Publications

Metabolic priming by multiple enzyme systems supports glycolysis, HIF1α stabilisation, and human cancer cell survival in early hypoxia

Authors (11)

The EMBO Journal

Published 16 April 2024

Crick labs/ facilities

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Systematic diet composition swap in a mouse genome-scale metabolic model reveals determinants of obesogenic diet metabolism in liver cancer

Authors (7)

Frederick Clasen
Patricia Figueiredo Nunes
Gholamreza Bidkhori
Nourdine Bah
Stefan Boeing
Saeed Shoaie
Dimitrios Anastasiou

iScience

Published 17 February 2023

Crick labs/ facilities

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MOG analogues to explore the MCT2 pharmacophore, α-ketoglutarate biology and cellular effects of N-oxalylglycine

Authors (9)

Communications Biology

Published 26 August 2022

Crick labs/ facilities

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Fibrometabolism-An emerging therapeutic frontier in pulmonary fibrosis

Authors (4)

Brintha Selvarajah
Ilan Azuelos
Dimitrios Anastasiou
Rachel C Chambers

Science Signaling

Published 24 August 2021

Crick labs

Dimitrios Anastasiou

Full details

Fructose in the diet expands the surface of the gut and promotes nutrient absorption

Authors (2)

Nature

Published 9 September 2021

Crick labs

Dimitrios Anastasiou

Full details

IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma

Authors (57)

Satoshi Kofuji
Akiyoshi Hirayama
Alexander Otto Eberhardt
Risa Kawaguchi
Yuki Sugiura
Oltea Sampetrean
[...]
Hideyuki Saya
Tomoyoshi Soga
Ingrid Grummt
Holger Bierhoff
Atsuo T Sasaki

Nature Cell Biology

Published 1 August 2019

Crick labs

Dimitrios Anastasiou

Full details

Functional cross-talk between allosteric effects of activating and inhibiting ligands underlies PKM2 regulation

Authors (12)

James Macpherson
Alina Theisen
Laura Masino
Louise Fets
Paul Driscoll
Vesela Encheva
[...]
Stephen R Martin
Jens Kleinjung
Perdita E Barran
Franca Fraternali
Dimitrios Anastasiou

eLife

Published 2 July 2019

Crick labs/ facilities

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Hypoxia-induced switch in SNAT2/SLC38A2 regulation generates endocrine resistance in breast cancer

Authors (19)

Matteo Morotti
Esther Bridges
Alessandro Valli
Hani Choudhry
Helen Sheldon
Simon Wigfield
[...]
Syed Haider
Alan McIntyre
Deborah CI Goberdhan
Francesca Buffa
Adrian L Harris

Proceedings of the National Academy of Sciences of the United States of America

Published 18 June 2019

Crick labs

Dimitrios Anastasiou

Full details

mTORC1 amplifies the ATF4-dependent de novo serine-glycine pathway to supply glycine during TGF-β1-induced collagen biosynthesis

Authors (16)

Brintha Selvarajah
Ilan Azuelos
Manuela Platé
Delphine Guillotin
Ellen J Forty
Greg Contento
[...]
Riccardo Ronzoni
Andy D Blanchard
Paul F Mercer
Dimitrios Anastasiou
Rachel C Chambers

Science Signaling

Published 21 May 2019

Crick labs/ facilities

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MCT2 mediates concentration-dependent inhibition of glutamine metabolism by MOG

Authors (18)

Louise Fets
Paul Driscoll
Fiona Grimm
Aakriti Jain
Patricia Figueiredo Nunes
Michalis Gounis
[...]
Alan J Wright
Cyril H Benes
Kevin D Courtney
David House
Dimitrios Anastasiou

Nature Chemical Biology

Published 8 October 2018

Crick labs/ facilities

Full details

Tumour microenvironment factors shaping the cancer metabolism landscape

Authors (1)

Dimitrios Anastasiou

British Journal of Cancer

Published 22 December 2017

Crick labs

Dimitrios Anastasiou

Full details

An engineered photoswitchable mammalian pyruvate kinase

Authors (9)

Stefanie Gehrig
James Macpherson
Paul Driscoll
Alastair Symon
Stephen R Martin
James Macrae
Jens Kleinjung
Franca Fraternali
Dimitrios Anastasiou

FEBS Journal

Published 1 September 2017

Crick labs/ facilities

Full details

Allosteric regulation of metabolism in cancer: endogenous mechanisms and considerations for drug design

Authors (2)

Current Opinion in Biotechnology

Published 18 April 2017

Crick labs

Dimitrios Anastasiou

Full details

PARK2 depletion connects energy and oxidative stress to PI3K/Akt activation via PTEN S-nitrosylation

Authors (15)

Amit Gupta
Sara Anjomani-Virmouni
Nikos Koundouros
Maria Dimitriadi
Rayman Choo-Wing
Adamo Valle
[...]
John M Asara
Dimitrios Anastasiou
Mark J Arends
Lewis C Cantley
George Poulogiannis

Molecular Cell

Published 16 March 2017

Crick labs

Dimitrios Anastasiou

Full details

Hippo's Q for a big liver

Authors (1)

Dimitrios Anastasiou

Nature Cell Biology

Published 27 July 2016

Crick labs

Dimitrios Anastasiou

Full details

The lipid kinase PI5P4Kβ is an intracellular GTP sensor for metabolism and tumorigenesis

Authors (21)

Kazutaka Sumita
Yu-Hua Lo
Koh Takeuchi
Miki Senda
Satoshi Kofuji
Yoshiki Ikeda
[...]
Jason W Locasale
Takiko Daikoku
Dimitrios Anastasiou
Toshiya Senda
Atsuo T Sasaki

Molecular Cell

Published 21 January 2016

Crick labs

Dimitrios Anastasiou

Full details

Gas chromatography coupled to mass spectrometry (GC-MS) to study metabolism in cultured cells

Authors (3)

Advances in Experimental Medicine and Biology

Published 1 January 2016

Crick labs

Dimitrios Anastasiou

Full details

Metabolic reprogramming in cancer cells

Authors (1)

Dimitrios Anastasiou

Biochemist

Published 1 February 2015

Crick labs

Dimitrios Anastasiou

Full details

Degradation of activated K-Ras orthologue via K-Ras-specific lysine residues is required for cytokinesis

Authors (15)

Kazutaka Sumita
Hirofumi Yoshino
Mika Sasaki
Nazanin Majd
Emily Rose Kahoud
Hidenori Takahashi
[...]
Kosuke Takeda
John M Asara
Richard A Firtel
Dimitrios Anastasiou
Atsuo T Sasaki

Journal of Biological Chemistry

Published 18 December 2014

Crick labs

Dimitrios Anastasiou

Full details

p73 keeps metabolic control in the family

Authors (2)

Nature Cell Biology

Published 1 August 2013

Crick labs

Dimitrios Anastasiou

Full details

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Publications

Metabolic priming by multiple enzyme systems supports glycolysis, HIF1α stabilisation, and human cancer cell survival in early hypoxia

Systematic diet composition swap in a mouse genome-scale metabolic model reveals determinants of obesogenic diet metabolism in liver cancer

MOG analogues to explore the MCT2 pharmacophore, α-ketoglutarate biology and cellular effects of N-oxalylglycine

Fibrometabolism-An emerging therapeutic frontier in pulmonary fibrosis

Fructose in the diet expands the surface of the gut and promotes nutrient absorption

IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma

Functional cross-talk between allosteric effects of activating and inhibiting ligands underlies PKM2 regulation

Hypoxia-induced switch in SNAT2/SLC38A2 regulation generates endocrine resistance in breast cancer

mTORC1 amplifies the ATF4-dependent de novo serine-glycine pathway to supply glycine during TGF-β1-induced collagen biosynthesis

MCT2 mediates concentration-dependent inhibition of glutamine metabolism by MOG

Tumour microenvironment factors shaping the cancer metabolism landscape

An engineered photoswitchable mammalian pyruvate kinase

Allosteric regulation of metabolism in cancer: endogenous mechanisms and considerations for drug design

PARK2 depletion connects energy and oxidative stress to PI3K/Akt activation via PTEN S-nitrosylation

Hippo's Q for a big liver

The lipid kinase PI5P4Kβ is an intracellular GTP sensor for metabolism and tumorigenesis

Gas chromatography coupled to mass spectrometry (GC-MS) to study metabolism in cultured cells

Metabolic reprogramming in cancer cells

Degradation of activated K-Ras orthologue via K-Ras-specific lysine residues is required for cytokinesis

p73 keeps metabolic control in the family

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Postdoctoral clinical fellows

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