Swanton lab Cancer Evolution and Genome Instability Laboratory : Publications

Published 1 March 2018

Crick labs

Charles Swanton

Optimizing panel-based tumor mutational burden (TMB) measurement

Authors (13)

J Budczies
M Allgäuer
Kevin Litchfield
E Rempel
P Christopoulos
D Kazdal
[...]
S Fröhling
S Peters
Charles Swanton
P Schirmacher
A Stenzinger

Published 1 September 2019

Crick labs

Charles Swanton

Tumour mutational burden: primary versus metastatic tissue creates systematic bias

Authors (3)

Immuno-Oncology and Technology

Published 1 December 2019

Crick labs

A clonal expression biomarker associates with lung cancer mortality

Authors (36)

Dhruva Biswas
Nicolai Birkbak
Rachel Rosenthal
Crispin T Hiley
Emilia Lim
Krisztian Papp
[...]
Zoltan Szallasi
Javier Herrero
Nicholas McGranahan
Charles Swanton
TRACERx Consortium

Published 7 October 2019

Crick labs/ facilities

Pulmonary venous circulating tumor cell dissemination before tumor resection and disease relapse

Authors (35)

Francesca Chemi
Dominic G Rothwell
Nicholas McGranahan
Sakshi Gulati
Chris Abbosh
Simon P Pearce
[...]
Allan Hackshaw
Ged Brady
Charles Swanton
Caroline Dive
TRACERx Consortium

Published 7 October 2019

Crick labs

Charles Swanton

Spatial heterogeneity of the T cell receptor repertoire reflects the mutational landscape in lung cancer

Authors (35)

Kroopa Joshi
Marc Robert de Massy
Mazlina Ismail
James L Reading
Imran Uddin
Annemarie Woolston
[...]
Nicholas McGranahan
Charles Swanton
TRACERx Consortium
Sergio A Quezada
Benny Chain

Published 7 October 2019

Crick labs

Charles Swanton

UVB-induced tumor heterogeneity diminishes immune response in melanoma

Authors (29)

Yochai Wolf
Osnat Bartok
Sushant Patkar
Gitit Bar Eli
Sapir Cohen
Kevin Litchfield
[...]
Lea Eisenbach
Arie Admon
Charles Swanton
Eytan Ruppin
Yardena Samuels

Cell

Published 19 September 2019

Crick labs

Charles Swanton

Neoantigen quality, not quantity

Authors (2)

Nicholas McGranahan
Charles Swanton

Science Translational Medicine

Published 21 August 2019

Crick labs

Charles Swanton

Spatial and temporal heterogeneity of panel-based tumor mutational burden in pulmonary adenocarcinoma: separating biology from technical artifacts

Authors (33)

Daniel Kazdal
Volker Endris
Michael Allgäuer
Mark Kriegsmann
Jonas Leichsenring
Anna-Lena Volckmar
[...]
Charles Swanton
Michael Thomas
Peter Schirmacher
Jan Budczies
Albrecht Stenzinger

Journal of Thoracic Oncology

Published 1 November 2019

Crick labs

Charles Swanton

Optimizing panel-based tumor mutational burden (TMB) measurement

Authors (13)

J Budczies
M Allgäuer
Kevin Litchfield
E Rempel
P Christopoulos
D Kazdal
[...]
S Fröhling
S Peters
Charles Swanton
P Schirmacher
A Stenzinger

Published 1 September 2019

Crick labs

Charles Swanton

An emerging regulatory network of NHEJ via DYNLL1-mediated 53BP1 redistribution

Authors (3)

Annals of Translational Medicine

Published 1 July 2019

Crick labs

Charles Swanton

An immunotherapy survivor population: health-related quality of life and toxicity in patients with metastatic melanoma treated with immune checkpoint inhibitors

Authors (18)

Aine O'Reilly
Peta Hughes
Jasmine Mann
Zhuangming Lai
Jhia Jiat Teh
Emma Mclean
[...]
Theresa Wiseman
Samra Turajlic
Martin Gore
James Larkin
Olga Husson

Supportive Care in Cancer

Published 1 February 2020

Crick labs

Resolving genetic heterogeneity in cancer

Authors (4)

Samra Turajlic
Andrea Sottoriva
Trevor Graham
Charles Swanton

Nature Reviews Genetics

Published 1 July 2019

Crick labs

Predicting response to cancer immunotherapy using noninvasive radiomic biomarkers

Authors (18)

S Trebeschi
SG Drago
Nicolai Birkbak
I Kurilova
AM Cǎlin
A Delli Pizzi
[...]
JBAG Haanen
CU Blank
EF Smit
RGH Beets-Tan
HJWL Aerts

Published 1 June 2019

Crick labs

Charles Swanton

Prospective analysis of 895 patients on a UK Genomics Review Board

Authors (15)

DA Moore
M Kushnir
G Mak
H Winter
T Curiel
M Voskoboynik
[...]
M Forster
A Kulkarni
D Haynes
Charles Swanton
H-T Arkenau

ESMO Open

Published 21 March 2019

Crick labs

Charles Swanton

Neoantigen-directed immune escape in lung cancer evolution

Authors (29)

Rachel Rosenthal
Elizabeth Larose Cadieux
Roberto Salgado
Maise Al Bakir
David A Moore
Crispin T Hiley
[...]
Peter Van Loo
Stephan Beck
Nicholas McGranahan
Charles Swanton
The TRACERx Consortium

Nature

Published 20 March 2019

Crick labs/ facilities

Pertuzumab plus trastuzumab for HER2-amplified metastatic colorectal cancer (MyPathway): an updated report from a multicentre, open-label, phase 2a, multiple basket study

Authors (18)

Funda Meric-Bernstam
Herbert Hurwitz
Kanwal Pratap Singh Raghav
Robert R McWilliams
Marwan Fakih
Ari VanderWalde
[...]
Steven Blotner
Alyssa Stone
Katja Schulze
Vaikunth Cuchelkar
John Hainsworth

Lancet Oncology

Published 4 April 2019

Crick labs

Charles Swanton

Standing on the shoulders of giants

Authors (1)

Samra Turajlic

Published 6 March 2019

Crick labs

Searching for the needle in the haystack: deconvoluting the evolutionary dynamics of residual disease in human glioblastoma

Authors (3)

Published 1 March 2019

Crick labs

Artificial intelligence in cancer imaging: Clinical challenges and applications

Authors (19)

Wenya Linda Bi
Ahmed Hosny
Matthew B Schabath
Maryellen L Giger
Nicolai Birkbak
Alireza Mehrtash
[...]
Udo Hoffmann
Lawrence H Schwartz
Robert J Gillies
Raymond Y Huang
Hugo JWL Aerts

CA: a cancer journal for clinicians

Published 5 February 2019

Crick labs

Charles Swanton