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Breadcrumb Dominique Bonnet Bonnet lab Haematopoietic Stem Cell Laboratory : Publications Lab contentLab contentIn this section Overview Vacancies Areas of interest Publications Members Visualisation of Leukaemic cells initiating and invading the bone marrow microenvironment Toggle to view hero caption PublicationsYear published2024 (2)2023 (6)2022 (2)2021 (13)2020 (14)2019 (3)2018 (4)2017 (10)2016 (8)2015 (10)2014 (6)2013 (10)2012 (11)2011 (3)2010 (6) Facet Year publishedResearch topicsHuman Biology & Physiology (68)Stem Cells (68)Tumour Biology (68)Genetics & Genomics (22)Genome Integrity & Repair (17)Chemical Biology & High Throughput (16)Computational & Systems Biology (16)Model Organisms (14)Immunology (11)Cell Biology (7)Imaging (7)Infectious Disease (6)Cell Cycle & Chromosomes (4)Signalling & Oncogenes (4)Biochemistry & Proteomics (3)Developmental Biology (3)Gene Expression (3)Structural Biology & Biophysics (2)Metabolism (1)Microfabrication & Bioengineering (1)Neurosciences (1)Synthetic Biology (1) Facet Research topicsPublication typeJournal article (108)Primary research (80)Review (20)Method (4)Commentary (3)Editorial (1) Facet Publication typeJournalBlood (11)Leukemia (10)Haematologica (7)Nature Communications (6)British Journal of Haematology (4)Cancer Research (3)Cell Stem Cell (3)Experimental Hematology (3)Journal of Experimental Medicine (3)Stem Cell Reports (3)Blood Cancer Discovery (2)Cancer Cell (2)Cell Reports (2)HemaSphere (2)Journal of Clinical Investigation (2)Nature Reviews Cancer (2)PLOS ONE (2)Science Translational Medicine (2)Stem Cells International (2)Aging Cell (1)Analyst (1)Annals of Hematology (1)Best Practice & Research. 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- 40 of 108Last updated : 20 April 2024 02:54 Advances in human immune system mouse models for studying human hematopoiesis and cancer immunotherapy Authors (3)Syed Mian Fernando Anjos-AfonsoDominique Bonnet Frontiers in Immunology Published 2 February 2021 Crick labsDominique BonnetFull details Loss of tRNA-modifying enzyme Elp3 activates a p53-dependent antitumor checkpoint in hematopoiesis Authors (17) Adeline Rosu Najla El Hachem Francesca RapinoKevin Rouault-Pierre Joseph Jorssen Joan Somja[...]Dominique Bonnet Alain Chariot Pierre Close Fabrice Bureau Christophe J Desmet Journal of Experimental Medicine Published 1 March 2021 Crick labsDominique BonnetFull details Understanding of the crosstalk between normal residual hematopoietic stem cells and the leukemic niche in acute myeloid leukemia Authors (3)Antoniana BatsivariWilliam GreyDominique Bonnet Experimental Hematology Published 1 March 2021 Crick labsDominique BonnetFull details Ectopic humanized mesenchymal niche in mice enables robust engraftment of myelodysplastic stem cells Authors (13)Syed Mian Ander Abarrategi Kar Lok KongKevin Rouault-Pierre Henry WoodCaroline Oedekoven[...]Linda Ariza-McnaughtonPeter JohnsonThomas Snoeks Ghulam J MuftiDominique Bonnet Blood Cancer Discovery Published 1 March 2021 Crick labs/ facilitiesDominique BonnetIn Vivo ImagingBiological Research FacilityFlow CytometryExperimental HistopathologyFull details Ectopic humanized mesenchymal niche in mice enables robust engraftment of myelodysplastic stem cells Authors (13)Syed Mian Ander Abarrategi Kar Lok KongKevin Rouault-Pierre Henry WoodCaroline Oedekoven[...]Linda Ariza-McnaughtonPeter JohnsonThomas Snoeks Ghulam J MuftiDominique Bonnet Blood Cancer Discovery Published 1 March 2021 Crick labs/ facilitiesDominique BonnetIn Vivo ImagingBiological Research FacilityFlow CytometryExperimental HistopathologyFull details Generation of neighbor-labeling cells to study intercellular interactions in vivo Authors (10)Luigi OmbratoEmma NolanDiana Passaro Ivana KurelacVicky BridgemanAlexander Waclawiczek Delfim Duarte Cristina Lo CelsoDominique BonnetIlaria Malanchi Nature Protocols Published 1 February 2021 Crick labs/ facilitiesIlaria MalanchiDominique BonnetFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityFull details Reconstitution of a functional human thymus by postnatal stromal progenitor cells and natural whole-organ scaffolds Authors (22)Sara CampinotiAsllan GjinovciRoberta RagazziniLuca ZanieriLinda Ariza-Mcnaughton Marco Catucci[...] Sarah A Teichmann Neil J SebireAdrian HaydayDominique BonnetPaola Bonfanti Nature Communications Published 11 December 2020 Crick labs/ facilitiesAdrian HaydayDominique BonnetPaola BonfantiBioinformatics and BiostatisticsLight MicroscopyFlow CytometryExperimental HistopathologyElectron MicroscopyBiological Research FacilityAdvanced SequencingFull details Engineering human hematopoietic environments through ossicle and bioreactor technologies exploitation Authors (5) Pia Sommerkamp François E Mercier Adam C WilkinsonDominique Bonnet Paul E Bourgine Experimental Hematology Published 1 February 2021 Crick labsDominique BonnetFull details Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers Authors (341) Catherine F Houlihan Nina Vora Thomas Byrne Dan LewerGavin Kelly Judith Heaney[...] Andrew Hayward Richard Gilson Gavin KellyFiona Roberts Emine Hatipoglu The Lancet Published 25 July 2020 Crick labs/ facilitiesAndreas WackKaren VousdenJernej UleJames TurnerMoritz TreeckCharles SwantonAdam SaterialeErik SahaiCaetano Reis e SousaPeter RatcliffeLucia Prieto-GodinoVenizelos PapayannopoulosAnne O’GarraPaul NurseGeorge KassiotisMaximiliano GutierrezSonia GandhiSteve GamblinPeter Cherepanov Luiz Pedro CarvalhoDominique BonnetMike BlackmanRupert BealeWorldwide Influenza CentreStructural BiologyMetabolomicsHuman Embryonic Stem CellHigh Throughput ScreeningGenetic Modification ServiceFlow CytometryFermentationExperimental HistopathologyElectron MicroscopyCell ServicesBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Activation of the receptor tyrosine kinase RET improves long-term hematopoietic stem cell outgrowth and potency Authors (7)William GreyRakhee ChauhanMarion PiganeauHector Huerga EncaboManuel Garcia AlbornozNeil McDonaldDominique Bonnet Blood Published 26 November 2020 Crick labs/ facilitiesNeil McDonaldDominique BonnetFlow CytometryBiological Research FacilityFull details Innovations, challenges, and minimal information for standardization of humanized mice Authors (23) Renata Stripecke Christian Münz Jan Jacob Schuringa Karl-Dimiter Bissig Brian Soper Terrence Meeham[...] Amar Deep Sharma Andreas Trumpp Livio Trusolino Carol Bult Leonard Shultz EMBO Molecular Medicine Published 7 July 2020 Crick labsDominique BonnetFull details Mesenchymal niche remodeling impairs hematopoiesis via stanniocalcin 1 in acute myeloid leukemia Authors (11)Alexander Waclawiczek Ashley HamiltonKevin Rouault-Pierre Ander Abarrategi Manuel Garcia Albornoz Farideh Miraki-Moud Nourdine Bah John Gribben Jude Fitzgibbon David TaussigDominique Bonnet Journal of Clinical Investigation Published 1 June 2020 Crick labs/ facilitiesDominique BonnetBioinformatics and BiostatisticsFull details Treg sensitivity to FasL and relative IL-2 deprivation drive idiopathic aplastic anemia immune dysfunction Authors (19) Shok Ping Lim Benedetta CostantiniSyed Mian Pilar Perez Abellan Shreyans A Gandhi Marc Martinez Llordella[...] Giovanna Lombardi Judith CW MarshDominique Bonnet Shahram Kordasti Ghulam J Mufti Blood Published 13 August 2020 Crick labs/ facilitiesDominique BonnetFlow CytometryExperimental HistopathologyBiological Research FacilityFull details Selective inhibition of cancer cell self-renewal through a Quisinostat-histone H1.0 axis Authors (17)Cristina Morales TorresMary WuSebastijan HoborElanor Wainwright Matthew J Martin Harshil Patel[...]Dominique Bonnet Paul D SmithCharles SwantonMichael HowellPaola Scaffidi Nature Communications Published 14 April 2020 Crick labs/ facilitiesCharles SwantonPaola ScaffidiDominique BonnetProteomicsHigh Throughput ScreeningExperimental HistopathologyBioinformatics and BiostatisticsBiological Research FacilityAdvanced SequencingFull details Myelodysplastic syndrome patient-derived xenografts: from no options to many Authors (4) Christophe Côme Alexander BalhuizenDominique Bonnet Bo T Porse Haematologica Published 1 April 2020 Crick labsDominique BonnetFull details Bone marrow niches in haematological malignancies Authors (8) Simón Méndez-FerrerDominique Bonnet David P Steensma Robert P Hasserjian Irene M Ghobrial John G Gribben Michael Andreeff Daniela S Krause Nature Reviews Cancer Published 1 May 2020 Crick labsDominique BonnetFull details Dynamic responses of the haematopoietic stem cell niche to diverse stresses Authors (6)Antoniana Batsivari Myriam Ludymila Rachelle HaltalliDiana Passaro Constandina Pospori Cristina Lo CelsoDominique Bonnet Nature Cell Biology Published 6 January 2020 Crick labsDominique BonnetFull details A humanized bone niche model reveals bone tissue preservation upon targeting mitochondrial complex I in pseudo-orthotopic osteosarcoma Authors (10) Ivana Kurelac Ander Abarrategi Moira Ragazzi Luisa Iommarini Nikkitha Umesh GaneshThomas SnoeksDominique Bonnet Anna Maria PorcelliIlaria Malanchi Giuseppe Gasparre Journal of Clinical Medicine Published 11 December 2019 Crick labs/ facilitiesIlaria MalanchiDominique BonnetIn Vivo ImagingBiological Research FacilityFlow CytometryFull details Despite mutation acquisition in hematopoietic stem cells, JMML-propagating cells are not always restricted to this compartment Authors (19) Aurélie CayeKevin Rouault-Pierre Marion Strullu Elodie Lainey Ander Abarrategi Odile Fenneteau[...] Jean-Hugues Dalle André Baruchel Christine Chomienne Hélène CavéDominique Bonnet Leukemia Published 1 June 2020 Crick labs/ facilitiesDominique BonnetFlow CytometryExperimental HistopathologyBiological Research FacilityFull details Updates on the hematological tumor microenvironment and its therapeutic targeting Authors (5) Dorian Forte Daniela S Krause Michael AndreeffDominique Bonnet Simón Méndez-Ferrer Haematologica Published 1 October 2019 Crick labsDominique BonnetFull details Pagination First page First Previous page Previous Page 1 Current page 2 Page 3 Page 4 Page 5 Page 6 Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Advances in human immune system mouse models for studying human hematopoiesis and cancer immunotherapy Authors (3)Syed Mian Fernando Anjos-AfonsoDominique Bonnet Frontiers in Immunology Published 2 February 2021 Crick labsDominique BonnetFull details
Loss of tRNA-modifying enzyme Elp3 activates a p53-dependent antitumor checkpoint in hematopoiesis Authors (17) Adeline Rosu Najla El Hachem Francesca RapinoKevin Rouault-Pierre Joseph Jorssen Joan Somja[...]Dominique Bonnet Alain Chariot Pierre Close Fabrice Bureau Christophe J Desmet Journal of Experimental Medicine Published 1 March 2021 Crick labsDominique BonnetFull details
Understanding of the crosstalk between normal residual hematopoietic stem cells and the leukemic niche in acute myeloid leukemia Authors (3)Antoniana BatsivariWilliam GreyDominique Bonnet Experimental Hematology Published 1 March 2021 Crick labsDominique BonnetFull details
Ectopic humanized mesenchymal niche in mice enables robust engraftment of myelodysplastic stem cells Authors (13)Syed Mian Ander Abarrategi Kar Lok KongKevin Rouault-Pierre Henry WoodCaroline Oedekoven[...]Linda Ariza-McnaughtonPeter JohnsonThomas Snoeks Ghulam J MuftiDominique Bonnet Blood Cancer Discovery Published 1 March 2021 Crick labs/ facilitiesDominique BonnetIn Vivo ImagingBiological Research FacilityFlow CytometryExperimental HistopathologyFull details
Ectopic humanized mesenchymal niche in mice enables robust engraftment of myelodysplastic stem cells Authors (13)Syed Mian Ander Abarrategi Kar Lok KongKevin Rouault-Pierre Henry WoodCaroline Oedekoven[...]Linda Ariza-McnaughtonPeter JohnsonThomas Snoeks Ghulam J MuftiDominique Bonnet Blood Cancer Discovery Published 1 March 2021 Crick labs/ facilitiesDominique BonnetIn Vivo ImagingBiological Research FacilityFlow CytometryExperimental HistopathologyFull details
Generation of neighbor-labeling cells to study intercellular interactions in vivo Authors (10)Luigi OmbratoEmma NolanDiana Passaro Ivana KurelacVicky BridgemanAlexander Waclawiczek Delfim Duarte Cristina Lo CelsoDominique BonnetIlaria Malanchi Nature Protocols Published 1 February 2021 Crick labs/ facilitiesIlaria MalanchiDominique BonnetFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityFull details
Reconstitution of a functional human thymus by postnatal stromal progenitor cells and natural whole-organ scaffolds Authors (22)Sara CampinotiAsllan GjinovciRoberta RagazziniLuca ZanieriLinda Ariza-Mcnaughton Marco Catucci[...] Sarah A Teichmann Neil J SebireAdrian HaydayDominique BonnetPaola Bonfanti Nature Communications Published 11 December 2020 Crick labs/ facilitiesAdrian HaydayDominique BonnetPaola BonfantiBioinformatics and BiostatisticsLight MicroscopyFlow CytometryExperimental HistopathologyElectron MicroscopyBiological Research FacilityAdvanced SequencingFull details
Engineering human hematopoietic environments through ossicle and bioreactor technologies exploitation Authors (5) Pia Sommerkamp François E Mercier Adam C WilkinsonDominique Bonnet Paul E Bourgine Experimental Hematology Published 1 February 2021 Crick labsDominique BonnetFull details
Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers Authors (341) Catherine F Houlihan Nina Vora Thomas Byrne Dan LewerGavin Kelly Judith Heaney[...] Andrew Hayward Richard Gilson Gavin KellyFiona Roberts Emine Hatipoglu The Lancet Published 25 July 2020 Crick labs/ facilitiesAndreas WackKaren VousdenJernej UleJames TurnerMoritz TreeckCharles SwantonAdam SaterialeErik SahaiCaetano Reis e SousaPeter RatcliffeLucia Prieto-GodinoVenizelos PapayannopoulosAnne O’GarraPaul NurseGeorge KassiotisMaximiliano GutierrezSonia GandhiSteve GamblinPeter Cherepanov Luiz Pedro CarvalhoDominique BonnetMike BlackmanRupert BealeWorldwide Influenza CentreStructural BiologyMetabolomicsHuman Embryonic Stem CellHigh Throughput ScreeningGenetic Modification ServiceFlow CytometryFermentationExperimental HistopathologyElectron MicroscopyCell ServicesBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Activation of the receptor tyrosine kinase RET improves long-term hematopoietic stem cell outgrowth and potency Authors (7)William GreyRakhee ChauhanMarion PiganeauHector Huerga EncaboManuel Garcia AlbornozNeil McDonaldDominique Bonnet Blood Published 26 November 2020 Crick labs/ facilitiesNeil McDonaldDominique BonnetFlow CytometryBiological Research FacilityFull details
Innovations, challenges, and minimal information for standardization of humanized mice Authors (23) Renata Stripecke Christian Münz Jan Jacob Schuringa Karl-Dimiter Bissig Brian Soper Terrence Meeham[...] Amar Deep Sharma Andreas Trumpp Livio Trusolino Carol Bult Leonard Shultz EMBO Molecular Medicine Published 7 July 2020 Crick labsDominique BonnetFull details
Mesenchymal niche remodeling impairs hematopoiesis via stanniocalcin 1 in acute myeloid leukemia Authors (11)Alexander Waclawiczek Ashley HamiltonKevin Rouault-Pierre Ander Abarrategi Manuel Garcia Albornoz Farideh Miraki-Moud Nourdine Bah John Gribben Jude Fitzgibbon David TaussigDominique Bonnet Journal of Clinical Investigation Published 1 June 2020 Crick labs/ facilitiesDominique BonnetBioinformatics and BiostatisticsFull details
Treg sensitivity to FasL and relative IL-2 deprivation drive idiopathic aplastic anemia immune dysfunction Authors (19) Shok Ping Lim Benedetta CostantiniSyed Mian Pilar Perez Abellan Shreyans A Gandhi Marc Martinez Llordella[...] Giovanna Lombardi Judith CW MarshDominique Bonnet Shahram Kordasti Ghulam J Mufti Blood Published 13 August 2020 Crick labs/ facilitiesDominique BonnetFlow CytometryExperimental HistopathologyBiological Research FacilityFull details
Selective inhibition of cancer cell self-renewal through a Quisinostat-histone H1.0 axis Authors (17)Cristina Morales TorresMary WuSebastijan HoborElanor Wainwright Matthew J Martin Harshil Patel[...]Dominique Bonnet Paul D SmithCharles SwantonMichael HowellPaola Scaffidi Nature Communications Published 14 April 2020 Crick labs/ facilitiesCharles SwantonPaola ScaffidiDominique BonnetProteomicsHigh Throughput ScreeningExperimental HistopathologyBioinformatics and BiostatisticsBiological Research FacilityAdvanced SequencingFull details
Myelodysplastic syndrome patient-derived xenografts: from no options to many Authors (4) Christophe Côme Alexander BalhuizenDominique Bonnet Bo T Porse Haematologica Published 1 April 2020 Crick labsDominique BonnetFull details
Bone marrow niches in haematological malignancies Authors (8) Simón Méndez-FerrerDominique Bonnet David P Steensma Robert P Hasserjian Irene M Ghobrial John G Gribben Michael Andreeff Daniela S Krause Nature Reviews Cancer Published 1 May 2020 Crick labsDominique BonnetFull details
Dynamic responses of the haematopoietic stem cell niche to diverse stresses Authors (6)Antoniana Batsivari Myriam Ludymila Rachelle HaltalliDiana Passaro Constandina Pospori Cristina Lo CelsoDominique Bonnet Nature Cell Biology Published 6 January 2020 Crick labsDominique BonnetFull details
A humanized bone niche model reveals bone tissue preservation upon targeting mitochondrial complex I in pseudo-orthotopic osteosarcoma Authors (10) Ivana Kurelac Ander Abarrategi Moira Ragazzi Luisa Iommarini Nikkitha Umesh GaneshThomas SnoeksDominique Bonnet Anna Maria PorcelliIlaria Malanchi Giuseppe Gasparre Journal of Clinical Medicine Published 11 December 2019 Crick labs/ facilitiesIlaria MalanchiDominique BonnetIn Vivo ImagingBiological Research FacilityFlow CytometryFull details
Despite mutation acquisition in hematopoietic stem cells, JMML-propagating cells are not always restricted to this compartment Authors (19) Aurélie CayeKevin Rouault-Pierre Marion Strullu Elodie Lainey Ander Abarrategi Odile Fenneteau[...] Jean-Hugues Dalle André Baruchel Christine Chomienne Hélène CavéDominique Bonnet Leukemia Published 1 June 2020 Crick labs/ facilitiesDominique BonnetFlow CytometryExperimental HistopathologyBiological Research FacilityFull details
Updates on the hematological tumor microenvironment and its therapeutic targeting Authors (5) Dorian Forte Daniela S Krause Michael AndreeffDominique Bonnet Simón Méndez-Ferrer Haematologica Published 1 October 2019 Crick labsDominique BonnetFull details