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Breadcrumb Charles Swanton Swanton lab Cancer Evolution and Genome Instability Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members Vacancies Illustration of chromosomes from a cancer cell showing large-scale alterations. Toggle to view hero caption PublicationsYear published (-)2019 (26) Facet Year publishedResearch topicsComputational & Systems Biology (26)Genetics & Genomics (26)Genome Integrity & Repair (26)Signalling & Oncogenes (26)Tumour Biology (26)Chemical Biology & High Throughput (25)Human Biology & Physiology (25)Biochemistry & Proteomics (1)Cell Biology (1)Cell Cycle & Chromosomes (1)Gene Expression (1) Facet Research topicsPublication typeJournal article (26)Primary research (15)Review (5)Commentary (2)Editorial (2)Method (2) Facet Publication typeJournalAnnals of Oncology (6)Nature Medicine (5)Methods in Molecular Biology (2)Annals of Translational Medicine (1)CA: a cancer journal for clinicians (1)Cell (1)ESMO Open (1)Immuno-Oncology and Technology (1)Journal of Thoracic Oncology (1)Lancet Oncology (1)Nature (1)Nature Communications (1)Nature Reviews Genetics (1)Nucleic Acids Research (1)Science Translational Medicine (1)Supportive Care in Cancer (1) Facet Journal Publications Displaying 1 - 20 of 26Last updated : 28 March 2024 02:20 Tumour mutational burden: primary versus metastatic tissue creates systematic bias Authors (3)Desiree SchnidrigSamra TurajlicKevin Litchfield Immuno-Oncology and Technology Published 1 December 2019 Crick labsSamra TurajlicCharles SwantonFull details A clonal expression biomarker associates with lung cancer mortality Authors (36)Dhruva BiswasNicolai BirkbakRachel Rosenthal Crispin T HileyEmilia Lim Krisztian Papp[...] Zoltan Szallasi Javier Herrero Nicholas McGranahanCharles Swanton TRACERx Consortium Nature Medicine Published 7 October 2019 Crick labs/ facilitiesCharles SwantonBioinformatics and BiostatisticsAdvanced SequencingFull details Pulmonary venous circulating tumor cell dissemination before tumor resection and disease relapse Authors (35) Francesca Chemi Dominic G Rothwell Nicholas McGranahan Sakshi Gulati Chris Abbosh Simon P Pearce[...] Allan Hackshaw Ged BradyCharles Swanton Caroline Dive TRACERx Consortium Nature Medicine Published 7 October 2019 Crick labsCharles SwantonFull details Spatial heterogeneity of the T cell receptor repertoire reflects the mutational landscape in lung cancer Authors (35) Kroopa Joshi Marc Robert de Massy Mazlina Ismail James L Reading Imran Uddin Annemarie Woolston[...] Nicholas McGranahanCharles Swanton TRACERx Consortium Sergio A Quezada Benny Chain Nature Medicine Published 7 October 2019 Crick labsCharles SwantonFull details UVB-induced tumor heterogeneity diminishes immune response in melanoma Authors (29) Yochai Wolf Osnat Bartok Sushant Patkar Gitit Bar Eli Sapir CohenKevin Litchfield[...] Lea Eisenbach Arie AdmonCharles Swanton Eytan Ruppin Yardena Samuels Cell Published 19 September 2019 Crick labsCharles SwantonFull details Neoantigen quality, not quantity Authors (2) Nicholas McGranahanCharles Swanton Science Translational Medicine Published 21 August 2019 Crick labsCharles SwantonFull details Spatial and temporal heterogeneity of panel-based tumor mutational burden in pulmonary adenocarcinoma: separating biology from technical artifacts Authors (33) Daniel Kazdal Volker Endris Michael Allgäuer Mark Kriegsmann Jonas Leichsenring Anna-Lena Volckmar[...]Charles Swanton Michael Thomas Peter Schirmacher Jan Budczies Albrecht Stenzinger Journal of Thoracic Oncology Published 1 November 2019 Crick labsCharles SwantonFull details Optimizing panel-based tumor mutational burden (TMB) measurement Authors (13) J Budczies M AllgäuerKevin Litchfield E Rempel P Christopoulos D Kazdal[...] S Fröhling S PetersCharles Swanton P Schirmacher A Stenzinger Annals of Oncology Published 1 September 2019 Crick labsCharles SwantonFull details An emerging regulatory network of NHEJ via DYNLL1-mediated 53BP1 redistribution Authors (3)Lykourgos-Panagiotis ZalmasWei-Ting Lu Nnennaya Kanu Annals of Translational Medicine Published 1 July 2019 Crick labsCharles SwantonFull details An immunotherapy survivor population: health-related quality of life and toxicity in patients with metastatic melanoma treated with immune checkpoint inhibitors Authors (18) Aine O'Reilly Peta Hughes Jasmine Mann Zhuangming Lai Jhia Jiat Teh Emma Mclean[...] Theresa WisemanSamra Turajlic Martin Gore James Larkin Olga Husson Supportive Care in Cancer Published 1 February 2020 Crick labsSamra TurajlicCharles SwantonFull details Resolving genetic heterogeneity in cancer Authors (4)Samra Turajlic Andrea Sottoriva Trevor GrahamCharles Swanton Nature Reviews Genetics Published 1 July 2019 Crick labsSamra TurajlicCharles SwantonFull details Predicting response to cancer immunotherapy using noninvasive radiomic biomarkers Authors (18) S Trebeschi SG DragoNicolai Birkbak I Kurilova AM Cǎlin A Delli Pizzi[...] JBAG Haanen CU Blank EF Smit RGH Beets-Tan HJWL Aerts Annals of Oncology Published 1 June 2019 Crick labsCharles SwantonFull details Prospective analysis of 895 patients on a UK Genomics Review Board Authors (15) DA Moore M Kushnir G Mak H Winter T Curiel M Voskoboynik[...] M Forster A Kulkarni D HaynesCharles Swanton H-T Arkenau ESMO Open Published 21 March 2019 Crick labsCharles SwantonFull details Neoantigen-directed immune escape in lung cancer evolution Authors (29)Rachel RosenthalElizabeth Larose Cadieux Roberto SalgadoMaise Al Bakir David A Moore Crispin T Hiley[...]Peter Van Loo Stephan Beck Nicholas McGranahanCharles Swanton The TRACERx Consortium Nature Published 20 March 2019 Crick labs/ facilitiesPeter Van LooCharles SwantonExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Pertuzumab plus trastuzumab for HER2-amplified metastatic colorectal cancer (MyPathway): an updated report from a multicentre, open-label, phase 2a, multiple basket study Authors (18) Funda Meric-Bernstam Herbert Hurwitz Kanwal Pratap Singh Raghav Robert R McWilliams Marwan Fakih Ari VanderWalde[...] Steven Blotner Alyssa Stone Katja Schulze Vaikunth Cuchelkar John Hainsworth Lancet Oncology Published 4 April 2019 Crick labsCharles SwantonFull details Standing on the shoulders of giants Authors (1)Samra Turajlic Nature Medicine Published 6 March 2019 Crick labsSamra TurajlicCharles SwantonFull details Searching for the needle in the haystack: deconvoluting the evolutionary dynamics of residual disease in human glioblastoma Authors (3)Scott ShepherdKevin LitchfieldSamra Turajlic Annals of Oncology Published 1 March 2019 Crick labsSamra TurajlicCharles SwantonFull details Artificial intelligence in cancer imaging: Clinical challenges and applications Authors (19) Wenya Linda Bi Ahmed Hosny Matthew B Schabath Maryellen L GigerNicolai Birkbak Alireza Mehrtash[...] Udo Hoffmann Lawrence H Schwartz Robert J Gillies Raymond Y Huang Hugo JWL Aerts CA: a cancer journal for clinicians Published 5 February 2019 Crick labsCharles SwantonFull details Deciphering the genomic, epigenomic, and transcriptomic landscapes of pre-invasive lung cancer lesions Authors (32) Vitor H Teixeira Christodoulos P Pipinikas Adam Pennycuick Henry Lee-Six Deepak Chandrasekharan Jennifer Beane[...] Phillip Jeremy George Avrum Spira Peter J Campbell Christina Thirlwell Sam M Janes Nature Medicine Published 21 January 2019 Crick labsCharles SwantonFull details Clonal haematopoiesis: a source of biological noise in cell-free DNA analyses Authors (3) C AbboshCharles SwantonNicolai Birkbak Annals of Oncology Published 15 January 2019 Crick labsCharles SwantonFull details Pagination Current page 1 Page 2 Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Tumour mutational burden: primary versus metastatic tissue creates systematic bias Authors (3)Desiree SchnidrigSamra TurajlicKevin Litchfield Immuno-Oncology and Technology Published 1 December 2019 Crick labsSamra TurajlicCharles SwantonFull details
A clonal expression biomarker associates with lung cancer mortality Authors (36)Dhruva BiswasNicolai BirkbakRachel Rosenthal Crispin T HileyEmilia Lim Krisztian Papp[...] Zoltan Szallasi Javier Herrero Nicholas McGranahanCharles Swanton TRACERx Consortium Nature Medicine Published 7 October 2019 Crick labs/ facilitiesCharles SwantonBioinformatics and BiostatisticsAdvanced SequencingFull details
Pulmonary venous circulating tumor cell dissemination before tumor resection and disease relapse Authors (35) Francesca Chemi Dominic G Rothwell Nicholas McGranahan Sakshi Gulati Chris Abbosh Simon P Pearce[...] Allan Hackshaw Ged BradyCharles Swanton Caroline Dive TRACERx Consortium Nature Medicine Published 7 October 2019 Crick labsCharles SwantonFull details
Spatial heterogeneity of the T cell receptor repertoire reflects the mutational landscape in lung cancer Authors (35) Kroopa Joshi Marc Robert de Massy Mazlina Ismail James L Reading Imran Uddin Annemarie Woolston[...] Nicholas McGranahanCharles Swanton TRACERx Consortium Sergio A Quezada Benny Chain Nature Medicine Published 7 October 2019 Crick labsCharles SwantonFull details
UVB-induced tumor heterogeneity diminishes immune response in melanoma Authors (29) Yochai Wolf Osnat Bartok Sushant Patkar Gitit Bar Eli Sapir CohenKevin Litchfield[...] Lea Eisenbach Arie AdmonCharles Swanton Eytan Ruppin Yardena Samuels Cell Published 19 September 2019 Crick labsCharles SwantonFull details
Neoantigen quality, not quantity Authors (2) Nicholas McGranahanCharles Swanton Science Translational Medicine Published 21 August 2019 Crick labsCharles SwantonFull details
Spatial and temporal heterogeneity of panel-based tumor mutational burden in pulmonary adenocarcinoma: separating biology from technical artifacts Authors (33) Daniel Kazdal Volker Endris Michael Allgäuer Mark Kriegsmann Jonas Leichsenring Anna-Lena Volckmar[...]Charles Swanton Michael Thomas Peter Schirmacher Jan Budczies Albrecht Stenzinger Journal of Thoracic Oncology Published 1 November 2019 Crick labsCharles SwantonFull details
Optimizing panel-based tumor mutational burden (TMB) measurement Authors (13) J Budczies M AllgäuerKevin Litchfield E Rempel P Christopoulos D Kazdal[...] S Fröhling S PetersCharles Swanton P Schirmacher A Stenzinger Annals of Oncology Published 1 September 2019 Crick labsCharles SwantonFull details
An emerging regulatory network of NHEJ via DYNLL1-mediated 53BP1 redistribution Authors (3)Lykourgos-Panagiotis ZalmasWei-Ting Lu Nnennaya Kanu Annals of Translational Medicine Published 1 July 2019 Crick labsCharles SwantonFull details
An immunotherapy survivor population: health-related quality of life and toxicity in patients with metastatic melanoma treated with immune checkpoint inhibitors Authors (18) Aine O'Reilly Peta Hughes Jasmine Mann Zhuangming Lai Jhia Jiat Teh Emma Mclean[...] Theresa WisemanSamra Turajlic Martin Gore James Larkin Olga Husson Supportive Care in Cancer Published 1 February 2020 Crick labsSamra TurajlicCharles SwantonFull details
Resolving genetic heterogeneity in cancer Authors (4)Samra Turajlic Andrea Sottoriva Trevor GrahamCharles Swanton Nature Reviews Genetics Published 1 July 2019 Crick labsSamra TurajlicCharles SwantonFull details
Predicting response to cancer immunotherapy using noninvasive radiomic biomarkers Authors (18) S Trebeschi SG DragoNicolai Birkbak I Kurilova AM Cǎlin A Delli Pizzi[...] JBAG Haanen CU Blank EF Smit RGH Beets-Tan HJWL Aerts Annals of Oncology Published 1 June 2019 Crick labsCharles SwantonFull details
Prospective analysis of 895 patients on a UK Genomics Review Board Authors (15) DA Moore M Kushnir G Mak H Winter T Curiel M Voskoboynik[...] M Forster A Kulkarni D HaynesCharles Swanton H-T Arkenau ESMO Open Published 21 March 2019 Crick labsCharles SwantonFull details
Neoantigen-directed immune escape in lung cancer evolution Authors (29)Rachel RosenthalElizabeth Larose Cadieux Roberto SalgadoMaise Al Bakir David A Moore Crispin T Hiley[...]Peter Van Loo Stephan Beck Nicholas McGranahanCharles Swanton The TRACERx Consortium Nature Published 20 March 2019 Crick labs/ facilitiesPeter Van LooCharles SwantonExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Pertuzumab plus trastuzumab for HER2-amplified metastatic colorectal cancer (MyPathway): an updated report from a multicentre, open-label, phase 2a, multiple basket study Authors (18) Funda Meric-Bernstam Herbert Hurwitz Kanwal Pratap Singh Raghav Robert R McWilliams Marwan Fakih Ari VanderWalde[...] Steven Blotner Alyssa Stone Katja Schulze Vaikunth Cuchelkar John Hainsworth Lancet Oncology Published 4 April 2019 Crick labsCharles SwantonFull details
Standing on the shoulders of giants Authors (1)Samra Turajlic Nature Medicine Published 6 March 2019 Crick labsSamra TurajlicCharles SwantonFull details
Searching for the needle in the haystack: deconvoluting the evolutionary dynamics of residual disease in human glioblastoma Authors (3)Scott ShepherdKevin LitchfieldSamra Turajlic Annals of Oncology Published 1 March 2019 Crick labsSamra TurajlicCharles SwantonFull details
Artificial intelligence in cancer imaging: Clinical challenges and applications Authors (19) Wenya Linda Bi Ahmed Hosny Matthew B Schabath Maryellen L GigerNicolai Birkbak Alireza Mehrtash[...] Udo Hoffmann Lawrence H Schwartz Robert J Gillies Raymond Y Huang Hugo JWL Aerts CA: a cancer journal for clinicians Published 5 February 2019 Crick labsCharles SwantonFull details
Deciphering the genomic, epigenomic, and transcriptomic landscapes of pre-invasive lung cancer lesions Authors (32) Vitor H Teixeira Christodoulos P Pipinikas Adam Pennycuick Henry Lee-Six Deepak Chandrasekharan Jennifer Beane[...] Phillip Jeremy George Avrum Spira Peter J Campbell Christina Thirlwell Sam M Janes Nature Medicine Published 21 January 2019 Crick labsCharles SwantonFull details
Clonal haematopoiesis: a source of biological noise in cell-free DNA analyses Authors (3) C AbboshCharles SwantonNicolai Birkbak Annals of Oncology Published 15 January 2019 Crick labsCharles SwantonFull details