Johnson lab
Systems Chemical Biology of Infection and Resistance Laboratory
: Publications

Publications

Displaying 1 - 13 of 13

Last updated : 16 April 2024 03:08

Opportunities and limitations of genomics for diagnosing bedaquiline-resistant tuberculosis: a systematic review and individual isolate meta-analysis

Authors (11)

Camus Nimmo
Neda Bionghi
Matthew J Cummings
Rubeshan Perumal
Madeleine Hopson
Shamim Al Jubaer
Kogieleum Naidoo
Allison Wolf
Barun Mathema
Michelle H Larsen
Max O'Donnell

Lancet Microbe

Published 1 February 2024

Crick labs

Eachan Johnson

Full details

Therapeutic failure and acquired bedaquiline and delamanid resistance in treatment of drug-resistant TB

Authors (4)

James Millard
Stephanie Rimmer
Camus Nimmo
Max O'Donnell

Emerging Infectious Diseases

Published 1 May 2023

Crick labs

Eachan Johnson

Full details

Chemical validation of Mycobacterium tuberculosis phosphopantetheine adenylyltransferase using fragment linking and CRISPR interference

Authors (13)

Jamal El Bakali
Michal Blaszczyk
Joanna Evans
Jennifer A Boland
William McCarthy
Imam Fathoni
[...]
Anthony G Coyne
Valerie Mizrahi
Tom L Blundell
Chris Abell
Christina Spry

Angewandte Chemie International Edition

Published 17 April 2023

Crick labs

Eachan Johnson

Full details

Chemical validation of Mycobacterium tuberculosis phosphopantetheine adenylyltransferase using fragment linking and CRISPR interference

Authors (13)

Jamal El Bakali
Michal Blaszczyk
Joanna Evans
Jennifer A Boland
William McCarthy
Imam Fathoni
[...]
Anthony G Coyne
Valerie Mizrahi
Tom L Blundell
Chris Abell
Christina Spry

Angewandte Chemie

Published 17 April 2023

Crick labs

Eachan Johnson

Full details

Evolution of Mycobacterium tuberculosis drug resistance in the genomic era

Authors (6)

Frontiers in Cellular and Infection Microbiology

Published 7 October 2022

Crick labs

Eachan Johnson

Full details

Cellular and molecular mechanisms in mycobacterial infection

Authors (2)

Natalie E Nieuwenhuizen
Joanna Evans

International Journal of Molecular Sciences

Published 29 June 2022

Crick labs

Eachan Johnson

Full details

Using proteolytic hypomorphs to detect small molecule mechanism of action

Authors (2)

Eachan Johnson
Deborah T Hung

Methods in Molecular Biology

Published 1 January 2021

Crick labs

Eachan Johnson

Full details

Large-scale chemical-genetic strategy enables the design of antimicrobial combination chemotherapy in Mycobacteria

Authors (5)

Eachan Johnson
Emma Office
Tomohiko Kawate
Marek Orzechowski
Deborah T Hung

ACS Infectious Diseases

Published 10 January 2020

Crick labs

Eachan Johnson

Full details

A point of inflection and reflection on systems chemical biology

Authors (2)

Eachan Johnson
Deborah T Hung

ACS Chemical Biology

Published 20 December 2019

Crick labs

Eachan Johnson

Full details

Large-scale chemical-genetics yields new M. tuberculosis inhibitor classes

Authors (44)

Eachan Johnson
Emily LaVerriere
Emma Office
Mary Stanley
Elisabeth Meyer
Tomohiko Kawate
[...]
Michael Fitzgerald
Eric J Rubin
Christopher M Sassetti
Dirk Schnappinger
Deborah T Hung

Nature

Published 4 July 2019

Crick labs

Eachan Johnson

Full details

A structural model of a P450-ferredoxin complex from orientation-selective double electron-electron resonance spectroscopy

Authors (12)

Alice M Bowen
Eachan Johnson
Francesco Mercuri
Nicola J Hoskins
Ruihong Qiao
James SO McCullagh
[...]
Stephen G Bell
Weihong Zhou
Christiane R Timmel
Luet Lok Wong
Jeffrey R Harmer

Journal of the American Chemical Society

Published 21 February 2018

Crick labs

Eachan Johnson

Full details

Partial fusion of a cytochrome P450 system by carboxy-terminal attachment of putidaredoxin reductase to P450cam (CYP101A1)

Authors (2)

Eachan Johnson
Luet-Lok Wong

Catalysis Science and Technology

Published 21 October 2016

Crick labs

Eachan Johnson

Full details

Tailoring an alien ferredoxin to support native-like P450 monooxygenase activity

Authors (6)

Stephen G Bell
James HC McMillan
Jake A Yorke
Emma Kavanagh
Eachan Johnson
Luet-Lok Wong

Chemical Communications

Published 5 November 2012

Crick labs

Eachan Johnson

Full details

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Johnson lab
Systems Chemical Biology of Infection and Resistance Laboratory
: Publications

Lab content

Publications

Year published

Research topics

Publication type

Journal

Opportunities and limitations of genomics for diagnosing bedaquiline-resistant tuberculosis: a systematic review and individual isolate meta-analysis

Therapeutic failure and acquired bedaquiline and delamanid resistance in treatment of drug-resistant TB

Chemical validation of Mycobacterium tuberculosis phosphopantetheine adenylyltransferase using fragment linking and CRISPR interference

Chemical validation of Mycobacterium tuberculosis phosphopantetheine adenylyltransferase using fragment linking and CRISPR interference

Evolution of Mycobacterium tuberculosis drug resistance in the genomic era

Cellular and molecular mechanisms in mycobacterial infection

Using proteolytic hypomorphs to detect small molecule mechanism of action

Large-scale chemical-genetic strategy enables the design of antimicrobial combination chemotherapy in Mycobacteria

A point of inflection and reflection on systems chemical biology

Large-scale chemical-genetics yields new M. tuberculosis inhibitor classes

A structural model of a P450-ferredoxin complex from orientation-selective double electron-electron resonance spectroscopy

Partial fusion of a cytochrome P450 system by carboxy-terminal attachment of putidaredoxin reductase to P450cam (CYP101A1)

Tailoring an alien ferredoxin to support native-like P450 monooxygenase activity

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Research case studies

Postdoctoral clinical fellows

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News and reports

About us

Lab content

Publications

Year published

Research topics

Publication type

Journal

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