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Breadcrumb Erik Sahai Sahai lab Tumour Cell Biology Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members Vacancies Co-culture of cancer cells (darker cells) with stromal fibroblasts (lighter cells) with a signalling molecule shown in green speckles. Toggle to view hero caption PublicationsYear published2024 (2)2023 (5)2022 (3)2021 (12)2020 (9)2019 (7)2018 (8)2017 (7)2016 (4)2015 (14)2014 (5)2013 (7)2012 (2)2011 (5)2010 (4) Facet Year publishedResearch topicsCell Biology (70)Model Organisms (70)Imaging (69)Tumour Biology (69)Computational & Systems Biology (21)Chemical Biology & High Throughput (18)Genetics & Genomics (17)Genome Integrity & Repair (16)Signalling & Oncogenes (10)Human Biology & Physiology (9)Immunology (9)Structural Biology & Biophysics (8)Infectious Disease (7)Stem Cells (7)Gene Expression (6)Developmental Biology (5)Biochemistry & Proteomics (4)Cell Cycle & Chromosomes (4)Metabolism (2)Microfabrication & Bioengineering (2)Neurosciences (1)Synthetic Biology (1) Facet Research topicsPublication typeJournal article (94)Primary research (69)Review (16)Method (4)Commentary (3)Editorial (2) Facet Publication typeJournalNature Cell Biology (11)Nature Communications (6)Cancer Cell (4)Cancer Research (4)Cell Reports (4)Journal of Cell Science (4)Cell (3)Developmental Cell (3)Journal of Cell Biology (3)Journal of Pathology (2)Nature Ecology and Evolution (2)Oncogene (2)PLoS Computational Biology (2)Science Immunology (2)Blood (1)Breast Cancer Research (1)British Journal of Cancer (1)Cancers (1)Cancers (Basel) (1)Carcinogenesis (1)Cell systems (1)Clinical and Experimental Metastasis (1)Cold Spring Harbor Perspectives in Medicine (1)Current Opinion in Cell Biology (1)Current Protocols in Cell Biology (1)Development (1)eLife (1)EMBO Journal (1)EMBO Reports (1)Essays in Biochemistry (1)European Respiratory Review (1)Faculty Reviews (1)Front Cell Dev Biol (1)iScience (1)Journal for ImmunoTherapy of Cancer (1)Journal of Biophotonics (1)Journal of Mathematical Biology (1)Journal of the National Cancer Institute (1)Journal of the Royal Society Interface (1)Life Science Alliance (1)Methods in Molecular Biology (1)Molecular Systems Biology (1)Nature (1)Nature Cancer (1)Nature Materials (1)Nature Physics (1)Nature Reviews Cancer (1)Nature Reviews Clinical Oncology (1)Nature Reviews Molecular Cell Biology (1)Neuro-Oncology (1)Pigment Cell & Melanoma Research (1)Proceedings of the National Academy of Sciences of the United States of America (1)Science advances (1)Scientific Reports (1)The Lancet (1)Trends in Cell Biology (1) Facet Journal Publications Displaying 1 - 20 of 94Last updated : 29 March 2024 03:21 Astrocyte-induced mGluR1 activates human lung cancer brain metastasis via glutamate-dependent stabilization of EGFR Authors (18) Kojiro Ishibashi Toshiya Ichinose Riki Kadokawa Ryo Mizutani Sadahiro Iwabuchi Sumihito Togi[...] Shinichi HashimotoErik Sahai Seiji Yano Mitsutoshi Nakada Eishu Hirata Developmental Cell Published 11 March 2024 Crick labsErik SahaiFull details The artificial intelligence-based model ANORAK improves histopathological grading of lung adenocarcinoma Authors (20) Xiaoxi Pan Khalid AbdulJabbar Jose Coelho-Lima Anca-Ioana Grapa Hanyun Zhang Alvin Ho Kwan Cheung[...] TRACERx ConsortiumCharles Swanton Yinyin Yuan John Le Quesne David A Moore Nature Cancer Published 1 February 2024 Crick labs/ facilitiesPeter Van LooSamra TurajlicCharles SwantonErik SahaiGeorge KassiotisFlow CytometryExperimental HistopathologyBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Understanding the microenvironment and how this controls cell fate Authors (6) Elaine FuchsErik Sahai Ashani T Weeraratna Benjamin Deneen Carmen Chak-Lui Wong András Simon Developmental Cell Published 18 December 2023 Crick labsErik SahaiFull details Emergent mechanical control of vascular morphogenesis Authors (29) Jordan Whisler Somayeh ShahrezaKarin Schlegelmilch Nil Ege Yousef Javanmardi Andrea Malandrino[...] Fernando Calvo Christiana RuhrbergErik Sahai Roger Kamm Emad Moeendarbary Science advances Published 11 August 2023 Crick labs/ facilitiesErik SahaiExperimental HistopathologyElectron MicroscopyFull details Application of digital pathology-based advanced analytics of tumour microenvironment organisation to predict prognosis and therapeutic response Authors (3)Xiao FuErik Sahai Anna Wilkins Journal of Pathology Published 1 August 2023 Crick labsErik SahaiFull details Multisite assessment of reproducibility in high-content cell migration imaging data Authors (23) Jianjiang Hu Xavier Serra-Picamal Gert-Jan Bakker Marleen Van Troys Sabina Winograd-Katz Nil Ege[...] Christophe Ampe Benjamin Geiger Peter Friedl Matteo Bottai Staffan Strömblad Molecular Systems Biology Published 12 June 2023 Crick labsErik SahaiFull details Interplay of adherens junctions and matrix proteolysis determines the invasive pattern and growth of squamous cell carcinoma Authors (12) Takuya KatoRob Jenkins Stefanie Derzsi Melda TozluogluToni Rullan IriarteSteven Hooper[...] Holly JoyceXiao Fu Selvam ThavarajPaul BatesErik Sahai eLife Published 9 March 2023 Crick labs/ facilitiesErik SahaiPaul BatesLight MicroscopyFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityFull details Selective advantage of epigenetically disrupted cancer cells via phenotypic inertia Authors (15)Ioannis LoukasFabrizio SimeoniMarta MilanPaolo Inglese Harshil PatelRobert Goldstone[...] Wenhao TangColin RatcliffeErik Sahai Vahid ShahrezaeiPaola Scaffidi Cancer Cell Published 9 January 2023 Crick labs/ facilitiesPaola ScaffidiErik SahaiBioinformatics and BiostatisticsStructural BiologyLight MicroscopyFlow CytometryExperimental HistopathologyBiological Research FacilityAdvanced SequencingFull details Loss of secreted gelsolin enhances response to anticancer therapies Authors (8)Jonathan LimEvangelos GiampazoliasOliver SchulzNeil Rogers Anna WilkinsErik Sahai Jessica StridCaetano Reis e Sousa Journal for ImmunoTherapy of Cancer Published 26 September 2022 Crick labs/ facilitiesErik SahaiCaetano Reis e SousaBiological Research FacilityFull details Adhesion-independent topography-based leukocyte migration Authors (4) Peter Friedl Konstantinos KonstantopoulosErik Sahai Orion Weiner Faculty Reviews Published 21 July 2022 Crick labsErik SahaiFull details Spatial patterns of tumour growth impact clonal diversification in a computational model and the TRACERx Renal study Authors (35)Xiao Fu Yue Zhao Jose I LopezAndrew RowanLewis AuAnnika Fendler[...]Erik SahaiKevin LitchfieldSamra Turajlic TRACERx Renal ConsortiumPaul Bates Nature Ecology and Evolution Published 1 January 2022 Crick labs/ facilitiesSamra TurajlicCharles SwantonErik SahaiPaul BatesExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingFull details Recruitment of dendritic cell progenitors to foci of influenza A virus infection sustains immunity Authors (18)Maria Del Mar Cabeza CabrerizoCarlos Munoz Minutti Mariana Pereira da CostaAna Matos Cardoso Da SilvaRob JenkinsJustina Kulikauskaite[...] Judith E Allen Manolis PasparakisAndreas WackErik SahaiCaetano Reis e Sousa Science Immunology Published 5 November 2021 Crick labs/ facilitiesAndreas WackErik SahaiCaetano Reis e SousaNicola LewisDominique BonnetWorldwide Influenza CentreFlow CytometryBiological Research FacilityBioinformatics and BiostatisticsFull details An optogenetic method for interrogating YAP1 and TAZ nuclear-cytoplasmic shuttling Authors (11)Anna DowbajRob Jenkins Daniel Williamson John M HeddlestonAlessandro CiccarelliTodd Fallesen Klaus M Hahn Reuben D O'Dea John R King Marco MontagnerErik Sahai Journal of Cell Science Published 9 July 2021 Crick labs/ facilitiesErik SahaiLight MicroscopyFlow CytometryCell ServicesFull details The PI3K/Akt/mTOR pathway as a preventive target in melanoma brain metastasis Authors (14) Cedric Tehranian Laura Fankhauser Patrick N HarterColin Ratcliffe Pia S Zeiner Julia M Messmer[...] Michael W RonellenfitschErik Sahai Wolfgang Wick Matthia A Karreman Frank Winkler Neuro-Oncology Published 1 February 2022 Crick labsErik SahaiFull details Parameter estimation in fluorescence recovery after photobleaching: quantitative analysis of protein binding reactions and diffusion Authors (5) Daniel E WilliamsonErik SahaiRob Jenkins Reuben D O'Dea John R King Journal of Mathematical Biology Published 15 June 2021 Crick labsErik SahaiFull details An optogenetic method for interrogating YAP1 and TAZ nuclear-cytoplasmic shuttling Authors (11)Anna DowbajRob Jenkins Daniel Williamson John M HeddlestonAlessandro CiccarelliTodd Fallesen Klaus M Hahn Reuben D O'Dea John R King Marco MontagnerErik Sahai Journal of Cell Science Published 1 July 2021 Crick labs/ facilitiesErik SahaiLight MicroscopyFlow CytometryCell ServicesFull details Selection of metastasis competent subclones in the tumour interior Authors (27) Yue ZhaoXiao Fu Jose I LopezAndrew RowanLewis AuAnnika Fendler[...]Paul BatesCharles SwantonSamra Turajlic TRACERx Renal Consortium Kevin Litchfield Nature Ecology and Evolution Published 1 July 2021 Crick labs/ facilitiesSamra TurajlicCharles SwantonErik SahaiPaul BatesExperimental HistopathologyBioinformatics and BiostatisticsFull details Biochemistry: one molecule at a time Authors (1)Dominika Gruszka Essays in Biochemistry Published 16 April 2021 Crick labsErik SahaiFull details EphB6 regulates TFEB-lysosomal pathway and survival of disseminated indolent breast cancer cells Authors (11) Manuela Zangrossi Patrizia Romani Probir ChakravartyColin RatcliffeSteven Hooper Martina Dori Mattia Forcato Silvio Bicciato Sirio DupontErik Sahai Marco Montagner Cancers Published 3 March 2021 Crick labs/ facilitiesErik SahaiBioinformatics and BiostatisticsFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityAdvanced SequencingFull details A lung organotypic coculture reveals a role for TFEB-lysosomal axis in the survival of disseminated dormant cancer cells Authors (7) Manuela Zangrossi Probir Chakravarty Patrizia Romani Sirio DupontSteven HooperErik Sahai Marco Montagner Cancers (Basel) Published 28 February 2021 Crick labs/ facilitiesErik SahaiBioinformatics and BiostatisticsFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityAdvanced SequencingFull details Pagination Current page 1 Page 2 Page 3 Page 4 Page 5 Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Astrocyte-induced mGluR1 activates human lung cancer brain metastasis via glutamate-dependent stabilization of EGFR Authors (18) Kojiro Ishibashi Toshiya Ichinose Riki Kadokawa Ryo Mizutani Sadahiro Iwabuchi Sumihito Togi[...] Shinichi HashimotoErik Sahai Seiji Yano Mitsutoshi Nakada Eishu Hirata Developmental Cell Published 11 March 2024 Crick labsErik SahaiFull details
The artificial intelligence-based model ANORAK improves histopathological grading of lung adenocarcinoma Authors (20) Xiaoxi Pan Khalid AbdulJabbar Jose Coelho-Lima Anca-Ioana Grapa Hanyun Zhang Alvin Ho Kwan Cheung[...] TRACERx ConsortiumCharles Swanton Yinyin Yuan John Le Quesne David A Moore Nature Cancer Published 1 February 2024 Crick labs/ facilitiesPeter Van LooSamra TurajlicCharles SwantonErik SahaiGeorge KassiotisFlow CytometryExperimental HistopathologyBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Understanding the microenvironment and how this controls cell fate Authors (6) Elaine FuchsErik Sahai Ashani T Weeraratna Benjamin Deneen Carmen Chak-Lui Wong András Simon Developmental Cell Published 18 December 2023 Crick labsErik SahaiFull details
Emergent mechanical control of vascular morphogenesis Authors (29) Jordan Whisler Somayeh ShahrezaKarin Schlegelmilch Nil Ege Yousef Javanmardi Andrea Malandrino[...] Fernando Calvo Christiana RuhrbergErik Sahai Roger Kamm Emad Moeendarbary Science advances Published 11 August 2023 Crick labs/ facilitiesErik SahaiExperimental HistopathologyElectron MicroscopyFull details
Application of digital pathology-based advanced analytics of tumour microenvironment organisation to predict prognosis and therapeutic response Authors (3)Xiao FuErik Sahai Anna Wilkins Journal of Pathology Published 1 August 2023 Crick labsErik SahaiFull details
Multisite assessment of reproducibility in high-content cell migration imaging data Authors (23) Jianjiang Hu Xavier Serra-Picamal Gert-Jan Bakker Marleen Van Troys Sabina Winograd-Katz Nil Ege[...] Christophe Ampe Benjamin Geiger Peter Friedl Matteo Bottai Staffan Strömblad Molecular Systems Biology Published 12 June 2023 Crick labsErik SahaiFull details
Interplay of adherens junctions and matrix proteolysis determines the invasive pattern and growth of squamous cell carcinoma Authors (12) Takuya KatoRob Jenkins Stefanie Derzsi Melda TozluogluToni Rullan IriarteSteven Hooper[...] Holly JoyceXiao Fu Selvam ThavarajPaul BatesErik Sahai eLife Published 9 March 2023 Crick labs/ facilitiesErik SahaiPaul BatesLight MicroscopyFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityFull details
Selective advantage of epigenetically disrupted cancer cells via phenotypic inertia Authors (15)Ioannis LoukasFabrizio SimeoniMarta MilanPaolo Inglese Harshil PatelRobert Goldstone[...] Wenhao TangColin RatcliffeErik Sahai Vahid ShahrezaeiPaola Scaffidi Cancer Cell Published 9 January 2023 Crick labs/ facilitiesPaola ScaffidiErik SahaiBioinformatics and BiostatisticsStructural BiologyLight MicroscopyFlow CytometryExperimental HistopathologyBiological Research FacilityAdvanced SequencingFull details
Loss of secreted gelsolin enhances response to anticancer therapies Authors (8)Jonathan LimEvangelos GiampazoliasOliver SchulzNeil Rogers Anna WilkinsErik Sahai Jessica StridCaetano Reis e Sousa Journal for ImmunoTherapy of Cancer Published 26 September 2022 Crick labs/ facilitiesErik SahaiCaetano Reis e SousaBiological Research FacilityFull details
Adhesion-independent topography-based leukocyte migration Authors (4) Peter Friedl Konstantinos KonstantopoulosErik Sahai Orion Weiner Faculty Reviews Published 21 July 2022 Crick labsErik SahaiFull details
Spatial patterns of tumour growth impact clonal diversification in a computational model and the TRACERx Renal study Authors (35)Xiao Fu Yue Zhao Jose I LopezAndrew RowanLewis AuAnnika Fendler[...]Erik SahaiKevin LitchfieldSamra Turajlic TRACERx Renal ConsortiumPaul Bates Nature Ecology and Evolution Published 1 January 2022 Crick labs/ facilitiesSamra TurajlicCharles SwantonErik SahaiPaul BatesExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingFull details
Recruitment of dendritic cell progenitors to foci of influenza A virus infection sustains immunity Authors (18)Maria Del Mar Cabeza CabrerizoCarlos Munoz Minutti Mariana Pereira da CostaAna Matos Cardoso Da SilvaRob JenkinsJustina Kulikauskaite[...] Judith E Allen Manolis PasparakisAndreas WackErik SahaiCaetano Reis e Sousa Science Immunology Published 5 November 2021 Crick labs/ facilitiesAndreas WackErik SahaiCaetano Reis e SousaNicola LewisDominique BonnetWorldwide Influenza CentreFlow CytometryBiological Research FacilityBioinformatics and BiostatisticsFull details
An optogenetic method for interrogating YAP1 and TAZ nuclear-cytoplasmic shuttling Authors (11)Anna DowbajRob Jenkins Daniel Williamson John M HeddlestonAlessandro CiccarelliTodd Fallesen Klaus M Hahn Reuben D O'Dea John R King Marco MontagnerErik Sahai Journal of Cell Science Published 9 July 2021 Crick labs/ facilitiesErik SahaiLight MicroscopyFlow CytometryCell ServicesFull details
The PI3K/Akt/mTOR pathway as a preventive target in melanoma brain metastasis Authors (14) Cedric Tehranian Laura Fankhauser Patrick N HarterColin Ratcliffe Pia S Zeiner Julia M Messmer[...] Michael W RonellenfitschErik Sahai Wolfgang Wick Matthia A Karreman Frank Winkler Neuro-Oncology Published 1 February 2022 Crick labsErik SahaiFull details
Parameter estimation in fluorescence recovery after photobleaching: quantitative analysis of protein binding reactions and diffusion Authors (5) Daniel E WilliamsonErik SahaiRob Jenkins Reuben D O'Dea John R King Journal of Mathematical Biology Published 15 June 2021 Crick labsErik SahaiFull details
An optogenetic method for interrogating YAP1 and TAZ nuclear-cytoplasmic shuttling Authors (11)Anna DowbajRob Jenkins Daniel Williamson John M HeddlestonAlessandro CiccarelliTodd Fallesen Klaus M Hahn Reuben D O'Dea John R King Marco MontagnerErik Sahai Journal of Cell Science Published 1 July 2021 Crick labs/ facilitiesErik SahaiLight MicroscopyFlow CytometryCell ServicesFull details
Selection of metastasis competent subclones in the tumour interior Authors (27) Yue ZhaoXiao Fu Jose I LopezAndrew RowanLewis AuAnnika Fendler[...]Paul BatesCharles SwantonSamra Turajlic TRACERx Renal Consortium Kevin Litchfield Nature Ecology and Evolution Published 1 July 2021 Crick labs/ facilitiesSamra TurajlicCharles SwantonErik SahaiPaul BatesExperimental HistopathologyBioinformatics and BiostatisticsFull details
Biochemistry: one molecule at a time Authors (1)Dominika Gruszka Essays in Biochemistry Published 16 April 2021 Crick labsErik SahaiFull details
EphB6 regulates TFEB-lysosomal pathway and survival of disseminated indolent breast cancer cells Authors (11) Manuela Zangrossi Patrizia Romani Probir ChakravartyColin RatcliffeSteven Hooper Martina Dori Mattia Forcato Silvio Bicciato Sirio DupontErik Sahai Marco Montagner Cancers Published 3 March 2021 Crick labs/ facilitiesErik SahaiBioinformatics and BiostatisticsFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityAdvanced SequencingFull details
A lung organotypic coculture reveals a role for TFEB-lysosomal axis in the survival of disseminated dormant cancer cells Authors (7) Manuela Zangrossi Probir Chakravarty Patrizia Romani Sirio DupontSteven HooperErik Sahai Marco Montagner Cancers (Basel) Published 28 February 2021 Crick labs/ facilitiesErik SahaiBioinformatics and BiostatisticsFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityAdvanced SequencingFull details