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Breadcrumb Eachan Johnson Johnson lab Systems Chemical Biology of Infection and Resistance Laboratory : Publications Lab contentLab contentIn this section Overview Vacancies Publications Members PublicationsYear published2024 (1)2023 (3)2022 (2) Facet Year publishedResearch topicsGenetics & Genomics (6)Infectious Disease (6)Chemical Biology & High Throughput (5)Computational & Systems Biology (5) Facet Research topicsPublication typeJournal article (6)Primary research (2)Case report (1)Editorial (1)Review (1)Systematic review (1) Facet Publication typeJournalAngewandte Chemie (1)Angewandte Chemie International Edition (1)Emerging Infectious Diseases (1)Frontiers in Cellular and Infection Microbiology (1)International Journal of Molecular Sciences (1)Lancet Microbe (1) Facet Journal Publications Displaying 1 - 13 of 13Last updated : 18 April 2024 02:50 Opportunities and limitations of genomics for diagnosing bedaquiline-resistant tuberculosis: a systematic review and individual isolate meta-analysis Authors (11)Camus Nimmo Neda Bionghi Matthew J Cummings Rubeshan Perumal Madeleine Hopson Shamim Al Jubaer Kogieleum Naidoo Allison Wolf Barun Mathema Michelle H Larsen Max O'Donnell Lancet Microbe Published 1 February 2024 Crick labsEachan JohnsonFull details Therapeutic failure and acquired bedaquiline and delamanid resistance in treatment of drug-resistant TB Authors (4) James Millard Stephanie RimmerCamus Nimmo Max O'Donnell Emerging Infectious Diseases Published 1 May 2023 Crick labsEachan JohnsonFull details Chemical validation of Mycobacterium tuberculosis phosphopantetheine adenylyltransferase using fragment linking and CRISPR interference Authors (13) Jamal El Bakali Michal BlaszczykJoanna Evans Jennifer A BolandWilliam McCarthy Imam Fathoni[...] Anthony G Coyne Valerie Mizrahi Tom L Blundell Chris Abell Christina Spry Angewandte Chemie International Edition Published 17 April 2023 Crick labsEachan JohnsonFull details Chemical validation of Mycobacterium tuberculosis phosphopantetheine adenylyltransferase using fragment linking and CRISPR interference Authors (13) Jamal El Bakali Michal BlaszczykJoanna Evans Jennifer A BolandWilliam McCarthy Imam Fathoni[...] Anthony G Coyne Valerie Mizrahi Tom L Blundell Chris Abell Christina Spry Angewandte Chemie Published 17 April 2023 Crick labsEachan JohnsonFull details Evolution of Mycobacterium tuberculosis drug resistance in the genomic era Authors (6)Camus Nimmo James MillardValwynne FaulknerJohana MonteserinHannah PughEachan Johnson Frontiers in Cellular and Infection Microbiology Published 7 October 2022 Crick labsEachan JohnsonFull details Cellular and molecular mechanisms in mycobacterial infection Authors (2) Natalie E NieuwenhuizenJoanna Evans International Journal of Molecular Sciences Published 29 June 2022 Crick labsEachan JohnsonFull details Using proteolytic hypomorphs to detect small molecule mechanism of action Authors (2)Eachan Johnson Deborah T Hung Methods in Molecular Biology Published 1 January 2021 Crick labsEachan JohnsonFull details Large-scale chemical-genetic strategy enables the design of antimicrobial combination chemotherapy in Mycobacteria Authors (5)Eachan Johnson Emma Office Tomohiko Kawate Marek Orzechowski Deborah T Hung ACS Infectious Diseases Published 10 January 2020 Crick labsEachan JohnsonFull details A point of inflection and reflection on systems chemical biology Authors (2)Eachan Johnson Deborah T Hung ACS Chemical Biology Published 20 December 2019 Crick labsEachan JohnsonFull details Large-scale chemical-genetics yields new M. tuberculosis inhibitor classes Authors (44)Eachan Johnson Emily LaVerriere Emma Office Mary Stanley Elisabeth Meyer Tomohiko Kawate[...] Michael Fitzgerald Eric J Rubin Christopher M Sassetti Dirk Schnappinger Deborah T Hung Nature Published 4 July 2019 Crick labsEachan JohnsonFull details A structural model of a P450-ferredoxin complex from orientation-selective double electron-electron resonance spectroscopy Authors (12) Alice M BowenEachan Johnson Francesco Mercuri Nicola J Hoskins Ruihong Qiao James SO McCullagh[...] Stephen G Bell Weihong Zhou Christiane R Timmel Luet Lok Wong Jeffrey R Harmer Journal of the American Chemical Society Published 21 February 2018 Crick labsEachan JohnsonFull details Partial fusion of a cytochrome P450 system by carboxy-terminal attachment of putidaredoxin reductase to P450cam (CYP101A1) Authors (2)Eachan Johnson Luet-Lok Wong Catalysis Science and Technology Published 21 October 2016 Crick labsEachan JohnsonFull details Tailoring an alien ferredoxin to support native-like P450 monooxygenase activity Authors (6) Stephen G Bell James HC McMillan Jake A Yorke Emma KavanaghEachan Johnson Luet-Lok Wong Chemical Communications Published 5 November 2012 Crick labsEachan JohnsonFull details Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Opportunities and limitations of genomics for diagnosing bedaquiline-resistant tuberculosis: a systematic review and individual isolate meta-analysis Authors (11)Camus Nimmo Neda Bionghi Matthew J Cummings Rubeshan Perumal Madeleine Hopson Shamim Al Jubaer Kogieleum Naidoo Allison Wolf Barun Mathema Michelle H Larsen Max O'Donnell Lancet Microbe Published 1 February 2024 Crick labsEachan JohnsonFull details
Therapeutic failure and acquired bedaquiline and delamanid resistance in treatment of drug-resistant TB Authors (4) James Millard Stephanie RimmerCamus Nimmo Max O'Donnell Emerging Infectious Diseases Published 1 May 2023 Crick labsEachan JohnsonFull details
Chemical validation of Mycobacterium tuberculosis phosphopantetheine adenylyltransferase using fragment linking and CRISPR interference Authors (13) Jamal El Bakali Michal BlaszczykJoanna Evans Jennifer A BolandWilliam McCarthy Imam Fathoni[...] Anthony G Coyne Valerie Mizrahi Tom L Blundell Chris Abell Christina Spry Angewandte Chemie International Edition Published 17 April 2023 Crick labsEachan JohnsonFull details
Chemical validation of Mycobacterium tuberculosis phosphopantetheine adenylyltransferase using fragment linking and CRISPR interference Authors (13) Jamal El Bakali Michal BlaszczykJoanna Evans Jennifer A BolandWilliam McCarthy Imam Fathoni[...] Anthony G Coyne Valerie Mizrahi Tom L Blundell Chris Abell Christina Spry Angewandte Chemie Published 17 April 2023 Crick labsEachan JohnsonFull details
Evolution of Mycobacterium tuberculosis drug resistance in the genomic era Authors (6)Camus Nimmo James MillardValwynne FaulknerJohana MonteserinHannah PughEachan Johnson Frontiers in Cellular and Infection Microbiology Published 7 October 2022 Crick labsEachan JohnsonFull details
Cellular and molecular mechanisms in mycobacterial infection Authors (2) Natalie E NieuwenhuizenJoanna Evans International Journal of Molecular Sciences Published 29 June 2022 Crick labsEachan JohnsonFull details
Using proteolytic hypomorphs to detect small molecule mechanism of action Authors (2)Eachan Johnson Deborah T Hung Methods in Molecular Biology Published 1 January 2021 Crick labsEachan JohnsonFull details
Large-scale chemical-genetic strategy enables the design of antimicrobial combination chemotherapy in Mycobacteria Authors (5)Eachan Johnson Emma Office Tomohiko Kawate Marek Orzechowski Deborah T Hung ACS Infectious Diseases Published 10 January 2020 Crick labsEachan JohnsonFull details
A point of inflection and reflection on systems chemical biology Authors (2)Eachan Johnson Deborah T Hung ACS Chemical Biology Published 20 December 2019 Crick labsEachan JohnsonFull details
Large-scale chemical-genetics yields new M. tuberculosis inhibitor classes Authors (44)Eachan Johnson Emily LaVerriere Emma Office Mary Stanley Elisabeth Meyer Tomohiko Kawate[...] Michael Fitzgerald Eric J Rubin Christopher M Sassetti Dirk Schnappinger Deborah T Hung Nature Published 4 July 2019 Crick labsEachan JohnsonFull details
A structural model of a P450-ferredoxin complex from orientation-selective double electron-electron resonance spectroscopy Authors (12) Alice M BowenEachan Johnson Francesco Mercuri Nicola J Hoskins Ruihong Qiao James SO McCullagh[...] Stephen G Bell Weihong Zhou Christiane R Timmel Luet Lok Wong Jeffrey R Harmer Journal of the American Chemical Society Published 21 February 2018 Crick labsEachan JohnsonFull details
Partial fusion of a cytochrome P450 system by carboxy-terminal attachment of putidaredoxin reductase to P450cam (CYP101A1) Authors (2)Eachan Johnson Luet-Lok Wong Catalysis Science and Technology Published 21 October 2016 Crick labsEachan JohnsonFull details
Tailoring an alien ferredoxin to support native-like P450 monooxygenase activity Authors (6) Stephen G Bell James HC McMillan Jake A Yorke Emma KavanaghEachan Johnson Luet-Lok Wong Chemical Communications Published 5 November 2012 Crick labsEachan JohnsonFull details