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Breadcrumb Charles Swanton Swanton lab Cancer Evolution and Genome Instability Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members Vacancies Illustration of chromosomes from a cancer cell showing large-scale alterations. 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80 of 396Last updated : 20 April 2024 02:18 Cell-free DNA-based multi-cancer early detection test in an asymptomatic screening population (NHS-Galleri): Design of a pragmatic, prospective randomised controlled trial Authors (8) Richard D Neal Peter Johnson Christina A Clarke Stephanie A Hamilton Nan Zhang Harpal KumarCharles Swanton Peter Sasieni Cancers (Basel) Published 1 October 2022 Crick labsCharles SwantonFull details Functional immune responses against SARS-CoV-2 variants of concern after fourth COVID-19 vaccine dose or infection in patients with blood cancer Authors (64)Annika FendlerScott ShepherdLewis AuMary Wu Ruth HarveyKatalin Wilkinson[...] Emma Nicholson Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic Cell Reports Medicine Published 18 October 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyMetabolomicsHigh Throughput ScreeningScientific computingFull details RAS oncogenic activity predicts response to chemotherapy and outcome in lung adenocarcinoma Authors (11)Phil EastGavin KellyDhruva Biswas Michela MaraniDavid Hancock Todd Creasy Kris SachsenmeierCharles Swanton TRACERx consortiumJulian DownwardSophie de Carne Nature Communications Published 26 September 2022 Crick labs/ facilitiesCharles SwantonJulian DownwardBioinformatics and BiostatisticsFull details Leveraging extrachromosomal DNA to fine-tune trials of targeted therapy for glioblastoma: opportunities and challenges Authors (3)Imran Noorani Paul S MischelCharles Swanton Nature Reviews Clinical Oncology Published 1 November 2022 Crick labsCharles SwantonFull details The evolutionary dynamics of extrachromosomal DNA in human cancers Authors (22) Joshua T Lange John C Rose Celine Y Chen Yuriy Pichugin Liangqi Xie Jun Tang[...] Howard Y Chang Vineet Bafna Anton G Henssen Benjamin Werner Paul S Mischel Nature Genetics Published 1 October 2022 Crick labsCharles SwantonFull details An immunogenic model of KRAS-mutant lung cancer enables evaluation of targeted therapy and immunotherapy combinations Authors (26)Jesse BoumelhaSophie de Carne Emily K Law Pablo Romero-Clavijo Matthew A CoelhoKevin Ng[...]George KassiotisMiriam Molina ArcasCharles Swanton Reuben HarrisJulian Downward Cancer Research Published 1 October 2022 Crick labs/ facilitiesCharles SwantonGeorge KassiotisJulian DownwardExperimental HistopathologyBioinformatics and BiostatisticsScientific computingFlow CytometryCell ServicesBiological Research FacilityFull details SARS-CoV-2 S2-targeted vaccination elicits broadly neutralizing antibodies Authors (21)Kevin NgNikhil FaulknerKatja FinsterbuschMary Wu Ruth HarveySaira Hussain[...]Michael Howell Hisashi AraseAndreas WackDavid LV BauerGeorge Kassiotis Science Translational Medicine Published 27 July 2022 Crick labs/ facilitiesAndreas WackCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinPeter Cherepanov Rupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningFlow CytometryCell ServicesBiological Research FacilityFull details When can we be confident of surgical cure with ctDNA? Authors (2)Alexander Frankell Mariam Jamal-Hanjani Nature Reviews Clinical Oncology Published 1 September 2022 Crick labsCharles SwantonFull details CKS1 inhibition depletes leukemic stem cells and protects healthy hematopoietic stem cells in acute myeloid leukemia Authors (14)William Grey Ana Rio-Machin Pedro CasadoEva GronroosSara Ali Juho J Miettinen[...]Charles Swanton Pedro R Cutillas John Gribben Jude FitzgibbonDominique Bonnet Science Translational Medicine Published 22 June 2022 Crick labs/ facilitiesCharles SwantonDominique BonnetFlow CytometryCell ServicesBiological Research FacilityFull details Estimation of tumor cell total mRNA expression in 15 cancer types predicts disease progression Authors (40) Shaolong Cao Jennifer R Wang Shuangxi Ji Peng Yang Yaoyi Dai Shuai Guo[...] Hongtu Zhu Alfonso UrbanucciJonas DemeulemeesterPeter Van Loo Wenyi Wang Nature Biotechnology Published 1 November 2022 Crick labsPeter Van LooCharles SwantonFull details A local human Vδ1 T cell population is associated with survival in nonsmall-cell lung cancer Authors (21) Yin WuDhruva Biswas Ieva UsaiteMihaela AngelovaStefan BoeingTakahiro Karasaki[...] Mariam Jamal-Hanjani Allan Hackshaw Sergio A QuezadaAdrian HaydayCharles Swanton Nature Cancer Published 1 June 2022 Crick labs/ facilitiesCharles SwantonAdrian HaydayBioinformatics and BiostatisticsFull details Allele-informed copy number evaluation of plasma DNA samples from metastatic prostate cancer patients: the PCF_SELECT consortium assay Authors (259) Francesco Orlando Alessandro Romanel Blanca Trujillo Michael Sigouros Daniel Wetterskog Orsetta Quaini[...] Mark A Rubin Alexander W Wyatt Himisha Beltran Gerhardt Attard Francesca Demichelis NAR Cancer Published 8 April 2022 Crick labsCharles SwantonFull details The translational challenges of precision oncology Authors (6) Oriol Pich Chris BaileyTom Watkins Simone Zaccaria Mariam Jamal-HanjaniCharles Swanton Cancer Cell Published 9 May 2022 Crick labsCharles SwantonFull details Combinatorial inactivation of tumor suppressors efficiently initiates lung adenocarcinoma with therapeutic vulnerabilities Authors (22) Maryam Yousefi Gábor Boross Carly Weiss Christopher W Murray Jess D Hebert Hongchen Cai[...] Pauline ChuCharles Swanton Christian A Kunder Dmitri A Petrov Monte M Winslow Cancer Research Published 15 April 2022 Crick labsCharles SwantonFull details Immune determinants of the association between tumor mutational burden and immunotherapy response across cancer types Authors (9) Neelam Sinha Sanju Sinha Cristina Valero Alejandro A Schäffer Kenneth AldapeKevin Litchfield Timothy A Chan Luc GT Morris Eytan Ruppin Cancer Research Published 6 June 2022 Crick labsCharles SwantonFull details Omicron neutralising antibodies after third COVID-19 vaccine dose in patients with cancer Authors (62)Annika FendlerScott ShepherdLewis AuMary Wu Ruth Harvey Andreas M Schmitt[...] Emma Nicholson Susanna Walker James LarkinSamra Turajlic The CAPTURE consortium The Lancet Published 5 March 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyMetabolomicsHigh Throughput ScreeningBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Omicron neutralising antibodies after COVID-19 vaccination in haemodialysis patients Authors (19)Edward CarrMary Wu Ruth Harvey Roseanne E Billany Emma C WallGavin Kelly[...] Rachel B Jones Rona M Smith Stephen McAdoo Michelle WillicombeRupert Beale The Lancet Published 26 February 2022 Crick labs/ facilitiesCharles SwantonGitta StockingerNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreHigh Throughput ScreeningBioinformatics and BiostatisticsFull details Three-dose vaccination elicits neutralising antibodies against omicron Authors (26)Mary Wu Emma C WallEdward Carr Ruth Harvey Hermaleigh TownsleyHarriet Mears[...] Vincenzo Libri Bryan WilliamsSonia GandhiCharles SwantonDavid LV Bauer The Lancet Published 19 February 2022 Crick labs/ facilitiesCharles SwantonGitta StockingerNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningBioinformatics and BiostatisticsScientific computingFull details APOBEC3 as a driver of genetic intratumor heterogeneity Authors (7)Mani VenkatesanMihaela Angelova Jirina Bartkova Samuel F Bakhoum Jiri Bartek Nnennaya KanuCharles Swanton Molecular and Cellular Oncology Published 1 January 2023 Crick labsCharles SwantonFull details Immune responses following third COVID-19 vaccination are reduced in patients with hematological malignancies compared to patients with solid cancer Authors (65)Annika FendlerScott ShepherdLewis AuKatalin WilkinsonMary Wu Andreas M Schmitt[...] Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic CAPTURE consortium Cancer Cell Published 14 February 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyProteomicsMetabolomicsHigh Throughput ScreeningBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Pagination First page First Previous page Previous Page 1 Page 2 Page 3 Current page 4 Page 5 Page 6 Page 7 Page 8 Page 9 … Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Cell-free DNA-based multi-cancer early detection test in an asymptomatic screening population (NHS-Galleri): Design of a pragmatic, prospective randomised controlled trial Authors (8) Richard D Neal Peter Johnson Christina A Clarke Stephanie A Hamilton Nan Zhang Harpal KumarCharles Swanton Peter Sasieni Cancers (Basel) Published 1 October 2022 Crick labsCharles SwantonFull details
Functional immune responses against SARS-CoV-2 variants of concern after fourth COVID-19 vaccine dose or infection in patients with blood cancer Authors (64)Annika FendlerScott ShepherdLewis AuMary Wu Ruth HarveyKatalin Wilkinson[...] Emma Nicholson Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic Cell Reports Medicine Published 18 October 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyMetabolomicsHigh Throughput ScreeningScientific computingFull details
RAS oncogenic activity predicts response to chemotherapy and outcome in lung adenocarcinoma Authors (11)Phil EastGavin KellyDhruva Biswas Michela MaraniDavid Hancock Todd Creasy Kris SachsenmeierCharles Swanton TRACERx consortiumJulian DownwardSophie de Carne Nature Communications Published 26 September 2022 Crick labs/ facilitiesCharles SwantonJulian DownwardBioinformatics and BiostatisticsFull details
Leveraging extrachromosomal DNA to fine-tune trials of targeted therapy for glioblastoma: opportunities and challenges Authors (3)Imran Noorani Paul S MischelCharles Swanton Nature Reviews Clinical Oncology Published 1 November 2022 Crick labsCharles SwantonFull details
The evolutionary dynamics of extrachromosomal DNA in human cancers Authors (22) Joshua T Lange John C Rose Celine Y Chen Yuriy Pichugin Liangqi Xie Jun Tang[...] Howard Y Chang Vineet Bafna Anton G Henssen Benjamin Werner Paul S Mischel Nature Genetics Published 1 October 2022 Crick labsCharles SwantonFull details
An immunogenic model of KRAS-mutant lung cancer enables evaluation of targeted therapy and immunotherapy combinations Authors (26)Jesse BoumelhaSophie de Carne Emily K Law Pablo Romero-Clavijo Matthew A CoelhoKevin Ng[...]George KassiotisMiriam Molina ArcasCharles Swanton Reuben HarrisJulian Downward Cancer Research Published 1 October 2022 Crick labs/ facilitiesCharles SwantonGeorge KassiotisJulian DownwardExperimental HistopathologyBioinformatics and BiostatisticsScientific computingFlow CytometryCell ServicesBiological Research FacilityFull details
SARS-CoV-2 S2-targeted vaccination elicits broadly neutralizing antibodies Authors (21)Kevin NgNikhil FaulknerKatja FinsterbuschMary Wu Ruth HarveySaira Hussain[...]Michael Howell Hisashi AraseAndreas WackDavid LV BauerGeorge Kassiotis Science Translational Medicine Published 27 July 2022 Crick labs/ facilitiesAndreas WackCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinPeter Cherepanov Rupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningFlow CytometryCell ServicesBiological Research FacilityFull details
When can we be confident of surgical cure with ctDNA? Authors (2)Alexander Frankell Mariam Jamal-Hanjani Nature Reviews Clinical Oncology Published 1 September 2022 Crick labsCharles SwantonFull details
CKS1 inhibition depletes leukemic stem cells and protects healthy hematopoietic stem cells in acute myeloid leukemia Authors (14)William Grey Ana Rio-Machin Pedro CasadoEva GronroosSara Ali Juho J Miettinen[...]Charles Swanton Pedro R Cutillas John Gribben Jude FitzgibbonDominique Bonnet Science Translational Medicine Published 22 June 2022 Crick labs/ facilitiesCharles SwantonDominique BonnetFlow CytometryCell ServicesBiological Research FacilityFull details
Estimation of tumor cell total mRNA expression in 15 cancer types predicts disease progression Authors (40) Shaolong Cao Jennifer R Wang Shuangxi Ji Peng Yang Yaoyi Dai Shuai Guo[...] Hongtu Zhu Alfonso UrbanucciJonas DemeulemeesterPeter Van Loo Wenyi Wang Nature Biotechnology Published 1 November 2022 Crick labsPeter Van LooCharles SwantonFull details
A local human Vδ1 T cell population is associated with survival in nonsmall-cell lung cancer Authors (21) Yin WuDhruva Biswas Ieva UsaiteMihaela AngelovaStefan BoeingTakahiro Karasaki[...] Mariam Jamal-Hanjani Allan Hackshaw Sergio A QuezadaAdrian HaydayCharles Swanton Nature Cancer Published 1 June 2022 Crick labs/ facilitiesCharles SwantonAdrian HaydayBioinformatics and BiostatisticsFull details
Allele-informed copy number evaluation of plasma DNA samples from metastatic prostate cancer patients: the PCF_SELECT consortium assay Authors (259) Francesco Orlando Alessandro Romanel Blanca Trujillo Michael Sigouros Daniel Wetterskog Orsetta Quaini[...] Mark A Rubin Alexander W Wyatt Himisha Beltran Gerhardt Attard Francesca Demichelis NAR Cancer Published 8 April 2022 Crick labsCharles SwantonFull details
The translational challenges of precision oncology Authors (6) Oriol Pich Chris BaileyTom Watkins Simone Zaccaria Mariam Jamal-HanjaniCharles Swanton Cancer Cell Published 9 May 2022 Crick labsCharles SwantonFull details
Combinatorial inactivation of tumor suppressors efficiently initiates lung adenocarcinoma with therapeutic vulnerabilities Authors (22) Maryam Yousefi Gábor Boross Carly Weiss Christopher W Murray Jess D Hebert Hongchen Cai[...] Pauline ChuCharles Swanton Christian A Kunder Dmitri A Petrov Monte M Winslow Cancer Research Published 15 April 2022 Crick labsCharles SwantonFull details
Immune determinants of the association between tumor mutational burden and immunotherapy response across cancer types Authors (9) Neelam Sinha Sanju Sinha Cristina Valero Alejandro A Schäffer Kenneth AldapeKevin Litchfield Timothy A Chan Luc GT Morris Eytan Ruppin Cancer Research Published 6 June 2022 Crick labsCharles SwantonFull details
Omicron neutralising antibodies after third COVID-19 vaccine dose in patients with cancer Authors (62)Annika FendlerScott ShepherdLewis AuMary Wu Ruth Harvey Andreas M Schmitt[...] Emma Nicholson Susanna Walker James LarkinSamra Turajlic The CAPTURE consortium The Lancet Published 5 March 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyMetabolomicsHigh Throughput ScreeningBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Omicron neutralising antibodies after COVID-19 vaccination in haemodialysis patients Authors (19)Edward CarrMary Wu Ruth Harvey Roseanne E Billany Emma C WallGavin Kelly[...] Rachel B Jones Rona M Smith Stephen McAdoo Michelle WillicombeRupert Beale The Lancet Published 26 February 2022 Crick labs/ facilitiesCharles SwantonGitta StockingerNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreHigh Throughput ScreeningBioinformatics and BiostatisticsFull details
Three-dose vaccination elicits neutralising antibodies against omicron Authors (26)Mary Wu Emma C WallEdward Carr Ruth Harvey Hermaleigh TownsleyHarriet Mears[...] Vincenzo Libri Bryan WilliamsSonia GandhiCharles SwantonDavid LV Bauer The Lancet Published 19 February 2022 Crick labs/ facilitiesCharles SwantonGitta StockingerNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningBioinformatics and BiostatisticsScientific computingFull details
APOBEC3 as a driver of genetic intratumor heterogeneity Authors (7)Mani VenkatesanMihaela Angelova Jirina Bartkova Samuel F Bakhoum Jiri Bartek Nnennaya KanuCharles Swanton Molecular and Cellular Oncology Published 1 January 2023 Crick labsCharles SwantonFull details
Immune responses following third COVID-19 vaccination are reduced in patients with hematological malignancies compared to patients with solid cancer Authors (65)Annika FendlerScott ShepherdLewis AuKatalin WilkinsonMary Wu Andreas M Schmitt[...] Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic CAPTURE consortium Cancer Cell Published 14 February 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyProteomicsMetabolomicsHigh Throughput ScreeningBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details