Publications

Clonal evolution in healthy and premalignant tissues: implications for early cancer interception strategies

Authors (4)

Cancer Prevention Research

Published 17 March 2023

Crick labs

Charles Swanton

Full details

Spatial positioning of immune hotspots reflects the interplay between B and T cells in lung squamous cell carcinoma

Authors (14)

Hanyun Zhang
Khalid AbdulJabbar
David A Moore
Ayse Akarca
Katey Enfield
Mariam Jamal-Hanjani
[...]
Nicholas McGranahan
John Le Quesne
Charles Swanton
Teresa Marafioti
Yinyin Yuan

Cancer Research

Published 28 February 2023

Crick labs

Charles Swanton

Full details

Intratumoral CD8+ T cells with a tissue-resident memory phenotype mediate local immunity and immune checkpoint responses in breast cancer

Authors (26)

Balaji Virassamy
Franco Caramia
Peter Savas
Sneha Sant
Jianan Wang
Susan N Christo
[...]
Terence P Speed
Phillip K Darcy
Paul J Neeson
Laura K Mackay
Sherene Loi

Cancer Cell

Published 13 March 2023

Crick labs

Charles Swanton

Full details

Distinct mutagenic activity of APOBEC3G cytidine deaminase identified in bladder cancer

Authors (2)

Cancer Research

Published 15 February 2023

Crick labs

Charles Swanton

Full details

An HLA-G/SPAG9/STAT3 axis promotes brain metastases

Authors (20)

Blessing Iquo Bassey-Archibong
Chirayu Rajendra Chokshi
Nikoo Aghaei
Agata Monika Kieliszek
Nazanin Tatari
Dillon McKenna
[...]
Shawn Christopher Chafe
Charles Swanton
Rob Hynds
Chitra Venugopal
Sheila Kumari Singh

Proceedings of the National Academy of Sciences of USA

Published 21 February 2023

Crick labs

Charles Swanton

Full details

Strong peak immunogenicity but rapid antibody waning following third vaccine dose in older residents of care homes

Authors (68)

G Tut
T Lancaster
M Krutikov
P Sylla
D Bone
E Spalkova
[...]
A Irwin-Singer
A Hayward
A Copas
L Shallcross
P Moss

Nature Aging

Published 1 January 2023

Crick labs/ facilities

Full details

USP7 inactivation suppresses APC-mutant intestinal hyperproliferation and tumor development

Authors (11)

Stem Cell Reports

Published 14 February 2023

Crick labs/ facilities

Full details

Open questions in human lung organoid research

Authors (4)

Tessa Hughes
Krijn Dijkstra
Emma L Rawlins
Rob Hynds

Frontiers in Pharmacology

Crick labs

Charles Swanton

Full details

The Cancer Research UK Stratified Medicine Programme as a model for delivering personalised cancer care

Authors (21)

Maria Antonietta Cerone
Tara C Mills
Rowena Sharpe
David McBride
Moira MacDonald
Suzanne MacMahon
[...]
Sanjay Popat
Gary Middleton
Peter Johnson
Charles Swanton
SMP2 consortium

British Journal of Cancer

Published 19 January 2023

Crick labs

Charles Swanton

Full details

Performance of a targeted methylation-based multi-cancer early detection test by race and ethnicity

Authors (11)

WH Wilson Tang
Habte Yimer
Mohan Tummala
Spencer Shao
Gina Chung
Jessica Clement
Bong Chul Chu
Earl Hubbell
Kathryn N Kurtzman
Charles Swanton
Lewis R Roberts

Preventive Medicine

Published 1 February 2023

Crick labs

Charles Swanton

Full details

Evaluation of cell-free DNA approaches for multi-cancer early detection

Authors (49)

Arash Jamshidi
Minetta C Liu
Eric A Klein
Oliver Venn
Earl Hubbell
John F Beausang
[...]
Mikkael A Sekeres
Alan Bryce
Alexander M Aravanis
Michael V Seiden
Charles Swanton

Cancer Cell

Published 12 December 2022

Crick labs

Charles Swanton

Full details

MEDICC2: whole-genome doubling aware copy-number phylogenies for cancer evolution

Authors (13)

Tom L Kaufmann
Marina Petkovic
Tom Watkins
Emma C Colliver
Sofya Laskina
Nisha Thapa
[...]
Charles Swanton
Peter Van Loo
Kerstin Haase
Maxime Tarabichi
Roland F Schwarz

Genome Biology

Published 14 November 2022

Crick labs

Full details

Multi-cancer early detection test sensitivity for cancers with and without current population-level screening options

Authors (11)

Spencer H Shao
Brian Allen
Jessica Clement
Gina Chung
Jingjing Gao
Earl Hubbell
Minetta C Liu
Charles Swanton
WH Wilson Tang
Habte Yimer
Mohan Tummala

Tumori Journal

Published 31 October 2022

Crick labs

Charles Swanton

Full details

Clonal somatic copy number altered driver events inform drug sensitivity in high-grade serous ovarian cancer

Authors (33)

Filipe Correia Martins
Dominique-Laurent Couturier
Ines de Santiago
Carolin Margarethe Sauer
Maria Vias
Mihaela Angelova
[...]
Iain McNeish
Carlos Caldas
Gerard Evan
Charles Swanton
James D Brenton

Nature Communications

Published 26 October 2022

Crick labs

Full details

Targeted profiling of human extrachromosomal DNA by CRISPR-CATCH

Authors (26)

King L Hung
Jens Luebeck
Siavash R Dehkordi
Caterina I Colón
Rui Li
Ivy Tsz-Lo Wong
[...]
William J Greenleaf
Roger S Lo
Paul S Mischel
Vineet Bafna
Howard Y Chang

Nature Genetics

Published 1 November 2022

Crick labs

Charles Swanton

Full details

WHO's therapeutics and COVID-19 living guideline on mAbs needs to be reassessed

Authors (19)

Mary Wu
Edward J Carr
Ruth Harvey
Harriet Mears
Svend Kjaer
Hermaleigh Townsley
[...]
Bryan Williams
Sonia Gandhi
Charles Swanton
Emma C Wall
David LV Bauer

The Lancet

Published 17 December 2022

Crick labs/ facilities

Full details

Cell-free DNA-based multi-cancer early detection test in an asymptomatic screening population (NHS-Galleri): Design of a pragmatic, prospective randomised controlled trial

Authors (8)

Richard D Neal
Peter Johnson
Christina A Clarke
Stephanie A Hamilton
Nan Zhang
Harpal Kumar
Charles Swanton
Peter Sasieni

Cancers (Basel)

Published 1 October 2022

Crick labs

Charles Swanton

Full details

Functional immune responses against SARS-CoV-2 variants of concern after fourth COVID-19 vaccine dose or infection in patients with blood cancer

Authors (64)

Annika Fendler
Scott Shepherd
Lewis Au
Mary Wu
Ruth Harvey
Katalin Wilkinson
[...]
Emma Nicholson
Susanna Walker
Robert Wilkinson
James Larkin
Samra Turajlic

Cell Reports Medicine

Published 18 October 2022

Crick labs/ facilities

Full details

RAS oncogenic activity predicts response to chemotherapy and outcome in lung adenocarcinoma

Authors (11)

Phil East
Gavin Kelly
Dhruva Biswas
Michela Marani
David Hancock
Todd Creasy
Kris Sachsenmeier
Charles Swanton
TRACERx consortium
Julian Downward
Sophie de Carne

Nature Communications

Published 26 September 2022

Crick labs/ facilities

Full details

Leveraging extrachromosomal DNA to fine-tune trials of targeted therapy for glioblastoma: opportunities and challenges

Authors (3)

Nature Reviews Clinical Oncology

Published 1 November 2022

Crick labs

Charles Swanton

Full details

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Publications

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Clonal evolution in healthy and premalignant tissues: implications for early cancer interception strategies

Spatial positioning of immune hotspots reflects the interplay between B and T cells in lung squamous cell carcinoma

Intratumoral CD8+ T cells with a tissue-resident memory phenotype mediate local immunity and immune checkpoint responses in breast cancer

Distinct mutagenic activity of APOBEC3G cytidine deaminase identified in bladder cancer

An HLA-G/SPAG9/STAT3 axis promotes brain metastases

Strong peak immunogenicity but rapid antibody waning following third vaccine dose in older residents of care homes

USP7 inactivation suppresses APC-mutant intestinal hyperproliferation and tumor development

Open questions in human lung organoid research

The Cancer Research UK Stratified Medicine Programme as a model for delivering personalised cancer care

Performance of a targeted methylation-based multi-cancer early detection test by race and ethnicity

Evaluation of cell-free DNA approaches for multi-cancer early detection

MEDICC2: whole-genome doubling aware copy-number phylogenies for cancer evolution

Multi-cancer early detection test sensitivity for cancers with and without current population-level screening options

Clonal somatic copy number altered driver events inform drug sensitivity in high-grade serous ovarian cancer

Targeted profiling of human extrachromosomal DNA by CRISPR-CATCH

WHO's therapeutics and COVID-19 living guideline on mAbs needs to be reassessed

Cell-free DNA-based multi-cancer early detection test in an asymptomatic screening population (NHS-Galleri): Design of a pragmatic, prospective randomised controlled trial

Functional immune responses against SARS-CoV-2 variants of concern after fourth COVID-19 vaccine dose or infection in patients with blood cancer

RAS oncogenic activity predicts response to chemotherapy and outcome in lung adenocarcinoma

Leveraging extrachromosomal DNA to fine-tune trials of targeted therapy for glioblastoma: opportunities and challenges

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PhD student recruitment

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About us

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Research topics

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