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Breadcrumb Caetano Reis e Sousa Reis e Sousa lab Immunobiology Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members Vacancies News Alumni Dendritic cells are white blood cells that get their name from their tree-like shape (dendron is the Greek word for tree). 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(1)The Lancet (1)Wellcome Open Research (1) Facet Journal Publications Displaying 1 - 15 of 15Last updated : 24 April 2024 02:16 Endothelial AHR activity prevents lung barrier disruption in viral infection Authors (13)Jack MajorStefania CrottaKatja Finsterbusch Probir ChakravartyKathleen ShahBruno Frederico[...] Lucy Meader Alejandro Suarez-BonnetSimon PriestnallBrigitta StockingerAndreas Wack Nature Published 28 September 2023 Crick labs/ facilitiesAndreas WackGitta StockingerCaetano Reis e SousaLight MicroscopyExperimental HistopathologyBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityAdvanced SequencingFull details Loss of TET2 in human hematopoietic stem cells alters the development and function of neutrophils Authors (22)Hector Huerga EncaboIker Valle AramburuManuel Garcia AlbornozMarion Piganeau Henry Wood Anna Song[...] Daniel H Wiseman Kiran Batta Rajeev GuptaVenizelos PapayannopoulosDominique Bonnet Cell Stem Cell Published 1 June 2023 Crick labs/ facilitiesCaetano Reis e SousaVenizelos PapayannopoulosDominique BonnetLight MicroscopyElectron MicroscopyBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityAdvanced SequencingFull details Loss of secreted gelsolin enhances response to anticancer therapies Authors (8)Jonathan LimEvangelos GiampazoliasOliver SchulzNeil Rogers Anna WilkinsErik Sahai Jessica StridCaetano Reis e Sousa Journal for ImmunoTherapy of Cancer Published 26 September 2022 Crick labs/ facilitiesErik SahaiCaetano Reis e SousaBiological Research FacilityFull details DNGR-1-tracing marks an ependymal cell subset with damage-responsive neural stem cell potential Authors (17)Bruno Frederico Isaura Martins Diana ChapelaFrancesca Gasparrini Probir ChakravartyTobias Ackels[...]James BriscoeFrancois GuillemotAndreas Schaefer Leonor SaúdeCaetano Reis e Sousa Developmental Cell Published 22 August 2022 Crick labs/ facilitiesAndreas SchaeferCaetano Reis e SousaFrancois GuillemotJames BriscoeLight MicroscopyExperimental HistopathologyElectron MicroscopyBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityFull details Recruitment of dendritic cell progenitors to foci of influenza A virus infection sustains immunity Authors (18)Maria Del Mar Cabeza CabrerizoCarlos Munoz Minutti Mariana Pereira da CostaAna Matos Cardoso Da SilvaRob JenkinsJustina Kulikauskaite[...] Judith E Allen Manolis PasparakisAndreas WackErik SahaiCaetano Reis e Sousa Science Immunology Published 5 November 2021 Crick labs/ facilitiesAndreas WackErik SahaiCaetano Reis e SousaNicola LewisDominique BonnetWorldwide Influenza CentreFlow CytometryBiological Research FacilityBioinformatics and BiostatisticsFull details Secreted gelsolin inhibits DNGR-1-dependent cross-presentation and cancer immunity Authors (17)Evangelos GiampazoliasOliver SchulzJonathan LimNeil Rogers Probir Chakravarty Naren Srinivasan[...] Stefano Sammicheli Natalia MoncautSunita Varsani-BrownIan RosewellCaetano Reis e Sousa Cell Published 22 July 2021 Crick labs/ facilitiesCaetano Reis e SousaGenetic Modification ServiceBiological Research FacilityBioinformatics and BiostatisticsFlow CytometryFull details SARS-CoV-2 detection by a clinical diagnostic RT-LAMP assay Authors (40)Michael BuckEnzo PoirierAna Matos Cardoso Da SilvaBruno Frederico J CantonSam Barrell[...]Charles SwantonSamra TurajlicMary WuCaetano Reis e Sousa The Crick COVID-19 Consortium Wellcome Open Research Published 21 May 2021 Crick labs/ facilitiesSamra TurajlicCharles SwantonCaetano Reis e SousaGeorge KassiotisSonia GandhiRupert BealeMetabolomicsHigh Throughput ScreeningGenetic Modification ServiceBiological Research FacilityAdvanced SequencingStructural BiologyScientific computingFull details The receptor DNGR-1 signals for phagosomal rupture to promote cross-presentation of dead-cell-associated antigens Authors (18) Johnathan CantonHanna BleesConor HenryMichael BuckOliver SchulzNeil Rogers[...] Sebastian AmigorenaVenizelos Papayannopoulos David C Thomas Felix RandowCaetano Reis e Sousa Nature Immunology Published 1 February 2021 Crick labs/ facilitiesCaetano Reis e SousaFlow CytometryElectron MicroscopyProteomicsBiological Research FacilityFull details Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers Authors (341) Catherine F Houlihan Nina Vora Thomas Byrne Dan LewerGavin Kelly Judith Heaney[...] Andrew Hayward Richard Gilson Gavin KellyFiona Roberts Emine Hatipoglu The Lancet Published 25 July 2020 Crick labs/ facilitiesAndreas WackKaren VousdenJernej UleJames TurnerMoritz TreeckCharles SwantonAdam SaterialeErik SahaiCaetano Reis e SousaPeter RatcliffeLucia Prieto-GodinoVenizelos PapayannopoulosAnne O’GarraPaul NurseGeorge KassiotisMaximiliano GutierrezSonia GandhiSteve GamblinPeter Cherepanov Luiz Pedro CarvalhoDominique BonnetMike BlackmanRupert BealeWorldwide Influenza CentreStructural BiologyMetabolomicsHuman Embryonic Stem CellHigh Throughput ScreeningGenetic Modification ServiceFlow CytometryFermentationExperimental HistopathologyElectron MicroscopyCell ServicesBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Tissue clonality of dendritic cell subsets and emergency DCpoiesis revealed by multicolor fate mapping of DC progenitors Authors (19)Maria Del Mar Cabeza Cabrerizo Janneke van Blijswijk Stephan Wienert Daniel HeimRob Jenkins Probir Chakravarty[...] Michael Gerner Ronald N GermainErik Sahai Frederick KlauschenCaetano Reis e Sousa Science Immunology Published 1 March 2019 Crick labs/ facilitiesErik SahaiCaetano Reis e SousaBioinformatics and BiostatisticsLight MicroscopyFlow CytometryBiological Research FacilityFull details Myosin II synergizes with F-actin to promote DNGR-1-dependent cross-presentation of dead cell-associated antigens Authors (7)Oliver Schulz Pavel Hanč Jan P Böttcher Robbert Hoogeboom Sandra S DieboldPavel TolarCaetano Reis e Sousa Cell Reports Published 10 July 2018 Crick labsPavel TolarCaetano Reis e SousaFull details NK cells stimulate recruitment of cDC1 into the tumor microenvironment promoting cancer immune control Authors (10) Jan P Böttcher Eduardo Bonavita Probir ChakravartyHanna BleesMaria Del Mar Cabeza Cabrerizo Stefano SammicheliNeil RogersErik Sahai Santiago ZelenayCaetano Reis e Sousa Cell Published 22 February 2018 Crick labs/ facilitiesErik SahaiCaetano Reis e SousaBioinformatics and BiostatisticsFull details Mouse superkiller-2-like helicase DDX60 is dispensable for type I IFN induction and immunity to multiple viruses Authors (10) Delphine Goubau Annemarthe G van der Veen Probir Chakravarty Rongtuan LinNeil Rogers Jan Rehwinkel Safia DeddoucheIan Rosewell John HiscottCaetano Reis e Sousa European Journal of Immunology Published 1 December 2015 Crick labs/ facilitiesCaetano Reis e SousaGenetic Modification ServiceBiological Research FacilityBioinformatics and BiostatisticsStructural BiologyAdvanced SequencingFull details Cyclooxygenase-dependent tumor growth through evasion of immunity Authors (12) Santiago Zelenay Annemarthe G van der Veen Jan P Böttcher Kathryn J SnelgroveNeil Rogers Sophie E Acton[...] Maria Romina Girotti Richard Marais Sergio A QuezadaErik SahaiCaetano Reis e Sousa Cell Published 10 September 2015 Crick labs/ facilitiesErik SahaiCaetano Reis e SousaBioinformatics and BiostatisticsFull details Structure of the complex of F-actin and DNGR-1, a C-type lectin receptor involved in dendritic cell cross-presentation of dead cell-associated antigens Authors (12) Pavel Hanč Takashi Fujii Salvador Iborra Yurika Yamada Jatta HuotariOliver Schulz[...]Svend KjaerMichael Way David Sancho Keiichi NambaCaetano Reis e Sousa Immunity Published 19 May 2015 Crick labs/ facilitiesMichael WayCaetano Reis e SousaStructural BiologyFlow CytometryAdvanced SequencingFull details Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Endothelial AHR activity prevents lung barrier disruption in viral infection Authors (13)Jack MajorStefania CrottaKatja Finsterbusch Probir ChakravartyKathleen ShahBruno Frederico[...] Lucy Meader Alejandro Suarez-BonnetSimon PriestnallBrigitta StockingerAndreas Wack Nature Published 28 September 2023 Crick labs/ facilitiesAndreas WackGitta StockingerCaetano Reis e SousaLight MicroscopyExperimental HistopathologyBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityAdvanced SequencingFull details
Loss of TET2 in human hematopoietic stem cells alters the development and function of neutrophils Authors (22)Hector Huerga EncaboIker Valle AramburuManuel Garcia AlbornozMarion Piganeau Henry Wood Anna Song[...] Daniel H Wiseman Kiran Batta Rajeev GuptaVenizelos PapayannopoulosDominique Bonnet Cell Stem Cell Published 1 June 2023 Crick labs/ facilitiesCaetano Reis e SousaVenizelos PapayannopoulosDominique BonnetLight MicroscopyElectron MicroscopyBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityAdvanced SequencingFull details
Loss of secreted gelsolin enhances response to anticancer therapies Authors (8)Jonathan LimEvangelos GiampazoliasOliver SchulzNeil Rogers Anna WilkinsErik Sahai Jessica StridCaetano Reis e Sousa Journal for ImmunoTherapy of Cancer Published 26 September 2022 Crick labs/ facilitiesErik SahaiCaetano Reis e SousaBiological Research FacilityFull details
DNGR-1-tracing marks an ependymal cell subset with damage-responsive neural stem cell potential Authors (17)Bruno Frederico Isaura Martins Diana ChapelaFrancesca Gasparrini Probir ChakravartyTobias Ackels[...]James BriscoeFrancois GuillemotAndreas Schaefer Leonor SaúdeCaetano Reis e Sousa Developmental Cell Published 22 August 2022 Crick labs/ facilitiesAndreas SchaeferCaetano Reis e SousaFrancois GuillemotJames BriscoeLight MicroscopyExperimental HistopathologyElectron MicroscopyBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityFull details
Recruitment of dendritic cell progenitors to foci of influenza A virus infection sustains immunity Authors (18)Maria Del Mar Cabeza CabrerizoCarlos Munoz Minutti Mariana Pereira da CostaAna Matos Cardoso Da SilvaRob JenkinsJustina Kulikauskaite[...] Judith E Allen Manolis PasparakisAndreas WackErik SahaiCaetano Reis e Sousa Science Immunology Published 5 November 2021 Crick labs/ facilitiesAndreas WackErik SahaiCaetano Reis e SousaNicola LewisDominique BonnetWorldwide Influenza CentreFlow CytometryBiological Research FacilityBioinformatics and BiostatisticsFull details
Secreted gelsolin inhibits DNGR-1-dependent cross-presentation and cancer immunity Authors (17)Evangelos GiampazoliasOliver SchulzJonathan LimNeil Rogers Probir Chakravarty Naren Srinivasan[...] Stefano Sammicheli Natalia MoncautSunita Varsani-BrownIan RosewellCaetano Reis e Sousa Cell Published 22 July 2021 Crick labs/ facilitiesCaetano Reis e SousaGenetic Modification ServiceBiological Research FacilityBioinformatics and BiostatisticsFlow CytometryFull details
SARS-CoV-2 detection by a clinical diagnostic RT-LAMP assay Authors (40)Michael BuckEnzo PoirierAna Matos Cardoso Da SilvaBruno Frederico J CantonSam Barrell[...]Charles SwantonSamra TurajlicMary WuCaetano Reis e Sousa The Crick COVID-19 Consortium Wellcome Open Research Published 21 May 2021 Crick labs/ facilitiesSamra TurajlicCharles SwantonCaetano Reis e SousaGeorge KassiotisSonia GandhiRupert BealeMetabolomicsHigh Throughput ScreeningGenetic Modification ServiceBiological Research FacilityAdvanced SequencingStructural BiologyScientific computingFull details
The receptor DNGR-1 signals for phagosomal rupture to promote cross-presentation of dead-cell-associated antigens Authors (18) Johnathan CantonHanna BleesConor HenryMichael BuckOliver SchulzNeil Rogers[...] Sebastian AmigorenaVenizelos Papayannopoulos David C Thomas Felix RandowCaetano Reis e Sousa Nature Immunology Published 1 February 2021 Crick labs/ facilitiesCaetano Reis e SousaFlow CytometryElectron MicroscopyProteomicsBiological Research FacilityFull details
Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers Authors (341) Catherine F Houlihan Nina Vora Thomas Byrne Dan LewerGavin Kelly Judith Heaney[...] Andrew Hayward Richard Gilson Gavin KellyFiona Roberts Emine Hatipoglu The Lancet Published 25 July 2020 Crick labs/ facilitiesAndreas WackKaren VousdenJernej UleJames TurnerMoritz TreeckCharles SwantonAdam SaterialeErik SahaiCaetano Reis e SousaPeter RatcliffeLucia Prieto-GodinoVenizelos PapayannopoulosAnne O’GarraPaul NurseGeorge KassiotisMaximiliano GutierrezSonia GandhiSteve GamblinPeter Cherepanov Luiz Pedro CarvalhoDominique BonnetMike BlackmanRupert BealeWorldwide Influenza CentreStructural BiologyMetabolomicsHuman Embryonic Stem CellHigh Throughput ScreeningGenetic Modification ServiceFlow CytometryFermentationExperimental HistopathologyElectron MicroscopyCell ServicesBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Tissue clonality of dendritic cell subsets and emergency DCpoiesis revealed by multicolor fate mapping of DC progenitors Authors (19)Maria Del Mar Cabeza Cabrerizo Janneke van Blijswijk Stephan Wienert Daniel HeimRob Jenkins Probir Chakravarty[...] Michael Gerner Ronald N GermainErik Sahai Frederick KlauschenCaetano Reis e Sousa Science Immunology Published 1 March 2019 Crick labs/ facilitiesErik SahaiCaetano Reis e SousaBioinformatics and BiostatisticsLight MicroscopyFlow CytometryBiological Research FacilityFull details
Myosin II synergizes with F-actin to promote DNGR-1-dependent cross-presentation of dead cell-associated antigens Authors (7)Oliver Schulz Pavel Hanč Jan P Böttcher Robbert Hoogeboom Sandra S DieboldPavel TolarCaetano Reis e Sousa Cell Reports Published 10 July 2018 Crick labsPavel TolarCaetano Reis e SousaFull details
NK cells stimulate recruitment of cDC1 into the tumor microenvironment promoting cancer immune control Authors (10) Jan P Böttcher Eduardo Bonavita Probir ChakravartyHanna BleesMaria Del Mar Cabeza Cabrerizo Stefano SammicheliNeil RogersErik Sahai Santiago ZelenayCaetano Reis e Sousa Cell Published 22 February 2018 Crick labs/ facilitiesErik SahaiCaetano Reis e SousaBioinformatics and BiostatisticsFull details
Mouse superkiller-2-like helicase DDX60 is dispensable for type I IFN induction and immunity to multiple viruses Authors (10) Delphine Goubau Annemarthe G van der Veen Probir Chakravarty Rongtuan LinNeil Rogers Jan Rehwinkel Safia DeddoucheIan Rosewell John HiscottCaetano Reis e Sousa European Journal of Immunology Published 1 December 2015 Crick labs/ facilitiesCaetano Reis e SousaGenetic Modification ServiceBiological Research FacilityBioinformatics and BiostatisticsStructural BiologyAdvanced SequencingFull details
Cyclooxygenase-dependent tumor growth through evasion of immunity Authors (12) Santiago Zelenay Annemarthe G van der Veen Jan P Böttcher Kathryn J SnelgroveNeil Rogers Sophie E Acton[...] Maria Romina Girotti Richard Marais Sergio A QuezadaErik SahaiCaetano Reis e Sousa Cell Published 10 September 2015 Crick labs/ facilitiesErik SahaiCaetano Reis e SousaBioinformatics and BiostatisticsFull details
Structure of the complex of F-actin and DNGR-1, a C-type lectin receptor involved in dendritic cell cross-presentation of dead cell-associated antigens Authors (12) Pavel Hanč Takashi Fujii Salvador Iborra Yurika Yamada Jatta HuotariOliver Schulz[...]Svend KjaerMichael Way David Sancho Keiichi NambaCaetano Reis e Sousa Immunity Published 19 May 2015 Crick labs/ facilitiesMichael WayCaetano Reis e SousaStructural BiologyFlow CytometryAdvanced SequencingFull details