Research case studies Explore a selection of reports that spotlight particular areas of research at the Crick over the past five years.
Postdoctoral clinical fellows Opportunities for postdoctoral clinicians to consolidate their research experience.
Breadcrumb David Balchin Balchin lab Protein Biogenesis Laboratory : Publications Lab contentLab contentIn this section Overview Members Vacancies Publications A cartoon of protein folding during translation at the ribosome. Toggle to view hero caption PublicationsCrick/Pre-Crick (-)Pre-Crick publications (12) Facet Crick/Pre-Crick Publications Displaying 1 - 12 of 12Last updated : 23 April 2024 03:57 Calmodulin regulates protease versus co-chaperone activity of a metacaspase Authors (11) Anna Maria Eisele-Bürger Frederik Eisele Sandra Malmgren Hill Xinxin Hao Kara L Schneider Rahmi ImamogluDavid Balchin Beidong Liu F Ulrich Hartl Peter V Bozhkov Thomas Nyström Cell Reports Published 28 November 2023 Crick labsDavid BalchinFull details Efficient catalysis of protein folding by GroEL/ES of the obligate chaperonin substrate MetF Authors (5) Amit K SinghDavid Balchin Rahmi Imamoglu Manajit Hayer-Hartl F Ulrich Hartl Journal of Molecular Biology Published 27 March 2020 Crick labsDavid BalchinFull details Bacterial Hsp70 resolves misfolded states and accelerates productive folding of a multi-domain protein Authors (4) Rahmi ImamogluDavid Balchin Manajit Hayer-Hartl F Ulrich Hartl Nature Communications Published 17 January 2020 Crick labsDavid BalchinFull details Chaperone function of Hgh1 in the biogenesis of eukaryotic elongation factor 2 Authors (6) Leonie Mönkemeyer Courtney L KlaipsDavid Balchin Roman Körner F Ulrich Hartl Andreas Bracher Molecular Cell Published 4 April 2019 Crick labsDavid BalchinFull details Tc toxin activation requires unfolding and refolding of a β-propeller Authors (8) Christos Gatsogiannis Felipe Merino Daniel RodererDavid Balchin Evelyn Schubert Anne Kuhlee Manajit Hayer-Hartl Stefan Raunser Nature Published 8 November 2018 Crick labsDavid BalchinFull details Pathway of actin folding directed by the eukaryotic chaperonin TRiC Authors (5)David Balchin Goran Miličić Mike Strauss Manajit Hayer-Hartl F Ulrich Hartl Cell Published 6 September 2018 Crick labsDavid BalchinFull details In vivo aspects of protein folding and quality control Authors (3)David Balchin Manajit Hayer-Hartl F Ulrich Hartl Science Published 1 July 2016 Crick labsDavid BalchinFull details S-Nitrosation destabilizes glutathione transferase P1-1 Authors (3)David Balchin Stoyan H Stoychev Heini W Dirr Biochemistry Published 23 December 2013 Crick labsDavid BalchinFull details S-Nitrosation of glutathione transferase P1-1 is controlled by the conformation of a dynamic active site helix Authors (3)David Balchin Louise Wallace Heini W Dirr Journal of Biological Chemistry Published 24 May 2013 Crick labsDavid BalchinFull details Energetics of ligand binding to human glutathione transferase A1-1: Tyr-9 associated localisation of the C-terminal helix is ligand-dependent Authors (3)David Balchin Heini W Dirr Yasien Sayed Biophysical Chemistry Published 1 July 2011 Crick labsDavid BalchinFull details Stability of the domain interface contributes towards the catalytic function at the H-site of class alpha glutathione transferase A1-1 Authors (8)David Balchin Sylvia Fanucchi Ikechukwu Achilonu Roslin J Adamson Jonathan Burke Manuel Fernandes Samantha Gildenhuys Heini W Dirr Biochimica et Biophysica Acta Published 1 December 2010 Crick labsDavid BalchinFull details Class Pi glutathione transferase unfolds via a dimeric and not monomeric intermediate: functional implications for an unstable monomer Authors (6) Samantha Gildenhuys Louise A Wallace Jonathan P BurkeDavid Balchin Yasien Sayed Heini W Dirr Biochemistry Published 22 June 2010 Crick labsDavid BalchinFull details Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Calmodulin regulates protease versus co-chaperone activity of a metacaspase Authors (11) Anna Maria Eisele-Bürger Frederik Eisele Sandra Malmgren Hill Xinxin Hao Kara L Schneider Rahmi ImamogluDavid Balchin Beidong Liu F Ulrich Hartl Peter V Bozhkov Thomas Nyström Cell Reports Published 28 November 2023 Crick labsDavid BalchinFull details
Efficient catalysis of protein folding by GroEL/ES of the obligate chaperonin substrate MetF Authors (5) Amit K SinghDavid Balchin Rahmi Imamoglu Manajit Hayer-Hartl F Ulrich Hartl Journal of Molecular Biology Published 27 March 2020 Crick labsDavid BalchinFull details
Bacterial Hsp70 resolves misfolded states and accelerates productive folding of a multi-domain protein Authors (4) Rahmi ImamogluDavid Balchin Manajit Hayer-Hartl F Ulrich Hartl Nature Communications Published 17 January 2020 Crick labsDavid BalchinFull details
Chaperone function of Hgh1 in the biogenesis of eukaryotic elongation factor 2 Authors (6) Leonie Mönkemeyer Courtney L KlaipsDavid Balchin Roman Körner F Ulrich Hartl Andreas Bracher Molecular Cell Published 4 April 2019 Crick labsDavid BalchinFull details
Tc toxin activation requires unfolding and refolding of a β-propeller Authors (8) Christos Gatsogiannis Felipe Merino Daniel RodererDavid Balchin Evelyn Schubert Anne Kuhlee Manajit Hayer-Hartl Stefan Raunser Nature Published 8 November 2018 Crick labsDavid BalchinFull details
Pathway of actin folding directed by the eukaryotic chaperonin TRiC Authors (5)David Balchin Goran Miličić Mike Strauss Manajit Hayer-Hartl F Ulrich Hartl Cell Published 6 September 2018 Crick labsDavid BalchinFull details
In vivo aspects of protein folding and quality control Authors (3)David Balchin Manajit Hayer-Hartl F Ulrich Hartl Science Published 1 July 2016 Crick labsDavid BalchinFull details
S-Nitrosation destabilizes glutathione transferase P1-1 Authors (3)David Balchin Stoyan H Stoychev Heini W Dirr Biochemistry Published 23 December 2013 Crick labsDavid BalchinFull details
S-Nitrosation of glutathione transferase P1-1 is controlled by the conformation of a dynamic active site helix Authors (3)David Balchin Louise Wallace Heini W Dirr Journal of Biological Chemistry Published 24 May 2013 Crick labsDavid BalchinFull details
Energetics of ligand binding to human glutathione transferase A1-1: Tyr-9 associated localisation of the C-terminal helix is ligand-dependent Authors (3)David Balchin Heini W Dirr Yasien Sayed Biophysical Chemistry Published 1 July 2011 Crick labsDavid BalchinFull details
Stability of the domain interface contributes towards the catalytic function at the H-site of class alpha glutathione transferase A1-1 Authors (8)David Balchin Sylvia Fanucchi Ikechukwu Achilonu Roslin J Adamson Jonathan Burke Manuel Fernandes Samantha Gildenhuys Heini W Dirr Biochimica et Biophysica Acta Published 1 December 2010 Crick labsDavid BalchinFull details
Class Pi glutathione transferase unfolds via a dimeric and not monomeric intermediate: functional implications for an unstable monomer Authors (6) Samantha Gildenhuys Louise A Wallace Jonathan P BurkeDavid Balchin Yasien Sayed Heini W Dirr Biochemistry Published 22 June 2010 Crick labsDavid BalchinFull details
