reis e SousaFlow CytometryElectron MicroscopyProteomicsBiological Research FacilityFull details
Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers Authors (341) Catherine F Houlihan Nina Vora Thomas Byrne Dan LewerGavin Kelly Judith Heaney[...] Andrew Hayward Richard Gilson Gavin KellyFiona Roberts Emine Hatipoglu The Lancet Published 25 July 2020 Crick labs/ facilitiesAndreas WackKaren VousdenJernej UleJames TurnerMoritz TreeckCharles SwantonAdam SaterialeErik SahaiCaetano Reis e SousaPeter RatcliffeLucia Prieto-GodinoVenizelos PapayannopoulosAnne O’GarraPaul NurseGeorge KassiotisMaximiliano GutierrezSonia GandhiSteve GamblinPeter Cherepanov Luiz Pedro CarvalhoDominique BonnetMike BlackmanRupert BealeWorldwide Influenza CentreStructural BiologyMetabolomicsHuman Embryonic Stem CellHigh Throughput ScreeningGenetic Modification ServiceFlow CytometryFermentationExperimental HistopathologyElectron MicroscopyCell ServicesBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Scalable and robust SARS-CoV-2 testing in an academic center Authors (81) Jim Aitken Karen Ambrose Sam BarrellRupert Beale Ganka Bineva-Todd Dhruva Biswas[...]Sophie Ward Wai Keong WongJoshua Wright Mary Wu The Crick COVID-19 Consortium Nature Biotechnology Published 1 August 2020 Crick labs/ facilitiesAndreas WackJames TurnerCharles SwantonCaetano Reis e SousaPeter RatcliffeVenizelos PapayannopoulosGeorge KassiotisSonia GandhiSteve GamblinPeter Cherepanov Rupert BealeStructural BiologyMetabolomicsHigh Throughput ScreeningGenetic Modification ServiceFermentationBiological Research FacilityAdvanced SequencingScientific computingFull details
Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition) Authors (436) Andrea Cossarizza Hyun-Dong Chang Andreas Radbruch Andreas Acs Dieter Adam Sabine Adam-Klages[...] Yi Zhao Susanne Maria Ziegler Christina Zielinski Jakob Zimmermann Arturo Zychlinsky European Journal of Immunology Published 21 October 2019 Crick labs/ facilitiesRobert J WilkinsonCaetano Reis e SousaFlow CytometryFull details
Tissue clonality of dendritic cell subsets and emergency DCpoiesis revealed by multicolor fate mapping of DC progenitors Authors (19)Maria Del Mar Cabeza Cabrerizo Janneke van Blijswijk Stephan Wienert Daniel HeimRob Jenkins Probir Chakravarty[...] Michael Gerner Ronald N GermainErik Sahai Frederick KlauschenCaetano Reis e Sousa Science Immunology Published 1 March 2019 Crick labs/ facilitiesErik SahaiCaetano Reis e SousaBioinformatics and BiostatisticsLight MicroscopyFlow CytometryBiological Research FacilityFull details
Myosin II synergizes with F-actin to promote DNGR-1-dependent cross-presentation of dead cell-associated antigens Authors (7)Oliver Schulz Pavel Hanč Jan P Böttcher Robbert Hoogeboom Sandra S DieboldPavel TolarCaetano Reis e Sousa Cell Reports Published 10 July 2018 Crick labsPavel TolarCaetano Reis e SousaFull details
Cysteine-reactive free ISG15 generates IL-1β-producing CD8α+ dendritic cells at the site of infection Authors (11) Anna Napolitano Annemarthe G van der Veen Monique BunyanAnnabel BorgDavid Frith Steven HowellSvend Kjaer Antje BelingBram Snijders Klaus-Peter Knobeloch Eva-Maria Frickel Journal of Immunology Published 15 July 2018 Crick labs/ facilitiesCaetano Reis e SousaEva FrickelStructural BiologyProteomicsFlow CytometryBiological Research FacilityFull details
NK cells stimulate recruitment of cDC1 into the tumor microenvironment promoting cancer immune control Authors (10) Jan P Böttcher Eduardo Bonavita Probir ChakravartyHanna BleesMaria Del Mar Cabeza Cabrerizo Stefano SammicheliNeil RogersErik Sahai Santiago ZelenayCaetano Reis e Sousa Cell Published 22 February 2018 Crick labs/ facilitiesErik SahaiCaetano Reis e SousaBioinformatics and BiostatisticsFull details
Cyclooxygenase-dependent tumor growth through evasion of immunity Authors (12) Santiago Zelenay Annemarthe G van der Veen Jan P Böttcher Kathryn J SnelgroveNeil Rogers Sophie E Acton[...] Maria Romina Girotti Richard Marais Sergio A QuezadaErik SahaiCaetano Reis e Sousa Cell Published 10 September 2015 Crick labs/ facilitiesErik SahaiCaetano Reis e SousaBioinformatics and BiostatisticsFull details
Structure of the complex of F-actin and DNGR-1, a C-type lectin receptor involved in dendritic cell cross-presentation of dead cell-associated antigens Authors (12) Pavel Hanč Takashi Fujii Salvador Iborra Yurika Yamada Jatta HuotariOliver Schulz[...]Svend KjaerMichael Way David Sancho Keiichi NambaCaetano Reis e Sousa Immunity Published 19 May 2015 Crick labs/ facilitiesMichael WayCaetano Reis e SousaStructural BiologyFlow CytometryAdvanced SequencingFull details