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Breadcrumb Erik Sahai Sahai lab Tumour Cell Biology Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members Vacancies Co-culture of cancer cells (darker cells) with stromal fibroblasts (lighter cells) with a signalling molecule shown in green speckles. Toggle to view hero caption PublicationsYear published2024 (2)2023 (1)2022 (1)2021 (6)2020 (2)2019 (3)2018 (1)2017 (1)2016 (1)2015 (4) Facet Year publishedResearch topicsCell Biology (22)Imaging (22)Tumour Biology (22)Model Organisms (21)Chemical Biology & High Throughput (16)Genetics & Genomics (16)Genome Integrity & Repair (15)Signalling & Oncogenes (10)Structural Biology & Biophysics (8)Human Biology & Physiology (7)Immunology (7)Developmental Biology (5)Infectious Disease (5)Stem Cells (5)Gene Expression (4)Cell Cycle & Chromosomes (3)Biochemistry & Proteomics (2)Metabolism (2)Microfabrication & Bioengineering (1)Neurosciences (1)Synthetic Biology (1) (-)Computational & Systems Biology (22) Facet Research topicsPublication typeJournal article (22)Primary research (19)Commentary (1)Method (1)Review (1) Facet Publication typeJournalCell (2)Cell Reports (2)Nature Ecology and Evolution (2)Cancer Cell (1)Cancer Discovery (1)Cancers (1)Cancers (Basel) (1)Development (1)eLife (1)Journal of Cell Biology (1)Journal of the Royal Society Interface (1)Life Science Alliance (1)Nature Cancer (1)Nature Cell Biology (1)Nature Materials (1)Nature Reviews Clinical Oncology (1)PLoS Computational Biology (1)Science Immunology (1)The Lancet (1) Facet Journal Publications Displaying 1 - 20 of 22Last updated : 18 April 2024 03:03 Spatial architecture of myeloid and T cells orchestrates immune evasion and clinical outcome in lung cancer Authors (35)Katey Enfield Emma Colliver Claudia Lee Alastair Magness David A Moore Monica Sivakumar[...]Crispin HileyJulian DownwardErik SahaiCharles SwantonMihaela Angelova Cancer Discovery Published 6 April 2024 Crick labs/ facilitiesCharles SwantonErik SahaiJulian DownwardFlow CytometryExperimental HistopathologyScientific computingProteomicsLight MicroscopyCell ServicesBiological Research FacilityAdvanced SequencingFull details The artificial intelligence-based model ANORAK improves histopathological grading of lung adenocarcinoma Authors (20) Xiaoxi Pan Khalid AbdulJabbar Jose Coelho-Lima Anca-Ioana Grapa Hanyun Zhang Alvin Ho Kwan Cheung[...] TRACERx ConsortiumCharles Swanton Yinyin Yuan John Le Quesne David A Moore Nature Cancer Published 1 February 2024 Crick labs/ facilitiesPeter Van LooSamra TurajlicCharles SwantonErik SahaiGeorge KassiotisFlow CytometryExperimental HistopathologyBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Interplay of adherens junctions and matrix proteolysis determines the invasive pattern and growth of squamous cell carcinoma Authors (12) Takuya KatoRob Jenkins Stefanie Derzsi Melda TozluogluToni Rullan IriarteSteven Hooper[...] Holly JoyceXiao Fu Selvam ThavarajPaul BatesErik Sahai eLife Published 9 March 2023 Crick labs/ facilitiesErik SahaiPaul BatesLight MicroscopyFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityFull details Selective advantage of epigenetically disrupted cancer cells via phenotypic inertia Authors (15)Ioannis LoukasFabrizio SimeoniMarta MilanPaolo Inglese Harshil PatelRobert Goldstone[...] Wenhao TangColin RatcliffeErik Sahai Vahid ShahrezaeiPaola Scaffidi Cancer Cell Published 9 January 2023 Crick labs/ facilitiesPaola ScaffidiErik SahaiBioinformatics and BiostatisticsStructural BiologyLight MicroscopyFlow CytometryExperimental HistopathologyBiological Research FacilityAdvanced SequencingFull details Spatial patterns of tumour growth impact clonal diversification in a computational model and the TRACERx Renal study Authors (35)Xiao Fu Yue Zhao Jose I LopezAndrew RowanLewis AuAnnika Fendler[...]Erik SahaiKevin LitchfieldSamra Turajlic TRACERx Renal ConsortiumPaul Bates Nature Ecology and Evolution Published 1 January 2022 Crick labs/ facilitiesSamra TurajlicCharles SwantonErik SahaiPaul BatesExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingFull details Selection of metastasis competent subclones in the tumour interior Authors (27) Yue ZhaoXiao Fu Jose I LopezAndrew RowanLewis AuAnnika Fendler[...]Paul BatesCharles SwantonSamra Turajlic TRACERx Renal Consortium Kevin Litchfield Nature Ecology and Evolution Published 1 July 2021 Crick labs/ facilitiesSamra TurajlicCharles SwantonErik SahaiPaul BatesExperimental HistopathologyBioinformatics and BiostatisticsFull details EphB6 regulates TFEB-lysosomal pathway and survival of disseminated indolent breast cancer cells Authors (11) Manuela Zangrossi Patrizia Romani Probir ChakravartyColin RatcliffeSteven Hooper Martina Dori Mattia Forcato Silvio Bicciato Sirio DupontErik Sahai Marco Montagner Cancers Published 3 March 2021 Crick labs/ facilitiesErik SahaiBioinformatics and BiostatisticsFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityAdvanced SequencingFull details A lung organotypic coculture reveals a role for TFEB-lysosomal axis in the survival of disseminated dormant cancer cells Authors (7) Manuela Zangrossi Probir Chakravarty Patrizia Romani Sirio DupontSteven HooperErik Sahai Marco Montagner Cancers (Basel) Published 28 February 2021 Crick labs/ facilitiesErik SahaiBioinformatics and BiostatisticsFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityAdvanced SequencingFull details Single-cell resolved imaging reveals intra-tumor heterogeneity in glycolysis, transitions between metabolic states, and their regulatory mechanisms Authors (9)Hiroshi KondoColin RatcliffeSteven HooperJames EllisJames MacraeMarc Hennequart Christopher W DunsbyKurt AndersonErik Sahai Cell Reports Published 16 February 2021 Crick labs/ facilitiesKaren VousdenErik SahaiMetabolomicsLight MicroscopyFlow CytometryCell ServicesBiological Research FacilityFull details A FIJI macro for quantifying pattern in extracellular matrix Authors (11)Esther WershofDanielle ParkDavid BarryRob JenkinsToni Rullan Iriarte Anna WilkinsKarin Schlegelmilch Ioannis RoxanisKurt AndersonPaul BatesErik Sahai Life Science Alliance Published 1 March 2021 Crick labs/ facilitiesErik SahaiPaul BatesLight MicroscopyFull details Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers Authors (341) Catherine F Houlihan Nina Vora Thomas Byrne Dan LewerGavin Kelly Judith Heaney[...] Andrew Hayward Richard Gilson Gavin KellyFiona Roberts Emine Hatipoglu The Lancet Published 25 July 2020 Crick labs/ facilitiesAndreas WackKaren VousdenJernej UleJames TurnerMoritz TreeckCharles SwantonAdam SaterialeErik SahaiCaetano Reis e SousaPeter RatcliffeLucia Prieto-GodinoVenizelos PapayannopoulosAnne O’GarraPaul NurseGeorge KassiotisMaximiliano GutierrezSonia GandhiSteve GamblinPeter Cherepanov Luiz Pedro CarvalhoDominique BonnetMike BlackmanRupert BealeWorldwide Influenza CentreStructural BiologyMetabolomicsHuman Embryonic Stem CellHigh Throughput ScreeningGenetic Modification ServiceFlow CytometryFermentationExperimental HistopathologyElectron MicroscopyCell ServicesBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Crosstalk with lung epithelial cells regulates Sfrp2-mediated latency in breast cancer dissemination Authors (12) Marco Montagner Rahul BhomeSteven Hooper Probir Chakravarty Xiao Qin Jahangir Sufi[...]Colin Ratcliffe Yutaka Naito Arianna Pocaterra Christopher J TapeErik Sahai Nature Cell Biology Published 1 March 2020 Crick labs/ facilitiesErik SahaiBioinformatics and BiostatisticsFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityAdvanced SequencingFull details Extracellular matrix anisotropy is determined by TFAP2C-dependent regulation of cell collisions Authors (9)Danielle ParkEsther WershofStefan Boeing Anna LabernadieRob Jenkins Samantha George Xavier TrepatPaul BatesErik Sahai Nature Materials Published 1 February 2020 Crick labs/ facilitiesErik SahaiPaul BatesBioinformatics and BiostatisticsLight MicroscopyCell ServicesBiological Research FacilityAdvanced SequencingFull details Matrix feedback enables diverse higher-order patterning of the extracellular matrix Authors (6)Esther WershofDanielle ParkRob JenkinsDavid BarryErik SahaiPaul Bates PLoS Computational Biology Published 28 October 2019 Crick labs/ facilitiesErik SahaiPaul BatesLight MicroscopyBioinformatics and BiostatisticsFull details Tissue clonality of dendritic cell subsets and emergency DCpoiesis revealed by multicolor fate mapping of DC progenitors Authors (19)Maria Del Mar Cabeza Cabrerizo Janneke van Blijswijk Stephan Wienert Daniel HeimRob Jenkins Probir Chakravarty[...] Michael Gerner Ronald N GermainErik Sahai Frederick KlauschenCaetano Reis e Sousa Science Immunology Published 1 March 2019 Crick labs/ facilitiesErik SahaiCaetano Reis e SousaBioinformatics and BiostatisticsLight MicroscopyFlow CytometryBiological Research FacilityFull details NK cells stimulate recruitment of cDC1 into the tumor microenvironment promoting cancer immune control Authors (10) Jan P Böttcher Eduardo Bonavita Probir ChakravartyHanna BleesMaria Del Mar Cabeza Cabrerizo Stefano SammicheliNeil RogersErik Sahai Santiago ZelenayCaetano Reis e Sousa Cell Published 22 February 2018 Crick labs/ facilitiesErik SahaiCaetano Reis e SousaBioinformatics and BiostatisticsFull details Evolution and cancer medicine - transformative insights Authors (3)Erik SahaiCharles Swanton CRUK Marshall Symposium Nature Reviews Clinical Oncology Published 22 August 2017 Crick labsCharles SwantonErik SahaiFull details Integrin signalling regulates YAP and TAZ to control skin homeostasis Authors (16)Ahmed Elbediwy ZI Vincent-Mistiaen B Spencer-DeneRichard StoneStefan Boeing SK Wculek[...] H GerhardtAxel BehrensIlaria Malanchi OJ Sansom BJ Thompson Development Published 15 May 2016 Crick labs/ facilitiesBarry ThompsonErik SahaiIlaria MalanchiAxel BehrensExperimental HistopathologyBioinformatics and BiostatisticsFull details Mesenchymal cancer cell-stroma crosstalk promotes niche activation, epithelial reversion, and metastatic colonization Authors (11) Yaiza del Pozo MartinDanielle ParkAnassuya RamachandranLuigi Ombrato Fernando Calvo Probir Chakravarty Bradley Spencer-Dene Stefanie DerzsiCaroline HillErik SahaiIlaria Malanchi Cell Reports Published 22 December 2015 Crick labs/ facilitiesErik SahaiIlaria MalanchiCaroline HillExperimental HistopathologyBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityFull details MST kinases in development and disease Authors (2) Barry J ThompsonErik Sahai Journal of Cell Biology Published 14 September 2015 Crick labsBarry ThompsonErik SahaiFull details Pagination Current page 1 Page 2 Next page Next Last page Last Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
Spatial architecture of myeloid and T cells orchestrates immune evasion and clinical outcome in lung cancer Authors (35)Katey Enfield Emma Colliver Claudia Lee Alastair Magness David A Moore Monica Sivakumar[...]Crispin HileyJulian DownwardErik SahaiCharles SwantonMihaela Angelova Cancer Discovery Published 6 April 2024 Crick labs/ facilitiesCharles SwantonErik SahaiJulian DownwardFlow CytometryExperimental HistopathologyScientific computingProteomicsLight MicroscopyCell ServicesBiological Research FacilityAdvanced SequencingFull details
The artificial intelligence-based model ANORAK improves histopathological grading of lung adenocarcinoma Authors (20) Xiaoxi Pan Khalid AbdulJabbar Jose Coelho-Lima Anca-Ioana Grapa Hanyun Zhang Alvin Ho Kwan Cheung[...] TRACERx ConsortiumCharles Swanton Yinyin Yuan John Le Quesne David A Moore Nature Cancer Published 1 February 2024 Crick labs/ facilitiesPeter Van LooSamra TurajlicCharles SwantonErik SahaiGeorge KassiotisFlow CytometryExperimental HistopathologyBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Interplay of adherens junctions and matrix proteolysis determines the invasive pattern and growth of squamous cell carcinoma Authors (12) Takuya KatoRob Jenkins Stefanie Derzsi Melda TozluogluToni Rullan IriarteSteven Hooper[...] Holly JoyceXiao Fu Selvam ThavarajPaul BatesErik Sahai eLife Published 9 March 2023 Crick labs/ facilitiesErik SahaiPaul BatesLight MicroscopyFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityFull details
Selective advantage of epigenetically disrupted cancer cells via phenotypic inertia Authors (15)Ioannis LoukasFabrizio SimeoniMarta MilanPaolo Inglese Harshil PatelRobert Goldstone[...] Wenhao TangColin RatcliffeErik Sahai Vahid ShahrezaeiPaola Scaffidi Cancer Cell Published 9 January 2023 Crick labs/ facilitiesPaola ScaffidiErik SahaiBioinformatics and BiostatisticsStructural BiologyLight MicroscopyFlow CytometryExperimental HistopathologyBiological Research FacilityAdvanced SequencingFull details
Spatial patterns of tumour growth impact clonal diversification in a computational model and the TRACERx Renal study Authors (35)Xiao Fu Yue Zhao Jose I LopezAndrew RowanLewis AuAnnika Fendler[...]Erik SahaiKevin LitchfieldSamra Turajlic TRACERx Renal ConsortiumPaul Bates Nature Ecology and Evolution Published 1 January 2022 Crick labs/ facilitiesSamra TurajlicCharles SwantonErik SahaiPaul BatesExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingFull details
Selection of metastasis competent subclones in the tumour interior Authors (27) Yue ZhaoXiao Fu Jose I LopezAndrew RowanLewis AuAnnika Fendler[...]Paul BatesCharles SwantonSamra Turajlic TRACERx Renal Consortium Kevin Litchfield Nature Ecology and Evolution Published 1 July 2021 Crick labs/ facilitiesSamra TurajlicCharles SwantonErik SahaiPaul BatesExperimental HistopathologyBioinformatics and BiostatisticsFull details
EphB6 regulates TFEB-lysosomal pathway and survival of disseminated indolent breast cancer cells Authors (11) Manuela Zangrossi Patrizia Romani Probir ChakravartyColin RatcliffeSteven Hooper Martina Dori Mattia Forcato Silvio Bicciato Sirio DupontErik Sahai Marco Montagner Cancers Published 3 March 2021 Crick labs/ facilitiesErik SahaiBioinformatics and BiostatisticsFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityAdvanced SequencingFull details
A lung organotypic coculture reveals a role for TFEB-lysosomal axis in the survival of disseminated dormant cancer cells Authors (7) Manuela Zangrossi Probir Chakravarty Patrizia Romani Sirio DupontSteven HooperErik Sahai Marco Montagner Cancers (Basel) Published 28 February 2021 Crick labs/ facilitiesErik SahaiBioinformatics and BiostatisticsFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityAdvanced SequencingFull details
Single-cell resolved imaging reveals intra-tumor heterogeneity in glycolysis, transitions between metabolic states, and their regulatory mechanisms Authors (9)Hiroshi KondoColin RatcliffeSteven HooperJames EllisJames MacraeMarc Hennequart Christopher W DunsbyKurt AndersonErik Sahai Cell Reports Published 16 February 2021 Crick labs/ facilitiesKaren VousdenErik SahaiMetabolomicsLight MicroscopyFlow CytometryCell ServicesBiological Research FacilityFull details
A FIJI macro for quantifying pattern in extracellular matrix Authors (11)Esther WershofDanielle ParkDavid BarryRob JenkinsToni Rullan Iriarte Anna WilkinsKarin Schlegelmilch Ioannis RoxanisKurt AndersonPaul BatesErik Sahai Life Science Alliance Published 1 March 2021 Crick labs/ facilitiesErik SahaiPaul BatesLight MicroscopyFull details
Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers Authors (341) Catherine F Houlihan Nina Vora Thomas Byrne Dan LewerGavin Kelly Judith Heaney[...] Andrew Hayward Richard Gilson Gavin KellyFiona Roberts Emine Hatipoglu The Lancet Published 25 July 2020 Crick labs/ facilitiesAndreas WackKaren VousdenJernej UleJames TurnerMoritz TreeckCharles SwantonAdam SaterialeErik SahaiCaetano Reis e SousaPeter RatcliffeLucia Prieto-GodinoVenizelos PapayannopoulosAnne O’GarraPaul NurseGeorge KassiotisMaximiliano GutierrezSonia GandhiSteve GamblinPeter Cherepanov Luiz Pedro CarvalhoDominique BonnetMike BlackmanRupert BealeWorldwide Influenza CentreStructural BiologyMetabolomicsHuman Embryonic Stem CellHigh Throughput ScreeningGenetic Modification ServiceFlow CytometryFermentationExperimental HistopathologyElectron MicroscopyCell ServicesBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Crosstalk with lung epithelial cells regulates Sfrp2-mediated latency in breast cancer dissemination Authors (12) Marco Montagner Rahul BhomeSteven Hooper Probir Chakravarty Xiao Qin Jahangir Sufi[...]Colin Ratcliffe Yutaka Naito Arianna Pocaterra Christopher J TapeErik Sahai Nature Cell Biology Published 1 March 2020 Crick labs/ facilitiesErik SahaiBioinformatics and BiostatisticsFlow CytometryExperimental HistopathologyCell ServicesBiological Research FacilityAdvanced SequencingFull details
Extracellular matrix anisotropy is determined by TFAP2C-dependent regulation of cell collisions Authors (9)Danielle ParkEsther WershofStefan Boeing Anna LabernadieRob Jenkins Samantha George Xavier TrepatPaul BatesErik Sahai Nature Materials Published 1 February 2020 Crick labs/ facilitiesErik SahaiPaul BatesBioinformatics and BiostatisticsLight MicroscopyCell ServicesBiological Research FacilityAdvanced SequencingFull details
Matrix feedback enables diverse higher-order patterning of the extracellular matrix Authors (6)Esther WershofDanielle ParkRob JenkinsDavid BarryErik SahaiPaul Bates PLoS Computational Biology Published 28 October 2019 Crick labs/ facilitiesErik SahaiPaul BatesLight MicroscopyBioinformatics and BiostatisticsFull details
Tissue clonality of dendritic cell subsets and emergency DCpoiesis revealed by multicolor fate mapping of DC progenitors Authors (19)Maria Del Mar Cabeza Cabrerizo Janneke van Blijswijk Stephan Wienert Daniel HeimRob Jenkins Probir Chakravarty[...] Michael Gerner Ronald N GermainErik Sahai Frederick KlauschenCaetano Reis e Sousa Science Immunology Published 1 March 2019 Crick labs/ facilitiesErik SahaiCaetano Reis e SousaBioinformatics and BiostatisticsLight MicroscopyFlow CytometryBiological Research FacilityFull details
NK cells stimulate recruitment of cDC1 into the tumor microenvironment promoting cancer immune control Authors (10) Jan P Böttcher Eduardo Bonavita Probir ChakravartyHanna BleesMaria Del Mar Cabeza Cabrerizo Stefano SammicheliNeil RogersErik Sahai Santiago ZelenayCaetano Reis e Sousa Cell Published 22 February 2018 Crick labs/ facilitiesErik SahaiCaetano Reis e SousaBioinformatics and BiostatisticsFull details
Evolution and cancer medicine - transformative insights Authors (3)Erik SahaiCharles Swanton CRUK Marshall Symposium Nature Reviews Clinical Oncology Published 22 August 2017 Crick labsCharles SwantonErik SahaiFull details
Integrin signalling regulates YAP and TAZ to control skin homeostasis Authors (16)Ahmed Elbediwy ZI Vincent-Mistiaen B Spencer-DeneRichard StoneStefan Boeing SK Wculek[...] H GerhardtAxel BehrensIlaria Malanchi OJ Sansom BJ Thompson Development Published 15 May 2016 Crick labs/ facilitiesBarry ThompsonErik SahaiIlaria MalanchiAxel BehrensExperimental HistopathologyBioinformatics and BiostatisticsFull details
Mesenchymal cancer cell-stroma crosstalk promotes niche activation, epithelial reversion, and metastatic colonization Authors (11) Yaiza del Pozo MartinDanielle ParkAnassuya RamachandranLuigi Ombrato Fernando Calvo Probir Chakravarty Bradley Spencer-Dene Stefanie DerzsiCaroline HillErik SahaiIlaria Malanchi Cell Reports Published 22 December 2015 Crick labs/ facilitiesErik SahaiIlaria MalanchiCaroline HillExperimental HistopathologyBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityFull details
MST kinases in development and disease Authors (2) Barry J ThompsonErik Sahai Journal of Cell Biology Published 14 September 2015 Crick labsBarry ThompsonErik SahaiFull details