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Breadcrumb Dominique Bonnet Bonnet lab Haematopoietic Stem Cell Laboratory : Publications Lab contentLab contentIn this section Overview Vacancies Areas of interest Publications Members Visualisation of Leukaemic cells initiating and invading the bone marrow microenvironment Toggle to view hero caption PublicationsYear published2024 (1)2023 (5)2022 (2)2021 (7)2020 (8)2019 (2)2018 (1)2017 (8)2016 (5)2015 (10)2014 (3)2013 (10)2012 (10)2011 (2)2010 (6) Facet Year publishedResearch topicsHuman Biology & Physiology (45)Stem Cells (45)Tumour Biology (45)Genetics & Genomics (21)Genome Integrity & Repair (17)Chemical Biology & High Throughput (16)Computational & Systems Biology (16)Model Organisms (13)Immunology (10)Imaging (7)Cell Biology (6)Infectious Disease (5)Cell Cycle & Chromosomes (4)Signalling & Oncogenes (4)Biochemistry & Proteomics (3)Developmental Biology (3)Gene Expression (3)Structural Biology & Biophysics (2)Metabolism (1)Microfabrication & Bioengineering (1)Neurosciences (1)Synthetic Biology (1) Facet Research topicsPublication typeJournal article (80) (-)Primary research (80) Facet Publication typeJournalBlood (10)Leukemia (10)Nature Communications (6)British Journal of Haematology (4)Cancer Research (3)Cell Stem Cell (3)Haematologica (3)Stem Cell Reports (3)Blood Cancer Discovery (2)Cancer Cell (2)Cell Reports (2)Journal of Clinical Investigation (2)Journal of Experimental Medicine (2)PLOS ONE (2)Science Translational Medicine (2)Aging Cell (1)Analyst (1)Annals of Hematology (1)Cytotherapy (1)Developmental Cell (1)Epigenetics (1)European Journal of Immunology (1)Experimental Hematology (1)Frontiers in Cellular Neuroscience (1)HemaSphere (1)Journal of biomedical science (1)Journal of Clinical Medicine (1)Journal of Immunology (1)Journal of Mathematical Imaging and Vision (1)Nature (1)Nature Immunology (1)Oncoimmunology (1)Proceedings of the National Academy of Sciences of the United States of America (1)Proceedings of the National Academy of Sciences of USA (1)Science Immunology (1)Scientific Reports (1)Stem Cells (1)Stem Cells Translational Medicine (1)The Lancet (1) Facet Journal Publications Displaying 1 - 20 of 80Last updated : 23 April 2024 02:27 Distinct ontogenetic lineages dictate cDC2 heterogeneity Authors (15)Carlos Munoz MinuttiCecile PiotMariana Pereira Da Costa Probir ChakravartyNeil RogersHector Huerga Encabo[...] Jean LanghorneDominique Bonnet Marc Dalod Elena TomaselloCaetano Reis e Sousa Nature Immunology Published 1 March 2024 Crick labs/ facilitiesCaetano Reis e SousaJean LanghorneGeorge KassiotisDominique BonnetBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityAdvanced SequencingFull details Defining the identity and the niches of epithelial stem cells with highly pleiotropic multilineage potency in the human thymus Authors (17)Roberta RagazziniStefan BoeingLuca ZanieriMary GreenGiuseppe D'Agostino Kerol Bartolovic[...] David Scoville Andy NamAdrian HaydayDominique BonnetPaola Bonfanti Developmental Cell Published 20 November 2023 Crick labs/ facilitiesAdrian HaydayDominique BonnetPaola BonfantiFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsLight MicroscopyAdvanced SequencingFull details CRISPR/dCas9 DNA methylation editing is heritable during human hematopoiesis and shapes immune progeny Authors (9) Emily A SaundersonHector Huerga Encabo Julie Devis Kevin Rouault-PierreMarion Piganeau Christopher G Bell John G GribbenDominique Bonnet Gabriella Ficz Proceedings of the National Academy of Sciences of USA Published 22 August 2023 Crick labs/ facilitiesDominique BonnetBiological Research FacilityFull details Loss of TET2 in human hematopoietic stem cells alters the development and function of neutrophils Authors (22)Hector Huerga EncaboIker Valle AramburuManuel Garcia AlbornozMarion Piganeau Henry Wood Anna Song[...] Daniel H Wiseman Kiran Batta Rajeev GuptaVenizelos PapayannopoulosDominique Bonnet Cell Stem Cell Published 1 June 2023 Crick labs/ facilitiesCaetano Reis e SousaVenizelos PapayannopoulosDominique BonnetLight MicroscopyElectron MicroscopyBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityAdvanced SequencingFull details The CKS1/CKS2 proteostasis axis is crucial to maintain hematopoietic stem cell function Authors (11)William GreySamantha Atkinson Beatrice Rix Pedro CasadoLinda Ariza-Mcnaughton Cathy Hawley Miriam L Sopoena Katherine S Bridge David Kent Pedro R CutillasDominique Bonnet HemaSphere Published 1 March 2023 Crick labs/ facilitiesDominique BonnetBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityFull details Vitamin B5 and succinyl-CoA improve ineffective erythropoiesis in SF3B1-mutated myelodysplasia Authors (23)Syed Mian Céline Philippe Eleni Maniati Pantelitsa Protopapa Tiffany BergotMarion Piganeau[...] Daniel H WisemanDominique Bonnet Delphine G Bernard John G Gribben Kevin Rouault-Pierre Science Translational Medicine Published 1 March 2023 Crick labsDominique BonnetFull details CKS1 inhibition depletes leukemic stem cells and protects healthy hematopoietic stem cells in acute myeloid leukemia Authors (14)William Grey Ana Rio-Machin Pedro CasadoEva GronroosSara Ali Juho J Miettinen[...]Charles Swanton Pedro R Cutillas John Gribben Jude FitzgibbonDominique Bonnet Science Translational Medicine Published 22 June 2022 Crick labs/ facilitiesCharles SwantonDominique BonnetFlow CytometryCell ServicesBiological Research FacilityFull details Single cell analyses identify a highly regenerative and homogenous human CD34+ hematopoietic stem cell population Authors (9) Fernando Anjos-Afonso Florian Buettner Syed A MianHefin RhysJimena Perez-LloretManuel Garcia Albornoz Namrata RastogiLinda Ariza-McnaughtonDominique Bonnet Nature Communications Published 19 April 2022 Crick labs/ facilitiesDominique BonnetFlow CytometryAdvanced SequencingBiological Research FacilityFull details Recruitment of dendritic cell progenitors to foci of influenza A virus infection sustains immunity Authors (18)Maria Del Mar Cabeza CabrerizoCarlos Munoz Minutti Mariana Pereira da CostaAna Matos Cardoso Da SilvaRob JenkinsJustina Kulikauskaite[...] Judith E Allen Manolis PasparakisAndreas WackErik SahaiCaetano Reis e Sousa Science Immunology Published 5 November 2021 Crick labs/ facilitiesAndreas WackErik SahaiCaetano Reis e SousaNicola LewisDominique BonnetWorldwide Influenza CentreFlow CytometryBiological Research FacilityBioinformatics and BiostatisticsFull details Adipocytes disrupt the translational programme of acute lymphoblastic leukaemia to favour tumour survival and persistence Authors (24) Q Heydt C Xintaropoulou A Clear M Austin I Pislariu F Miraki-Moud[...] A WilczynskaLinda Ariza-McnaughtonDominique Bonnet F Mardakheh B Patel Nature Communications Published 17 September 2021 Crick labsDominique BonnetFull details Generation of tubular and membranous shape textures with curvature functionals Authors (1) Anna Song Journal of Mathematical Imaging and Vision Published 1 January 2022 Crick labsDominique BonnetFull details Integrated OMICs unveil the bone-marrow microenvironment in human leukemia Authors (13)Diana PassaroManuel Garcia Albornoz Giovanni Diana Probir ChakravartyLinda Ariza-McnaughtonAntoniana Batsivari[...]Alexander WaclawiczekLuigi OmbratoIlaria Malanchi John GribbenDominique Bonnet Cell Reports Published 11 May 2021 Crick labs/ facilitiesIlaria MalanchiDominique BonnetBioinformatics and BiostatisticsProteomicsFlow CytometryBiological Research FacilityAdvanced SequencingFull details Dynamic contrast-enhanced magnetic resonance imaging quantification of leukemia-induced changes in bone marrow vascular function Authors (5)Ana Gomes John GribbenBernard SiowDiana PassaroDominique Bonnet Haematologica Published 1 August 2021 Crick labs/ facilitiesDominique BonnetIn Vivo ImagingBiological Research FacilityFlow CytometryFull details Human erythroid progenitors are directly infected by SARS-CoV-2: Implications for emerging erythropoiesis in severe COVID-19 patients Authors (11)Hector Huerga EncaboWilliam GreyManuel Garcia Albornoz Henry WoodRachel Ulferts Iker Valle Aramburu Austin G Kulasekararaj Ghulam MuftiVenizelos PapayannopoulosRupert BealeDominique Bonnet Stem Cell Reports Published 9 March 2021 Crick labs/ facilitiesVenizelos PapayannopoulosDominique BonnetRupert BealeFlow CytometryFull details Loss of tRNA-modifying enzyme Elp3 activates a p53-dependent antitumor checkpoint in hematopoiesis Authors (17) Adeline Rosu Najla El Hachem Francesca RapinoKevin Rouault-Pierre Joseph Jorssen Joan Somja[...]Dominique Bonnet Alain Chariot Pierre Close Fabrice Bureau Christophe J Desmet Journal of Experimental Medicine Published 1 March 2021 Crick labsDominique BonnetFull details Ectopic humanized mesenchymal niche in mice enables robust engraftment of myelodysplastic stem cells Authors (13)Syed Mian Ander Abarrategi Kar Lok KongKevin Rouault-Pierre Henry WoodCaroline Oedekoven[...]Linda Ariza-McnaughtonPeter JohnsonThomas Snoeks Ghulam J MuftiDominique Bonnet Blood Cancer Discovery Published 1 March 2021 Crick labs/ facilitiesDominique BonnetIn Vivo ImagingBiological Research FacilityFlow CytometryExperimental HistopathologyFull details Ectopic humanized mesenchymal niche in mice enables robust engraftment of myelodysplastic stem cells Authors (13)Syed Mian Ander Abarrategi Kar Lok KongKevin Rouault-Pierre Henry WoodCaroline Oedekoven[...]Linda Ariza-McnaughtonPeter JohnsonThomas Snoeks Ghulam J MuftiDominique Bonnet Blood Cancer Discovery Published 1 March 2021 Crick labs/ facilitiesDominique BonnetIn Vivo ImagingBiological Research FacilityFlow CytometryExperimental HistopathologyFull details Reconstitution of a functional human thymus by postnatal stromal progenitor cells and natural whole-organ scaffolds Authors (22)Sara CampinotiAsllan GjinovciRoberta RagazziniLuca ZanieriLinda Ariza-Mcnaughton Marco Catucci[...] Sarah A Teichmann Neil J SebireAdrian HaydayDominique BonnetPaola Bonfanti Nature Communications Published 11 December 2020 Crick labs/ facilitiesAdrian HaydayDominique BonnetPaola BonfantiBioinformatics and BiostatisticsLight MicroscopyFlow CytometryExperimental HistopathologyElectron MicroscopyBiological Research FacilityAdvanced SequencingFull details Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers Authors (341) Catherine F Houlihan Nina Vora Thomas Byrne Dan LewerGavin Kelly Judith Heaney[...] Andrew Hayward Richard Gilson Gavin KellyFiona Roberts Emine Hatipoglu The Lancet Published 25 July 2020 Crick labs/ facilitiesAndreas WackKaren VousdenJernej UleJames TurnerMoritz TreeckCharles SwantonAdam SaterialeErik SahaiCaetano Reis e SousaPeter RatcliffeLucia Prieto-GodinoVenizelos PapayannopoulosAnne O’GarraPaul NurseGeorge KassiotisMaximiliano GutierrezSonia GandhiSteve GamblinPeter Cherepanov Luiz Pedro CarvalhoDominique BonnetMike BlackmanRupert BealeWorldwide Influenza CentreStructural BiologyMetabolomicsHuman Embryonic Stem CellHigh Throughput ScreeningGenetic Modification ServiceFlow CytometryFermentationExperimental HistopathologyElectron MicroscopyCell ServicesBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Activation of the receptor tyrosine kinase RET improves long-term hematopoietic stem cell outgrowth and potency Authors (7)William GreyRakhee ChauhanMarion PiganeauHector Huerga EncaboManuel Garcia AlbornozNeil McDonaldDominique Bonnet Blood Published 26 November 2020 Crick labs/ facilitiesNeil McDonaldDominique BonnetFlow CytometryBiological Research FacilityFull details Pagination Current page 1 Page 2 Page 3 Page 4 Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Distinct ontogenetic lineages dictate cDC2 heterogeneity Authors (15)Carlos Munoz MinuttiCecile PiotMariana Pereira Da Costa Probir ChakravartyNeil RogersHector Huerga Encabo[...] Jean LanghorneDominique Bonnet Marc Dalod Elena TomaselloCaetano Reis e Sousa Nature Immunology Published 1 March 2024 Crick labs/ facilitiesCaetano Reis e SousaJean LanghorneGeorge KassiotisDominique BonnetBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityAdvanced SequencingFull details
Defining the identity and the niches of epithelial stem cells with highly pleiotropic multilineage potency in the human thymus Authors (17)Roberta RagazziniStefan BoeingLuca ZanieriMary GreenGiuseppe D'Agostino Kerol Bartolovic[...] David Scoville Andy NamAdrian HaydayDominique BonnetPaola Bonfanti Developmental Cell Published 20 November 2023 Crick labs/ facilitiesAdrian HaydayDominique BonnetPaola BonfantiFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsLight MicroscopyAdvanced SequencingFull details
CRISPR/dCas9 DNA methylation editing is heritable during human hematopoiesis and shapes immune progeny Authors (9) Emily A SaundersonHector Huerga Encabo Julie Devis Kevin Rouault-PierreMarion Piganeau Christopher G Bell John G GribbenDominique Bonnet Gabriella Ficz Proceedings of the National Academy of Sciences of USA Published 22 August 2023 Crick labs/ facilitiesDominique BonnetBiological Research FacilityFull details
Loss of TET2 in human hematopoietic stem cells alters the development and function of neutrophils Authors (22)Hector Huerga EncaboIker Valle AramburuManuel Garcia AlbornozMarion Piganeau Henry Wood Anna Song[...] Daniel H Wiseman Kiran Batta Rajeev GuptaVenizelos PapayannopoulosDominique Bonnet Cell Stem Cell Published 1 June 2023 Crick labs/ facilitiesCaetano Reis e SousaVenizelos PapayannopoulosDominique BonnetLight MicroscopyElectron MicroscopyBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityAdvanced SequencingFull details
The CKS1/CKS2 proteostasis axis is crucial to maintain hematopoietic stem cell function Authors (11)William GreySamantha Atkinson Beatrice Rix Pedro CasadoLinda Ariza-Mcnaughton Cathy Hawley Miriam L Sopoena Katherine S Bridge David Kent Pedro R CutillasDominique Bonnet HemaSphere Published 1 March 2023 Crick labs/ facilitiesDominique BonnetBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityFull details
Vitamin B5 and succinyl-CoA improve ineffective erythropoiesis in SF3B1-mutated myelodysplasia Authors (23)Syed Mian Céline Philippe Eleni Maniati Pantelitsa Protopapa Tiffany BergotMarion Piganeau[...] Daniel H WisemanDominique Bonnet Delphine G Bernard John G Gribben Kevin Rouault-Pierre Science Translational Medicine Published 1 March 2023 Crick labsDominique BonnetFull details
CKS1 inhibition depletes leukemic stem cells and protects healthy hematopoietic stem cells in acute myeloid leukemia Authors (14)William Grey Ana Rio-Machin Pedro CasadoEva GronroosSara Ali Juho J Miettinen[...]Charles Swanton Pedro R Cutillas John Gribben Jude FitzgibbonDominique Bonnet Science Translational Medicine Published 22 June 2022 Crick labs/ facilitiesCharles SwantonDominique BonnetFlow CytometryCell ServicesBiological Research FacilityFull details
Single cell analyses identify a highly regenerative and homogenous human CD34+ hematopoietic stem cell population Authors (9) Fernando Anjos-Afonso Florian Buettner Syed A MianHefin RhysJimena Perez-LloretManuel Garcia Albornoz Namrata RastogiLinda Ariza-McnaughtonDominique Bonnet Nature Communications Published 19 April 2022 Crick labs/ facilitiesDominique BonnetFlow CytometryAdvanced SequencingBiological Research FacilityFull details
Recruitment of dendritic cell progenitors to foci of influenza A virus infection sustains immunity Authors (18)Maria Del Mar Cabeza CabrerizoCarlos Munoz Minutti Mariana Pereira da CostaAna Matos Cardoso Da SilvaRob JenkinsJustina Kulikauskaite[...] Judith E Allen Manolis PasparakisAndreas WackErik SahaiCaetano Reis e Sousa Science Immunology Published 5 November 2021 Crick labs/ facilitiesAndreas WackErik SahaiCaetano Reis e SousaNicola LewisDominique BonnetWorldwide Influenza CentreFlow CytometryBiological Research FacilityBioinformatics and BiostatisticsFull details
Adipocytes disrupt the translational programme of acute lymphoblastic leukaemia to favour tumour survival and persistence Authors (24) Q Heydt C Xintaropoulou A Clear M Austin I Pislariu F Miraki-Moud[...] A WilczynskaLinda Ariza-McnaughtonDominique Bonnet F Mardakheh B Patel Nature Communications Published 17 September 2021 Crick labsDominique BonnetFull details
Generation of tubular and membranous shape textures with curvature functionals Authors (1) Anna Song Journal of Mathematical Imaging and Vision Published 1 January 2022 Crick labsDominique BonnetFull details
Integrated OMICs unveil the bone-marrow microenvironment in human leukemia Authors (13)Diana PassaroManuel Garcia Albornoz Giovanni Diana Probir ChakravartyLinda Ariza-McnaughtonAntoniana Batsivari[...]Alexander WaclawiczekLuigi OmbratoIlaria Malanchi John GribbenDominique Bonnet Cell Reports Published 11 May 2021 Crick labs/ facilitiesIlaria MalanchiDominique BonnetBioinformatics and BiostatisticsProteomicsFlow CytometryBiological Research FacilityAdvanced SequencingFull details
Dynamic contrast-enhanced magnetic resonance imaging quantification of leukemia-induced changes in bone marrow vascular function Authors (5)Ana Gomes John GribbenBernard SiowDiana PassaroDominique Bonnet Haematologica Published 1 August 2021 Crick labs/ facilitiesDominique BonnetIn Vivo ImagingBiological Research FacilityFlow CytometryFull details
Human erythroid progenitors are directly infected by SARS-CoV-2: Implications for emerging erythropoiesis in severe COVID-19 patients Authors (11)Hector Huerga EncaboWilliam GreyManuel Garcia Albornoz Henry WoodRachel Ulferts Iker Valle Aramburu Austin G Kulasekararaj Ghulam MuftiVenizelos PapayannopoulosRupert BealeDominique Bonnet Stem Cell Reports Published 9 March 2021 Crick labs/ facilitiesVenizelos PapayannopoulosDominique BonnetRupert BealeFlow CytometryFull details
Loss of tRNA-modifying enzyme Elp3 activates a p53-dependent antitumor checkpoint in hematopoiesis Authors (17) Adeline Rosu Najla El Hachem Francesca RapinoKevin Rouault-Pierre Joseph Jorssen Joan Somja[...]Dominique Bonnet Alain Chariot Pierre Close Fabrice Bureau Christophe J Desmet Journal of Experimental Medicine Published 1 March 2021 Crick labsDominique BonnetFull details
Ectopic humanized mesenchymal niche in mice enables robust engraftment of myelodysplastic stem cells Authors (13)Syed Mian Ander Abarrategi Kar Lok KongKevin Rouault-Pierre Henry WoodCaroline Oedekoven[...]Linda Ariza-McnaughtonPeter JohnsonThomas Snoeks Ghulam J MuftiDominique Bonnet Blood Cancer Discovery Published 1 March 2021 Crick labs/ facilitiesDominique BonnetIn Vivo ImagingBiological Research FacilityFlow CytometryExperimental HistopathologyFull details
Ectopic humanized mesenchymal niche in mice enables robust engraftment of myelodysplastic stem cells Authors (13)Syed Mian Ander Abarrategi Kar Lok KongKevin Rouault-Pierre Henry WoodCaroline Oedekoven[...]Linda Ariza-McnaughtonPeter JohnsonThomas Snoeks Ghulam J MuftiDominique Bonnet Blood Cancer Discovery Published 1 March 2021 Crick labs/ facilitiesDominique BonnetIn Vivo ImagingBiological Research FacilityFlow CytometryExperimental HistopathologyFull details
Reconstitution of a functional human thymus by postnatal stromal progenitor cells and natural whole-organ scaffolds Authors (22)Sara CampinotiAsllan GjinovciRoberta RagazziniLuca ZanieriLinda Ariza-Mcnaughton Marco Catucci[...] Sarah A Teichmann Neil J SebireAdrian HaydayDominique BonnetPaola Bonfanti Nature Communications Published 11 December 2020 Crick labs/ facilitiesAdrian HaydayDominique BonnetPaola BonfantiBioinformatics and BiostatisticsLight MicroscopyFlow CytometryExperimental HistopathologyElectron MicroscopyBiological Research FacilityAdvanced SequencingFull details
Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers Authors (341) Catherine F Houlihan Nina Vora Thomas Byrne Dan LewerGavin Kelly Judith Heaney[...] Andrew Hayward Richard Gilson Gavin KellyFiona Roberts Emine Hatipoglu The Lancet Published 25 July 2020 Crick labs/ facilitiesAndreas WackKaren VousdenJernej UleJames TurnerMoritz TreeckCharles SwantonAdam SaterialeErik SahaiCaetano Reis e SousaPeter RatcliffeLucia Prieto-GodinoVenizelos PapayannopoulosAnne O’GarraPaul NurseGeorge KassiotisMaximiliano GutierrezSonia GandhiSteve GamblinPeter Cherepanov Luiz Pedro CarvalhoDominique BonnetMike BlackmanRupert BealeWorldwide Influenza CentreStructural BiologyMetabolomicsHuman Embryonic Stem CellHigh Throughput ScreeningGenetic Modification ServiceFlow CytometryFermentationExperimental HistopathologyElectron MicroscopyCell ServicesBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Activation of the receptor tyrosine kinase RET improves long-term hematopoietic stem cell outgrowth and potency Authors (7)William GreyRakhee ChauhanMarion PiganeauHector Huerga EncaboManuel Garcia AlbornozNeil McDonaldDominique Bonnet Blood Published 26 November 2020 Crick labs/ facilitiesNeil McDonaldDominique BonnetFlow CytometryBiological Research FacilityFull details