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Breadcrumb Charles Swanton Swanton lab Cancer Evolution and Genome Instability Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members Vacancies Illustration of chromosomes from a cancer cell showing large-scale alterations. Toggle to view hero caption PublicationsYear published2023 (2)2022 (2)2020 (1)2017 (2)2014 (1) Facet Year publishedResearch topicsGenetics & Genomics (7)Genome Integrity & Repair (7)Tumour Biology (7)Chemical Biology & High Throughput (6)Computational & Systems Biology (6)Human Biology & Physiology (6)Signalling & Oncogenes (6)Gene Expression (1)Model Organisms (1) Facet Research topicsPublication typeJournal article (8)Primary research (7)Commentary (1) Facet Publication typeJournal (-)Nature Genetics (8) Facet Journal Publications Displaying 1 - 8 of 8Last updated : 18 April 2024 03:30 The role of APOBEC3B in lung tumor evolution and targeted cancer therapy resistance Authors (85)Deborah Caswell Philippe Gui Manasi K Mayekar Emily K Law Oriol Pich Chris Bailey[...] Nnennaya Kanu Reuben S HarrisJulian Downward Trever G BivonaCharles Swanton Nature Genetics Published 1 January 2024 Crick labs/ facilitiesKaren VousdenCharles SwantonJulian DownwardExperimental HistopathologyBiological Research FacilityFull details Tumor heterogeneity impairs immunogenicity in mismatch repair deficient tumors Authors (3) James L ReadingDeborah CaswellCharles Swanton Nature Genetics Published 1 October 2023 Crick labsCharles SwantonFull details Targeted profiling of human extrachromosomal DNA by CRISPR-CATCH Authors (26) King L Hung Jens Luebeck Siavash R Dehkordi Caterina I Colón Rui Li Ivy Tsz-Lo Wong[...] William J Greenleaf Roger S Lo Paul S Mischel Vineet Bafna Howard Y Chang Nature Genetics Published 1 November 2022 Crick labsCharles SwantonFull details The evolutionary dynamics of extrachromosomal DNA in human cancers Authors (22) Joshua T Lange John C Rose Celine Y Chen Yuriy Pichugin Liangqi Xie Jun Tang[...] Howard Y Chang Vineet Bafna Anton G Henssen Benjamin Werner Paul S Mischel Nature Genetics Published 1 October 2022 Crick labsCharles SwantonFull details Interplay between whole-genome doubling and the accumulation of deleterious alterations in cancer evolution Authors (17) Saioa LópezEmilia Lim Stuart HorswellKerstin HaaseAriana HuebnerMichelle Dietzen[...]Peter Van Loo Mariam Jamal-Hanjani TRACERx ConsortiumCharles Swanton Nicholas McGranahan Nature Genetics Published 5 March 2020 Crick labs/ facilitiesPeter Van LooCharles SwantonBioinformatics and BiostatisticsFull details Evolution and clinical impact of co-occurring genetic alterations in advanced-stage EGFR-mutant lung cancers Authors (29) Collin M BlakelyTom Watkins Wei Wu Beatrice Gini Jacob J Chabon Caroline E McCoach[...] Robert C Doebele Jonathan W Riess Maximilian DiehnCharles Swanton Trever G Bivona Nature Genetics Published 6 November 2017 Crick labsCharles SwantonFull details Spatial heterogeneity in medulloblastoma Authors (79) A Sorana Morrissy Florence MG Cavalli Marc Remke Vijay Ramaswamy David JH Shih Borja L Holgado[...] Sunit Das David Malkin Nada Jabado Marco A Marra Michael D Taylor Nature Genetics Published 1 May 2017 Crick labsCharles SwantonFull details Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing Authors (25) Marco Gerlinger Stuart Horswell James LarkinAndrew Rowan Max P Salm Ignacio Varela[...] David L Nicol Steven Hazell P Andrew FutrealAengus StewartCharles Swanton Nature Genetics Published 1 March 2014 Crick labs/ facilitiesCharles SwantonPaul BatesExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingFull details Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
The role of APOBEC3B in lung tumor evolution and targeted cancer therapy resistance Authors (85)Deborah Caswell Philippe Gui Manasi K Mayekar Emily K Law Oriol Pich Chris Bailey[...] Nnennaya Kanu Reuben S HarrisJulian Downward Trever G BivonaCharles Swanton Nature Genetics Published 1 January 2024 Crick labs/ facilitiesKaren VousdenCharles SwantonJulian DownwardExperimental HistopathologyBiological Research FacilityFull details
Tumor heterogeneity impairs immunogenicity in mismatch repair deficient tumors Authors (3) James L ReadingDeborah CaswellCharles Swanton Nature Genetics Published 1 October 2023 Crick labsCharles SwantonFull details
Targeted profiling of human extrachromosomal DNA by CRISPR-CATCH Authors (26) King L Hung Jens Luebeck Siavash R Dehkordi Caterina I Colón Rui Li Ivy Tsz-Lo Wong[...] William J Greenleaf Roger S Lo Paul S Mischel Vineet Bafna Howard Y Chang Nature Genetics Published 1 November 2022 Crick labsCharles SwantonFull details
The evolutionary dynamics of extrachromosomal DNA in human cancers Authors (22) Joshua T Lange John C Rose Celine Y Chen Yuriy Pichugin Liangqi Xie Jun Tang[...] Howard Y Chang Vineet Bafna Anton G Henssen Benjamin Werner Paul S Mischel Nature Genetics Published 1 October 2022 Crick labsCharles SwantonFull details
Interplay between whole-genome doubling and the accumulation of deleterious alterations in cancer evolution Authors (17) Saioa LópezEmilia Lim Stuart HorswellKerstin HaaseAriana HuebnerMichelle Dietzen[...]Peter Van Loo Mariam Jamal-Hanjani TRACERx ConsortiumCharles Swanton Nicholas McGranahan Nature Genetics Published 5 March 2020 Crick labs/ facilitiesPeter Van LooCharles SwantonBioinformatics and BiostatisticsFull details
Evolution and clinical impact of co-occurring genetic alterations in advanced-stage EGFR-mutant lung cancers Authors (29) Collin M BlakelyTom Watkins Wei Wu Beatrice Gini Jacob J Chabon Caroline E McCoach[...] Robert C Doebele Jonathan W Riess Maximilian DiehnCharles Swanton Trever G Bivona Nature Genetics Published 6 November 2017 Crick labsCharles SwantonFull details
Spatial heterogeneity in medulloblastoma Authors (79) A Sorana Morrissy Florence MG Cavalli Marc Remke Vijay Ramaswamy David JH Shih Borja L Holgado[...] Sunit Das David Malkin Nada Jabado Marco A Marra Michael D Taylor Nature Genetics Published 1 May 2017 Crick labsCharles SwantonFull details
Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing Authors (25) Marco Gerlinger Stuart Horswell James LarkinAndrew Rowan Max P Salm Ignacio Varela[...] David L Nicol Steven Hazell P Andrew FutrealAengus StewartCharles Swanton Nature Genetics Published 1 March 2014 Crick labs/ facilitiesCharles SwantonPaul BatesExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingFull details