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Breadcrumb Caetano Reis e Sousa Reis e Sousa lab Immunobiology Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members Vacancies News Alumni Dendritic cells are white blood cells that get their name from their tree-like shape (dendron is the Greek word for tree). Toggle to view hero caption PublicationsYear published2023 (3)2022 (1)2021 (3)2020 (2)2019 (1)2018 (2)2017 (1)2016 (2)2015 (4) Facet Year publishedResearch topicsChemical Biology & High Throughput (19)Computational & Systems Biology (19)Genetics & Genomics (19)Infectious Disease (19)Tumour Biology (19)Immunology (18)Model Organisms (18)Human Biology & Physiology (10)Imaging (10)Cell Biology (8)Stem Cells (8)Signalling & Oncogenes (7)Developmental Biology (6)Neurosciences (5)Biochemistry & Proteomics (4)Metabolism (4)Structural Biology & Biophysics (3)Cell Cycle & Chromosomes (2)Gene Expression (2)Microfabrication & Bioengineering (2)Synthetic Biology (2) (-)Genome Integrity & Repair (19) Facet Research topicsPublication typeJournal article (19)Primary research (16)Method (2)Letter (1) Facet Publication typeJournalCell (3)eLife (2)Immunity (2)Nature (2)Cell Reports (1)Cell Stem Cell (1)Developmental Cell (1)European Journal of Immunology (1)Nature Biotechnology (1)Nature Communications (1)Science (1)Science Immunology (1)The Lancet (1)Wellcome Open Research (1) Facet Journal Publications Displaying 1 - 19 of 19Last updated : 25 April 2024 02:37 Endothelial AHR activity prevents lung barrier disruption in viral infection Authors (13)Jack MajorStefania CrottaKatja Finsterbusch Probir ChakravartyKathleen ShahBruno Frederico[...] Lucy Meader Alejandro Suarez-BonnetSimon PriestnallBrigitta StockingerAndreas Wack Nature Published 28 September 2023 Crick labs/ facilitiesAndreas WackGitta StockingerCaetano Reis e SousaLight MicroscopyExperimental HistopathologyBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityAdvanced SequencingFull details Loss of TET2 in human hematopoietic stem cells alters the development and function of neutrophils Authors (22)Hector Huerga EncaboIker Valle AramburuManuel Garcia AlbornozMarion Piganeau Henry Wood Anna Song[...] Daniel H Wiseman Kiran Batta Rajeev GuptaVenizelos PapayannopoulosDominique Bonnet Cell Stem Cell Published 1 June 2023 Crick labs/ facilitiesCaetano Reis e SousaVenizelos PapayannopoulosDominique BonnetLight MicroscopyElectron MicroscopyBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityAdvanced SequencingFull details The dietary sweetener sucralose is a negative modulator of T cell-mediated responses Authors (16)Fabio ZaniJulianna Blagih Tim GruberMichael Buck Nicholas JonesMarc Hennequart[...]Eric Cheung Ian S GilmoreAlex Gould Cristina Garcia-CaceresKaren Vousden Nature Published 23 March 2023 Crick labs/ facilitiesKaren VousdenCaetano Reis e SousaAlex GouldMetabolomicsBioinformatics and BiostatisticsLight MicroscopyFlow CytometryBiological Research FacilityAdvanced SequencingFull details DNGR-1-tracing marks an ependymal cell subset with damage-responsive neural stem cell potential Authors (17)Bruno Frederico Isaura Martins Diana ChapelaFrancesca Gasparrini Probir ChakravartyTobias Ackels[...]James BriscoeFrancois GuillemotAndreas Schaefer Leonor SaúdeCaetano Reis e Sousa Developmental Cell Published 22 August 2022 Crick labs/ facilitiesAndreas SchaeferCaetano Reis e SousaFrancois GuillemotJames BriscoeLight MicroscopyExperimental HistopathologyElectron MicroscopyBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityFull details An isoform of Dicer protects mammalian stem cells against multiple RNA viruses Authors (10)Enzo PoirierMichael Buck Probir ChakravartyJoana Do Vale Viegas Silva CarvalhoBruno FredericoAna Matos Cardoso Da SilvaLyn HealyRachel UlfertsRupert BealeCaetano Reis e Sousa Science Published 9 July 2021 Crick labs/ facilitiesCaetano Reis e SousaRupert BealeHuman Embryonic Stem CellExperimental HistopathologyBioinformatics and BiostatisticsFlow CytometryAdvanced SequencingFull details Secreted gelsolin inhibits DNGR-1-dependent cross-presentation and cancer immunity Authors (17)Evangelos GiampazoliasOliver SchulzJonathan LimNeil Rogers Probir Chakravarty Naren Srinivasan[...] Stefano Sammicheli Natalia MoncautSunita Varsani-BrownIan RosewellCaetano Reis e Sousa Cell Published 22 July 2021 Crick labs/ facilitiesCaetano Reis e SousaGenetic Modification ServiceBiological Research FacilityBioinformatics and BiostatisticsFlow CytometryFull details SARS-CoV-2 detection by a clinical diagnostic RT-LAMP assay Authors (40)Michael BuckEnzo PoirierAna Matos Cardoso Da SilvaBruno Frederico J CantonSam Barrell[...]Charles SwantonSamra TurajlicMary WuCaetano Reis e Sousa The Crick COVID-19 Consortium Wellcome Open Research Published 21 May 2021 Crick labs/ facilitiesSamra TurajlicCharles SwantonCaetano Reis e SousaGeorge KassiotisSonia GandhiRupert BealeMetabolomicsHigh Throughput ScreeningGenetic Modification ServiceBiological Research FacilityAdvanced SequencingStructural BiologyScientific computingFull details Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers Authors (341) Catherine F Houlihan Nina Vora Thomas Byrne Dan LewerGavin Kelly Judith Heaney[...] Andrew Hayward Richard Gilson Gavin KellyFiona Roberts Emine Hatipoglu The Lancet Published 25 July 2020 Crick labs/ facilitiesAndreas WackKaren VousdenJernej UleJames TurnerMoritz TreeckCharles SwantonAdam SaterialeErik SahaiCaetano Reis e SousaPeter RatcliffeLucia Prieto-GodinoVenizelos PapayannopoulosAnne O’GarraPaul NurseGeorge KassiotisMaximiliano GutierrezSonia GandhiSteve GamblinPeter Cherepanov Luiz Pedro CarvalhoDominique BonnetMike BlackmanRupert BealeWorldwide Influenza CentreStructural BiologyMetabolomicsHuman Embryonic Stem CellHigh Throughput ScreeningGenetic Modification ServiceFlow CytometryFermentationExperimental HistopathologyElectron MicroscopyCell ServicesBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Scalable and robust SARS-CoV-2 testing in an academic center Authors (81) Jim Aitken Karen Ambrose Sam BarrellRupert Beale Ganka Bineva-Todd Dhruva Biswas[...]Sophie Ward Wai Keong WongJoshua Wright Mary Wu The Crick COVID-19 Consortium Nature Biotechnology Published 1 August 2020 Crick labs/ facilitiesAndreas WackJames TurnerCharles SwantonCaetano Reis e SousaPeter RatcliffeVenizelos PapayannopoulosGeorge KassiotisSonia GandhiSteve GamblinPeter Cherepanov Rupert BealeStructural BiologyMetabolomicsHigh Throughput ScreeningGenetic Modification ServiceFermentationBiological Research FacilityAdvanced SequencingScientific computingFull details Tissue clonality of dendritic cell subsets and emergency DCpoiesis revealed by multicolor fate mapping of DC progenitors Authors (19)Maria Del Mar Cabeza Cabrerizo Janneke van Blijswijk Stephan Wienert Daniel HeimRob Jenkins Probir Chakravarty[...] Michael Gerner Ronald N GermainErik Sahai Frederick KlauschenCaetano Reis e Sousa Science Immunology Published 1 March 2019 Crick labs/ facilitiesErik SahaiCaetano Reis e SousaBioinformatics and BiostatisticsLight MicroscopyFlow CytometryBiological Research FacilityFull details α-actinin accounts for the bioactivity of actin preparations in inducing STAT target genes in Drosophila melanogaster Authors (19)Oliver GordonConor Henry Naren Srinivasan Susan Ahrens Anna Franz Safia Deddouche[...] Luis Teixeira Barry Thompson Marc S Dionne Will WoodCaetano Reis e Sousa eLife Published 27 September 2018 Crick labs/ facilitiesBarry ThompsonCaetano Reis e SousaStructural BiologyProteomicsBioinformatics and BiostatisticsAdvanced SequencingFull details NK cells stimulate recruitment of cDC1 into the tumor microenvironment promoting cancer immune control Authors (10) Jan P Böttcher Eduardo Bonavita Probir ChakravartyHanna BleesMaria Del Mar Cabeza Cabrerizo Stefano SammicheliNeil RogersErik Sahai Santiago ZelenayCaetano Reis e Sousa Cell Published 22 February 2018 Crick labs/ facilitiesErik SahaiCaetano Reis e SousaBioinformatics and BiostatisticsFull details Dendritic cell lineage potential in human early hematopoietic progenitors Authors (6) Julie HelftFernando Dos Anjos Afonso Annemarthe G van der Veen Probir ChakravartyDominique BonnetCaetano Reis e Sousa Cell Reports Published 18 July 2017 Crick labs/ facilitiesCaetano Reis e SousaDominique BonnetBioinformatics and BiostatisticsFlow CytometryFull details Actin is an evolutionarily-conserved damage-associated molecular pattern that signals tissue injury in Drosophila melanogaster Authors (15) Naren SrinivasanOliver Gordon Susan Ahrens Anna Franz Safia Deddouche Probir Chakravarty[...] Luis Teixeira Barry Thompson Marc S Dionne Will WoodCaetano Reis e Sousa eLife Published 22 November 2016 Crick labs/ facilitiesBarry ThompsonCaetano Reis e SousaBioinformatics and BiostatisticsAdvanced SequencingAdvanced SequencingFull details Alive but confused: heterogeneity of CD11c+ MHC class II+ cells in GM-CSF mouse bone marrow cultures Authors (8) Julie Helft Jan P Böttcher Probir Chakravarty Santiago Zelenay Jatta Huotari Barbara U Schraml Delphine GoubauCaetano Reis e Sousa Immunity Published 19 January 2016 Crick labs/ facilitiesCaetano Reis e SousaBioinformatics and BiostatisticsFull details Mouse superkiller-2-like helicase DDX60 is dispensable for type I IFN induction and immunity to multiple viruses Authors (10) Delphine Goubau Annemarthe G van der Veen Probir Chakravarty Rongtuan LinNeil Rogers Jan Rehwinkel Safia DeddoucheIan Rosewell John HiscottCaetano Reis e Sousa European Journal of Immunology Published 1 December 2015 Crick labs/ facilitiesCaetano Reis e SousaGenetic Modification ServiceBiological Research FacilityBioinformatics and BiostatisticsStructural BiologyAdvanced SequencingFull details Cyclooxygenase-dependent tumor growth through evasion of immunity Authors (12) Santiago Zelenay Annemarthe G van der Veen Jan P Böttcher Kathryn J SnelgroveNeil Rogers Sophie E Acton[...] Maria Romina Girotti Richard Marais Sergio A QuezadaErik SahaiCaetano Reis e Sousa Cell Published 10 September 2015 Crick labs/ facilitiesErik SahaiCaetano Reis e SousaBioinformatics and BiostatisticsFull details GM-CSF mouse bone marrow cultures comprise a heterogeneous population of CD11c+MHCII+ macrophages and dendritic cells Authors (8) Julie Helft Jan Böttcher Probir Chakravarty Santiago Zelenay Jatta Huotari Barbara U Schraml Delphine GoubauCaetano Reis e Sousa Immunity Published 16 June 2015 Crick labs/ facilitiesCaetano Reis e SousaBioinformatics and BiostatisticsFlow CytometryFull details Intestinal intraepithelial lymphocyte activation promotes innate antiviral resistance Authors (12) Mahima Swamy Lucie Abeler-Dörner James Chettle Tanel Mahlakõiv Delphine Goubau Probir Chakravarty[...]Caetano Reis e Sousa Peter Staeheli Barbara A Blacklaws Jonathan L HeeneyAdrian Hayday Nature Communications Published 19 May 2015 Crick labs/ facilitiesCaetano Reis e SousaAdrian HaydayBioinformatics and BiostatisticsFlow CytometryExperimental HistopathologyBiological Research FacilityFull details Share the page Share on Twitter Share on Facebook Share 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Endothelial AHR activity prevents lung barrier disruption in viral infection Authors (13)Jack MajorStefania CrottaKatja Finsterbusch Probir ChakravartyKathleen ShahBruno Frederico[...] Lucy Meader Alejandro Suarez-BonnetSimon PriestnallBrigitta StockingerAndreas Wack Nature Published 28 September 2023 Crick labs/ facilitiesAndreas WackGitta StockingerCaetano Reis e SousaLight MicroscopyExperimental HistopathologyBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityAdvanced SequencingFull details
Loss of TET2 in human hematopoietic stem cells alters the development and function of neutrophils Authors (22)Hector Huerga EncaboIker Valle AramburuManuel Garcia AlbornozMarion Piganeau Henry Wood Anna Song[...] Daniel H Wiseman Kiran Batta Rajeev GuptaVenizelos PapayannopoulosDominique Bonnet Cell Stem Cell Published 1 June 2023 Crick labs/ facilitiesCaetano Reis e SousaVenizelos PapayannopoulosDominique BonnetLight MicroscopyElectron MicroscopyBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityAdvanced SequencingFull details
The dietary sweetener sucralose is a negative modulator of T cell-mediated responses Authors (16)Fabio ZaniJulianna Blagih Tim GruberMichael Buck Nicholas JonesMarc Hennequart[...]Eric Cheung Ian S GilmoreAlex Gould Cristina Garcia-CaceresKaren Vousden Nature Published 23 March 2023 Crick labs/ facilitiesKaren VousdenCaetano Reis e SousaAlex GouldMetabolomicsBioinformatics and BiostatisticsLight MicroscopyFlow CytometryBiological Research FacilityAdvanced SequencingFull details
DNGR-1-tracing marks an ependymal cell subset with damage-responsive neural stem cell potential Authors (17)Bruno Frederico Isaura Martins Diana ChapelaFrancesca Gasparrini Probir ChakravartyTobias Ackels[...]James BriscoeFrancois GuillemotAndreas Schaefer Leonor SaúdeCaetano Reis e Sousa Developmental Cell Published 22 August 2022 Crick labs/ facilitiesAndreas SchaeferCaetano Reis e SousaFrancois GuillemotJames BriscoeLight MicroscopyExperimental HistopathologyElectron MicroscopyBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityFull details
An isoform of Dicer protects mammalian stem cells against multiple RNA viruses Authors (10)Enzo PoirierMichael Buck Probir ChakravartyJoana Do Vale Viegas Silva CarvalhoBruno FredericoAna Matos Cardoso Da SilvaLyn HealyRachel UlfertsRupert BealeCaetano Reis e Sousa Science Published 9 July 2021 Crick labs/ facilitiesCaetano Reis e SousaRupert BealeHuman Embryonic Stem CellExperimental HistopathologyBioinformatics and BiostatisticsFlow CytometryAdvanced SequencingFull details
Secreted gelsolin inhibits DNGR-1-dependent cross-presentation and cancer immunity Authors (17)Evangelos GiampazoliasOliver SchulzJonathan LimNeil Rogers Probir Chakravarty Naren Srinivasan[...] Stefano Sammicheli Natalia MoncautSunita Varsani-BrownIan RosewellCaetano Reis e Sousa Cell Published 22 July 2021 Crick labs/ facilitiesCaetano Reis e SousaGenetic Modification ServiceBiological Research FacilityBioinformatics and BiostatisticsFlow CytometryFull details
SARS-CoV-2 detection by a clinical diagnostic RT-LAMP assay Authors (40)Michael BuckEnzo PoirierAna Matos Cardoso Da SilvaBruno Frederico J CantonSam Barrell[...]Charles SwantonSamra TurajlicMary WuCaetano Reis e Sousa The Crick COVID-19 Consortium Wellcome Open Research Published 21 May 2021 Crick labs/ facilitiesSamra TurajlicCharles SwantonCaetano Reis e SousaGeorge KassiotisSonia GandhiRupert BealeMetabolomicsHigh Throughput ScreeningGenetic Modification ServiceBiological Research FacilityAdvanced SequencingStructural BiologyScientific computingFull details
Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers Authors (341) Catherine F Houlihan Nina Vora Thomas Byrne Dan LewerGavin Kelly Judith Heaney[...] Andrew Hayward Richard Gilson Gavin KellyFiona Roberts Emine Hatipoglu The Lancet Published 25 July 2020 Crick labs/ facilitiesAndreas WackKaren VousdenJernej UleJames TurnerMoritz TreeckCharles SwantonAdam SaterialeErik SahaiCaetano Reis e SousaPeter RatcliffeLucia Prieto-GodinoVenizelos PapayannopoulosAnne O’GarraPaul NurseGeorge KassiotisMaximiliano GutierrezSonia GandhiSteve GamblinPeter Cherepanov Luiz Pedro CarvalhoDominique BonnetMike BlackmanRupert BealeWorldwide Influenza CentreStructural BiologyMetabolomicsHuman Embryonic Stem CellHigh Throughput ScreeningGenetic Modification ServiceFlow CytometryFermentationExperimental HistopathologyElectron MicroscopyCell ServicesBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Scalable and robust SARS-CoV-2 testing in an academic center Authors (81) Jim Aitken Karen Ambrose Sam BarrellRupert Beale Ganka Bineva-Todd Dhruva Biswas[...]Sophie Ward Wai Keong WongJoshua Wright Mary Wu The Crick COVID-19 Consortium Nature Biotechnology Published 1 August 2020 Crick labs/ facilitiesAndreas WackJames TurnerCharles SwantonCaetano Reis e SousaPeter RatcliffeVenizelos PapayannopoulosGeorge KassiotisSonia GandhiSteve GamblinPeter Cherepanov Rupert BealeStructural BiologyMetabolomicsHigh Throughput ScreeningGenetic Modification ServiceFermentationBiological Research FacilityAdvanced SequencingScientific computingFull details
Tissue clonality of dendritic cell subsets and emergency DCpoiesis revealed by multicolor fate mapping of DC progenitors Authors (19)Maria Del Mar Cabeza Cabrerizo Janneke van Blijswijk Stephan Wienert Daniel HeimRob Jenkins Probir Chakravarty[...] Michael Gerner Ronald N GermainErik Sahai Frederick KlauschenCaetano Reis e Sousa Science Immunology Published 1 March 2019 Crick labs/ facilitiesErik SahaiCaetano Reis e SousaBioinformatics and BiostatisticsLight MicroscopyFlow CytometryBiological Research FacilityFull details
α-actinin accounts for the bioactivity of actin preparations in inducing STAT target genes in Drosophila melanogaster Authors (19)Oliver GordonConor Henry Naren Srinivasan Susan Ahrens Anna Franz Safia Deddouche[...] Luis Teixeira Barry Thompson Marc S Dionne Will WoodCaetano Reis e Sousa eLife Published 27 September 2018 Crick labs/ facilitiesBarry ThompsonCaetano Reis e SousaStructural BiologyProteomicsBioinformatics and BiostatisticsAdvanced SequencingFull details
NK cells stimulate recruitment of cDC1 into the tumor microenvironment promoting cancer immune control Authors (10) Jan P Böttcher Eduardo Bonavita Probir ChakravartyHanna BleesMaria Del Mar Cabeza Cabrerizo Stefano SammicheliNeil RogersErik Sahai Santiago ZelenayCaetano Reis e Sousa Cell Published 22 February 2018 Crick labs/ facilitiesErik SahaiCaetano Reis e SousaBioinformatics and BiostatisticsFull details
Dendritic cell lineage potential in human early hematopoietic progenitors Authors (6) Julie HelftFernando Dos Anjos Afonso Annemarthe G van der Veen Probir ChakravartyDominique BonnetCaetano Reis e Sousa Cell Reports Published 18 July 2017 Crick labs/ facilitiesCaetano Reis e SousaDominique BonnetBioinformatics and BiostatisticsFlow CytometryFull details
Actin is an evolutionarily-conserved damage-associated molecular pattern that signals tissue injury in Drosophila melanogaster Authors (15) Naren SrinivasanOliver Gordon Susan Ahrens Anna Franz Safia Deddouche Probir Chakravarty[...] Luis Teixeira Barry Thompson Marc S Dionne Will WoodCaetano Reis e Sousa eLife Published 22 November 2016 Crick labs/ facilitiesBarry ThompsonCaetano Reis e SousaBioinformatics and BiostatisticsAdvanced SequencingAdvanced SequencingFull details
Alive but confused: heterogeneity of CD11c+ MHC class II+ cells in GM-CSF mouse bone marrow cultures Authors (8) Julie Helft Jan P Böttcher Probir Chakravarty Santiago Zelenay Jatta Huotari Barbara U Schraml Delphine GoubauCaetano Reis e Sousa Immunity Published 19 January 2016 Crick labs/ facilitiesCaetano Reis e SousaBioinformatics and BiostatisticsFull details
Mouse superkiller-2-like helicase DDX60 is dispensable for type I IFN induction and immunity to multiple viruses Authors (10) Delphine Goubau Annemarthe G van der Veen Probir Chakravarty Rongtuan LinNeil Rogers Jan Rehwinkel Safia DeddoucheIan Rosewell John HiscottCaetano Reis e Sousa European Journal of Immunology Published 1 December 2015 Crick labs/ facilitiesCaetano Reis e SousaGenetic Modification ServiceBiological Research FacilityBioinformatics and BiostatisticsStructural BiologyAdvanced SequencingFull details
Cyclooxygenase-dependent tumor growth through evasion of immunity Authors (12) Santiago Zelenay Annemarthe G van der Veen Jan P Böttcher Kathryn J SnelgroveNeil Rogers Sophie E Acton[...] Maria Romina Girotti Richard Marais Sergio A QuezadaErik SahaiCaetano Reis e Sousa Cell Published 10 September 2015 Crick labs/ facilitiesErik SahaiCaetano Reis e SousaBioinformatics and BiostatisticsFull details
GM-CSF mouse bone marrow cultures comprise a heterogeneous population of CD11c+MHCII+ macrophages and dendritic cells Authors (8) Julie Helft Jan Böttcher Probir Chakravarty Santiago Zelenay Jatta Huotari Barbara U Schraml Delphine GoubauCaetano Reis e Sousa Immunity Published 16 June 2015 Crick labs/ facilitiesCaetano Reis e SousaBioinformatics and BiostatisticsFlow CytometryFull details
Intestinal intraepithelial lymphocyte activation promotes innate antiviral resistance Authors (12) Mahima Swamy Lucie Abeler-Dörner James Chettle Tanel Mahlakõiv Delphine Goubau Probir Chakravarty[...]Caetano Reis e Sousa Peter Staeheli Barbara A Blacklaws Jonathan L HeeneyAdrian Hayday Nature Communications Published 19 May 2015 Crick labs/ facilitiesCaetano Reis e SousaAdrian HaydayBioinformatics and BiostatisticsFlow CytometryExperimental HistopathologyBiological Research FacilityFull details