Research case studies Explore a selection of reports that spotlight particular areas of research at the Crick over the past five years.
Postdoctoral clinical fellows Opportunities for postdoctoral clinicians to consolidate their research experience.
Breadcrumb Erik Sahai Sahai lab Tumour Cell Biology Laboratory : Publications Lab contentLab contentIn this section Overview Areas of interest Publications Members Vacancies Co-culture of cancer cells (darker cells) with stromal fibroblasts (lighter cells) with a signalling molecule shown in green speckles. Toggle to view hero caption PublicationsYear published2024 (1)2021 (3)2020 (1)2018 (1)2017 (1)2016 (1)2015 (2) Facet Year publishedResearch topicsCell Biology (10)Imaging (10)Model Organisms (10)Tumour Biology (10)Chemical Biology & High Throughput (9)Computational & Systems Biology (9)Genetics & Genomics (8)Genome Integrity & Repair (7)Human Biology & Physiology (6)Developmental Biology (5)Gene Expression (4)Stem Cells (4)Biochemistry & Proteomics (3)Immunology (3)Structural Biology & Biophysics (3)Cell Cycle & Chromosomes (2)Infectious Disease (2)Metabolism (2)Microfabrication & Bioengineering (1)Neurosciences (1)Synthetic Biology (1) (-)Signalling & Oncogenes (10) Facet Research topicsPublication typeJournal article (10)Primary research (8)Commentary (1)Review (1) Facet Publication typeJournalCell Reports (2)Nature Ecology and Evolution (2)Cell systems (1)Development (1)Journal of Cell Biology (1)Nature Cancer (1)Nature Reviews Clinical Oncology (1)The Lancet (1) Facet Journal Publications Displaying 1 - 10 of 10Last updated : 28 March 2024 03:36 The artificial intelligence-based model ANORAK improves histopathological grading of lung adenocarcinoma Authors (20) Xiaoxi Pan Khalid AbdulJabbar Jose Coelho-Lima Anca-Ioana Grapa Hanyun Zhang Alvin Ho Kwan Cheung[...] TRACERx ConsortiumCharles Swanton Yinyin Yuan John Le Quesne David A Moore Nature Cancer Published 1 February 2024 Crick labs/ facilitiesPeter Van LooSamra TurajlicCharles SwantonErik SahaiGeorge KassiotisFlow CytometryExperimental HistopathologyBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Spatial patterns of tumour growth impact clonal diversification in a computational model and the TRACERx Renal study Authors (35)Xiao Fu Yue Zhao Jose I LopezAndrew RowanLewis AuAnnika Fendler[...]Erik SahaiKevin LitchfieldSamra Turajlic TRACERx Renal ConsortiumPaul Bates Nature Ecology and Evolution Published 1 January 2022 Crick labs/ facilitiesSamra TurajlicCharles SwantonErik SahaiPaul BatesExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingFull details Selection of metastasis competent subclones in the tumour interior Authors (27) Yue ZhaoXiao Fu Jose I LopezAndrew RowanLewis AuAnnika Fendler[...]Paul BatesCharles SwantonSamra Turajlic TRACERx Renal Consortium Kevin Litchfield Nature Ecology and Evolution Published 1 July 2021 Crick labs/ facilitiesSamra TurajlicCharles SwantonErik SahaiPaul BatesExperimental HistopathologyBioinformatics and BiostatisticsFull details Single-cell resolved imaging reveals intra-tumor heterogeneity in glycolysis, transitions between metabolic states, and their regulatory mechanisms Authors (9)Hiroshi KondoColin RatcliffeSteven HooperJames EllisJames MacraeMarc Hennequart Christopher W DunsbyKurt AndersonErik Sahai Cell Reports Published 16 February 2021 Crick labs/ facilitiesKaren VousdenErik SahaiMetabolomicsLight MicroscopyFlow CytometryCell ServicesBiological Research FacilityFull details Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers Authors (341) Catherine F Houlihan Nina Vora Thomas Byrne Dan LewerGavin Kelly Judith Heaney[...] Andrew Hayward Richard Gilson Gavin KellyFiona Roberts Emine Hatipoglu The Lancet Published 25 July 2020 Crick labs/ facilitiesAndreas WackKaren VousdenJernej UleJames TurnerMoritz TreeckCharles SwantonAdam SaterialeErik SahaiCaetano Reis e SousaPeter RatcliffeLucia Prieto-GodinoVenizelos PapayannopoulosAnne O’GarraPaul NurseGeorge KassiotisMaximiliano GutierrezSonia GandhiSteve GamblinPeter Cherepanov Luiz Pedro CarvalhoDominique BonnetMike BlackmanRupert BealeWorldwide Influenza CentreStructural BiologyMetabolomicsHuman Embryonic Stem CellHigh Throughput ScreeningGenetic Modification ServiceFlow CytometryFermentationExperimental HistopathologyElectron MicroscopyCell ServicesBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details Quantitative analysis reveals that actin and Src-family kinases regulate nuclear YAP1 and its export Authors (8) Nil EgeAnna DowbajMing JiangMichael HowellSteven Hooper Charles FosterRob JenkinsErik Sahai Cell systems Published 27 June 2018 Crick labs/ facilitiesRichard TreismanErik SahaiHigh Throughput ScreeningFull details Evolution and cancer medicine - transformative insights Authors (3)Erik SahaiCharles Swanton CRUK Marshall Symposium Nature Reviews Clinical Oncology Published 22 August 2017 Crick labsCharles SwantonErik SahaiFull details Integrin signalling regulates YAP and TAZ to control skin homeostasis Authors (16)Ahmed Elbediwy ZI Vincent-Mistiaen B Spencer-DeneRichard StoneStefan Boeing SK Wculek[...] H GerhardtAxel BehrensIlaria Malanchi OJ Sansom BJ Thompson Development Published 15 May 2016 Crick labs/ facilitiesBarry ThompsonErik SahaiIlaria MalanchiAxel BehrensExperimental HistopathologyBioinformatics and BiostatisticsFull details Mesenchymal cancer cell-stroma crosstalk promotes niche activation, epithelial reversion, and metastatic colonization Authors (11) Yaiza del Pozo MartinDanielle ParkAnassuya RamachandranLuigi Ombrato Fernando Calvo Probir Chakravarty Bradley Spencer-Dene Stefanie DerzsiCaroline HillErik SahaiIlaria Malanchi Cell Reports Published 22 December 2015 Crick labs/ facilitiesErik SahaiIlaria MalanchiCaroline HillExperimental HistopathologyBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityFull details MST kinases in development and disease Authors (2) Barry J ThompsonErik Sahai Journal of Cell Biology Published 14 September 2015 Crick labsBarry ThompsonErik SahaiFull details Share the page Share on Twitter Share on Facebook Share on LinkedIn Share on Email
The artificial intelligence-based model ANORAK improves histopathological grading of lung adenocarcinoma Authors (20) Xiaoxi Pan Khalid AbdulJabbar Jose Coelho-Lima Anca-Ioana Grapa Hanyun Zhang Alvin Ho Kwan Cheung[...] TRACERx ConsortiumCharles Swanton Yinyin Yuan John Le Quesne David A Moore Nature Cancer Published 1 February 2024 Crick labs/ facilitiesPeter Van LooSamra TurajlicCharles SwantonErik SahaiGeorge KassiotisFlow CytometryExperimental HistopathologyBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Spatial patterns of tumour growth impact clonal diversification in a computational model and the TRACERx Renal study Authors (35)Xiao Fu Yue Zhao Jose I LopezAndrew RowanLewis AuAnnika Fendler[...]Erik SahaiKevin LitchfieldSamra Turajlic TRACERx Renal ConsortiumPaul Bates Nature Ecology and Evolution Published 1 January 2022 Crick labs/ facilitiesSamra TurajlicCharles SwantonErik SahaiPaul BatesExperimental HistopathologyBioinformatics and BiostatisticsAdvanced SequencingFull details
Selection of metastasis competent subclones in the tumour interior Authors (27) Yue ZhaoXiao Fu Jose I LopezAndrew RowanLewis AuAnnika Fendler[...]Paul BatesCharles SwantonSamra Turajlic TRACERx Renal Consortium Kevin Litchfield Nature Ecology and Evolution Published 1 July 2021 Crick labs/ facilitiesSamra TurajlicCharles SwantonErik SahaiPaul BatesExperimental HistopathologyBioinformatics and BiostatisticsFull details
Single-cell resolved imaging reveals intra-tumor heterogeneity in glycolysis, transitions between metabolic states, and their regulatory mechanisms Authors (9)Hiroshi KondoColin RatcliffeSteven HooperJames EllisJames MacraeMarc Hennequart Christopher W DunsbyKurt AndersonErik Sahai Cell Reports Published 16 February 2021 Crick labs/ facilitiesKaren VousdenErik SahaiMetabolomicsLight MicroscopyFlow CytometryCell ServicesBiological Research FacilityFull details
Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers Authors (341) Catherine F Houlihan Nina Vora Thomas Byrne Dan LewerGavin Kelly Judith Heaney[...] Andrew Hayward Richard Gilson Gavin KellyFiona Roberts Emine Hatipoglu The Lancet Published 25 July 2020 Crick labs/ facilitiesAndreas WackKaren VousdenJernej UleJames TurnerMoritz TreeckCharles SwantonAdam SaterialeErik SahaiCaetano Reis e SousaPeter RatcliffeLucia Prieto-GodinoVenizelos PapayannopoulosAnne O’GarraPaul NurseGeorge KassiotisMaximiliano GutierrezSonia GandhiSteve GamblinPeter Cherepanov Luiz Pedro CarvalhoDominique BonnetMike BlackmanRupert BealeWorldwide Influenza CentreStructural BiologyMetabolomicsHuman Embryonic Stem CellHigh Throughput ScreeningGenetic Modification ServiceFlow CytometryFermentationExperimental HistopathologyElectron MicroscopyCell ServicesBiological Research FacilityBioinformatics and BiostatisticsAdvanced SequencingScientific computingFull details
Quantitative analysis reveals that actin and Src-family kinases regulate nuclear YAP1 and its export Authors (8) Nil EgeAnna DowbajMing JiangMichael HowellSteven Hooper Charles FosterRob JenkinsErik Sahai Cell systems Published 27 June 2018 Crick labs/ facilitiesRichard TreismanErik SahaiHigh Throughput ScreeningFull details
Evolution and cancer medicine - transformative insights Authors (3)Erik SahaiCharles Swanton CRUK Marshall Symposium Nature Reviews Clinical Oncology Published 22 August 2017 Crick labsCharles SwantonErik SahaiFull details
Integrin signalling regulates YAP and TAZ to control skin homeostasis Authors (16)Ahmed Elbediwy ZI Vincent-Mistiaen B Spencer-DeneRichard StoneStefan Boeing SK Wculek[...] H GerhardtAxel BehrensIlaria Malanchi OJ Sansom BJ Thompson Development Published 15 May 2016 Crick labs/ facilitiesBarry ThompsonErik SahaiIlaria MalanchiAxel BehrensExperimental HistopathologyBioinformatics and BiostatisticsFull details
Mesenchymal cancer cell-stroma crosstalk promotes niche activation, epithelial reversion, and metastatic colonization Authors (11) Yaiza del Pozo MartinDanielle ParkAnassuya RamachandranLuigi Ombrato Fernando Calvo Probir Chakravarty Bradley Spencer-Dene Stefanie DerzsiCaroline HillErik SahaiIlaria Malanchi Cell Reports Published 22 December 2015 Crick labs/ facilitiesErik SahaiIlaria MalanchiCaroline HillExperimental HistopathologyBioinformatics and BiostatisticsFlow CytometryBiological Research FacilityFull details
MST kinases in development and disease Authors (2) Barry J ThompsonErik Sahai Journal of Cell Biology Published 14 September 2015 Crick labsBarry ThompsonErik SahaiFull details