Publications

An integrated cellular and molecular model of gastric neuroendocrine cancer evolution highlights therapeutic targets

Authors (36)

Joscha Griger
Sebastian A Widholz
Moritz Jesinghaus
Niklas de Andrade Krätzig
Sebastian Lange
Thomas Engleitner
[...]
Thomas Sommermann
Günter Klöppel
Klaus Rajewsky
Dieter Saur
Roland Rad

Cancer Cell

Published 10 July 2023

Crick labs

Dinis Calado

Full details

Tumor-activated lymph node fibroblasts suppress T cell function in diffuse large B cell lymphoma

Authors (31)

Benedetta Apollonio
Filomena Spada
Nedyalko Petrov
Domenico Cozzetto
Despoina Papazoglou
Peter Jarvis
[...]
Pablo Umana
Ruth F Jarrett
Christian Klein
Alexander Deutsch
Alan G Ramsay

Journal of Clinical Investigation

Published 3 July 2023

Crick labs

Dinis Calado

Full details

Distinct genetically determined origins of Myd88/Bcl2-driven aggressive lymphoma rationalize targeted therapeutic intervention strategies

Authors (36)

Ruth Flümann
Julia Hansen
Benedikt W Pelzer
Pascal Nieper
Tim Lohmann
Ilmars Kisis
[...]
Bastian von Tresckow
Ron D Jachimowicz
Ari M Melnick
Hans Christian Reinhardt
Gero Knittel

Blood Cancer Discovery

Published 1 January 2023

Crick labs

Dinis Calado

Full details

Leveraging the dynamic immune environment triad in patients with breast cancer: Tumour, lymph node, and peripheral blood

Authors (9)

Isobelle Wall
Victoire Boulat
Aekta Shah
Kim RM Blenman
Yin Wu
Elena Alberts
Dinis Calado
Roberto Salgado
Anita Grigoriadis

Cancers (Basel)

Published 17 September 2022

Crick labs

Dinis Calado

Full details

A preclinical model of peripheral T-cell lymphoma GATA3 reveals DNA damage response pathway vulnerability

Authors (12)

Elizabeth A Kuczynski
Giulia Morlino
Alison Peter
Anna ML Coenen-Stass
Jennifer I Moss
Neha Wali
[...]
Avinash Reddy
Anisha Solanki
Charles Sinclair
Dinis Calado
Larissa S Carnevalli

EMBO Molecular Medicine

Published 8 June 2022

Crick labs/ facilities

Full details

PHGDH is required for germinal center formation and is a therapeutic target in MYC-driven lymphoma

Authors (17)

Annalisa D'Avola
Nathalie Legrave
Mylene Tajan
Probir Chakravarty
Ryan L Shearer
Hamish W King
[...]
James Macrae
John G Gribben
Dinis Calado
Karen Vousden
John Riches

Journal of Clinical Investigation

Published 2 May 2022

Crick labs/ facilities

Full details

Generation and surgical analysis of genetic mouse models to study NF-κB-driven pathogenesis of Diffuse Large B Cell Lymphoma

Authors (5)

Bernard D Maybury
Yolanda Saavedra-Torres
Thomas Snoeks
Jude Fitzgibbon
Dinis Calado

Methods in Molecular Biology

Published 9 July 2021

Crick labs/ facilities

Full details

Immune crosstalk between lymph nodes and breast carcinomas, with a focus on B cells

Authors (4)

Elena Alberts
Isobelle Wall
Dinis Calado
Anita Grigoriadis

Frontiers in Molecular Biosciences

Published 1 May 2021

Crick labs

Dinis Calado

Full details

Positive selection in the light zone of germinal centers

Authors (2)

Frontiers in Immunology

Published 1 March 2021

Crick labs

Dinis Calado

Full details

Permissive selection followed by affinity-based proliferation of GC light zone B cells dictates cell fate and ensures clonal breadth

Authors (11)

Rinako Nakagawa
Amparo Toboso-Navasa
Marta Schips
George Young
Leena Bhaw-Rosun
Miriam Llorian-Sopena
Probir Chakravarty
Abdul Karim Sesay
George Kassiotis
Michael Meyer-Hermann
Dinis Calado

Proceedings of the National Academy of Sciences of USA

Published 12 January 2021

Crick labs/ facilities

Full details

Genetic timestamping of plasma cells in vivo reveals tissue-specific homeostatic population turnover

Authors (3)

An Qi Xu
Rita R Barbosa
Dinis Calado

eLife

Published 2 November 2020

Crick labs/ facilities

Full details

Restriction of memory B cell differentiation at the germinal center B cell positive selection stage

Authors (13)

Amparo Toboso-Navasa
Arief Gunawan
Giulia Morlino
Rinako Nakagawa
Andrea Taddei
Djamil Damry
[...]
Martin Janz
George Kassiotis
Robert Brink
Martin Eilers
Dinis Calado

Journal of Experimental Medicine

Published 6 July 2020

Crick labs/ facilities

Full details

RAC1P29S induces a mesenchymal phenotypic switch via serum response factor to promote melanoma development and therapy resistance

Authors (17)

Cancer Cell

Published 8 July 2019

Crick labs/ facilities

Full details

Validation and invalidation of chemical probes for the human N-myristoyltransferases

Authors (9)

Wouter W Kallemeijn
Gregor A Lueg
Monica Faronato
Kate Hadavizadeh
Andrea Goya Grocin
Ok-Ryul Song
Michael Howell
Dinis Calado
Edward W Tate

Cell Chemical Biology

Published 20 June 2019

Crick labs/ facilities

Full details

MicroRNA-155 protects group 2 innate lymphoid cells from apoptosis to promote type-2 immunity

Authors (8)

Martin D Knolle
Shau Bing Chin
Batika MJ Rana
Alexandros Englezakis
Rinako Nakagawa
Padraic G Fallon
Anna Git
Andrew NJ McKenzie

Frontiers in Immunology

Published 9 October 2018

Crick labs

Dinis Calado

Full details

Restoration of endogenous retrovirus infectivity impacts mouse cancer models

Authors (10)

Eleonora Ottina
Prisca Levy
Urszula Eksmond
Julia Merkenschlager
George Young
Juliette Roels
Jonathan Stoye
Thomas Tüting
Dinis Calado
George Kassiotis

Cancer Immunology Research

Published 1 November 2018

Crick labs/ facilities

Full details

BCL11A interacts with SOX2 to control the expression of epigenetic regulators in lung squamous carcinoma

Authors (20)

Kyren A Lazarus
Fazal Hadi
Elisabetta Zambon
Karsten Bach
Maria-Francesca Santolla
Julie K Watson
[...]
Frank M McCaughan
John Le Quesne
Joo-Hyeon Lee
Dinis Calado
Walid T Khaled

Nature Communications

Published 20 August 2018

Crick labs

Full details

Matrix stiffness controls lymphatic vessel formation through regulation of a GATA2-dependent transcriptional program

Authors (14)

Maike Frye
Andrea Taddei
Cathrin Dierkes
Ines Martinez-Corral
Matthew Fielden
Henrik Ortsäter
[...]
Marjo Salminen
Liqun He
Natasha L Harvey
Friedemann Kiefer
Taija Mäkinen

Nature Communications

Published 17 April 2018

Crick labs/ facilities

Full details

FOXO1 promotes resistance of non-Hodgkin lymphomas to anti-CD20-based therapy

Authors (19)

Beata Pyrzynska
Michal Dwojak
Abdessamad Zerrouqi
Giulia Morlino
Piotr Zapala
Nina Miazek
[...]
Dimitar G Efremov
Przemyslaw Juszczynski
Dinis Calado
Jakub Golab
Magdalena Winiarska

Oncoimmunology

Published 25 January 2018

Crick labs

Dinis Calado

Full details

VE-cadherin-mediated epigenetic regulation of endothelial gene expression

Authors (21)

Marco F Morini
Costanza Giampietro
Monica Corada
Federica Pisati
Elisa Lavarone
Sara I Cunha
[...]
Ugo Cavallaro
Diego Pasini
Dinis Calado
Elisabetta Dejana
Andrea Taddei

Circulation Research

Published 19 January 2018

Crick labs/ facilities

Full details

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An integrated cellular and molecular model of gastric neuroendocrine cancer evolution highlights therapeutic targets

Tumor-activated lymph node fibroblasts suppress T cell function in diffuse large B cell lymphoma

Distinct genetically determined origins of Myd88/Bcl2-driven aggressive lymphoma rationalize targeted therapeutic intervention strategies

Leveraging the dynamic immune environment triad in patients with breast cancer: Tumour, lymph node, and peripheral blood

A preclinical model of peripheral T-cell lymphoma GATA3 reveals DNA damage response pathway vulnerability

PHGDH is required for germinal center formation and is a therapeutic target in MYC-driven lymphoma

Generation and surgical analysis of genetic mouse models to study NF-κB-driven pathogenesis of Diffuse Large B Cell Lymphoma

Immune crosstalk between lymph nodes and breast carcinomas, with a focus on B cells

Positive selection in the light zone of germinal centers

Permissive selection followed by affinity-based proliferation of GC light zone B cells dictates cell fate and ensures clonal breadth

Genetic timestamping of plasma cells in vivo reveals tissue-specific homeostatic population turnover

Restriction of memory B cell differentiation at the germinal center B cell positive selection stage

RAC1P29S induces a mesenchymal phenotypic switch via serum response factor to promote melanoma development and therapy resistance

Validation and invalidation of chemical probes for the human N-myristoyltransferases

MicroRNA-155 protects group 2 innate lymphoid cells from apoptosis to promote type-2 immunity

Restoration of endogenous retrovirus infectivity impacts mouse cancer models

BCL11A interacts with SOX2 to control the expression of epigenetic regulators in lung squamous carcinoma

Matrix stiffness controls lymphatic vessel formation through regulation of a GATA2-dependent transcriptional program

FOXO1 promotes resistance of non-Hodgkin lymphomas to anti-CD20-based therapy

VE-cadherin-mediated epigenetic regulation of endothelial gene expression

The Francis Crick Institute is a unique partnership between

Research case studies

Vacancies

Cut + Paste exhibition

From local to global: preparing for the next pandemic

About us

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Year published

Research topics

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