Research case studies Explore a selection of reports that spotlight particular areas of research at the Crick over the past five years.
Postdoctoral clinical fellows Opportunities for postdoctoral clinicians to consolidate their research experience.
Breadcrumb Caetano Reis e Sousa Reis e Sousa lab Immunobiology Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members Vacancies News Alumni Dendritic cells are white blood cells that get their name from their tree-like shape (dendron is the Greek word for tree). Toggle to view hero caption PublicationsYear published2023 (6)2022 (3)2021 (9)2020 (5)2019 (4)2018 (9)2017 (2)2016 (7)2015 (9)2014 (1) Facet Year publishedResearch topicsInfectious Disease (55)Immunology (54)Model Organisms (54)Chemical Biology & High Throughput (25)Computational & Systems Biology (22)Genetics & Genomics (19)Genome Integrity & Repair (19)Cell Biology (15)Imaging (15)Human Biology & Physiology (14)Stem Cells (11)Biochemistry & Proteomics (9)Signalling & Oncogenes (9)Developmental Biology (6)Structural Biology & Biophysics (6)Neurosciences (5)Cell Cycle & Chromosomes (4)Metabolism (4)Gene Expression (2)Microfabrication & Bioengineering (2)Synthetic Biology (2) (-)Tumour Biology (55) Facet Research topicsPublication typeJournal article (55)Primary research (38)Review (8)Commentary (5)Method (3)Letter (1) Facet Publication typeJournalImmunity (6)Cell Reports (4)EMBO Journal (4)European Journal of Immunology (4)Cell (3)Journal of Immunology (3)Science Immunology (3)eLife (2)Nature (2)Nature Communications (2)Nature Immunology (2)Science (2)Annual Review of Immunology (1)BioEssays (1)Cell Stem Cell (1)Current Opinion in Immunology (1)Developmental Cell (1)EMBO Molecular Medicine (1)ESMO Open (1)Frontiers in Immunology (1)Immunological Reviews (1)Journal for ImmunoTherapy of Cancer (1)Nature Biotechnology (1)Oncoimmunology (1)Open Biol (1)Seminars in Immunology (1)The EMBO Journal (1)The Lancet (1)Trends in Cancer (1)Wellcome Open Research (1) Facet Journal Publications Displaying 1 - 20 of 55Last updated : 28 March 2024 02:02 SYK ubiquitination by CBL E3 ligases restrains cross-presentation of dead cell-associated antigens by type 1 dendritic cells Authors (15)Conor Henry Carlos A CastellanosMichael BuckEvangelos GiampazoliasBruno FredericoAna Matos Cardoso Da Silva[...]Peter FaullBram Snijders Bhopal Mohapatra Hamid BandCaetano Reis e Sousa Cell Reports Published 26 December 2023 Crick labs/ facilitiesCaetano Reis e SousaProteomicsFlow CytometryBiological Research FacilityFull details Endothelial AHR activity prevents lung barrier disruption in viral infection Authors (13)Jack MajorStefania CrottaKatja Finsterbusch Probir ChakravartyKathleen ShahBruno Frederico[...] Lucy Meader Alejandro Suarez-BonnetSimon PriestnallBrigitta StockingerAndreas Wack Nature Published 28 September 2023 Crick labs/ facilitiesAndreas WackGitta StockingerCaetano Reis e SousaLight MicroscopyExperimental HistopathologyBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityAdvanced SequencingFull details Interplay between CXCR4 and CCR2 regulates bone marrow exit of dendritic cell progenitors Authors (11)Mariana Pereira Da CostaCarlos Munoz MinuttiCecile PiotEvangelos GiampazoliasAna Matos Cardoso Da SilvaMaria Del Mar Cabeza CabrerizoNeil RogersMarta de Lebrusant FernandezChrysante IliakisAndreas WackCaetano Reis e Sousa Cell Reports Published 29 August 2023 Crick labs/ facilitiesAndreas WackCaetano Reis e SousaPatricia BarralFlow CytometryBiological Research FacilityFull details Loss of TET2 in human hematopoietic stem cells alters the development and function of neutrophils Authors (22)Hector Huerga EncaboIker Valle AramburuManuel Garcia AlbornozMarion Piganeau Henry Wood Anna Song[...] Daniel H Wiseman Kiran Batta Rajeev GuptaVenizelos PapayannopoulosDominique Bonnet Cell Stem Cell Published 1 June 2023 Crick labs/ facilitiesCaetano Reis e SousaVenizelos PapayannopoulosDominique BonnetLight MicroscopyElectron MicroscopyBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityAdvanced SequencingFull details The dietary sweetener sucralose is a negative modulator of T cell-mediated responses Authors (16)Fabio ZaniJulianna Blagih Tim GruberMichael Buck Nicholas JonesMarc Hennequart[...]Eric Cheung Ian S GilmoreAlex Gould Cristina Garcia-CaceresKaren Vousden Nature Published 23 March 2023 Crick labs/ facilitiesKaren VousdenCaetano Reis e SousaAlex GouldMetabolomicsBioinformatics and BiostatisticsLight MicroscopyFlow CytometryBiological Research FacilityAdvanced SequencingFull details DNGR-1-mediated cross-presentation of dead cell-associated antigens Authors (3)Conor Henry Carlos A CastellanosCaetano Reis e Sousa Seminars in Immunology Published 7 February 2023 Crick labsCaetano Reis e SousaFull details Loss of secreted gelsolin enhances response to anticancer therapies Authors (8)Jonathan LimEvangelos GiampazoliasOliver SchulzNeil Rogers Anna WilkinsErik Sahai Jessica StridCaetano Reis e Sousa Journal for ImmunoTherapy of Cancer Published 26 September 2022 Crick labs/ facilitiesErik SahaiCaetano Reis e SousaBiological Research FacilityFull details DNGR-1-tracing marks an ependymal cell subset with damage-responsive neural stem cell potential Authors (17)Bruno Frederico Isaura Martins Diana ChapelaFrancesca Gasparrini Probir ChakravartyTobias Ackels[...]James BriscoeFrancois GuillemotAndreas Schaefer Leonor SaúdeCaetano Reis e Sousa Developmental Cell Published 22 August 2022 Crick labs/ facilitiesAndreas SchaeferCaetano Reis e SousaFrancois GuillemotJames BriscoeLight MicroscopyExperimental HistopathologyElectron MicroscopyBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityFull details RNA sensing via the RIG-I-like receptor LGP2 is essential for the induction of a type I IFN response in ADAR1 deficiency Authors (8) Jorn E Stok Timo Oosenbrug Laurens R ter Haar Dennis Gravekamp Christian P Bromley Santiago ZelenayCaetano Reis e Sousa Annemarthe G van der Veen The EMBO Journal Published 15 March 2022 Crick labsCaetano Reis e SousaFull details The impact of COVID-19 on oncology professionals-one year on: lessons learned from the ESMO Resilience Task Force survey series Authors (17) KHJ Lim K Murali E Thorne K Punie K Kamposioras C Oing[...] CB Westphalen G Morgan JBAG Haanen C Hardy S Banerjee ESMO Open Published 1 February 2022 Crick labsCaetano Reis e SousaFull details Epithelial colonization by gut dendritic cells promotes their functional diversification Authors (23) Claudia A Rivera Violaine Randrian Wilfrid Richer Yohan Gerber-Ferder Maria-Graciela Delgado Aleksandra S Chikina[...] Hélène D Moreau Julie Helft Danijela Matic Vignjevic Eduardo J Villablanca Ana-Maria Lennon-Duménil Immunity Published 11 January 2022 Crick labsCaetano Reis e SousaFull details Maintenance and loss of endocytic organelle integrity: mechanisms and implications for antigen cross-presentation Authors (4)Eleanor ChildsConor Henry Johnathan CantonCaetano Reis e Sousa Open Biol Published 10 November 2021 Crick labsCaetano Reis e SousaFull details Recruitment of dendritic cell progenitors to foci of influenza A virus infection sustains immunity Authors (18)Maria Del Mar Cabeza CabrerizoCarlos Munoz Minutti Mariana Pereira da CostaAna Matos Cardoso Da SilvaRob JenkinsJustina Kulikauskaite[...] Judith E Allen Manolis PasparakisAndreas WackErik SahaiCaetano Reis e Sousa Science Immunology Published 5 November 2021 Crick labs/ facilitiesAndreas WackErik SahaiCaetano Reis e SousaNicola LewisDominique BonnetWorldwide Influenza CentreFlow CytometryBiological Research FacilityBioinformatics and BiostatisticsFull details From mRNA sensing to vaccines Authors (9) Anthony S Fauci Miriam Merad Soumya Swaminathan Sun Hur Eric Topol Kate FitzgeraldCaetano Reis e Sousa Kizzmekia S Corbett Stefan Bauer Immunity Published 14 December 2021 Crick labsCaetano Reis e SousaFull details An isoform of Dicer protects mammalian stem cells against multiple RNA viruses Authors (10)Enzo PoirierMichael Buck Probir ChakravartyJoana Do Vale Viegas Silva CarvalhoBruno FredericoAna Matos Cardoso Da SilvaLyn HealyRachel UlfertsRupert BealeCaetano Reis e Sousa Science Published 9 July 2021 Crick labs/ facilitiesCaetano Reis e SousaRupert BealeHuman Embryonic Stem CellExperimental HistopathologyBioinformatics and BiostatisticsFlow CytometryAdvanced SequencingFull details Secreted gelsolin inhibits DNGR-1-dependent cross-presentation and cancer immunity Authors (17)Evangelos GiampazoliasOliver SchulzJonathan LimNeil Rogers Probir Chakravarty Naren Srinivasan[...] Stefano Sammicheli Natalia MoncautSunita Varsani-BrownIan RosewellCaetano Reis e Sousa Cell Published 22 July 2021 Crick labs/ facilitiesCaetano Reis e SousaGenetic Modification ServiceBiological Research FacilityBioinformatics and BiostatisticsFlow CytometryFull details Dendritic cells revisited Authors (5)Maria Del Mar Cabeza CabrerizoAna Matos Cardoso Da SilvaCarlos Munoz MinuttiMariana Pereira Da CostaCaetano Reis e Sousa Annual Review of Immunology Published 1 April 2021 Crick labsCaetano Reis e SousaFull details SARS-CoV-2 detection by a clinical diagnostic RT-LAMP assay Authors (40)Michael BuckEnzo PoirierAna Matos Cardoso Da SilvaBruno Frederico J CantonSam Barrell[...]Charles SwantonSamra TurajlicMary WuCaetano Reis e Sousa The Crick COVID-19 Consortium Wellcome Open Research Published 21 May 2021 Crick labs/ facilitiesSamra TurajlicCharles SwantonCaetano Reis e SousaGeorge KassiotisSonia GandhiRupert BealeMetabolomicsHigh Throughput ScreeningGenetic Modification ServiceBiological Research FacilityAdvanced SequencingStructural BiologyScientific computingFull details The receptor DNGR-1 signals for phagosomal rupture to promote cross-presentation of dead-cell-associated antigens Authors (18) Johnathan CantonHanna BleesConor HenryMichael BuckOliver SchulzNeil Rogers[...] Sebastian AmigorenaVenizelos Papayannopoulos David C Thomas Felix RandowCaetano Reis e Sousa Nature Immunology Published 1 February 2021 Crick labs/ facilitiesCaetano Reis e SousaFlow CytometryElectron MicroscopyProteomicsBiological Research FacilityFull details Antagonistic inflammatory phenotypes dictate tumor fate and response to immune checkpoint blockade Authors (20) Eduardo Bonavita Christian P Bromley Gustav Jonsson Victoria S Pelly Sudhakar Sahoo Katherine Walwyn-Brown[...] Alberto MantovaniCaetano Reis e Sousa Nadia Guerra Daniel M Davis Santiago Zelenay Immunity Published 15 December 2020 Crick labsCaetano Reis e SousaFull details Pagination Current page 1 Page 2 Page 3 Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
SYK ubiquitination by CBL E3 ligases restrains cross-presentation of dead cell-associated antigens by type 1 dendritic cells Authors (15)Conor Henry Carlos A CastellanosMichael BuckEvangelos GiampazoliasBruno FredericoAna Matos Cardoso Da Silva[...]Peter FaullBram Snijders Bhopal Mohapatra Hamid BandCaetano Reis e Sousa Cell Reports Published 26 December 2023 Crick labs/ facilitiesCaetano Reis e SousaProteomicsFlow CytometryBiological Research FacilityFull details
Endothelial AHR activity prevents lung barrier disruption in viral infection Authors (13)Jack MajorStefania CrottaKatja Finsterbusch Probir ChakravartyKathleen ShahBruno Frederico[...] Lucy Meader Alejandro Suarez-BonnetSimon PriestnallBrigitta StockingerAndreas Wack Nature Published 28 September 2023 Crick labs/ facilitiesAndreas WackGitta StockingerCaetano Reis e SousaLight MicroscopyExperimental HistopathologyBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityAdvanced SequencingFull details
Interplay between CXCR4 and CCR2 regulates bone marrow exit of dendritic cell progenitors Authors (11)Mariana Pereira Da CostaCarlos Munoz MinuttiCecile PiotEvangelos GiampazoliasAna Matos Cardoso Da SilvaMaria Del Mar Cabeza CabrerizoNeil RogersMarta de Lebrusant FernandezChrysante IliakisAndreas WackCaetano Reis e Sousa Cell Reports Published 29 August 2023 Crick labs/ facilitiesAndreas WackCaetano Reis e SousaPatricia BarralFlow CytometryBiological Research FacilityFull details
Loss of TET2 in human hematopoietic stem cells alters the development and function of neutrophils Authors (22)Hector Huerga EncaboIker Valle AramburuManuel Garcia AlbornozMarion Piganeau Henry Wood Anna Song[...] Daniel H Wiseman Kiran Batta Rajeev GuptaVenizelos PapayannopoulosDominique Bonnet Cell Stem Cell Published 1 June 2023 Crick labs/ facilitiesCaetano Reis e SousaVenizelos PapayannopoulosDominique BonnetLight MicroscopyElectron MicroscopyBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityAdvanced SequencingFull details
The dietary sweetener sucralose is a negative modulator of T cell-mediated responses Authors (16)Fabio ZaniJulianna Blagih Tim GruberMichael Buck Nicholas JonesMarc Hennequart[...]Eric Cheung Ian S GilmoreAlex Gould Cristina Garcia-CaceresKaren Vousden Nature Published 23 March 2023 Crick labs/ facilitiesKaren VousdenCaetano Reis e SousaAlex GouldMetabolomicsBioinformatics and BiostatisticsLight MicroscopyFlow CytometryBiological Research FacilityAdvanced SequencingFull details
DNGR-1-mediated cross-presentation of dead cell-associated antigens Authors (3)Conor Henry Carlos A CastellanosCaetano Reis e Sousa Seminars in Immunology Published 7 February 2023 Crick labsCaetano Reis e SousaFull details
Loss of secreted gelsolin enhances response to anticancer therapies Authors (8)Jonathan LimEvangelos GiampazoliasOliver SchulzNeil Rogers Anna WilkinsErik Sahai Jessica StridCaetano Reis e Sousa Journal for ImmunoTherapy of Cancer Published 26 September 2022 Crick labs/ facilitiesErik SahaiCaetano Reis e SousaBiological Research FacilityFull details
DNGR-1-tracing marks an ependymal cell subset with damage-responsive neural stem cell potential Authors (17)Bruno Frederico Isaura Martins Diana ChapelaFrancesca Gasparrini Probir ChakravartyTobias Ackels[...]James BriscoeFrancois GuillemotAndreas Schaefer Leonor SaúdeCaetano Reis e Sousa Developmental Cell Published 22 August 2022 Crick labs/ facilitiesAndreas SchaeferCaetano Reis e SousaFrancois GuillemotJames BriscoeLight MicroscopyExperimental HistopathologyElectron MicroscopyBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityFull details
RNA sensing via the RIG-I-like receptor LGP2 is essential for the induction of a type I IFN response in ADAR1 deficiency Authors (8) Jorn E Stok Timo Oosenbrug Laurens R ter Haar Dennis Gravekamp Christian P Bromley Santiago ZelenayCaetano Reis e Sousa Annemarthe G van der Veen The EMBO Journal Published 15 March 2022 Crick labsCaetano Reis e SousaFull details
The impact of COVID-19 on oncology professionals-one year on: lessons learned from the ESMO Resilience Task Force survey series Authors (17) KHJ Lim K Murali E Thorne K Punie K Kamposioras C Oing[...] CB Westphalen G Morgan JBAG Haanen C Hardy S Banerjee ESMO Open Published 1 February 2022 Crick labsCaetano Reis e SousaFull details
Epithelial colonization by gut dendritic cells promotes their functional diversification Authors (23) Claudia A Rivera Violaine Randrian Wilfrid Richer Yohan Gerber-Ferder Maria-Graciela Delgado Aleksandra S Chikina[...] Hélène D Moreau Julie Helft Danijela Matic Vignjevic Eduardo J Villablanca Ana-Maria Lennon-Duménil Immunity Published 11 January 2022 Crick labsCaetano Reis e SousaFull details
Maintenance and loss of endocytic organelle integrity: mechanisms and implications for antigen cross-presentation Authors (4)Eleanor ChildsConor Henry Johnathan CantonCaetano Reis e Sousa Open Biol Published 10 November 2021 Crick labsCaetano Reis e SousaFull details
Recruitment of dendritic cell progenitors to foci of influenza A virus infection sustains immunity Authors (18)Maria Del Mar Cabeza CabrerizoCarlos Munoz Minutti Mariana Pereira da CostaAna Matos Cardoso Da SilvaRob JenkinsJustina Kulikauskaite[...] Judith E Allen Manolis PasparakisAndreas WackErik SahaiCaetano Reis e Sousa Science Immunology Published 5 November 2021 Crick labs/ facilitiesAndreas WackErik SahaiCaetano Reis e SousaNicola LewisDominique BonnetWorldwide Influenza CentreFlow CytometryBiological Research FacilityBioinformatics and BiostatisticsFull details
From mRNA sensing to vaccines Authors (9) Anthony S Fauci Miriam Merad Soumya Swaminathan Sun Hur Eric Topol Kate FitzgeraldCaetano Reis e Sousa Kizzmekia S Corbett Stefan Bauer Immunity Published 14 December 2021 Crick labsCaetano Reis e SousaFull details
An isoform of Dicer protects mammalian stem cells against multiple RNA viruses Authors (10)Enzo PoirierMichael Buck Probir ChakravartyJoana Do Vale Viegas Silva CarvalhoBruno FredericoAna Matos Cardoso Da SilvaLyn HealyRachel UlfertsRupert BealeCaetano Reis e Sousa Science Published 9 July 2021 Crick labs/ facilitiesCaetano Reis e SousaRupert BealeHuman Embryonic Stem CellExperimental HistopathologyBioinformatics and BiostatisticsFlow CytometryAdvanced SequencingFull details
Secreted gelsolin inhibits DNGR-1-dependent cross-presentation and cancer immunity Authors (17)Evangelos GiampazoliasOliver SchulzJonathan LimNeil Rogers Probir Chakravarty Naren Srinivasan[...] Stefano Sammicheli Natalia MoncautSunita Varsani-BrownIan RosewellCaetano Reis e Sousa Cell Published 22 July 2021 Crick labs/ facilitiesCaetano Reis e SousaGenetic Modification ServiceBiological Research FacilityBioinformatics and BiostatisticsFlow CytometryFull details
Dendritic cells revisited Authors (5)Maria Del Mar Cabeza CabrerizoAna Matos Cardoso Da SilvaCarlos Munoz MinuttiMariana Pereira Da CostaCaetano Reis e Sousa Annual Review of Immunology Published 1 April 2021 Crick labsCaetano Reis e SousaFull details
SARS-CoV-2 detection by a clinical diagnostic RT-LAMP assay Authors (40)Michael BuckEnzo PoirierAna Matos Cardoso Da SilvaBruno Frederico J CantonSam Barrell[...]Charles SwantonSamra TurajlicMary WuCaetano Reis e Sousa The Crick COVID-19 Consortium Wellcome Open Research Published 21 May 2021 Crick labs/ facilitiesSamra TurajlicCharles SwantonCaetano Reis e SousaGeorge KassiotisSonia GandhiRupert BealeMetabolomicsHigh Throughput ScreeningGenetic Modification ServiceBiological Research FacilityAdvanced SequencingStructural BiologyScientific computingFull details
The receptor DNGR-1 signals for phagosomal rupture to promote cross-presentation of dead-cell-associated antigens Authors (18) Johnathan CantonHanna BleesConor HenryMichael BuckOliver SchulzNeil Rogers[...] Sebastian AmigorenaVenizelos Papayannopoulos David C Thomas Felix RandowCaetano Reis e Sousa Nature Immunology Published 1 February 2021 Crick labs/ facilitiesCaetano Reis e SousaFlow CytometryElectron MicroscopyProteomicsBiological Research FacilityFull details
Antagonistic inflammatory phenotypes dictate tumor fate and response to immune checkpoint blockade Authors (20) Eduardo Bonavita Christian P Bromley Gustav Jonsson Victoria S Pelly Sudhakar Sahoo Katherine Walwyn-Brown[...] Alberto MantovaniCaetano Reis e Sousa Nadia Guerra Daniel M Davis Santiago Zelenay Immunity Published 15 December 2020 Crick labsCaetano Reis e SousaFull details