Publications

Loss of TET2 in human hematopoietic stem cells alters the development and function of neutrophils

Authors (22)

Hector Huerga Encabo
Iker Valle Aramburu
Manuel Garcia Albornoz
Marion Piganeau
Henry Wood
Anna Song
[...]
Daniel H Wiseman
Kiran Batta
Rajeev Gupta
Venizelos Papayannopoulos
Dominique Bonnet

Cell Stem Cell

Published 1 June 2023

Crick labs/ facilities

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Human CD34+ hematopoietic stem cell hierarchy: how far are we with its delineation at the most primitive level?

Authors (2)

Blood

Published 5 April 2023

Crick labs

Dominique Bonnet

Full details

The CKS1/CKS2 proteostasis axis is crucial to maintain hematopoietic stem cell function

Authors (11)

William Grey
Samantha Atkinson
Beatrice Rix
Pedro Casado
Linda Ariza-Mcnaughton
Cathy Hawley
Miriam L Sopoena
Katherine S Bridge
David Kent
Pedro R Cutillas
Dominique Bonnet

HemaSphere

Published 1 March 2023

Crick labs/ facilities

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Vitamin B5 and succinyl-CoA improve ineffective erythropoiesis in SF3B1-mutated myelodysplasia

Authors (23)

Syed Mian
Céline Philippe
Eleni Maniati
Pantelitsa Protopapa
Tiffany Bergot
Marion Piganeau
[...]
Daniel H Wiseman
Dominique Bonnet
Delphine G Bernard
John G Gribben
Kevin Rouault-Pierre

Science Translational Medicine

Published 1 March 2023

Crick labs

Dominique Bonnet

Full details

CKS1 inhibition depletes leukemic stem cells and protects healthy hematopoietic stem cells in acute myeloid leukemia

Authors (14)

William Grey
Ana Rio-Machin
Pedro Casado
Eva Gronroos
Sara Ali
Juho J Miettinen
[...]
Charles Swanton
Pedro R Cutillas
John Gribben
Jude Fitzgibbon
Dominique Bonnet

Science Translational Medicine

Published 22 June 2022

Crick labs/ facilities

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Single cell analyses identify a highly regenerative and homogenous human CD34+ hematopoietic stem cell population

Authors (9)

Fernando Anjos-Afonso
Florian Buettner
Syed A Mian
Hefin Rhys
Jimena Perez Lloret
Manuel Garcia Albornoz
Namrata Rastogi
Linda Ariza-Mcnaughton
Dominique Bonnet

Nature Communications

Published 19 April 2022

Crick labs/ facilities

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The EHA Research Roadmap: Normal hematopoiesis

Authors (41)

Thierry Jaffredo
Alessandra Balduini
Anna Bigas
Rosa Bernardi
Dominique Bonnet
Bruno Canque
[...]
Ivo Touw
William Vainchenker
Joan-Lluis Vives Corrons
Laurent Yvernogeau
Jan Jacob Schuringa

HemaSphere

Published 1 December 2021

Crick labs

Dominique Bonnet

Full details

Recruitment of dendritic cell progenitors to foci of influenza A virus infection sustains immunity

Authors (18)

Science Immunology

Published 5 November 2021

Crick labs/ facilities

Full details

Infecting human hematopoietic stem and progenitor cells with SARS-CoV-2

Authors (5)

STAR Protocols

Published 17 December 2021

Crick labs/ facilities

Full details

Adipocytes disrupt the translational programme of acute lymphoblastic leukaemia to favour tumour survival and persistence

Authors (24)

Q Heydt
C Xintaropoulou
A Clear
M Austin
I Pislariu
F Miraki-Moud
[...]
A Wilczynska
Linda Ariza-Mcnaughton
Dominique Bonnet
F Mardakheh
B Patel

Nature Communications

Published 17 September 2021

Crick labs

Dominique Bonnet

Full details

Generation of tubular and membranous shape textures with curvature functionals

Authors (1)

Anna Song

Journal of Mathematical Imaging and Vision

Published 1 January 2022

Crick labs

Dominique Bonnet

Full details

Nature or nurture? Role of the bone marrow microenvironment in the genesis and maintenance of myelodysplastic syndromes

Authors (2)

Syed A Mian
Dominique Bonnet

Cancers

Published 16 August 2021

Crick labs

Dominique Bonnet

Full details

Engraftment of human hematopoietic cells in biomaterials implanted in immunodeficient mouse models

Authors (2)

Methods in Molecular Biology

Published 1 January 2021

Crick labs

Dominique Bonnet

Full details

Integrated OMICs unveil the bone-marrow microenvironment in human leukemia

Authors (13)

Cell Reports

Published 11 May 2021

Crick labs/ facilities

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Dynamic contrast-enhanced magnetic resonance imaging quantification of leukemia-induced changes in bone marrow vascular function

Authors (5)

Haematologica

Published 1 August 2021

Crick labs/ facilities

Full details

Human erythroid progenitors are directly infected by SARS-CoV-2: Implications for emerging erythropoiesis in severe COVID-19 patients

Authors (11)

Stem Cell Reports

Published 9 March 2021

Crick labs/ facilities

Full details

Advances in human immune system mouse models for studying human hematopoiesis and cancer immunotherapy

Authors (3)

Syed Mian
Fernando Anjos-Afonso
Dominique Bonnet

Frontiers in Immunology

Published 2 February 2021

Crick labs

Dominique Bonnet

Full details

Loss of tRNA-modifying enzyme Elp3 activates a p53-dependent antitumor checkpoint in hematopoiesis

Authors (17)

Adeline Rosu
Najla El Hachem
Francesca Rapino
Kevin Rouault-Pierre
Joseph Jorssen
Joan Somja
[...]
Dominique Bonnet
Alain Chariot
Pierre Close
Fabrice Bureau
Christophe J Desmet

Journal of Experimental Medicine

Published 1 March 2021

Crick labs

Dominique Bonnet

Full details

Understanding of the crosstalk between normal residual hematopoietic stem cells and the leukemic niche in acute myeloid leukemia

Authors (3)

Experimental Hematology

Published 1 March 2021

Crick labs

Dominique Bonnet

Full details

Ectopic humanized mesenchymal niche in mice enables robust engraftment of myelodysplastic stem cells

Authors (13)

Blood Cancer Discovery

Published 1 March 2021

Crick labs/ facilities

Full details

Research case studies

Vacancies

Cut + Paste exhibition

Coronavirus (COVID-19) research

About us

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Haematopoietic Stem Cell Laboratory
: Publications

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Publications

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Loss of TET2 in human hematopoietic stem cells alters the development and function of neutrophils

Human CD34+ hematopoietic stem cell hierarchy: how far are we with its delineation at the most primitive level?

The CKS1/CKS2 proteostasis axis is crucial to maintain hematopoietic stem cell function

Vitamin B5 and succinyl-CoA improve ineffective erythropoiesis in SF3B1-mutated myelodysplasia

CKS1 inhibition depletes leukemic stem cells and protects healthy hematopoietic stem cells in acute myeloid leukemia

Single cell analyses identify a highly regenerative and homogenous human CD34+ hematopoietic stem cell population

The EHA Research Roadmap: Normal hematopoiesis

Recruitment of dendritic cell progenitors to foci of influenza A virus infection sustains immunity

Infecting human hematopoietic stem and progenitor cells with SARS-CoV-2

Adipocytes disrupt the translational programme of acute lymphoblastic leukaemia to favour tumour survival and persistence

Generation of tubular and membranous shape textures with curvature functionals

Nature or nurture? Role of the bone marrow microenvironment in the genesis and maintenance of myelodysplastic syndromes

Engraftment of human hematopoietic cells in biomaterials implanted in immunodeficient mouse models

Integrated OMICs unveil the bone-marrow microenvironment in human leukemia

Dynamic contrast-enhanced magnetic resonance imaging quantification of leukemia-induced changes in bone marrow vascular function

Human erythroid progenitors are directly infected by SARS-CoV-2: Implications for emerging erythropoiesis in severe COVID-19 patients

Advances in human immune system mouse models for studying human hematopoiesis and cancer immunotherapy

Loss of tRNA-modifying enzyme Elp3 activates a p53-dependent antitumor checkpoint in hematopoiesis

Understanding of the crosstalk between normal residual hematopoietic stem cells and the leukemic niche in acute myeloid leukemia

Ectopic humanized mesenchymal niche in mice enables robust engraftment of myelodysplastic stem cells

The Francis Crick Institute is a unique partnership between

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