Our lab combines chemical and genetic approaches to discover new aspects of malaria biology and identify novel anti-malarial targets.
Half of the world population is at risk of malaria, an infectious parasitic disease that kills close to half a million children every year. To make things worse, the parasites are rapidly developing resistance to new anti-malarial drugs, making the identification of drug targets and the development of new therapies extremely urgent.
Our lab uses a variety of chemical tools to discover new aspects of malaria biology and identify novel anti-malarial targets. We then apply the latest advances in malaria genetics to find the molecular function of these targets and evaluate whether they are essential for parasite survival. Finally, in partnership with the pharmaceutical industry we design small molecules able to block these targets as a starting point for drug development.
We hope that our work will lead to the development of life-saving novel therapies for malaria and will contribute to the fight against drug resistance.