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Breadcrumb David LV Bauer Bauer lab RNA Virus Replication Laboratory : Publications Lab contentLab contentIn this section Overview Lab members Areas of interest Vacancies Publications Publications Displaying 1 - 20 of 34Last updated : 29 March 2024 03:45 COVID-19 in non-hospitalised adults caused by either SARS-CoV-2 sub-variants Omicron BA.1, BA.2, BA.4/5 or Delta associates with similar illness duration, symptom severity and viral kinetics, irrespective of vaccination history Authors (37) Hermaleigh Townsley Joshua Gahir Timothy W Russell David GreenwoodEdward Carr Matala Dyke[...]Sonia Gandhi Adam J KucharskiCharles SwantonDavid LV Bauer Emma C Wall PLOS ONE Published 21 March 2024 Crick labs/ facilitiesRobert J WilkinsonCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingFull details Divergent performance of vaccines in the UK autumn 2023 COVID-19 booster campaign Authors (22) Marianne Shawe-Taylor David Greenwood Agnieszka Hobbs Giulia DowgierBecky PennTheo Sanderson[...]Sonia GandhiEdward CarrMary WuDavid LV Bauer Emma C Wall The Lancet Published 11 March 2024 Crick labs/ facilitiesCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinMike BlackmanRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Combined analyses of within-host SARS-CoV-2 viral kinetics and information on past exposures to the virus in a human cohort identifies intrinsic differences of Omicron and Delta variants Authors (26) Timothy W Russell Hermaleigh Townsley Sam Abbott Joel HellewellEdward Carr Lloyd AC Chapman[...]Charles SwantonRupert BealeDavid LV Bauer Emma C Wall Adam J Kucharski PLOS Biology Published 30 January 2024 Crick labs/ facilitiesCharles SwantonSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreBiological Research FacilityAdvanced SequencingFull details SARS-CoV-2 mucosal neutralising immunity after vaccination Authors (38)Edward Carr Guilia Dowgier David Greenwood Lou S Herman Agnieszka Hobbs Martina Ragno[...]Charles SwantonSonia GandhiDavid LV Bauer Emma WallMary Wu Lancet Infectious Diseases Published 1 January 2024 Crick labs/ facilitiesCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreHigh Throughput ScreeningBiological Research FacilityAdvanced SequencingFull details Independent SARS-CoV-2 staff testing protected academic and health-care institutions in northwest London Authors (54) Chris BaileyTheo Sanderson Hermaleigh Townsley Jacki Goldman James RM BlackGeorge Young[...]Jerome NicodSonia GandhiDavid LV Bauer Emma C WallCharles Swanton The Lancet Published 1 July 2023 Crick labs/ facilitiesSamra TurajlicCharles SwantonSam RodriquesSonia GandhiSteve GamblinMike BlackmanRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyMetabolomicsHigh Throughput ScreeningFlow CytometryBioinformatics and BiostatisticsAdvanced SequencingScientific computingBiological Research FacilityFull details Neutralising immunity to omicron sublineages BQ.1.1, XBB, and XBB.1.5 in healthy adults is boosted by bivalent BA.1-containing mRNA vaccination and previous Omicron infection Authors (36)Edward CarrMary Wu Joshua Gahir Ruth Harvey Hermaleigh Townsley Chris Bailey[...]Charles SwantonSonia GandhiDavid LV Bauer Emma C Wall Crick COVID Serology Consortium Lancet Infectious Diseases Published 1 July 2023 Crick labs/ facilitiesCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreHigh Throughput ScreeningBiological Research FacilityAdvanced SequencingScientific computingFull details Sotrovimab restores neutralization against current Omicron subvariants in patients with blood cancer Authors (67)Mary WuScott Shepherd Annika FendlerEdward CarrLewis Au Ruth Harvey[...] Emma Nicholson James Larkin Emma C WallSamra Turajlic CAPTURE consortium Cancer Cell Published 8 May 2023 Crick labs/ facilitiesSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreMetabolomicsHigh Throughput ScreeningBioinformatics and BiostatisticsScientific computingFull details Electron cryotomography of SARS-CoV-2 virions reveals cylinder-shaped particles with a double layer RNP assembly Authors (5)Lesley CalderTom CalcraftSaira Hussain Ruth HarveyPeter Rosenthal Communications Biology Published 10 November 2022 Crick labs/ facilitiesPeter RosenthalNicola LewisDavid LV BauerWorldwide Influenza CentreStructural BiologyScientific computingFull details WHO's therapeutics and COVID-19 living guideline on mAbs needs to be reassessed Authors (19)Mary WuEdward Carr Ruth HarveyHarriet MearsSvend Kjaer Hermaleigh Townsley[...] Bryan WilliamsSonia GandhiCharles Swanton Emma C WallDavid LV Bauer The Lancet Published 17 December 2022 Crick labs/ facilitiesCharles SwantonNicola LewisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningFull details Functional immune responses against SARS-CoV-2 variants of concern after fourth COVID-19 vaccine dose or infection in patients with blood cancer Authors (64)Annika FendlerScott ShepherdLewis AuMary Wu Ruth HarveyKatalin Wilkinson[...] Emma Nicholson Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic Cell Reports Medicine Published 18 October 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyMetabolomicsHigh Throughput ScreeningScientific computingFull details Transient RNA structures cause aberrant influenza virus replication and innate immune activation Authors (8) Hollie French Emmanuelle Pitré Michael S Oade Elizaveta Elshina Karishma Bisht Alannah KingDavid LV Bauer Aartjan JW te Velthuis Science advances Published 9 September 2022 Crick labsDavid LV BauerFull details SARS-CoV-2 S2-targeted vaccination elicits broadly neutralizing antibodies Authors (21)Kevin NgNikhil FaulknerKatja FinsterbuschMary Wu Ruth HarveySaira Hussain[...]Michael Howell Hisashi AraseAndreas WackDavid LV BauerGeorge Kassiotis Science Translational Medicine Published 27 July 2022 Crick labs/ facilitiesAndreas WackCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinPeter Cherepanov Rupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningFlow CytometryCell ServicesBiological Research FacilityFull details Interactions between influenza A virus nucleoprotein and gene segment untranslated regions facilitate selective modulation of viral gene expression Authors (6) Meghan Diefenbacher Timothy JC TanDavid LV Bauer Beth M Stadtmueller Nicholas C Wu Christopher B Brooke Journal of Virology Published 25 May 2022 Crick labsDavid LV BauerFull details Evolution of the SARS-CoV-2 spike protein in thehuman host Authors (9)Antoni WrobelDonald BentonChloe RoustanAnnabel BorgSaira Hussain Stephen R MartinPeter Rosenthal John J SkehelSteve Gamblin Nature Communications Published 4 March 2022 Crick labs/ facilitiesPeter RosenthalNicola LewisSteve GamblinDavid LV BauerWorldwide Influenza CentreStructural BiologyScientific computingFull details Omicron neutralising antibodies after third COVID-19 vaccine dose in patients with cancer Authors (62)Annika FendlerScott ShepherdLewis AuMary Wu Ruth Harvey Andreas M Schmitt[...] Emma Nicholson Susanna Walker James LarkinSamra Turajlic The CAPTURE consortium The Lancet Published 5 March 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyMetabolomicsHigh Throughput ScreeningBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Omicron neutralising antibodies after COVID-19 vaccination in haemodialysis patients Authors (19)Edward CarrMary Wu Ruth Harvey Roseanne E Billany Emma C WallGavin Kelly[...] Rachel B Jones Rona M Smith Stephen McAdoo Michelle WillicombeRupert Beale The Lancet Published 26 February 2022 Crick labs/ facilitiesCharles SwantonGitta StockingerNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreHigh Throughput ScreeningBioinformatics and BiostatisticsFull details Three-dose vaccination elicits neutralising antibodies against omicron Authors (26)Mary Wu Emma C WallEdward Carr Ruth Harvey Hermaleigh TownsleyHarriet Mears[...] Vincenzo Libri Bryan WilliamsSonia GandhiCharles SwantonDavid LV Bauer The Lancet Published 19 February 2022 Crick labs/ facilitiesCharles SwantonGitta StockingerNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningBioinformatics and BiostatisticsScientific computingFull details Immune responses following third COVID-19 vaccination are reduced in patients with hematological malignancies compared to patients with solid cancer Authors (65)Annika FendlerScott ShepherdLewis AuKatalin WilkinsonMary Wu Andreas M Schmitt[...] Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic CAPTURE consortium Cancer Cell Published 14 February 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyProteomicsMetabolomicsHigh Throughput ScreeningBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Real-time single-molecule studies of RNA polymerase-promoter open complex formation reveal substantial heterogeneity along the promoter-opening pathway Authors (9) Anssi M Malinen Jacob Bakermans Emil Aalto-Setälä Martin BlessingDavid LV Bauer Olena Parilova Georgiy A Belogurov David Dulin Achillefs N Kapanidis Journal of Molecular Biology Published 30 January 2022 Crick labsDavid LV BauerFull details Adaptive immunity and neutralizing antibodies against SARS-CoV-2 variants of concern following vaccination in patients with cancer: the CAPTURE study Authors (98)Annika FendlerScott ShepherdLewis AuKatalin WilkinsonMary WuFiona Byrne[...] Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic CAPTURE Consortium Nature Cancer Published 1 December 2021 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinDavid LV BauerWorldwide Influenza CentreMetabolomicsHigh Throughput ScreeningFlow CytometryBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Pagination Current page 1 Page 2 Next page Next Last page Last Share the page Share on 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COVID-19 in non-hospitalised adults caused by either SARS-CoV-2 sub-variants Omicron BA.1, BA.2, BA.4/5 or Delta associates with similar illness duration, symptom severity and viral kinetics, irrespective of vaccination history Authors (37) Hermaleigh Townsley Joshua Gahir Timothy W Russell David GreenwoodEdward Carr Matala Dyke[...]Sonia Gandhi Adam J KucharskiCharles SwantonDavid LV Bauer Emma C Wall PLOS ONE Published 21 March 2024 Crick labs/ facilitiesRobert J WilkinsonCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingFull details
Divergent performance of vaccines in the UK autumn 2023 COVID-19 booster campaign Authors (22) Marianne Shawe-Taylor David Greenwood Agnieszka Hobbs Giulia DowgierBecky PennTheo Sanderson[...]Sonia GandhiEdward CarrMary WuDavid LV Bauer Emma C Wall The Lancet Published 11 March 2024 Crick labs/ facilitiesCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinMike BlackmanRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Combined analyses of within-host SARS-CoV-2 viral kinetics and information on past exposures to the virus in a human cohort identifies intrinsic differences of Omicron and Delta variants Authors (26) Timothy W Russell Hermaleigh Townsley Sam Abbott Joel HellewellEdward Carr Lloyd AC Chapman[...]Charles SwantonRupert BealeDavid LV Bauer Emma C Wall Adam J Kucharski PLOS Biology Published 30 January 2024 Crick labs/ facilitiesCharles SwantonSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreBiological Research FacilityAdvanced SequencingFull details
SARS-CoV-2 mucosal neutralising immunity after vaccination Authors (38)Edward Carr Guilia Dowgier David Greenwood Lou S Herman Agnieszka Hobbs Martina Ragno[...]Charles SwantonSonia GandhiDavid LV Bauer Emma WallMary Wu Lancet Infectious Diseases Published 1 January 2024 Crick labs/ facilitiesCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreHigh Throughput ScreeningBiological Research FacilityAdvanced SequencingFull details
Independent SARS-CoV-2 staff testing protected academic and health-care institutions in northwest London Authors (54) Chris BaileyTheo Sanderson Hermaleigh Townsley Jacki Goldman James RM BlackGeorge Young[...]Jerome NicodSonia GandhiDavid LV Bauer Emma C WallCharles Swanton The Lancet Published 1 July 2023 Crick labs/ facilitiesSamra TurajlicCharles SwantonSam RodriquesSonia GandhiSteve GamblinMike BlackmanRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyMetabolomicsHigh Throughput ScreeningFlow CytometryBioinformatics and BiostatisticsAdvanced SequencingScientific computingBiological Research FacilityFull details
Neutralising immunity to omicron sublineages BQ.1.1, XBB, and XBB.1.5 in healthy adults is boosted by bivalent BA.1-containing mRNA vaccination and previous Omicron infection Authors (36)Edward CarrMary Wu Joshua Gahir Ruth Harvey Hermaleigh Townsley Chris Bailey[...]Charles SwantonSonia GandhiDavid LV Bauer Emma C Wall Crick COVID Serology Consortium Lancet Infectious Diseases Published 1 July 2023 Crick labs/ facilitiesCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreHigh Throughput ScreeningBiological Research FacilityAdvanced SequencingScientific computingFull details
Sotrovimab restores neutralization against current Omicron subvariants in patients with blood cancer Authors (67)Mary WuScott Shepherd Annika FendlerEdward CarrLewis Au Ruth Harvey[...] Emma Nicholson James Larkin Emma C WallSamra Turajlic CAPTURE consortium Cancer Cell Published 8 May 2023 Crick labs/ facilitiesSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreMetabolomicsHigh Throughput ScreeningBioinformatics and BiostatisticsScientific computingFull details
Electron cryotomography of SARS-CoV-2 virions reveals cylinder-shaped particles with a double layer RNP assembly Authors (5)Lesley CalderTom CalcraftSaira Hussain Ruth HarveyPeter Rosenthal Communications Biology Published 10 November 2022 Crick labs/ facilitiesPeter RosenthalNicola LewisDavid LV BauerWorldwide Influenza CentreStructural BiologyScientific computingFull details
WHO's therapeutics and COVID-19 living guideline on mAbs needs to be reassessed Authors (19)Mary WuEdward Carr Ruth HarveyHarriet MearsSvend Kjaer Hermaleigh Townsley[...] Bryan WilliamsSonia GandhiCharles Swanton Emma C WallDavid LV Bauer The Lancet Published 17 December 2022 Crick labs/ facilitiesCharles SwantonNicola LewisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningFull details
Functional immune responses against SARS-CoV-2 variants of concern after fourth COVID-19 vaccine dose or infection in patients with blood cancer Authors (64)Annika FendlerScott ShepherdLewis AuMary Wu Ruth HarveyKatalin Wilkinson[...] Emma Nicholson Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic Cell Reports Medicine Published 18 October 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyMetabolomicsHigh Throughput ScreeningScientific computingFull details
Transient RNA structures cause aberrant influenza virus replication and innate immune activation Authors (8) Hollie French Emmanuelle Pitré Michael S Oade Elizaveta Elshina Karishma Bisht Alannah KingDavid LV Bauer Aartjan JW te Velthuis Science advances Published 9 September 2022 Crick labsDavid LV BauerFull details
SARS-CoV-2 S2-targeted vaccination elicits broadly neutralizing antibodies Authors (21)Kevin NgNikhil FaulknerKatja FinsterbuschMary Wu Ruth HarveySaira Hussain[...]Michael Howell Hisashi AraseAndreas WackDavid LV BauerGeorge Kassiotis Science Translational Medicine Published 27 July 2022 Crick labs/ facilitiesAndreas WackCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinPeter Cherepanov Rupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningFlow CytometryCell ServicesBiological Research FacilityFull details
Interactions between influenza A virus nucleoprotein and gene segment untranslated regions facilitate selective modulation of viral gene expression Authors (6) Meghan Diefenbacher Timothy JC TanDavid LV Bauer Beth M Stadtmueller Nicholas C Wu Christopher B Brooke Journal of Virology Published 25 May 2022 Crick labsDavid LV BauerFull details
Evolution of the SARS-CoV-2 spike protein in thehuman host Authors (9)Antoni WrobelDonald BentonChloe RoustanAnnabel BorgSaira Hussain Stephen R MartinPeter Rosenthal John J SkehelSteve Gamblin Nature Communications Published 4 March 2022 Crick labs/ facilitiesPeter RosenthalNicola LewisSteve GamblinDavid LV BauerWorldwide Influenza CentreStructural BiologyScientific computingFull details
Omicron neutralising antibodies after third COVID-19 vaccine dose in patients with cancer Authors (62)Annika FendlerScott ShepherdLewis AuMary Wu Ruth Harvey Andreas M Schmitt[...] Emma Nicholson Susanna Walker James LarkinSamra Turajlic The CAPTURE consortium The Lancet Published 5 March 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyMetabolomicsHigh Throughput ScreeningBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Omicron neutralising antibodies after COVID-19 vaccination in haemodialysis patients Authors (19)Edward CarrMary Wu Ruth Harvey Roseanne E Billany Emma C WallGavin Kelly[...] Rachel B Jones Rona M Smith Stephen McAdoo Michelle WillicombeRupert Beale The Lancet Published 26 February 2022 Crick labs/ facilitiesCharles SwantonGitta StockingerNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreHigh Throughput ScreeningBioinformatics and BiostatisticsFull details
Three-dose vaccination elicits neutralising antibodies against omicron Authors (26)Mary Wu Emma C WallEdward Carr Ruth Harvey Hermaleigh TownsleyHarriet Mears[...] Vincenzo Libri Bryan WilliamsSonia GandhiCharles SwantonDavid LV Bauer The Lancet Published 19 February 2022 Crick labs/ facilitiesCharles SwantonGitta StockingerNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyHigh Throughput ScreeningBioinformatics and BiostatisticsScientific computingFull details
Immune responses following third COVID-19 vaccination are reduced in patients with hematological malignancies compared to patients with solid cancer Authors (65)Annika FendlerScott ShepherdLewis AuKatalin WilkinsonMary Wu Andreas M Schmitt[...] Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic CAPTURE consortium Cancer Cell Published 14 February 2022 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinRupert BealeDavid LV BauerWorldwide Influenza CentreStructural BiologyProteomicsMetabolomicsHigh Throughput ScreeningBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Real-time single-molecule studies of RNA polymerase-promoter open complex formation reveal substantial heterogeneity along the promoter-opening pathway Authors (9) Anssi M Malinen Jacob Bakermans Emil Aalto-Setälä Martin BlessingDavid LV Bauer Olena Parilova Georgiy A Belogurov David Dulin Achillefs N Kapanidis Journal of Molecular Biology Published 30 January 2022 Crick labsDavid LV BauerFull details
Adaptive immunity and neutralizing antibodies against SARS-CoV-2 variants of concern following vaccination in patients with cancer: the CAPTURE study Authors (98)Annika FendlerScott ShepherdLewis AuKatalin WilkinsonMary WuFiona Byrne[...] Susanna WalkerRobert Wilkinson James LarkinSamra Turajlic CAPTURE Consortium Nature Cancer Published 1 December 2021 Crick labs/ facilitiesRobert J WilkinsonSamra TurajlicCharles SwantonNicola LewisGeorge KassiotisSonia GandhiSteve GamblinDavid LV BauerWorldwide Influenza CentreMetabolomicsHigh Throughput ScreeningFlow CytometryBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details