Research case studies Explore a selection of reports that spotlight particular areas of research at the Crick over the past five years.
Postdoctoral clinical fellows Opportunities for postdoctoral clinicians to consolidate their research experience.
Breadcrumb Charles Swanton Swanton lab Cancer Evolution and Genome Instability Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members Vacancies Illustration of chromosomes from a cancer cell showing large-scale alterations. Toggle to view hero caption PublicationsYear published2024 (4)2023 (44)2022 (26)2021 (40)2020 (43)2019 (26)2018 (27)2017 (36)2016 (24)2015 (28)2014 (28)2013 (24)2012 (18)2011 (11)2010 (12) Facet Year publishedResearch topicsTumour Biology (288)Genetics & Genomics (287)Genome Integrity & Repair (287)Computational & Systems Biology (286)Human Biology & Physiology (286)Chemical Biology & High Throughput (285)Signalling & Oncogenes (285)Model Organisms (58)Cell Biology (55)Immunology (45)Stem Cells (45)Cell Cycle & Chromosomes (42)Infectious Disease (35)Structural Biology & Biophysics (32)Metabolism (30)Neurosciences (30)Biochemistry & Proteomics (25)Gene Expression (20)Developmental Biology (19)Imaging (19)Synthetic Biology (4)Microfabrication & Bioengineering (2) Facet Research topicsPublication typeJournal article (391)Primary research (216)Review (107)Commentary (31)Letter (17)Editorial (10)Method (5)Biography (1)Book review (1)Obituary (1)Policy letter (1) Facet Publication typeJournalAnnals of Oncology (38)Nature (18)Cancer Discovery (16)Cancer Cell (14)Nature Communications (14)Cancer Research (13)Cell (12)Nature Cancer (11)Nature Medicine (11)Nature Reviews Clinical Oncology (10)The Lancet (10)Lancet Oncology (9)Nature Genetics (8)British Journal of Cancer (7)Genome Biology (7)Journal of Pathology (7)New England Journal of Medicine (7)EPMA Journal (5)Journal of Clinical Oncology (5)Science (5)Science Translational Medicine (5)Lancet (4)npj Breast Cancer (4)Oncogene (4)PLOS ONE (4)Cell Reports (3)Clinical cancer research (3)Cold Spring Harbor Perspectives in Medicine (3)European Journal of Cancer (3)European Urology (3)Frontiers in Oncology (3)Nature Biotechnology (3)PLOS Medicine (3)The Lancet Oncology (3)Annual Review of Cancer Biology (2)ASCO Educational Book (2)Autophagy (2)Breast Cancer Research (2)Breast Cancer Research and Treatment (2)Cancer Prevention Research (2)Gastroenterology (2)Genome Medicine (2)Immunity (2)Journal of Cell Science (2)Journal of Clinical Investigation (2)Journal of Experimental Medicine (2)Journal of Thoracic Oncology (2)Lancet Infectious Diseases (2)Methods in Molecular Biology (2)Nature Ecology and Evolution (2)Nature Reviews Urology (2)Oncologist (2)Oncotarget (2)PLOS Biology (2)Trends in Cancer (2)American Journal of Pathology (1)Annals of the New York Academy of Sciences (1)Annals of Translational Medicine (1)Annual Review of Genetics (1)Biochemical Pharmacology (1)Biochemical Society Transactions (1)Biochimica et Biophysica Acta (1)BJU international (1)BMC Bioinformatics (1)BMC Medical Genomics (1)BMC Medicine (1)BMJ (1)Breast (1)CA: a cancer journal for clinicians (1)Cancer Epidemiology, Biomarkers & Prevention (1)Cancer Immunology, Immunotherapy (1)Cancer Letters (1)Cancers (Basel) (1)Cell Cycle (1)Cell Reports Medicine (1)Clinical Chemistry (1)Clinical Medicine (1)Clinical Oncology (1)Current Biology (1)Current Cancer Drug Targets (1)Current Opinion in Genetics & Development (1)Current Opinion in Pharmacology (1)Current Opinion in Systems Biology (1)Current Opinion in Urology (1)Disease Models & Mechanisms (1)Drugs (1)eLife (1)EMBO Molecular Medicine (1)EMBO Reports (1)Epilepsy and Behavior (1)ESMO Open (1)Evolutionary Applications (1)Expert Review of Anticancer Therapy (1)Frontiers in Pharmacology (1)G3 (1)Immuno-Oncology and Technology (1)Immunological Reviews (1)International Journal of Cancer (1)Investigational New Drugs (1)Journal for ImmunoTherapy of Cancer (1)Journal of Cellular Biochemistry (1)Journal of hepatology (1)Journal of the Royal Society of Medicine (1)Molecular & Cellular Oncology (1)Molecular and Cellular Oncology (1)Molecular Oncology (1)Mutagenesis (1)NAR Cancer (1)Nature Aging (1)Nature Protocols (1)Nature Reviews Cancer (1)Nature Reviews Disease Primers (1)Nature Reviews Drug Discovery (1)Nature Reviews Genetics (1)Neuro-Oncology (1)Nucleic Acids Research (1)Open Biology (1)Orvosi Hetilap (1)PLoS Computational Biology (1)Preventive Medicine (1)Proceedings of the National Academy of Sciences of USA (1)Scientific Reports (1)Seminars in Cancer Biology (1)Stem Cell Reports (1)Supportive Care in Cancer (1)The EMBO Journal (1)Trends in Cell Biology (1)Tumori Journal (1)Wellcome Open Research (1) Facet Journal Publications Displaying 341 - 360 of 391Last updated : 28 March 2024 02:31 Utility of prognostic genomic tests in breast cancer practice: The IMPAKT 2012 Working Group Consensus Statement Authors (12) HA Azim S Michiels F Zagouri S Delaloge M Filipits M Namer[...] WF Symmans A Thompson F André S LoiCharles Swanton Annals of Oncology Published 1 March 2013 Crick labsCharles SwantonFull details Replication stress links structural and numerical cancer chromosomal instability Authors (21) Rebecca A Burrell Sarah E McClelland David Endesfelder Petra Groth Marie-Christine Weller Nadeem Shaikh[...]Axel Behrens Thomas Helleday Jiri Bartek Ian P TomlinsonCharles Swanton Nature Published 28 February 2013 Crick labs/ facilitiesCharles SwantonAxel BehrensHigh Throughput ScreeningFull details Cancer heterogeneity: implications for targeted therapeutics Authors (3) R Fisher L PusztaiCharles Swanton British Journal of Cancer Published 19 February 2013 Crick labsCharles SwantonFull details A phase 1 study evaluating the combination of an allosteric AKT inhibitor (MK-2206) and trastuzumab in patients with HER2-positive solid tumors Authors (17) Clifford HudisCharles Swanton Yelena Y Janjigian Ray Lee Stephanie Sutherland Robert Lehman[...] Ernestina Tetteh Daniel M Sullivan Carolina Moreno Li Yan Hyo Sook Han Breast Cancer Research Published 1 January 2013 Crick labsCharles SwantonFull details Computational optimisation of targeted DNA sequencing for cancer detection Authors (5) Pierre Martinez Nicholas McGranahanNicolai Birkbak Marco GerlingerCharles Swanton Scientific Reports Published 1 January 2013 Crick labsCharles SwantonFull details Intra-tumor heterogeneity: lessons from microbial evolution and clinical implications Authors (3) Elza C de Bruin Tiffany B TaylorCharles Swanton Genome Medicine Published 1 January 2013 Crick labsCharles SwantonFull details Modelling the evolution of genetic instability during tumour progression Authors (5) Ruchira S Datta Alice GutteridgeCharles Swanton Carlo C Maley Trevor A Graham Evolutionary Applications Published 1 January 2013 Crick labsCharles SwantonFull details Molecular profiling and the reclassification of cancer: divide and conquer Authors (3) Javier MunozCharles Swanton Razelle Kurzrock ASCO Educational Book Published 1 January 2013 Crick labsCharles SwantonFull details Plasma-derived tumor DNA analysis at whole-genome resolution Authors (1)Charles Swanton Clinical Chemistry Published 1 January 2013 Crick labsCharles SwantonFull details The CIN4 chromosomal instability qPCR classifier defines tumor aneuploidy and stratifies outcome in grade 2 breast cancer Authors (13) Attila Marcell Szász Qiyuan Li Aron C Eklund Zsófia SztupinszkiAndrew Rowan Anna-Mária Tökes[...] Miklós Szendrői Balázs Győrffy Zoltán SzállásiCharles Swanton Janina Kulka PLOS ONE Published 1 January 2013 Crick labsCharles SwantonFull details General Report & recommendations in predictive, preventive and personalised medicine 2012: White paper of the European Association for Predictive, Preventive and Personalised Medicine Authors (95) O Golubnitschaja V Costigliola EPMA A Benini J Kastrup L Berliner[...] G Vittadini J Walkenhorst K Yamagishi H Yatsuya X Zhan EPMA Journal Published 1 November 2012 Crick labsCharles SwantonFull details The centriolar satellite protein Cep131 is important for genome stability Authors (9) Christopher J Staples Katie N Myers Ryan DD Beveridge Abhijit A PatilAlvin LeeCharles SwantonMichael HowellSimon Boulton Spencer J Collis Journal of Cell Science Published 15 October 2012 Crick labs/ facilitiesCharles SwantonSimon BoultonHigh Throughput ScreeningFull details Intratumor heterogeneity: evolution through space and time Authors (1)Charles Swanton Cancer Research Published 1 October 2012 Crick labsCharles SwantonFull details Genomic analyses to select patients for adjuvant chemotherapy: trials and tribulations Authors (3) B Weigelt JS Reis-FilhoCharles Swanton Annals of Oncology Published 1 September 2012 Crick labsCharles SwantonFull details Cancer chromosomal instability: therapeutic and diagnostic challenges Authors (5) Nicholas McGranahan Rebecca A Burrell David Endesfelder Marco R NovelliCharles Swanton EMBO Reports Published 1 June 2012 Crick labsCharles SwantonFull details Genome-wide RNA interference analysis of renal carcinoma survival regulators identifies MCT4 as a Warburg effect metabolic target Authors (17) Marco Gerlinger Claudio R Santos Bradley Spencer-Dene Pierre Martinez David Endesfelder Rebecca A Burrell[...] Gordon Stamp Jean Jacques Patard James LarkinMichael HowellCharles Swanton Journal of Pathology Published 1 June 2012 Crick labs/ facilitiesCharles SwantonHigh Throughput ScreeningExperimental HistopathologyBioinformatics and BiostatisticsFull details The authors reply Authors (3)Charles Swanton J Larkin M Gerlinger New England Journal of Medicine Published 31 May 2012 Crick labsCharles SwantonFull details A whole-genome massively parallel sequencing analysis of BRCA1 mutant oestrogen receptor-negative and -positive breast cancers Authors (33) Rachael Natrajan Alan Mackay Maryou B Lambros Britta Weigelt Paul M Wilkerson Elodie Manie[...] William D Foulkes Anne Vincent-Salomon Alan Ashworth Marc Henri Stern Jorge S Reis-Filho Journal of Pathology Published 1 May 2012 Crick labsCharles SwantonFull details Tumour heterogeneity and drug resistance: personalising cancer medicine through functional genomics Authors (2)Alvin LeeCharles Swanton Biochemical Pharmacology Published 15 April 2012 Crick labsCharles SwantonFull details Guidelines for the use and interpretation of assays for monitoring autophagy Authors (1270) Daniel J Klionsky Fabio C Abdalla Hagai Abeliovich Robert T Abraham Abraham Acevedo-Arozena Khosrow Adeli[...] Teresa Zoladek Wei-Xing Zong Antonio Zorzano Jürgen Zschocke Brian Zuckerbraun Autophagy Published 1 April 2012 Crick labsCharles SwantonFull details Pagination First page First Previous page Previous … Page 12 Page 13 Page 14 Page 15 Page 16 Page 17 Current page 18 Page 19 Page 20 Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Utility of prognostic genomic tests in breast cancer practice: The IMPAKT 2012 Working Group Consensus Statement Authors (12) HA Azim S Michiels F Zagouri S Delaloge M Filipits M Namer[...] WF Symmans A Thompson F André S LoiCharles Swanton Annals of Oncology Published 1 March 2013 Crick labsCharles SwantonFull details
Replication stress links structural and numerical cancer chromosomal instability Authors (21) Rebecca A Burrell Sarah E McClelland David Endesfelder Petra Groth Marie-Christine Weller Nadeem Shaikh[...]Axel Behrens Thomas Helleday Jiri Bartek Ian P TomlinsonCharles Swanton Nature Published 28 February 2013 Crick labs/ facilitiesCharles SwantonAxel BehrensHigh Throughput ScreeningFull details
Cancer heterogeneity: implications for targeted therapeutics Authors (3) R Fisher L PusztaiCharles Swanton British Journal of Cancer Published 19 February 2013 Crick labsCharles SwantonFull details
A phase 1 study evaluating the combination of an allosteric AKT inhibitor (MK-2206) and trastuzumab in patients with HER2-positive solid tumors Authors (17) Clifford HudisCharles Swanton Yelena Y Janjigian Ray Lee Stephanie Sutherland Robert Lehman[...] Ernestina Tetteh Daniel M Sullivan Carolina Moreno Li Yan Hyo Sook Han Breast Cancer Research Published 1 January 2013 Crick labsCharles SwantonFull details
Computational optimisation of targeted DNA sequencing for cancer detection Authors (5) Pierre Martinez Nicholas McGranahanNicolai Birkbak Marco GerlingerCharles Swanton Scientific Reports Published 1 January 2013 Crick labsCharles SwantonFull details
Intra-tumor heterogeneity: lessons from microbial evolution and clinical implications Authors (3) Elza C de Bruin Tiffany B TaylorCharles Swanton Genome Medicine Published 1 January 2013 Crick labsCharles SwantonFull details
Modelling the evolution of genetic instability during tumour progression Authors (5) Ruchira S Datta Alice GutteridgeCharles Swanton Carlo C Maley Trevor A Graham Evolutionary Applications Published 1 January 2013 Crick labsCharles SwantonFull details
Molecular profiling and the reclassification of cancer: divide and conquer Authors (3) Javier MunozCharles Swanton Razelle Kurzrock ASCO Educational Book Published 1 January 2013 Crick labsCharles SwantonFull details
Plasma-derived tumor DNA analysis at whole-genome resolution Authors (1)Charles Swanton Clinical Chemistry Published 1 January 2013 Crick labsCharles SwantonFull details
The CIN4 chromosomal instability qPCR classifier defines tumor aneuploidy and stratifies outcome in grade 2 breast cancer Authors (13) Attila Marcell Szász Qiyuan Li Aron C Eklund Zsófia SztupinszkiAndrew Rowan Anna-Mária Tökes[...] Miklós Szendrői Balázs Győrffy Zoltán SzállásiCharles Swanton Janina Kulka PLOS ONE Published 1 January 2013 Crick labsCharles SwantonFull details
General Report & recommendations in predictive, preventive and personalised medicine 2012: White paper of the European Association for Predictive, Preventive and Personalised Medicine Authors (95) O Golubnitschaja V Costigliola EPMA A Benini J Kastrup L Berliner[...] G Vittadini J Walkenhorst K Yamagishi H Yatsuya X Zhan EPMA Journal Published 1 November 2012 Crick labsCharles SwantonFull details
The centriolar satellite protein Cep131 is important for genome stability Authors (9) Christopher J Staples Katie N Myers Ryan DD Beveridge Abhijit A PatilAlvin LeeCharles SwantonMichael HowellSimon Boulton Spencer J Collis Journal of Cell Science Published 15 October 2012 Crick labs/ facilitiesCharles SwantonSimon BoultonHigh Throughput ScreeningFull details
Intratumor heterogeneity: evolution through space and time Authors (1)Charles Swanton Cancer Research Published 1 October 2012 Crick labsCharles SwantonFull details
Genomic analyses to select patients for adjuvant chemotherapy: trials and tribulations Authors (3) B Weigelt JS Reis-FilhoCharles Swanton Annals of Oncology Published 1 September 2012 Crick labsCharles SwantonFull details
Cancer chromosomal instability: therapeutic and diagnostic challenges Authors (5) Nicholas McGranahan Rebecca A Burrell David Endesfelder Marco R NovelliCharles Swanton EMBO Reports Published 1 June 2012 Crick labsCharles SwantonFull details
Genome-wide RNA interference analysis of renal carcinoma survival regulators identifies MCT4 as a Warburg effect metabolic target Authors (17) Marco Gerlinger Claudio R Santos Bradley Spencer-Dene Pierre Martinez David Endesfelder Rebecca A Burrell[...] Gordon Stamp Jean Jacques Patard James LarkinMichael HowellCharles Swanton Journal of Pathology Published 1 June 2012 Crick labs/ facilitiesCharles SwantonHigh Throughput ScreeningExperimental HistopathologyBioinformatics and BiostatisticsFull details
The authors reply Authors (3)Charles Swanton J Larkin M Gerlinger New England Journal of Medicine Published 31 May 2012 Crick labsCharles SwantonFull details
A whole-genome massively parallel sequencing analysis of BRCA1 mutant oestrogen receptor-negative and -positive breast cancers Authors (33) Rachael Natrajan Alan Mackay Maryou B Lambros Britta Weigelt Paul M Wilkerson Elodie Manie[...] William D Foulkes Anne Vincent-Salomon Alan Ashworth Marc Henri Stern Jorge S Reis-Filho Journal of Pathology Published 1 May 2012 Crick labsCharles SwantonFull details
Tumour heterogeneity and drug resistance: personalising cancer medicine through functional genomics Authors (2)Alvin LeeCharles Swanton Biochemical Pharmacology Published 15 April 2012 Crick labsCharles SwantonFull details
Guidelines for the use and interpretation of assays for monitoring autophagy Authors (1270) Daniel J Klionsky Fabio C Abdalla Hagai Abeliovich Robert T Abraham Abraham Acevedo-Arozena Khosrow Adeli[...] Teresa Zoladek Wei-Xing Zong Antonio Zorzano Jürgen Zschocke Brian Zuckerbraun Autophagy Published 1 April 2012 Crick labsCharles SwantonFull details