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Breadcrumb Dimitrios Anastasiou Anastasiou lab Cancer Metabolism Laboratory : Publications Lab contentLab contentIn this section Overview Vacancies Areas of interest Publications Members PublicationsYear published2023 (1)2022 (1)2021 (2)2019 (4)2018 (1)2017 (4)2016 (5)2014 (1)2013 (2)2012 (5)2011 (3) Facet Year publishedResearch topicsBiochemistry & Proteomics (16)Computational & Systems Biology (16)Human Biology & Physiology (16)Metabolism (16)Tumour Biology (16)Cell Biology (4)Chemical Biology & High Throughput (4)Developmental Biology (4)Immunology (4)Infectious Disease (4)Signalling & Oncogenes (4)Structural Biology & Biophysics (3)Genetics & Genomics (1)Genome Integrity & Repair (1) Facet Research topicsCrick/Pre-CrickCrick publications (19)Pre-Crick publications (8) Facet Crick/Pre-CrickPublication typeJournal article (27)Primary research (19)Review (6)Commentary (2) Facet Publication typeJournalNature Cell Biology (3)Science Signaling (3)Molecular Cell (2)Nature Chemical Biology (2)Advances in Experimental Medicine and Biology (1)Biomedical Research (1)Breast Cancer Research (1)British Journal of Cancer (1)Cell (1)Cell Research (1)Cell Stem Cell (1)Communications Biology (1)Current Opinion in Biotechnology (1)eLife (1)FEBS Journal (1)iScience (1)Journal of Biological Chemistry (1)Nature (1)Nature Genetics (1)Proceedings of the National Academy of Sciences of the United States of America (1)Science (1) Facet Journal Publications Displaying 1 - 20 of 29Last updated : 22 September 2023 02:53 Systematic diet composition swap in a mouse genome-scale metabolic model reveals determinants of obesogenic diet metabolism in liver cancer Authors (7) Frederick ClasenPatricia Figueiredo Nunes Gholamreza Bidkhori Nourdine Bah Stefan Boeing Saeed ShoaieDimitrios Anastasiou iScience Published 17 February 2023 Crick labs/ facilitiesDimitrios AnastasiouBioinformatics and BiostatisticsMetabolomicsIn Vivo ImagingBiological Research FacilityAdvanced SequencingFull details MOG analogues to explore the MCT2 pharmacophore, α-ketoglutarate biology and cellular effects of N-oxalylglycine Authors (9)Louise FetsNatalie BevanPatricia Figueiredo Nunes Sebastien CamposMariana Silva Dos Santos Emma SherriffJames MacraeDavid HouseDimitrios Anastasiou Communications Biology Published 26 August 2022 Crick labs/ facilitiesDimitrios AnastasiouMetabolomicsTranslation teamFull details Fibrometabolism-An emerging therapeutic frontier in pulmonary fibrosis Authors (4) Brintha Selvarajah Ilan AzuelosDimitrios Anastasiou Rachel C Chambers Science Signaling Published 24 August 2021 Crick labsDimitrios AnastasiouFull details Fructose in the diet expands the surface of the gut and promotes nutrient absorption Authors (2)Patricia Figueiredo NunesDimitrios Anastasiou Nature Published 9 September 2021 Crick labsDimitrios AnastasiouFull details IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma Authors (57) Satoshi Kofuji Akiyoshi Hirayama Alexander Otto Eberhardt Risa Kawaguchi Yuki Sugiura Oltea Sampetrean[...] Hideyuki Saya Tomoyoshi Soga Ingrid Grummt Holger Bierhoff Atsuo T Sasaki Nature Cell Biology Published 1 August 2019 Crick labsDimitrios AnastasiouFull details Functional cross-talk between allosteric effects of activating and inhibiting ligands underlies PKM2 regulation Authors (12)James Macpherson Alina TheisenLaura MasinoLouise FetsPaul Driscoll Vesela Encheva[...] Stephen R Martin Jens Kleinjung Perdita E Barran Franca FraternaliDimitrios Anastasiou eLife Published 2 July 2019 Crick labs/ facilitiesDimitrios AnastasiouStructural BiologyProteomicsMetabolomicsBioinformatics and BiostatisticsFull details Hypoxia-induced switch in SNAT2/SLC38A2 regulation generates endocrine resistance in breast cancer Authors (19) Matteo Morotti Esther Bridges Alessandro Valli Hani Choudhry Helen Sheldon Simon Wigfield[...] Syed Haider Alan McIntyre Deborah CI Goberdhan Francesca Buffa Adrian L Harris Proceedings of the National Academy of Sciences of the United States of America Published 18 June 2019 Crick labsDimitrios AnastasiouFull details mTORC1 amplifies the ATF4-dependent de novo serine-glycine pathway to supply glycine during TGF-β1-induced collagen biosynthesis Authors (16) Brintha Selvarajah Ilan Azuelos Manuela Platé Delphine Guillotin Ellen J Forty Greg Contento[...] Riccardo Ronzoni Andy D Blanchard Paul F MercerDimitrios Anastasiou Rachel C Chambers Science Signaling Published 21 May 2019 Crick labs/ facilitiesDimitrios AnastasiouMetabolomicsFull details MCT2 mediates concentration-dependent inhibition of glutamine metabolism by MOG Authors (18)Louise FetsPaul DriscollFiona GrimmAakriti JainPatricia Figueiredo Nunes Michalis Gounis[...] Alan J Wright Cyril H Benes Kevin D CourtneyDavid HouseDimitrios Anastasiou Nature Chemical Biology Published 8 October 2018 Crick labs/ facilitiesDimitrios AnastasiouMetabolomicsMRC Biomedical NMR CentreHigh Throughput ScreeningFlow CytometryFull details Tumour microenvironment factors shaping the cancer metabolism landscape Authors (1)Dimitrios Anastasiou British Journal of Cancer Published 22 December 2017 Crick labsDimitrios AnastasiouFull details An engineered photoswitchable mammalian pyruvate kinase Authors (9) Stefanie GehrigJames MacphersonPaul Driscoll Alastair Symon Stephen R MartinJames Macrae Jens Kleinjung Franca FraternaliDimitrios Anastasiou FEBS Journal Published 1 September 2017 Crick labs/ facilitiesDimitrios AnastasiouStructural BiologyMetabolomicsMaking LabBioinformatics and BiostatisticsMRC Biomedical NMR CentreFull details Allosteric regulation of metabolism in cancer: endogenous mechanisms and considerations for drug design Authors (2)James MacphersonDimitrios Anastasiou Current Opinion in Biotechnology Published 18 April 2017 Crick labsDimitrios AnastasiouFull details PARK2 depletion connects energy and oxidative stress to PI3K/Akt activation via PTEN S-nitrosylation Authors (15) Amit Gupta Sara Anjomani-Virmouni Nikos Koundouros Maria Dimitriadi Rayman Choo-Wing Adamo Valle[...] John M AsaraDimitrios Anastasiou Mark J Arends Lewis C Cantley George Poulogiannis Molecular Cell Published 16 March 2017 Crick labsDimitrios AnastasiouFull details Hippo's Q for a big liver Authors (1)Dimitrios Anastasiou Nature Cell Biology Published 27 July 2016 Crick labsDimitrios AnastasiouFull details The lipid kinase PI5P4Kβ is an intracellular GTP sensor for metabolism and tumorigenesis Authors (21) Kazutaka Sumita Yu-Hua Lo Koh Takeuchi Miki Senda Satoshi Kofuji Yoshiki Ikeda[...] Jason W Locasale Takiko DaikokuDimitrios Anastasiou Toshiya Senda Atsuo T Sasaki Molecular Cell Published 21 January 2016 Crick labsDimitrios AnastasiouFull details Gas chromatography coupled to mass spectrometry (GC-MS) to study metabolism in cultured cells Authors (3)Fiona GrimmLouise FetsDimitrios Anastasiou Advances in Experimental Medicine and Biology Published 1 January 2016 Crick labsDimitrios AnastasiouFull details Degradation of activated K-Ras orthologue via K-Ras-specific lysine residues is required for cytokinesis Authors (15) Kazutaka Sumita Hirofumi Yoshino Mika Sasaki Nazanin Majd Emily Rose Kahoud Hidenori Takahashi[...] Kosuke Takeda John M Asara Richard A FirtelDimitrios Anastasiou Atsuo T Sasaki Journal of Biological Chemistry Published 18 December 2014 Crick labsDimitrios AnastasiouFull details p73 keeps metabolic control in the family Authors (2)Louise FetsDimitrios Anastasiou Nature Cell Biology Published 1 August 2013 Crick labsDimitrios AnastasiouFull details Metformin: a case of divide and conquer Authors (1)Dimitrios Anastasiou Breast Cancer Research Published 11 March 2013 Crick labsDimitrios AnastasiouFull details Breathless cancer cells get fat on glutamine Authors (2)Dimitrios Anastasiou Lewis C Cantley Cell Research Published 1 January 2012 Crick labsDimitrios AnastasiouFull details Pagination Current page 1 Page 2 Next page Next Last page Last Share the page Share 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Systematic diet composition swap in a mouse genome-scale metabolic model reveals determinants of obesogenic diet metabolism in liver cancer Authors (7) Frederick ClasenPatricia Figueiredo Nunes Gholamreza Bidkhori Nourdine Bah Stefan Boeing Saeed ShoaieDimitrios Anastasiou iScience Published 17 February 2023 Crick labs/ facilitiesDimitrios AnastasiouBioinformatics and BiostatisticsMetabolomicsIn Vivo ImagingBiological Research FacilityAdvanced SequencingFull details
MOG analogues to explore the MCT2 pharmacophore, α-ketoglutarate biology and cellular effects of N-oxalylglycine Authors (9)Louise FetsNatalie BevanPatricia Figueiredo Nunes Sebastien CamposMariana Silva Dos Santos Emma SherriffJames MacraeDavid HouseDimitrios Anastasiou Communications Biology Published 26 August 2022 Crick labs/ facilitiesDimitrios AnastasiouMetabolomicsTranslation teamFull details
Fibrometabolism-An emerging therapeutic frontier in pulmonary fibrosis Authors (4) Brintha Selvarajah Ilan AzuelosDimitrios Anastasiou Rachel C Chambers Science Signaling Published 24 August 2021 Crick labsDimitrios AnastasiouFull details
Fructose in the diet expands the surface of the gut and promotes nutrient absorption Authors (2)Patricia Figueiredo NunesDimitrios Anastasiou Nature Published 9 September 2021 Crick labsDimitrios AnastasiouFull details
IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma Authors (57) Satoshi Kofuji Akiyoshi Hirayama Alexander Otto Eberhardt Risa Kawaguchi Yuki Sugiura Oltea Sampetrean[...] Hideyuki Saya Tomoyoshi Soga Ingrid Grummt Holger Bierhoff Atsuo T Sasaki Nature Cell Biology Published 1 August 2019 Crick labsDimitrios AnastasiouFull details
Functional cross-talk between allosteric effects of activating and inhibiting ligands underlies PKM2 regulation Authors (12)James Macpherson Alina TheisenLaura MasinoLouise FetsPaul Driscoll Vesela Encheva[...] Stephen R Martin Jens Kleinjung Perdita E Barran Franca FraternaliDimitrios Anastasiou eLife Published 2 July 2019 Crick labs/ facilitiesDimitrios AnastasiouStructural BiologyProteomicsMetabolomicsBioinformatics and BiostatisticsFull details
Hypoxia-induced switch in SNAT2/SLC38A2 regulation generates endocrine resistance in breast cancer Authors (19) Matteo Morotti Esther Bridges Alessandro Valli Hani Choudhry Helen Sheldon Simon Wigfield[...] Syed Haider Alan McIntyre Deborah CI Goberdhan Francesca Buffa Adrian L Harris Proceedings of the National Academy of Sciences of the United States of America Published 18 June 2019 Crick labsDimitrios AnastasiouFull details
mTORC1 amplifies the ATF4-dependent de novo serine-glycine pathway to supply glycine during TGF-β1-induced collagen biosynthesis Authors (16) Brintha Selvarajah Ilan Azuelos Manuela Platé Delphine Guillotin Ellen J Forty Greg Contento[...] Riccardo Ronzoni Andy D Blanchard Paul F MercerDimitrios Anastasiou Rachel C Chambers Science Signaling Published 21 May 2019 Crick labs/ facilitiesDimitrios AnastasiouMetabolomicsFull details
MCT2 mediates concentration-dependent inhibition of glutamine metabolism by MOG Authors (18)Louise FetsPaul DriscollFiona GrimmAakriti JainPatricia Figueiredo Nunes Michalis Gounis[...] Alan J Wright Cyril H Benes Kevin D CourtneyDavid HouseDimitrios Anastasiou Nature Chemical Biology Published 8 October 2018 Crick labs/ facilitiesDimitrios AnastasiouMetabolomicsMRC Biomedical NMR CentreHigh Throughput ScreeningFlow CytometryFull details
Tumour microenvironment factors shaping the cancer metabolism landscape Authors (1)Dimitrios Anastasiou British Journal of Cancer Published 22 December 2017 Crick labsDimitrios AnastasiouFull details
An engineered photoswitchable mammalian pyruvate kinase Authors (9) Stefanie GehrigJames MacphersonPaul Driscoll Alastair Symon Stephen R MartinJames Macrae Jens Kleinjung Franca FraternaliDimitrios Anastasiou FEBS Journal Published 1 September 2017 Crick labs/ facilitiesDimitrios AnastasiouStructural BiologyMetabolomicsMaking LabBioinformatics and BiostatisticsMRC Biomedical NMR CentreFull details
Allosteric regulation of metabolism in cancer: endogenous mechanisms and considerations for drug design Authors (2)James MacphersonDimitrios Anastasiou Current Opinion in Biotechnology Published 18 April 2017 Crick labsDimitrios AnastasiouFull details
PARK2 depletion connects energy and oxidative stress to PI3K/Akt activation via PTEN S-nitrosylation Authors (15) Amit Gupta Sara Anjomani-Virmouni Nikos Koundouros Maria Dimitriadi Rayman Choo-Wing Adamo Valle[...] John M AsaraDimitrios Anastasiou Mark J Arends Lewis C Cantley George Poulogiannis Molecular Cell Published 16 March 2017 Crick labsDimitrios AnastasiouFull details
Hippo's Q for a big liver Authors (1)Dimitrios Anastasiou Nature Cell Biology Published 27 July 2016 Crick labsDimitrios AnastasiouFull details
The lipid kinase PI5P4Kβ is an intracellular GTP sensor for metabolism and tumorigenesis Authors (21) Kazutaka Sumita Yu-Hua Lo Koh Takeuchi Miki Senda Satoshi Kofuji Yoshiki Ikeda[...] Jason W Locasale Takiko DaikokuDimitrios Anastasiou Toshiya Senda Atsuo T Sasaki Molecular Cell Published 21 January 2016 Crick labsDimitrios AnastasiouFull details
Gas chromatography coupled to mass spectrometry (GC-MS) to study metabolism in cultured cells Authors (3)Fiona GrimmLouise FetsDimitrios Anastasiou Advances in Experimental Medicine and Biology Published 1 January 2016 Crick labsDimitrios AnastasiouFull details
Degradation of activated K-Ras orthologue via K-Ras-specific lysine residues is required for cytokinesis Authors (15) Kazutaka Sumita Hirofumi Yoshino Mika Sasaki Nazanin Majd Emily Rose Kahoud Hidenori Takahashi[...] Kosuke Takeda John M Asara Richard A FirtelDimitrios Anastasiou Atsuo T Sasaki Journal of Biological Chemistry Published 18 December 2014 Crick labsDimitrios AnastasiouFull details
p73 keeps metabolic control in the family Authors (2)Louise FetsDimitrios Anastasiou Nature Cell Biology Published 1 August 2013 Crick labsDimitrios AnastasiouFull details
Metformin: a case of divide and conquer Authors (1)Dimitrios Anastasiou Breast Cancer Research Published 11 March 2013 Crick labsDimitrios AnastasiouFull details
Breathless cancer cells get fat on glutamine Authors (2)Dimitrios Anastasiou Lewis C Cantley Cell Research Published 1 January 2012 Crick labsDimitrios AnastasiouFull details