Research case studies Explore a selection of reports that spotlight particular areas of research at the Crick over the past five years.
Postdoctoral clinical fellows Opportunities for postdoctoral clinicians to consolidate their research experience.
Breadcrumb Dominique Bonnet Bonnet lab Haematopoietic Stem Cell Laboratory : Publications Lab contentLab contentIn this section Overview Vacancies Areas of interest Publications Members Visualisation of Leukaemic cells initiating and invading the bone marrow microenvironment Toggle to view hero caption PublicationsYear published2023 (3)2022 (2)2021 (2)2020 (7)2019 (1)2018 (1)2017 (4)2016 (1)2015 (1) Facet Year publishedResearch topicsHuman Biology & Physiology (22)Stem Cells (22)Tumour Biology (22)Genome Integrity & Repair (17)Chemical Biology & High Throughput (16)Computational & Systems Biology (16)Model Organisms (12)Imaging (6)Immunology (6)Cell Biology (4)Cell Cycle & Chromosomes (4)Developmental Biology (3)Gene Expression (3)Infectious Disease (3)Signalling & Oncogenes (3)Biochemistry & Proteomics (2)Metabolism (1)Microfabrication & Bioengineering (1)Neurosciences (1)Structural Biology & Biophysics (1)Synthetic Biology (1) (-)Genetics & Genomics (22) Facet Research topicsPublication typeJournal article (22)Primary research (21)Method (1) Facet Publication typeJournalNature Communications (4)Blood Cancer Discovery (2)Cell Reports (2)Annals of Hematology (1)Blood (1)Cancer Cell (1)Cell Stem Cell (1)Developmental Cell (1)Experimental Hematology (1)Haematologica (1)HemaSphere (1)Journal of Clinical Investigation (1)Journal of Clinical Medicine (1)Nature Protocols (1)Science Translational Medicine (1)Scientific Reports (1)The Lancet (1) Facet Journal Publications Displaying 1 - 20 of 22Last updated : 19 April 2024 02:30 Defining the identity and the niches of epithelial stem cells with highly pleiotropic multilineage potency in the human thymus Authors (17)Roberta RagazziniStefan BoeingLuca ZanieriMary GreenGiuseppe D'Agostino Kerol Bartolovic[...] David Scoville Andy NamAdrian HaydayDominique BonnetPaola Bonfanti Developmental Cell Published 20 November 2023 Crick labs/ facilitiesAdrian HaydayDominique BonnetPaola BonfantiFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsLight MicroscopyAdvanced SequencingFull details Loss of TET2 in human hematopoietic stem cells alters the development and function of neutrophils Authors (22)Hector Huerga EncaboIker Valle AramburuManuel Garcia AlbornozMarion Piganeau Henry Wood Anna Song[...] Daniel H Wiseman Kiran Batta Rajeev GuptaVenizelos PapayannopoulosDominique Bonnet Cell Stem Cell Published 1 June 2023 Crick labs/ facilitiesCaetano Reis e SousaVenizelos PapayannopoulosDominique BonnetLight MicroscopyElectron MicroscopyBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityAdvanced SequencingFull details The CKS1/CKS2 proteostasis axis is crucial to maintain hematopoietic stem cell function Authors (11)William GreySamantha Atkinson Beatrice Rix Pedro CasadoLinda Ariza-Mcnaughton Cathy Hawley Miriam L Sopoena Katherine S Bridge David Kent Pedro R CutillasDominique Bonnet HemaSphere Published 1 March 2023 Crick labs/ facilitiesDominique BonnetBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityFull details CKS1 inhibition depletes leukemic stem cells and protects healthy hematopoietic stem cells in acute myeloid leukemia Authors (14)William Grey Ana Rio-Machin Pedro CasadoEva GronroosSara Ali Juho J Miettinen[...]Charles Swanton Pedro R Cutillas John Gribben Jude FitzgibbonDominique Bonnet Science Translational Medicine Published 22 June 2022 Crick labs/ facilitiesCharles SwantonDominique BonnetFlow CytometryCell ServicesBiological Research FacilityFull details Single cell analyses identify a highly regenerative and homogenous human CD34+ hematopoietic stem cell population Authors (9) Fernando Anjos-Afonso Florian Buettner Syed A MianHefin RhysJimena Perez-LloretManuel Garcia Albornoz Namrata RastogiLinda Ariza-McnaughtonDominique Bonnet Nature Communications Published 19 April 2022 Crick labs/ facilitiesDominique BonnetFlow CytometryAdvanced SequencingBiological Research FacilityFull details Integrated OMICs unveil the bone-marrow microenvironment in human leukemia Authors (13)Diana PassaroManuel Garcia Albornoz Giovanni Diana Probir ChakravartyLinda Ariza-McnaughtonAntoniana Batsivari[...]Alexander WaclawiczekLuigi OmbratoIlaria Malanchi John GribbenDominique Bonnet Cell Reports Published 11 May 2021 Crick labs/ facilitiesIlaria MalanchiDominique BonnetBioinformatics and BiostatisticsProteomicsFlow CytometryBiological Research FacilityAdvanced SequencingFull details Dynamic contrast-enhanced magnetic resonance imaging quantification of leukemia-induced changes in bone marrow vascular function Authors (5)Ana Gomes John GribbenBernard SiowDiana PassaroDominique Bonnet Haematologica Published 1 August 2021 Crick labs/ facilitiesDominique BonnetIn Vivo ImagingBiological Research FacilityFlow CytometryFull details Ectopic humanized mesenchymal niche in mice enables robust engraftment of myelodysplastic stem cells Authors (13)Syed Mian Ander Abarrategi Kar Lok KongKevin Rouault-Pierre Henry WoodCaroline Oedekoven[...]Linda Ariza-McnaughtonPeter JohnsonThomas Snoeks Ghulam J MuftiDominique Bonnet Blood Cancer Discovery Published 1 March 2021 Crick labs/ facilitiesDominique BonnetIn Vivo ImagingBiological Research FacilityFlow CytometryExperimental HistopathologyFull details Ectopic humanized mesenchymal niche in mice enables robust engraftment of myelodysplastic stem cells Authors (13)Syed Mian Ander Abarrategi Kar Lok KongKevin Rouault-Pierre Henry WoodCaroline Oedekoven[...]Linda Ariza-McnaughtonPeter JohnsonThomas Snoeks Ghulam J MuftiDominique Bonnet Blood Cancer Discovery Published 1 March 2021 Crick labs/ facilitiesDominique BonnetIn Vivo ImagingBiological Research FacilityFlow CytometryExperimental HistopathologyFull details Generation of neighbor-labeling cells to study intercellular interactions in vivo Authors (10)Luigi OmbratoEmma NolanDiana Passaro Ivana KurelacVicky BridgemanAlexander Waclawiczek Delfim Duarte Cristina Lo CelsoDominique BonnetIlaria Malanchi Nature Protocols Published 1 February 2021 Crick labs/ facilitiesIlaria MalanchiDominique BonnetFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityFull details Reconstitution of a functional human thymus by postnatal stromal progenitor cells and natural whole-organ scaffolds Authors (22)Sara CampinotiAsllan GjinovciRoberta RagazziniLuca ZanieriLinda Ariza-Mcnaughton Marco Catucci[...] Sarah A Teichmann Neil J SebireAdrian HaydayDominique BonnetPaola Bonfanti Nature Communications Published 11 December 2020 Crick labs/ facilitiesAdrian HaydayDominique BonnetPaola BonfantiBioinformatics and BiostatisticsLight MicroscopyFlow CytometryExperimental HistopathologyElectron MicroscopyBiological Research FacilityAdvanced SequencingFull details Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers Authors (341) Catherine F Houlihan Nina Vora Thomas Byrne Dan LewerGavin Kelly Judith Heaney[...] Andrew Hayward Richard Gilson Gavin KellyFiona Roberts Emine Hatipoglu The Lancet Published 25 July 2020 Crick labs/ facilitiesAndreas WackKaren VousdenJernej UleJames TurnerMoritz TreeckCharles SwantonAdam SaterialeErik SahaiCaetano Reis e SousaPeter RatcliffeLucia Prieto-GodinoVenizelos PapayannopoulosAnne O’GarraPaul NurseGeorge KassiotisMaximiliano GutierrezSonia GandhiSteve GamblinPeter Cherepanov Luiz Pedro CarvalhoDominique BonnetMike BlackmanRupert BealeWorldwide Influenza CentreStructural BiologyMetabolomicsHuman Embryonic Stem CellHigh Throughput ScreeningGenetic Modification ServiceFlow CytometryFermentationExperimental HistopathologyElectron MicroscopyCell ServicesBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Mesenchymal niche remodeling impairs hematopoiesis via stanniocalcin 1 in acute myeloid leukemia Authors (11)Alexander Waclawiczek Ashley HamiltonKevin Rouault-Pierre Ander Abarrategi Manuel Garcia Albornoz Farideh Miraki-Moud Nourdine Bah John Gribben Jude Fitzgibbon David TaussigDominique Bonnet Journal of Clinical Investigation Published 1 June 2020 Crick labs/ facilitiesDominique BonnetBioinformatics and BiostatisticsFull details Selective inhibition of cancer cell self-renewal through a Quisinostat-histone H1.0 axis Authors (17)Cristina Morales TorresMary WuSebastijan HoborElanor Wainwright Matthew J Martin Harshil Patel[...]Dominique Bonnet Paul D SmithCharles SwantonMichael HowellPaola Scaffidi Nature Communications Published 14 April 2020 Crick labs/ facilitiesCharles SwantonPaola ScaffidiDominique BonnetProteomicsHigh Throughput ScreeningExperimental HistopathologyBioinformatics and BiostatisticsBiological Research FacilityAdvanced SequencingFull details A humanized bone niche model reveals bone tissue preservation upon targeting mitochondrial complex I in pseudo-orthotopic osteosarcoma Authors (10) Ivana Kurelac Ander Abarrategi Moira Ragazzi Luisa Iommarini Nikkitha Umesh GaneshThomas SnoeksDominique Bonnet Anna Maria PorcelliIlaria Malanchi Giuseppe Gasparre Journal of Clinical Medicine Published 11 December 2019 Crick labs/ facilitiesIlaria MalanchiDominique BonnetIn Vivo ImagingBiological Research FacilityFlow CytometryFull details c-Fos induces chondrogenic tumor formation in immortalized human mesenchymal progenitor cells Authors (13) Ander Abarrategi Stefano Gambera Arantzazu Alfranca Miguel A Rodriguez-Milla Raquel Perez-Tavarez Kevin Rouault-Pierre[...] Francisca Mulero César Trigueros Samuel NavarroDominique Bonnet Javier García-Castro Scientific Reports Published 23 October 2018 Crick labs/ facilitiesDominique BonnetBioinformatics and BiostatisticsIn Vivo ImagingFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityFull details Acute myeloid leukemia xenograft success prediction: saving time Authors (6) Emmanuel Griessinger Jacques Vargaftig Stuart Horswell David C Taussig John GribbenDominique Bonnet Experimental Hematology Published 1 March 2018 Crick labs/ facilitiesDominique BonnetBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityFull details The combination of CHK1 inhibitor with G-CSF overrides cytarabine resistance in human acute myeloid leukemia Authors (9) Alessandro Di TullioKevin Rouault-Pierre Ander AbarrategiSyed MianWilliam Grey John GribbenAengus Stewart Elizabeth BlackwoodDominique Bonnet Nature Communications Published 22 November 2017 Crick labs/ facilitiesDominique BonnetBioinformatics and BiostatisticsLight MicroscopyIn Vivo ImagingFlow CytometryExperimental HistopathologyBiological Research FacilityAdvanced SequencingFull details Increased vascular permeability in the bone marrow microenvironment contributes to disease progression and drug response in acute myeloid leukemia Authors (13)Diana Passaro Alessandro Di Tullio Ander AbarrategiKevin Rouault-Pierre Katie FosterLinda Ariza-Mcnaughton[...] Leena Bhaw Giovanni Diana François Lassailly John GribbenDominique Bonnet Cancer Cell Published 11 September 2017 Crick labs/ facilitiesDominique BonnetBioinformatics and BiostatisticsAdvanced SequencingLight MicroscopyIn Vivo ImagingFlow CytometryBiological Research FacilityFull details Dendritic cell lineage potential in human early hematopoietic progenitors Authors (6) Julie HelftFernando Dos Anjos Afonso Annemarthe G van der Veen Probir ChakravartyDominique BonnetCaetano Reis e Sousa Cell Reports Published 18 July 2017 Crick labs/ facilitiesCaetano Reis e SousaDominique BonnetBioinformatics and BiostatisticsFlow CytometryFull details Pagination Current page 1 Page 2 Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Defining the identity and the niches of epithelial stem cells with highly pleiotropic multilineage potency in the human thymus Authors (17)Roberta RagazziniStefan BoeingLuca ZanieriMary GreenGiuseppe D'Agostino Kerol Bartolovic[...] David Scoville Andy NamAdrian HaydayDominique BonnetPaola Bonfanti Developmental Cell Published 20 November 2023 Crick labs/ facilitiesAdrian HaydayDominique BonnetPaola BonfantiFlow CytometryExperimental HistopathologyBioinformatics and BiostatisticsLight MicroscopyAdvanced SequencingFull details
Loss of TET2 in human hematopoietic stem cells alters the development and function of neutrophils Authors (22)Hector Huerga EncaboIker Valle AramburuManuel Garcia AlbornozMarion Piganeau Henry Wood Anna Song[...] Daniel H Wiseman Kiran Batta Rajeev GuptaVenizelos PapayannopoulosDominique Bonnet Cell Stem Cell Published 1 June 2023 Crick labs/ facilitiesCaetano Reis e SousaVenizelos PapayannopoulosDominique BonnetLight MicroscopyElectron MicroscopyBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityAdvanced SequencingFull details
The CKS1/CKS2 proteostasis axis is crucial to maintain hematopoietic stem cell function Authors (11)William GreySamantha Atkinson Beatrice Rix Pedro CasadoLinda Ariza-Mcnaughton Cathy Hawley Miriam L Sopoena Katherine S Bridge David Kent Pedro R CutillasDominique Bonnet HemaSphere Published 1 March 2023 Crick labs/ facilitiesDominique BonnetBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityFull details
CKS1 inhibition depletes leukemic stem cells and protects healthy hematopoietic stem cells in acute myeloid leukemia Authors (14)William Grey Ana Rio-Machin Pedro CasadoEva GronroosSara Ali Juho J Miettinen[...]Charles Swanton Pedro R Cutillas John Gribben Jude FitzgibbonDominique Bonnet Science Translational Medicine Published 22 June 2022 Crick labs/ facilitiesCharles SwantonDominique BonnetFlow CytometryCell ServicesBiological Research FacilityFull details
Single cell analyses identify a highly regenerative and homogenous human CD34+ hematopoietic stem cell population Authors (9) Fernando Anjos-Afonso Florian Buettner Syed A MianHefin RhysJimena Perez-LloretManuel Garcia Albornoz Namrata RastogiLinda Ariza-McnaughtonDominique Bonnet Nature Communications Published 19 April 2022 Crick labs/ facilitiesDominique BonnetFlow CytometryAdvanced SequencingBiological Research FacilityFull details
Integrated OMICs unveil the bone-marrow microenvironment in human leukemia Authors (13)Diana PassaroManuel Garcia Albornoz Giovanni Diana Probir ChakravartyLinda Ariza-McnaughtonAntoniana Batsivari[...]Alexander WaclawiczekLuigi OmbratoIlaria Malanchi John GribbenDominique Bonnet Cell Reports Published 11 May 2021 Crick labs/ facilitiesIlaria MalanchiDominique BonnetBioinformatics and BiostatisticsProteomicsFlow CytometryBiological Research FacilityAdvanced SequencingFull details
Dynamic contrast-enhanced magnetic resonance imaging quantification of leukemia-induced changes in bone marrow vascular function Authors (5)Ana Gomes John GribbenBernard SiowDiana PassaroDominique Bonnet Haematologica Published 1 August 2021 Crick labs/ facilitiesDominique BonnetIn Vivo ImagingBiological Research FacilityFlow CytometryFull details
Ectopic humanized mesenchymal niche in mice enables robust engraftment of myelodysplastic stem cells Authors (13)Syed Mian Ander Abarrategi Kar Lok KongKevin Rouault-Pierre Henry WoodCaroline Oedekoven[...]Linda Ariza-McnaughtonPeter JohnsonThomas Snoeks Ghulam J MuftiDominique Bonnet Blood Cancer Discovery Published 1 March 2021 Crick labs/ facilitiesDominique BonnetIn Vivo ImagingBiological Research FacilityFlow CytometryExperimental HistopathologyFull details
Ectopic humanized mesenchymal niche in mice enables robust engraftment of myelodysplastic stem cells Authors (13)Syed Mian Ander Abarrategi Kar Lok KongKevin Rouault-Pierre Henry WoodCaroline Oedekoven[...]Linda Ariza-McnaughtonPeter JohnsonThomas Snoeks Ghulam J MuftiDominique Bonnet Blood Cancer Discovery Published 1 March 2021 Crick labs/ facilitiesDominique BonnetIn Vivo ImagingBiological Research FacilityFlow CytometryExperimental HistopathologyFull details
Generation of neighbor-labeling cells to study intercellular interactions in vivo Authors (10)Luigi OmbratoEmma NolanDiana Passaro Ivana KurelacVicky BridgemanAlexander Waclawiczek Delfim Duarte Cristina Lo CelsoDominique BonnetIlaria Malanchi Nature Protocols Published 1 February 2021 Crick labs/ facilitiesIlaria MalanchiDominique BonnetFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityFull details
Reconstitution of a functional human thymus by postnatal stromal progenitor cells and natural whole-organ scaffolds Authors (22)Sara CampinotiAsllan GjinovciRoberta RagazziniLuca ZanieriLinda Ariza-Mcnaughton Marco Catucci[...] Sarah A Teichmann Neil J SebireAdrian HaydayDominique BonnetPaola Bonfanti Nature Communications Published 11 December 2020 Crick labs/ facilitiesAdrian HaydayDominique BonnetPaola BonfantiBioinformatics and BiostatisticsLight MicroscopyFlow CytometryExperimental HistopathologyElectron MicroscopyBiological Research FacilityAdvanced SequencingFull details
Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers Authors (341) Catherine F Houlihan Nina Vora Thomas Byrne Dan LewerGavin Kelly Judith Heaney[...] Andrew Hayward Richard Gilson Gavin KellyFiona Roberts Emine Hatipoglu The Lancet Published 25 July 2020 Crick labs/ facilitiesAndreas WackKaren VousdenJernej UleJames TurnerMoritz TreeckCharles SwantonAdam SaterialeErik SahaiCaetano Reis e SousaPeter RatcliffeLucia Prieto-GodinoVenizelos PapayannopoulosAnne O’GarraPaul NurseGeorge KassiotisMaximiliano GutierrezSonia GandhiSteve GamblinPeter Cherepanov Luiz Pedro CarvalhoDominique BonnetMike BlackmanRupert BealeWorldwide Influenza CentreStructural BiologyMetabolomicsHuman Embryonic Stem CellHigh Throughput ScreeningGenetic Modification ServiceFlow CytometryFermentationExperimental HistopathologyElectron MicroscopyCell ServicesBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Mesenchymal niche remodeling impairs hematopoiesis via stanniocalcin 1 in acute myeloid leukemia Authors (11)Alexander Waclawiczek Ashley HamiltonKevin Rouault-Pierre Ander Abarrategi Manuel Garcia Albornoz Farideh Miraki-Moud Nourdine Bah John Gribben Jude Fitzgibbon David TaussigDominique Bonnet Journal of Clinical Investigation Published 1 June 2020 Crick labs/ facilitiesDominique BonnetBioinformatics and BiostatisticsFull details
Selective inhibition of cancer cell self-renewal through a Quisinostat-histone H1.0 axis Authors (17)Cristina Morales TorresMary WuSebastijan HoborElanor Wainwright Matthew J Martin Harshil Patel[...]Dominique Bonnet Paul D SmithCharles SwantonMichael HowellPaola Scaffidi Nature Communications Published 14 April 2020 Crick labs/ facilitiesCharles SwantonPaola ScaffidiDominique BonnetProteomicsHigh Throughput ScreeningExperimental HistopathologyBioinformatics and BiostatisticsBiological Research FacilityAdvanced SequencingFull details
A humanized bone niche model reveals bone tissue preservation upon targeting mitochondrial complex I in pseudo-orthotopic osteosarcoma Authors (10) Ivana Kurelac Ander Abarrategi Moira Ragazzi Luisa Iommarini Nikkitha Umesh GaneshThomas SnoeksDominique Bonnet Anna Maria PorcelliIlaria Malanchi Giuseppe Gasparre Journal of Clinical Medicine Published 11 December 2019 Crick labs/ facilitiesIlaria MalanchiDominique BonnetIn Vivo ImagingBiological Research FacilityFlow CytometryFull details
c-Fos induces chondrogenic tumor formation in immortalized human mesenchymal progenitor cells Authors (13) Ander Abarrategi Stefano Gambera Arantzazu Alfranca Miguel A Rodriguez-Milla Raquel Perez-Tavarez Kevin Rouault-Pierre[...] Francisca Mulero César Trigueros Samuel NavarroDominique Bonnet Javier García-Castro Scientific Reports Published 23 October 2018 Crick labs/ facilitiesDominique BonnetBioinformatics and BiostatisticsIn Vivo ImagingFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityFull details
Acute myeloid leukemia xenograft success prediction: saving time Authors (6) Emmanuel Griessinger Jacques Vargaftig Stuart Horswell David C Taussig John GribbenDominique Bonnet Experimental Hematology Published 1 March 2018 Crick labs/ facilitiesDominique BonnetBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityFull details
The combination of CHK1 inhibitor with G-CSF overrides cytarabine resistance in human acute myeloid leukemia Authors (9) Alessandro Di TullioKevin Rouault-Pierre Ander AbarrategiSyed MianWilliam Grey John GribbenAengus Stewart Elizabeth BlackwoodDominique Bonnet Nature Communications Published 22 November 2017 Crick labs/ facilitiesDominique BonnetBioinformatics and BiostatisticsLight MicroscopyIn Vivo ImagingFlow CytometryExperimental HistopathologyBiological Research FacilityAdvanced SequencingFull details
Increased vascular permeability in the bone marrow microenvironment contributes to disease progression and drug response in acute myeloid leukemia Authors (13)Diana Passaro Alessandro Di Tullio Ander AbarrategiKevin Rouault-Pierre Katie FosterLinda Ariza-Mcnaughton[...] Leena Bhaw Giovanni Diana François Lassailly John GribbenDominique Bonnet Cancer Cell Published 11 September 2017 Crick labs/ facilitiesDominique BonnetBioinformatics and BiostatisticsAdvanced SequencingLight MicroscopyIn Vivo ImagingFlow CytometryBiological Research FacilityFull details
Dendritic cell lineage potential in human early hematopoietic progenitors Authors (6) Julie HelftFernando Dos Anjos Afonso Annemarthe G van der Veen Probir ChakravartyDominique BonnetCaetano Reis e Sousa Cell Reports Published 18 July 2017 Crick labs/ facilitiesCaetano Reis e SousaDominique BonnetBioinformatics and BiostatisticsFlow CytometryFull details